Sherry L. Thornton, PhD

Biography & Affiliation Education Publications

Visit the Grom-Thornton Lab

Field Service Associate Professor, UC Department of Pediatrics

sherry.thornton@cchmc.org

513-636-1318

513-636-3328

Biography & Affiliation

Biography

Dr. Thornton received her PhD in Developmental Biology from the University of Cincinnati College of Medicine, and did her postdoctoral fellowship in the laboratory of Dr. Raphael Hirsch in the Division of Rheumatology at Cincinnati Children’s Hospital Medical Center. She then joined the faculty in the Division of Rheumatology at Cincinnati Children's in 2002 and became director of the Research Flow Cytometry Core in 2008. Her research involves analysis of genes involved in angiogenesis or hematopoietic processes and their contribution to the pathogenesis of arthritic disease in animal models, as well as, single cell gene expression analysis of cell types important in subtypes of Juvenile Idiopathic Arthritis. She has a passion for mentoring and career development and is the director of the Summer Undergraduate Research Fellowship program at Cincinnati Children's.

Research Interests

Evaluating targets for the treatment of rheumatic disease; angiogenesis; animal models of arthritis

Academic Affiliation

Field Service Associate Professor, UC Department of Pediatrics

Department

Rheumatology

Education

BS: Ball State University, Muncie, IN.

PhD: University of Cincinnati, College of Medicine, Cincinnati, OH.

Postdoctoral Research Fellow: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases. Thornton, S; Tan, R; Sproles, A; Do, T; Schick, J; Grom, AA; DeLay, M; Schulert, GS. Journal of immunology (Baltimore, Md. : 1950). 2019; 202:1635-1643.

Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Rheumatology. 2019; 58:321-330.

Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease. Brown, RA; Henderlight, M; Do, T; Yasin, S; Grom, AA; Delay, M; Thornton, S; Schulert, GS. Frontiers in Immunology. 2018; 9.

Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. Angeles-Han, ST; Yeh, S; Patel, P; Duong, D; Jenkins, K; Rouster-Stevens, KA; Altaye, M; Fall, N; Thornton, S; Prahalad, S; et al. Journal of Ophthalmic Inflammation and Infection. 2018; 8.

MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms. Do, T; Tan, R; Bennett, M; Medvedovic, M; Grom, AA; Shen, N; Thornton, S; Schulert, GS. Journal of Leukocyte Biology. 2018; 103:71-85.

Urine S100 proteins as potential biomarkers of lupus nephritis activity. Turnier, JL; Fall, N; Thornton, S; Witte, D; Bennett, MR; Appenzeller, S; Klein-Gitelman, MS; Grom, AA; Brunner, HI. Arthritis Research and Therapy. 2017; 19.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation. Kopec, AK; Abrahams, SR; Thornton, S; Palumbo, JS; Mullins, ES; Divanovic, S; Weiler, H; III, OA P; Mackman, N; Goss, A; et al. Journal of Clinical Investigation. 2017; 127:3152-3166.

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. Shaw, MA; Gao, Z; McElhinney, KE; Thornton, S; Flick, MJ; Lane, A; Degen, JL; Ryu, JK; Akassoglou, K; Mullins, ES. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017; 37:3776-3788.

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells. Thornton, S; Raghu, H; Cruz, C; Frederick, MD; Palumbo, JS; Mullins, ES; Almholt, K; Usher, PA; Flick, MJ. Blood Advances. 2017; 1:545-556.

Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA-125a-5p in Polarized Monocyte Phenotypes. Schulert, GS; Fall, N; Harley, JB; Shen, N; Lovell, DJ; Thornton, S; Grom, AA. Arthritis and Rheumatology. 2016; 68:2300-2313.