After 1 Year, Weekly Doses of Dupilumab Most Effective at Managing Eosinophilic Esophagitis
After one year of follow-up, a 65-center, 10-nation clinical study reinforces earlier findings that weekly dupilumab treatment for eosinophilic esophagitis (EoE) produces stronger histologic, symptomatic, endoscopic, and molecular improvements compared to treatment every two weeks.
Results from the study, led by Cincinnati Children’s physician–scientist Marc Rothenberg, MD, PhD, from Cincinnati Children’s, were published online Aug. 31, 2023, in The Lancet: Gastroenterology and Hepatology.
Dupilumab is a biologic that blocks the shared receptor component for interleukin 4 and interleukin 13, two cytokines known to be involved in pathogenesis of EoE. More information about this double-blind, randomized, placebo-controlled, phase 3 study can be found at ClinicalTrials.gov, number NCT03633617.
In addition to this study, the cover of the journal’s September print edition focuses on another research study led by Rothenberg and colleagues. Those findings, published online in June, report that the monoclonal antibody benralizumab successfully reduces eosinophil cell counts but does not improve the symptoms nor biomarker results for eosinophilic gastritis (EoG).
Read More: Wider Search Needed to Better Treat Eosinophilic Food Allergy.
(Published December 2023)
