Photo of { Aryeh Warmflash, PhD}

Aryeh Warmflash, PhD


  • Member, Division of Developmental Biology
  • Center for Stem Cell and Organoid Medicine
  • Professor, UC Department of Pediatrics

About

Interests

Human pluripotent stem cells; in vitro models of human development; morphogen signaling pathways and control of cell fates; BMP, WNT, and nodal signaling pathways; self-organized developmental patterning; germ layer formation and differentiation; ectoderm patterning and morphogenesis

Publications

Pattern Formation in Cell Cultures. Roy, K; Warmflash, A. Annual Review of Biophysics. 2026.

ETVs dictate hPSC differentiation by tuning biophysical properties. Ziojła, NM; Socha, M; Guerra, MC; Kizewska, D; Blaszczyk, K; Urbaniak, E; Henry, S; Grabowska, M; Niakan, KK; Warmflash, A; Borowiak, M. Nature Communications. 2025; 16(1):1999.

Criteria for the standardization of stem-cell-based embryo models. Martinez Arias, A; Rivron, N; Moris, N; Tam, P; Alev, C; Fu, J; Hadjantonakis, A-K; Hanna, JH; Minchiotti, G; Pourquie, O; Sheng, G; Solnica Krezel, L; Veenvliet, JV; Warmflash, A. Nature Cell Biology. 2024; 26(10):1625-1628.

Combinatorial interpretation of BMP and WNT controls the decision between primitive streak and extraembryonic fates. Camacho-Aguilar, E; Yoon, ST; Ortiz-Salazar, MA; Du, S; Guerra, MC; Warmflash, A. Cell Systems. 2024; 15(5):445-461.e4.

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Sempou, E; Kostiuk, V; Zhu, J; Cecilia Guerra, M; Tyan, L; Hwang, W; Camacho-Aguilar, E; Caplan, MJ; Zenisek, D; Warmflash, A; Owens, NDL; Khokha, MK. Nature Communications. 2022; 13(1):6681.

cytoNet: Spatiotemporal network analysis of cell communities. Mahadevan, AS; Long, BL; Hu, CW; Ryan, DT; Grandel, NE; Britton, GL; Bustos, M; Gonzalez Porras, MA; Stojkova, K; Ligeralde, A; Warmflash, A; Brey, EM; Kim, YS; Qutub, AA. PLoS Computational Biology. 2022; 18(6):e1009846.

Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids. Liu, L; Nemashkalo, A; Rezende, L; Jung, JY; Chhabra, S; Guerra, MC; Heemskerk, I; Warmflash, A. Nature Communications. 2022; 13(1):497.

Reaction-diffusion models for morphological patterning of hESCs. Bedekar, P; Timofeyev, I; Warmflash, A; Perepelitsa, M. Journal of Mathematical Biology. 2021; 83(5):55.

Human neural tube morphogenesis in vitro by geometric constraints. Karzbrun, E; Khankhel, AH; Megale, HC; Glasauer, SMK; Wyle, Y; Britton, G; Warmflash, A; Kosik, KS; Siggia, ED; Shraiman, BI; Streichan, SJ. Nature. 2021; 599(7884):268-272.

BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo. Chhabra, S; Warmflash, A. Biology Open. 2021; 10(9).