The skin microbiome plays a critical role in the development and progression of atopic dermatitis (AD). Alterations in microbial composition, particularly Staphylococcus aureus colonization, contribute to inflammation and disease exacerbation. Our lab investigates how S. aureus interacts with the host immune system, focusing on its gene expression alterations that impact disease severity. Through gene profiling and microbiome analysis, we aim to identify bacterial factors that drive skin inflammation and uncover potential therapeutic targets to prevent exacerbations and reduce the susceptibility of progression to other allergic conditions.

Immune cells play an important role in inflammatory responses during AD. Mast cells, specifically, are known to be critical drivers of allergic responses, but their role in AD is understudied. Our lab examines how mast cells interact with components of the skin, such as melanin, to influence their migration and degranulation. By studying these mechanisms, we aim to understand how mast cells contribute to skin inflammation and progression to allergic comorbidities. Our goal is to identify novel biomarkers that could inform early diagnosis of other allergic conditions thereby improving clinical outcomes for children with AD.