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In fiscal year 2019, the outstanding faculty of the Cincinnati Children’s Research Foundation have collaborated on an impressive body of work. The following stories summarize seven of our most significant findings of the year, as selected by a committee of senior research leaders.
First Human Esophagus Organoid Grown from Pluripotent Stem Cells James Wells, PhD, and Stephen Trisno
Probiotics Show No Benefit for Children with Acute Gastroenteritis David Schnadower, MD
PROTECT Study Produces New Model for Treating Children with Ulcerative Colitis Lee Denson, MD
Daily Hydroxyurea Pill Safely Lowers Sickle Cell Burden Among African Children Russell Ware, MD, PhD; Leon Tshilolo, MD, PhD; Adam Lane, PhD; Susan Stuber, MA; Teresa Latham, MA; and Patrick McGann, MD.
CYCLOPS Algorithm Helps Build Database of Cycling Genes in 13 Human Tissues Marc Ruben, PhD, John Hogenesch, PhD, and David Smith, MD
How the Gut Microbiome Influences Lean Vs. Obese Phenotypes Theresa Alenghat, VMD, PhD, Jordan Whitt, Vivienne Woo, Patrick Lee, Jessica Moncivaiz, Yael Haberman Ziv, MD, PhD, Lee Denson, MD, and Patrick Tso, PhD.
How Light Therapy Might Prevent Vision Problems in Preterm Infants Minh-Thanh Nguyen, PhD, and Richard Lang, PhD