Asthma Research

Publications

Aguree, S; Silveyra, P; Liu, N; Mersha, TB. Cardiometabolic and Inflammatory Profiles in Individuals With Asthma and Diabetes Comorbidity. Current Developments in Nutrition. 2025; 9:107006.

Akbaryan, A; Churchill, ML; McGrath, M; Alshawabkeh, A; Enlow, MB; Brennan, PA; Collazo Vargas, J; Costello, LA; D'Sa, V; Dunlop, A; Woodruff, T; Wright, RJ; Shuffrey, LC; ECHO Cohort Consortium, . COVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program. JAMA Network Open. 2025; 8:e2530346.

Alemu, R; Sharew, NT; Arsano, YY; Ahmed, M; Tekola-Ayele, F; Mersha, TB; Amare, AT. Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues. Human Genomics. 2025; 19:8.

Altman, MC; Janczyk, T; Murphy, RC; Jayavelu, ND; Calatroni, A; Kattan, M; Gill, MA; Stokes, J; Liu, AH; Khurana Hershey, GK; Gern, JE; Bacharier, LB; Busse, WW; Jackson, DJ. Inflammatory Pathways in Residual Asthma Exacerbations Among Mepolizumab-Treated Urban Children: A Secondary Analysis of a Randomized Clinical Trial. JAMA pediatrics. 2025; 179:957-970.

Assa'ad, AH; Ding, L; Duan, Q; Mersha, TB; Warren, C; Bilaver, L; Ullrich, M; Wlodarski, M; Jiang, J; Choi, JJ; Tobin, MC; Mahdavinia, M; Sharma, H; Gupta, RS. Total Serum IgE in a Cohort of Children With Food Allergy. The Journal of Allergy and Clinical Immunology: in Practice. 2025; 13:803-813.e3.

Barnes, CS; Khurana Hershey, GK. Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease. The Journal of Allergy and Clinical Immunology: in Practice. 2025; 13:1267-1271.

Bloom, MS; Upadhyaya, S; Nzegwu, AW; Kuiper, JR; Buckley, JP; Aschner, J; Barr, D; Barrett, ES; Bennett, DH; Dabelea, D; Woodcroft, K; Sitarik, A; Wegienka, G; Cassidy-Bushrow, A. Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort. Journal of Exposure Science and Environmental Epidemiology. 2025; 35:992-1002.

Bragg, MG; Rando, J; Carroll, KN; Eick, SM; Karagas, MR; Lin, P; Schmidt, RJ; Lyall, K; ECHO Cohort Consortium, . The Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort. The Journal of nutrition. 2025; 155:1938-1951.

Brunwasser, SM; Gebretsadik, T; Satish, A; Cole, JC; Dupont, WD; Joseph, C; Bendixsen, CG; Calatroni, A; Arbes, SJ; Fulkerson, PC; Teach, SJ; Zoratti, EM; Togias, A; Hartert, TV. Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children. Preventive Medicine Reports. 2025; 49:102936.

Cantrell, R; Alex Feldman, H; Rosenfeldt, L; Ali, A; Gourley, B; Sprague, C; Leino, D; Crosby, J; Revenko, A; Monia, B; Waggoner, SN; Palumbo, JS. Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice. JCI insight. 2025; 10:e181063.

Castro-Rodriguez, JA; Wolters, AA B; Rodriguez-Martinez, CE; Biagini, JM; Celedón, JC; Custovic, A; Koppelman, GH; Phipatanakal, W; Saglani, S; Forno, E. Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma. The Journal of Allergy and Clinical Immunology: in Practice. 2025; 13:2537-2551.

Chang, WC; Burkle, JW; Williams, LR; Hammonds, MK; Weheba, FA; Satish, L; Martin, LJ; Guilbert, TW; Sherenian, MG; Mersha, TB; Biagini, JM; Khurana Hershey, GK. Race-Specific and Race-Neutral Equations for Lung Function and Asthma Diagnosis in Black Children. JAMA Network Open. 2025; 8:e2462176.

da Silva Antunes, R; Sutherland, A; Abawi, A; Frazier, A; Pomés, A; Glesner, J; Slater, JE; Mindaye, ST; Cho, K; Zhou, G; Togias, A; Busse, WW; Jackson, DJ; Sette, A. Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content. Journal of Allergy and Clinical Immunology. 2025; 156:1303-1313.

