Acetaminophen and Codeine Phosphate (Capital and Codeine, Tylenol with Codeine)

(uh-seet-uh-MIN-oh-fin) (KOH-deen)

Acetaminophen and codeine (Capital and Codeine Phosphate, Tylenol with Codeine Phosphate) are a combination medicine used to relieve pain.

They can also be used to reduce coughing.

Special Instructions

  • Give only the amount prescribed by your child's doctor.
  • Your child should not take this medicine more than five times in one day.
  • If giving your child the liquid form, measure each dose using an oral syringe or medicine spoon. Be careful to ensure the amount is correct.
  • This medicine can be given with food to prevent stomach upset.
  • Do not give your child acetaminophen (Tylenol, Genapap, Panadol, Tempra) or other over-the-counter medicines that contain acetaminophen while using this medicine.
  • Check the labels on all over-the-counter medicines you give your child to make sure they do not contain acetaminophen. Too much acetaminophen may be harmful.
  • Do not give this medicine if your child is allergic to codeine or morphine. Contact your child’s doctor.
  • This medicine may make your child drowsy. Watch your child closely during tasks where they need to be alert (such as climbing stairs).
  • If your child needs this medicine for a long period of time, the dose may need to be slowly decreased and not stopped quickly.
  • Do not use after the expiration date on the bottle or package.
  • Keep this medicine out of the reach of children.
  • Contact your doctor if you give your child too much medicine.
  • If too much medicine is taken by mistake, call the Drug and Poison Information Center (DPIC) at 513-636-5111 or 1-800-222-1222, or call your child's doctor right away.

If Your Child Misses a Dose

If you have been told to give this medicine to your child on a routine schedule and you miss a dose, give it as soon as you remember it.

But, if it is almost time for the next dose, skip the missed dose. Go back to the normal dosing schedule. Do NOT give double the dose to catch up.

For information about your child's dosing schedule and/or missed doses, contact the doctor who prescribed the medicine.

Possible Side Effects of Medicine

It is possible to have serious side effects. This can include slowed breathing or other problems breathing. Children may be more likely to have these serious side effects, even more so if they already have breathing problems. 

Other side effects can include being:

  • Drowsy
  • Dizzy
  • Constipated
  • Nauseous (upset belly)

Call Your Child's Doctor If Your Child Has:

  • Problems breathing
  • Skin rashes, hives or itching
  • Nausea (upset belly) or is throwing up
  • Problems waking up or is very sleepy
  • A yellow tint to the skin or eyes

Other Information

Constipation (hard or few stools) can be a problem when taking any medicine with codeine. The doctor may also want your child to take a medicine to help them go to the bathroom. Be sure to keep your child well hydrated.

Call your child's doctor if the pain and/or cough are not helped by this medicine.

Dosage Forms Available


Tylenol with Codeine No. 2 (acetaminophen 300 mg + codeine 15 mg)
Tylenol with Codeine No. 3 (acetaminophen 300 mg + codeine 30 mg)
Tylenol with Codeine No. 4 (acetaminophen 300 mg + codeine 60 mg)

Suspension, Alcohol Free

Acetaminophen 120 mg + codeine 12 mg per 5 mL

Elixir, 7% Alcohol

Acetaminophen 120 mg + codeine 12 mg per 5 mL

Last Updated 11/2018