Jing Chen Lab

Publications

Zarate, YA; Abdelmoti, L; Oh, S; White, A; Starks, C; Au, MG; Chen, J; Weaver, NK; Korotkov, KV; Galperin, E. ACTC1 Variants Result in Isolated and Syndromic Cardiac Phenotypes. Clinical Genetics. 2025; 108(6):713-719.

Wang, X; Zhang, Y; Li, Z; Liu, B; Sakabe, M; Yang, T; Pan, M; Chen, J; Huang, W; Xin, M; Fan, G-C. Abstract 4355964: Probiotic Extracellular Vesicles Stimulate Macrophage Efferocytosis to Limit Ischemia/Reperfusion-Induced Damage by Delivering 5s-rRNA-Derived Short RNA. Circulation. 2025; 152(Suppl_3):a4355964-a4355964.

Chi, M; Lucas, F; Husami, A; Setayesh, T; Zhu, Z; Kaur, H; Tijani, A; Khanal, S; Chen, J; Zhang, W; Malik, P. Replicative stress-induced aging of hematopoietic stem progenitor cells increases oncogenic mutation burden and incidence of myelodysplasia in sickle cell disease mice. Blood. 2025; 146(Supplement 1):11.

Yang, Z; Shikany, A; Husami, A; Wang, X; Mendonca, E; Nicole Weaver, K; Chen, J. Sequencing validates deep learning models for EHR-based detection of Noonan syndrome in pediatric patients. npj Genomic Medicine. 2025; 10(1):56.

Srivastava, AK; Juodakis, J; Sole-Navais, P; Chen, J; Bacelis, J; Teramo, K; Hallman, M; Njølstad, PR; Evans, DM; Jacobsson, B; Muglia, LJ; Zhang, G. Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes. PLoS Genetics. 2025; 21(3):e1011575.

Zhu, R; Zhang, Y; Wang, X; Liu, BD; Chowdhury, D; Li, Z; Pan, M; Peng, T; Chen, J; Huang, W; Zhan, L; Fan, G-C. Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway. Molecular Medicine. 2024; 30(1):216.

Zhang, Y; Wang, X; Zhu, R; Sakabe, M; Chowdhury, D; Li, Z; Chen, J; Huang, W; Xin, M; Fan, G-C. Abstract 4118360: Lipocalin10 is Critical for Macrophage Efferocytosis to Repair Myocardial Ischemia/Reperfusion Injury. Circulation. 2024; 150(Suppl_1):a4118360-a4118360.

Herr, K; Lu, P; Diamreyan, K; Xu, H; Mendonca, E; Weaver, KN; Chen, J. Estimating prevalence of rare genetic disease diagnoses using electronic health records in a children's hospital. HGG Advances. 2024; 5(4):100341.

Xu, H; Zhang, G; Chen, J. A novel method for cell deconvolution using DNA methylation in PCA space. BMC Genomics. 2024; 25(1):798.

Wang, X; Du, W; Li, Y; Yang, H-H; Zhang, Y; Akbar, R; Morgan, H; Peng, T; Chen, J; Sadayappan, S; Hu, Y-C; Fan, Y; Huang, W; Fan, G-C. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI Insight. 2024; 9(5).

Monangi, NK; Xu, H; Fan, Y-M; Khanam, R; Khan, W; Deb, S; Pervin, J; Price, JT; Kaur, L; Al Mahmud, A; Stringer, JSA; Ashorn, P; Zhang, G; Muglia, LJ. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. American Journal of Clinical Nutrition. 2024; 119(1):221-231.

Beaumont, RN; Flatley, C; Vaudel, M; Wu, X; Chen, J; Moen, G-H; Skotte, L; Helgeland, Ø; Solé-Navais, P; Banasik, K; Johansson, S; Freathy, RM; Feenstra, B; Njølstad, PR. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics. 2023; 55(11):1807-1819.

Zhao, H; Wang, P; Wang, X; Du, W; Yang, H-H; Liu, Y; Cui, S-N; Huang, W; Peng, T; Chen, J; Ma, C; Fan, Y; Wang, C; Fan, G-C. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular Research (CVR). 2023; 119(10):1981-1996.

