Susan E. Wert, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4297

Fax 513-636-7868

Email susan.wert@cchmc.org

Clinical

Lung development, injury and repair as it pertains to molecular morphology (gene and protein expression in situ); ultrastructure, and histopathology of the developing and adult ung; the histopathology of the human lung as it relates to interstitial lung disease, especially to genetic disorders of surfactant dysfunction in the neonatal and pediatric population that are caused by mutations in the human SFTPC, SFTPB, and ABCA3 genes.

Research

Structural morphology of the lung; tissue responses to acute and chronic lung injury; morphogenesis and cytodifferentiation of the developing lung; use of gene knock out and transgenic mouse models to study mechanisms of lung development and genetic lung disease ; development of molecular markers for the study of respiratory epithelial cell differentiation and for cell lineage studies; image analysis and morphometry.

PhD: Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 1988.

Postdoctoral Fellowship: Perinatology, Division of Neonatology, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 1988-1991.

View PubMed Publications

Wert SE. Normal and Abnormal Structural Development of the Lung. In: “Fetal and Neonatal Physiology”; 5th edition; Polin RA, Abman SH, Rowitch DH, Benitz WE, Fox WW. (Eds); Saunders; Philadelphia. 2016;627-641.

Wert SE, Wikenhieser-Brokamp KA. Congenital Malformations of the Lung. In: “Fetal Lung Development”; Jobe A, Whitsett JA, Abman S (Eds.); Cambridge University Press; Cambridge. 2016;94-125.

Whitsett JA, Pryhuber GS, Rice WR, Wert SE. Acute respiratory disorders. In: "Avery’s Neonatology: Pathophysiology and Management of the Newborn"; 7th edition; MacDonald MG, Seshia MK (Eds). Wolters Kluwer (Lippincott, Williams & Wilkins; Philadelphia). 2016;397-415.

Fan LL, Dishop MK, Galambos C, Askin FB, White FV, Langston C, Liptzin DR, Kroehl ME, Deutsch GH, Young LR, Kurland G, Hagood J, Dell S, Trapnell BC, Deterding RR; Children’s Interstitial and Diffuse Lung Disease Research Network (chILDRN). Diffuse lung disease in biopsied children 2 to 18 years of age. Application of the chILD classification scheme. Ann Am Thorac Soc. 2015 Oct;12(10):1498-505.

Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Wert SE, Zorn AM. A molecular atlas of Xenopus respiratory system development. Dev Dyn. 2015 Jan;244(1):69-85.

Wagh PK, Gardner MA, Ma X, Callahan M, Shannon JM, Wert SE, Messinger YH, Dehner LP, Hill DA, Wikenheiser-Brokamp KA. Cell and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. J Pathol. 2015 May;236(1):41-52.

Whitsett JA, Wert SE, Weaver TE. Diseases of pulmonary surfactant homeostasis. Annu Rev Pathol. 2015 Jan 24;10:371-93.

Lange AW, Haitchi, HM, LeCras TD, Sridharan A, Xu Y, Wert SE, James J, Udell N, Thurner PJ, Whitsett JA. Sox17 is required for normal pulmonary vascular morphogenesis. Dev Biol. 2014 Mar 1;387(1):109-20.

Wambach JA, Casey AM, Fishman MP, Wegner DJ, Wert SE, Cole FS, Hamvas A, Nogee LM. Genotype-phenotype correlations for infants and children with ABCA3 deficiency. Am J Respir Crit Care Med. 2014 Jun 15;189(12):1538-43.

Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N, Whitsett JA. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39.

OSR Transcription Factors Regulate Embryonic Lung Development. Co-investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Aug 2012 - Dec 2017. R01HL114898.

Transcriptional programming of asthma related pathology in respiratory epithelia. Co-investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Apr 2013 - Mar 2018. R01HL095580-05.