Dahal, A; Chang, WC; Johansson, E; Grashel, B; Morgan, D; Williams, L; Hammonds, M; Sachdeva, S; Spagna, D; Satish, L; Biagini, JM; Martin, LJ; Haslam, DB; Ollberding, NJ; Khurana Hershey, GK. Skin Staphylococcus aureus detection and relationship to atopic dermatitis outcomes using culture and metagenomic sequencing. Scientific Reports. 2025; 15:17606.

Derbie, A; Maier, M; Amare, B; Misgan, E; Nibret, E; Biadglegne, F; Liebert, UG; Minas, TZ; Yenesew, MA; Nigatu, D; Mersha, TB; Enquobahrie, DA; Woldeamanuel, Y; Abebe, T. HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions. JAMA Network Open. 2025; 8:e2459698.

DeVore, SB; Khurana Hershey, GK. MYC is in the CARDs: CBM complexes coordinate immune and MYC-dependent cellular function. Frontiers in Molecular Medicine. 2025; 5.

Emmert, AS; Ruan, T; Sherenian, MG; Assa’ad, AH; Leitsinger, N; Schultz, L; Jain, VV; Sturm, PF; Jones, AC. Prevalence of metal hypersensitivity in pediatric spine surgery. Spine Deformity. 2025; 13:667-671.

Gaberino, CL; Altman, MC; Gill, MA; Bacharier, LB; Gruchalla, RS; O'Connor, GT; Kumar, R; Khurana Hershey, GK; Kattan, M; Liu, AH; Visness, C; Gern, JE; Busse, WW; Jackson, DJ. Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban children. Journal of Allergy and Clinical Immunology. 2025; 155:1499-1509.

Gaberino, CL; Segnitz, RM; Dill-McFarland, KA; Bacharier, LB; Calatroni, A; Gill, MA; Stokes, J; Liu, AH; Cohen, RT; Kumar, R; Togias, A; Busse, WW; Jackson, DJ; Altman, MC. Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma. Nature Communications. 2025; 16:8191.

Gallo, PH; Kathju, A; Satish, L. Bioluminescent monitoring of a co-culture model of pathogen growth to identify a novel probiotic bacterium. BMC Research Notes. 2025; 18:434.

Lawson, LP; Parameswaran, S; Panganiban, RA; Constantine, GM; Weirauch, MT; Kottyan, LC. Update on the genetics of allergic diseases. Journal of Allergy and Clinical Immunology. 2025; 155:1738-1752.

Liu, C; Chow, SM; Aris, IM; Dabelea, D; Neiderhiser, JM; Leve, LD; Blair, C; Catellier, DJ; Couzens, L; Braun, JM; Weiss, ST; Elliott, AJ; Hockett, CW; Ganiban, JM. Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort. JAMA Network Open. 2025; 8:e2511835.

Marchant, J; Ferrell, M; Wei, Y; Baron, K; Blackwell, CK; Sigal, A; Geiger, S; Schantz, SL; Hartert, T; Kelly, RS; Farzan, S; Gilliland, FD; Hertz-Picciotto, I; Bennett, DH D. Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study. Sleep Advances. 2025; 6:zpaf049.

Martin, LJ; He, H; Spagna, D; Jenkins, S; Grashel, B; Chang, WC; Williams, L; Hammonds, M; Johansson, E; Sherenian, MG; Biagini, JM; Satish, L; Kottyan, L; Khurana Hershey, GK. Genome-wide cross-trait analysis of heterogeneous outcomes in early life atopic dermatitis. Pediatric Allergy and Immunology. 2025; 36:e70253.

Melough, MM; McGrath, M; Palmore, M; Collett, BR; Kerver, JM; Hockett, CW; Schmidt, RJ; Kelly, RS; Lyall, K; Zhao, Q; Zoratti, EM; Habre, R; Farzan, S; Gilliland, FD. Gestational vitamin D concentration and child cognitive development: a longitudinal cohort study in the Environmental influences on Child Health Outcomes Program. American Journal of Clinical Nutrition. 2025; 122:571-581.

Mendy, A; Mersha, TB. Epigenetic age acceleration and mortality risk prediction in US adults. GeroScience. 2025; 47:6029-6038.