Wang, L; Rossi, RM; Chen, X; Chen, J; Runyon, J; Chawla, M; Miller, D; Forney, C; Lynch, A; Zhang, X; Kottyan, LC; Weirauch, MT; Zhang, G; Muglia, LJ. A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth. BMC Medicine. 2023; 21(1):258.

Elliott, KH; Balchand, SK; Bonatto Paese, CL; Chang, C-F; Yang, Y; Brown, KM; Rasicci, DT; He, H; Thorner, K; Chaturvedi, P; Murray, SA; Chen, J; Porollo, A; Peterson, KA; Brugmann, SA. Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. Development. 2023; 150(8).

Solé-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; Labella, AL; Westergaard, D; Bacelis, J; Freathy, RM; Johansson, S; Zhang, G; Jacobsson, B. Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics. 2023; 55(4):559-567.

Wunderlich, M; Clark, J; Chen, J; Lee, L. In Vivo Crispr Screening Identifies Novel Vulnerabilities in ETO2/GLIS2-rearranged Leukemia. Blood. 2022; 140(Supplement 1):3431-3432.

Yang, Z; Shikany, A; Ni, Y; Zhang, G; Weaver, KN; Chen, J. Using deep learning and electronic health records to detect Noonan syndrome in pediatric patients. Genetics in Medicine. 2022; 24(11):2329-2337.

Weaver, KN; Chen, J; Shikany, A; White, PS; Prada, CE; Gelb, BD; Cnota, JF. Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis. Circulation. Genomic and precision medicine. 2022; 15(4):e003635.

Chen, J; Navais, PS; Xu, H; Flatley, C; Bacelis, J; Monangi, N; Kacerovsky, M; Hallman, M; Teramo, K; Lawlor, DA; Murray, JC; Jacobsson, B; Muglia, LJ; Zhang, G. Interrogating the causal effects of maternal circulating CRP on gestational duration and birth weight. . 2022; 2022.05.16.22275164.

Sole-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; Labella, AL; Westergaard, D; Bacelis, J; Freathy, RM; Johanson, S; Zhang, G; Jacobsson, B. Genetic effects on the timing of parturition and links to fetal birth weight. . 2022; 2022.05.04.22274624.

Zhao, H; Wang, P; Wang, X; Li, Y; Li, Q; Chen, J; Ma, C; Wang, C; Fan, G-C. Abstract 386: Lipocalin 10 Protects Against Sepsis-triggered Vascular Leakage Through Activation Of The Ssh1-cofilin Signaling Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022; 42(Suppl_1):a386-a386.

Wunderlich, M; Chen, J; Sexton, C; Manning, N; Byerly, L; O’Brien, E; Perentesis, JP; Mulloy, JC; Mizukawa, B. PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets. bioRxiv. 2022; 2022.01.31.478534.

Li, Q; Li, Y; Huang, W; Wang, X; Liu, Z; Chen, J; Fan, Y; Peng, T; Sadayappan, S; Wang, Y; Fan, G-C. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in Immunology. 2022; 13:930397.

Ninomiya, M; Inoue, J; Krueger, EW; Chen, J; Cao, H; Masamune, A; Mcniven, MA. The Exosome-Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus. Hepatology Communications. 2021; 5(7):1238-1251.

Mu, X; Fan, H; Wang, P; Li, Y; Domenico, K; Li, Q; Wang, X; Essandoh, K; Chen, J; Peng, T; Fan, G-C. Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal. Molecular Therapy. 2021; 29(3):1294-1311.

Li, Y; Deng, S; Wang, X; Huang, W; Chen, J; Robbins, N; Mu, X; Essandoh, K; Peng, T; Jegga, AG; Rubinstein, J; Adams, DE; Wang, Y; Peng, J; Fan, G-C. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular Research (CVR). 2021; 117(3):890-902.

Chen, J; Zhang, D; Qin, X; Owzar, K; Mccann, JJ; Kastan, MB. DNA-Damage-Induced Alternative Splicing of p53. Cancers. 2021; 13(2).

Cao, H; Qiang, L; Chen, J; Johnson, KM; Mcniven, MA; Razidlo, GL. Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells. PLoS ONE. 2021; 16(3):e0248111.