A photo of Hector Wong.

Vice Chair, Department of Pediatrics

Professor, UC Department of Pediatrics

513-636-4259

513-636-4267

Board Certified

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My Biography & Research

Biography

Each year, 1.2 million children develop sepsis. The tremendous, but underappreciated, public health burden secondary to sepsis led me to research and care for this life-threatening condition.

In critical care medicine, we are in a unique position to watch what’s happening at the bedside and take that information back to the lab for formal hypothesis testing — and vice versa. In 2018, I received a National Institutes of Health Maximizing Investigators Award to do just that.

In my lab, we develop tools to disentangle the complexity of sepsis so we can bring precision medicine to critically ill children's bedsides. Our work is backed by a robust repository of biological samples and clinical data for children with sepsis. In fact, all of our current and planned laboratory-based research efforts are driven by discoveries generated from our clinical and biological database of children with sepsis.

Every day my team and I have the opportunity to positively impact the outcome of the sickest children.

Additional Languages

Spanish

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Pediatric Intensive Care Unit PICU

Research Divisions

Critical Care

My Education

MD: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, 1989.

Residency: Department of Pediatrics, George Washington University School of Medicine, Children's National Medical Center, Washington, DC, 1990 to 1992.

Fellowship: Clinical Fellow, Department of Anesthesiology, Division of Pediatric Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1992 to 1995; Research Fellow, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1992 to 1995.

Certification: National Board of Medical Examiners, 1990; Diplomate, American Board of Pediatrics, 1993; American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 1996.

My Publications

Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities. Meert, KL; Reeder, RW; Maddux, AB; Banks, R; Berg, RA; Newth, CJ; Hall, MW; Quasney, M; Carcillo, JA; McQuillen, PS; et al. Pediatric Critical Care Medicine. 2021; 22:e302-e313.

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Kangelaris, KN; Clemens, R; Fang, X; Jauregui, A; Liu, T; Vessel, K; Deiss, T; Sinha, P; Leligdowicz, A; Liu, KD; et al. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2021; 320:L892-L902.

Sepsis Subclasses: A Framework for Development and Interpretation. Demerle, KM; Angus, DC; Baillie, JK; Brant, E; Calfee, CS; Carcillo, J; Chang, CC H; Dickson, R; Evans, I; Gordon, AC; et al. Critical Care Medicine. 2021; 49:748-759.

T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis. Marsh, RA; Zoref-Lorenz, A; Owsley, E; Chaturvedi, V; Nguyen, TC; Goldman, JR; Henry, MM; Greenberg, JN; Ladisch, S; Hermiston, ML; et al. Blood. 2021; 137:2337-2346.

A Precision Medicine Approach to Biomarker Utilization in Pediatric Sepsis-Associated Acute Kidney Injury. Odum, JD; Wong, HR; Stanski, NL. Frontiers in Pediatrics. 2021; 9.

Circulatory Failure/Shock. Pfeiffer, S; Wong, HR. Pediatric Critical Care. 2021.

Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission. Banerjee, S; Mohammed, A; Wong, HR; Palaniyar, N; Kamaleswaran, R. Frontiers in Immunology. 2021; 12.

Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock. Kassam, AF; Levinsky, NC; Mallela, JP; Angel, K; Opoka, A; Lahni, P; Sahay, RD; Fei, L; Nomellini, V; Wong, HR; et al. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:216-223.

Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation. Wong, HR; Reeder, RW; Banks, R; Berg, RA; Meert, KL; Hall, MW; McQuillen, PS; Mourani, PM; Chima, RS; Sorenson, S; et al. Pediatric Critical Care Medicine. 2021; 22:8-15.

External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients. Wong, HR; Hart, KW; Lindsell, CJ; Sweeney, TE. Critical Care Medicine. 2021; 49:e98-e101.