Miller, RL; Schuh, H; Chandran, A; Habre, R; Angal, J; Aris, IM; Aschner, JL; Bendixsen, CG; Blossom, J; Bosquet-Enlow, M; Wright, RJ; Zanobetti, A; Zoratti, EM; Johnson, CC. Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program. Journal of Allergy and Clinical Immunology. 2025; 156:627-639.

Mirzakhani, H; Wang, AL; Sharma, R; Sun, M; Panganiban, R; Lu, Q; McGeachie, M; Lu, Z; Litonjua, AA; Tantisira, KG; Weiss, ST. Early-life microRNA signatures in cord blood associated with allergic rhinitis and asthma development. Journal of Allergy and Clinical Immunology. 2025; 156:129-138.

Nigra, AE; Bloomquist, TR; Rajeev, T; Burjak, M; Casey, JA; Goin, DE; Herbstman, JB; Ornelas Van Horne, Y; Wylie, BJ; Cerna-Turoff, I; Elliott, AJ; O'Connor, TG; Kress, AM; ECHO Cohort Consortium, . Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort. JAMA Network Open. 2025; 8:e2514084.

Niu, Z; Ako, AA; Geiger, SD; Howe, CG; Perng, W; Singh, R; Karagas, MR; Elliott, AJ; Cassidy-Bushrow, A; Camargo, CA; Breton, CV; Bastain, TM; Farzan, SF; ECHO Cohort Consortium, . Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years. JAMA Network Open. 2025; 8:e259205.

Palmore, M; Thompson, EE; Fang, F; Bastain, TM; Breton, C; Collingwood, S; Gilliland, FD; Gold, DR; Habre, R; Hartert, T; Gern, J; McKennan, C; Ober, C; Ladd-Acosta, C. Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO. Environmental Epigenetics. 2025; 11:dvaf013.

Phelan, KJ; Khurana Hershey, GK. Frequent exacerbator-a novel endotype of pediatric asthma. Journal of Allergy and Clinical Immunology. 2025; 156:61-69.

Phelan, KJ; Roskin, KM; Burkle, JW; Chang, WC; Martin, LJ; Biagini, JM; Satish, L; Haslam, DB; Spagna, D; Jenkins, S; Visness, CM; Altman, MC; Gern, JE; Khurana Hershey, GK. Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life. Journal of Allergy and Clinical Immunology. 2025; 156:640-650.

Pokhrel, D; Tahmin, N; Carlisle, A; Mersha, TB; Davis, RL; Khojandi, A. (2025) Assessing the Role of Social Determinants in Asthma Across Racial Groups: A Comparative Model Analysis. Institute of Electrical and Electronics Engineers (IEEE). 0:348-353.

Rabin, RL; Altman, MC; Arshad, SH; Beger, RD; Frischmeyer-Guerrerio, PA; Goleva, E; Hamilton, RG; Khurana Hershey, GK; Shamji, MH; Sampson, HA; Hise, K; Lee, J; Tripathi, A; Slater, JE. Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop. Journal of Allergy and Clinical Immunology. 2025; 155:1753-1766.

Rosas-Salazar, C; Gebretsadik, T; Seibold, MA; Moore, CM; Arbes, SJ; Bacharier, LB; Brunwasser, SM; Camargo, CA; Dupont, WD; Furuta, GT; Zoratti, EM; Togias, A; Fulkerson, PC; Hartert, TV. Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility. Journal of Allergy and Clinical Immunology. 2025; 156:1379-1389.e10.

Rose, T; Lambert, S; Liu, C; Raghunathan, RS; Musci, RJ; Sullivan, AD W; Lyall, K; Elliott, AJ; McEvoy, CT; Frazier, JA; Bennett, DH; Schweitzer, JB; Schmidt, RJ; LaSalle, JM. Socio-ecological domains and adolescent mental health: An application of the dual-factor model. Journal of Research on Adolescence. 2025; 35:e70029.

Schoettler, N; Gebretsadik, T; Singh, S; Gress, L; Mendonça, EA; Snyder, BM; Eapen, AA; LeBeau, P; Gangnon, R; Seroogy, CM; Pierce, M; Polacek, DA; Poleon, K; Rajamanickam, V. Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses. Pediatric Allergy and Immunology. 2025; 36:e70165.

