Human pluripotent stem cells; in vitro models of human development; morphogen signaling pathways and control of cell fates; BMP, WNT, and nodal signaling pathways; self-organized developmental patterning; germ layer formation and differentiation; ectoderm patterning and morphogenesis
Pattern Formation in Cell Cultures. Annual Review of Biophysics. 2026.
ETVs dictate hPSC differentiation by tuning biophysical properties. Nature Communications. 2025; 16(1):1999.
Criteria for the standardization of stem-cell-based embryo models. Nature Cell Biology. 2024; 26(10):1625-1628.
Combinatorial interpretation of BMP and WNT controls the decision between primitive streak and extraembryonic fates. Cell Systems. 2024; 15(5):445-461.e4.
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications. 2022; 13(1):6681.
cytoNet: Spatiotemporal network analysis of cell communities. PLoS Computational Biology. 2022; 18(6):e1009846.
Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids. Nature Communications. 2022; 13(1):497.
Reaction-diffusion models for morphological patterning of hESCs. Journal of Mathematical Biology. 2021; 83(5):55.
Human neural tube morphogenesis in vitro by geometric constraints. Nature. 2021; 599(7884):268-272.
BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo. Biology Open. 2021; 10(9).