There are four major types of EB. Although each subtype has a specific genetic causes, there is a wide range of severity, even within subtypes. Each type differs from mild to severe in terms of appearance, genetic makeup, the area of the skin where there is blistering, and how much other parts of the body are involved.
Epidermolysis Bullosa Simplex
In mild cases, there is blistering mainly on the hands and feet with little or no scarring. Severe cases have more widespread blistering and other serious medical conditions such as blisters in the mouth. and digestive tract.
Junctional Epidermolysis Bullosa
The milder forms have limited blistering that often improves with age. Children may also have hair loss and abnormal toenails and fingernails. In older children and adults, there can be blisters in the lining of the mouth and digestive tract, making it hard to eat and digest food. Children are more likely to have growth and malnutrition issues. Severe cases may be fatal in infancy.
Dystrophic Epidermolysis Bullosa
This is scarring type of EB. In mild cases, the blistering is primarily found on hands, feet, knees and elbows. Patients with more severe disease may experience a variety of serious medical conditions including blisters in the lining of the mouth and digestive tract, poor growth and nutrition, and anemia. With the severe type, there is a higher risk of developing skin cancer as they patients get older.
In addition to blistering, these individuals have an increased sensitivity to sunlight.