Sherenian, MG; Chang, WC; Almasri, C; Biagini, JM; Togias, A; Khurana Hershey, GK. Objective sensitization algorithm validates parental report of food allergy in children. Journal of Allergy and Clinical Immunology: Global. 2025; 4:100512.

Shook, MS; Lu, X; Chen, X; Edsall, LE; Granitto, M; Virolainen, SJ; Forney, C; Donmez, OA; Parameswaran, S; Fadden, C; Martin, LJ; Satish, L; Weirauch, MT; Kottyan, LC. Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants. Journal of Allergy and Clinical Immunology. 2025; 156:S0091-6749(25)00862-0.

Sitarik, AR; Eapen, AA; Biagini, JM; Jackson, DJ; Joseph, CL M; Kim, H; Martin, LJ; Rivera-Spoljaric, K; Schauberger, EM; Wegienka, G; Singh, S; Wright, AL; Gern, JE; Singh, AM. Phenotypes of Atopic Dermatitis and Development of Allergic Diseases. JAMA Network Open. 2025; 8:e2515094.

Tegegne, AS; Yenesew, MA; Asemahagn, MA; Mersha, TB; Deribew, A; Belete, MB; Mekonnen, A; Enquobahrie, DA; Awoke, W; Minas, TZ; Taye, B; Fentahun, N. Trends and spatio temporal distribution of HIV related programmatic indicators in North West Ethiopia from July 2018 up to June 2024. Scientific Reports. 2025; 15:15234.

Thompson, EE; Zhong, X; Carbonetto, P; Morin, A; Willwerscheid, J; Visness, CM; Bacharier, LB; Kattan, M; O'Connor, GT; Rivera-Spoljaric, K; Jackson, DJ; Gern, JE; McKennan, CG; Ober, C. Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children. The American Journal of Human Genetics. 2025; 112:1610-1624.

Togias, A; Gergen, PJ; Liu, AH; Kim, H; Wood, RA; O'Connor, GT; Makhija, M; Khurana Hershey, GK; Kercsmar, CM; Gruchalla, RS; Jackson, DJ; Visness, CM; Calatroni, A; Busse, WW. Rhinoconjunctivitis symptoms in children and adolescents with asthma: Longitudinal clustering analysis. Journal of Allergy and Clinical Immunology. 2025; 155:1490-1498.e10.

Wang, VA; Habre, R; Ryan, PH; Coull, BA; Datta, S; Luttmann-Gibson, H; Blossom, J; Just, AC; Schwartz, J; Yanosky, JD; Kattan, M; Khurana Hershey, GK; Lemanske, RF; Lynch, SV. Disparities in the association of ambient air pollution with childhood asthma incidence in the ECHO consortium: A US-wide multi-cohort study. Environmental Epidemiology. 2025; 9:e398.

Wang, VA; Habre, R; Ryan, PH; Datta, S; Luttmann-Gibson, H; Blossom, J; Aris, IM; Chandran, A; Kress, AM; Gilliland, F; Schuh, HB; Miller, RL; Gold, DR; Zanobetti, A. Residing in a low-income-low-food-access neighbourhood and asthma in early and middle childhood in the Environmental influences on Child Health Outcomes (ECHO) program: a multisite cohort study. BMJ Open. 2025; 15:e094317.

Ye, Z; Harrar, SW; Beyene, J; Mersha, TB. Incorporating type 2 inflammation status with clinical diagnosis and transcriptomics data in asthma risk classification. Annals of Allergy, Asthma, and Immunology. 2025; 135:329-332.

Zewale, TA; Wondmagegn, LY; Getahun, HA; Tariku, MK; Achamyeleh, AA; Asemahagn, MA; Enbiale, W; Mersha, TB; Muluneh, EK; Temesgen, AM. Trends of malaria incidence, prevalence, mortality, and disability-adjusted life years in Eastern Africa region from 1990 to 2021: a systematic analysis from Global Burden of Disease 2021 study. Malaria Journal. 2025; 24:207.

Zhao, B; Socha, J; Toth, A; Fernandes, S; Warheit-Niemi, H; Ruff, B; Khurana Hershey, GK; VanDussen, KL; Swarr, D; Zacharias, WJ. The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration. American Journal of Respiratory Cell and Molecular Biology. 2025; 72:678-687.