High Res

Sherry L. Thornton, PhD

Academic Affiliation

Field Service Associate Professor, UC Department of Pediatrics

Phone 513-636-1318

Fax 513-636-3328

Email sherry.thornton@cchmc.org

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Research Interests

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Evaluating targets for the treatment of rheumatic disease; angiogenesis; animal models of arthritis

Visit the Grom-Thornton Lab.

Biography

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Dr. Thornton received her PhD in Developmental Biology from the University of Cincinnati College of Medicine, and did her postdoctoral fellowship in the laboratory of Dr. Raphael Hirsch in the Division of Rheumatology at Cincinnati Children’s Hospital Medical Center. She then joined the faculty in the Division of Rheumatology at Cincinnati Children's in 2002 and became director of the Research Flow Cytometry Core in 2008. Her research involves analysis of genes involved in angiogenesis or hematopoietic processes and their contribution to the pathogenesis of arthritic disease in animal models, as well as, single cell gene expression analysis of cell types important in subtypes of Juvenile Idiopathic Arthritis. She has a passion for mentoring and career development and is the director of the Summer Undergraduate Research Fellowship program at Cincinnati Children's.

Education and Training

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BS: Ball State University, Muncie, IN.

PhD: University of Cincinnati, College of Medicine, Cincinnati, OH.

Postdoctoral Research Fellow: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

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View PubMed Publications

Thornton S, Strait RT. Head-to-head comparison of protocol modifications for the generation of collagen-induced arthritis in a specific-pathogen free facility using DBA/1 mice. Biotechniques. 2016 Mar;60(3):119-28.

Schulert GS, Fall N, Harley JB, Shen N, Lovell DJ, Thornton S, Grom AA. Monocyte microRNA expression in active systemic juvenile idiopathic arthritis implicates miR-125a-5p in polarized monocyte phenotypes. Arthritis Rheumatol. 2016 Sep;68(9):2300-13.

Strait R, Thornton S, Finkelman F. Cγ1 deficiency exacerbates collagen-induced arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1780-7.

Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JD, Flick MJ. Transglutaminase factor XIII promotes arthritis in mice through mechanisms linked to inflammation and bone erosion. Blood. 2015 Jan;125(3):427-37.

Chu Z, LaSance K, Blanco V, Stevens A, Kwon C-H, Kaur B, Frederick M, Thornton S, Lemen L, Qi X. In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles. JoVE, J Vis Exp. 2014 May;(87).

Raghu H, Jone A, Cruz C, Frederick MD, Thornton S, Degen JL, Flick MJ. Plasminogen is both a positive- and negative-determinant of TNFa-driven arthritis depending on precise joint location and the availability of fibrin(ogen). Arthtis Rheumatotol. 2014 Jun;66(6):1504-16.

Qi X, Flick MJ, Frederick M, Chu Z, Mason R, DeLay M, Thornton S. Saposin C Coupled Lipid Nanovesicles Specifically Target Arthritic Mouse Joints for Optical Imaging of Disease Severity. PLoS ONE. 2012;7(3):e33966.

Sikora K, Fall N, Thornton S, Grom A. The Limited Role of Interferon-γ in Systemic Juvenile idiopathic Arthritis Cannot Be Explained by Cellular Hyporesponsiveness. Arthritis Rheum. 2012 Nov;64(11):3799-808.

Hinze CH, Fall N, Thornton S, Mo JQ, Aronow BJ, Layh-Schmitt G, Griffin TA, Thompson SD, Colbert RA, Glass DN, Barnes MG, Grom AA. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res Ther. 2010;12(3):R123.

Hermann LM, Pinkerton M, Jennings K, Yang L, Grom A, Sowders D, Kersten S, Witte DP, Hirsch R, Thornton S. Angiopoietin-like-4 is a potential angiogenic mediator in arthritis. Clin Immunol. 2005 Apr;115(1):93-101.

Grants

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Single Cell Phenotyping Core. Principal Investigator. Single Cell Phenotyping Core; National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Aug 2016-Jun 2021. AR070549.

Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease. Flow Cytometry Core Director. Integrative Morphology Core. May 2013-May 2017. P30DK078392.