Photo of { Davy Vanhoutte, PhD}

Davy Vanhoutte, PhD

  • Assistant Professor, UC Department of Pediatrics

About

Interests

Extracellular matrix remodeling and cell–matrix communication in heart and skeletal muscle disease; molecular mechanisms of cardiomyopathy and muscular dystrophy; development of matrix-directed and gene-based therapies

Research Areas

Publications

Selected

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Nature Communications. 2021; 12(1):3928.

Selected

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; Ross, RS; Molkentin, JD. Nature Communications. 2019; 10(1):76.

Selected

Thrombospondin expression in myofibers stabilizes muscle membranes. Vanhoutte, D; Schips, TG; Kwong, JQ; Davis, J; Tjondrokoesoemo, A; Brody, MJ; Sargent, MA; Kanisicak, O; Yi, H; Gao, QQ; Rabinowitz, JE; Volk, T; Mcnally, EM; Molkentin, JD. eLife. 2016; 5.

Selected

A thrombospondin-dependent pathway for a protective ER stress response. Lynch, JM; Maillet, M; Vanhoutte, D; Schloemer, A; Sargent, MA; Blair, NS; Lynch, KA; Okada, T; Aronow, BJ; Osinska, H; Mori, K; Lawler, J; Robbins, J; Molkentin, JD. Cell. 2012; 149(6):1257-1268.

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AKT; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ESS; Kofron, JM; Devarajan, P. Scientific Reports. 2024; 14(1):29307.

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner. Vanhoutte, D; Schips, TG; Minerath, RA; Huo, J; Kavuri, NSS; Prasad, V; Lin, S-C; Bround, MJ; Sargent, MA; Adams, CM; Molkentin, JD. Cell reports. 2024; 43(5):114149.

Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis. Rudman-Melnick, V; Adam, M; Stowers, K; Potter, A; Ma, Q; Chokshi, SM; Vanhoutte, D; Valiente-Alandi, I; Lindquist, DM; Nieman, ML; Kofron, JM; Chung, E; Park, J-S; Potter, SS; Devarajan, P. Scientific Reports. 2024; 14(1):439.

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Huo, J; Prasad, V; Grimes, KM; Vanhoutte, D; Blair, NS; Lin, S-C; Bround, MJ; Bers, DM; Molkentin, JD. Cell reports. 2023; 42(11):113465.

Abstract P3186: Mcub Is An Inducible Regulator Of Calcium-dependent Mitochondrial Metabolism. Huo, J; Prasad, V; Grimes, K; Vanhoutte, D; Blair, S; Bround, M; Bers, DM; Molkentin, JD. Circulation Research. 2023; 133(Suppl_1).

Rpl3l gene deletion in mice reduces heart weight over time. Grimes, KM; Prasad, V; Huo, J; Kuwabara, Y; Vanhoutte, D; Baldwin, TA; Bowers, SLK; Johansen, AKZ; Sargent, MA; Lin, S-CJ; Molkentin, JD. Frontiers in Physiology. 2023; 14:1054169.

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