A photo of Sherry Thornton.

Field Service Associate Professor, UC Department of Pediatrics

513-636-1318

513-636-3328

Biography & Affiliation

Biography

I am a developmental and cell biologist who has spent over 20 years involved in research to determine the mechanisms underlying the pathogenesis of arthritis. My colleagues and I seek to determine the cells types that are associated with this condition.

I acquired a keen interest in the mechanisms of disease development when I was in graduate school, and I applied these mechanisms to gene therapy for arthritis as a postdoctoral fellow in the laboratory of Dr. Raphael Hirsch in the Division of Rheumatology at Cincinnati Children’s.

I joined the faculty in the Division of Rheumatology in 2002. In 2008, I became the director of the Research Flow Cytometry Core, a shared resource laboratory that provides the Cincinnati research community with a central location for flow cytometry instrumentation, training and education.

My research specifically involves the analysis of mechanisms underlying the pathogenesis of arthritis and specifically the determination of cell types important in subtypes of juvenile idiopathic arthritis.

I have a passion for mentoring and career development. As director of the Summer Undergraduate Research Fellowship Program at Cincinnati Children’s, I mentor undergraduate students to provide them with a foundation for making career choices in the biomedical sciences.

Research Interests

Evaluating targets for the treatment of rheumatic disease; angiogenesis; animal models of arthritis

Academic Affiliation

Field Service Associate Professor, UC Department of Pediatrics

Divisions

Rheumatology

Education

BS: Ball State University, Muncie, IN.

PhD: University of Cincinnati, College of Medicine, Cincinnati, OH.

Postdoctoral Research Fellow: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

FCRG - Fixation and Sorting for RNA. Loof, N; Mehrnoosh, A; Bergeron, A; Saluk, A; Box, A; Brundage, K; Adams, D; Dwyer, K; Meyer, E; Cochran, M; et al. Journal of Biomolecular Techniques. 2019; 30.

A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases. Thornton, S; Tan, R; Sproles, A; Do, T; Schick, J; Grom, AA; DeLay, M; Schulert, GS. Journal of immunology (Baltimore, Md. : 1950). 2019; 202:1635-1643.

Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Rheumatology. 2019; 58:321-330.

Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease. Brown, RA; Henderlight, M; Do, T; Yasin, S; Grom, AA; Delay, M; Thornton, S; Schulert, GS. Frontiers in Immunology. 2018; 9.

Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. Angeles-Han, ST; Yeh, S; Patel, P; Duong, D; Jenkins, K; Rouster-Stevens, KA; Altaye, M; Fall, N; Thornton, S; Prahalad, S; et al. Journal of Ophthalmic Inflammation and Infection. 2018; 8.

MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms. Do, T; Tan, R; Bennett, M; Medvedovic, M; Grom, AA; Shen, N; Thornton, S; Schulert, GS. Journal of Leukocyte Biology. 2018; 103:71-85.

Urine S100 proteins as potential biomarkers of lupus nephritis activity. Turnier, JL; Fall, N; Thornton, S; Witte, D; Bennett, MR; Appenzeller, S; Klein-Gitelman, MS; Grom, AA; Brunner, HI. Arthritis Research and Therapy. 2017; 19.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Journal of Clinical Investigation. 2017; 127:3152-3166.

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. Shaw, MA; Gao, Z; McElhinney, KE; Thornton, S; Flick, MJ; Lane, A; Degen, JL; Ryu, JK; Akassoglou, K; Mullins, ES. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017; 37:3776-3788.

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells. Thornton, S; Raghu, H; Cruz, C; Frederick, MD; Palumbo, JS; Mullins, ES; Almholt, K; Usher, PA; Flick, MJ. Blood Advances. 2017; 1:545-556.