Publications | Chen Lab

Chen, J; Bacelis, J; Sole-Navais, P; Srivastava, A; Juodakis, J; Rouse, A; Hallman, M; Teramo, K; Melbye, M; Feenstra, B; et al. Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs. PLoS Medicine. 2020; 17.

Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Novel phenotype-disease matching tool for rare genetic diseases. Genetics in Medicine. 2019; 21:339-346.

Chen, J; Hu, Z; Phatak, M; Reichard, J; Freudenberg, JM; Sivaganesan, S; Medvedovic, M. Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. PLoS Computational Biology. 2013; 9.

Chen, J; Aronow, BJ; Jegga, AG. Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics. 2009; 10.

Chen, J; Bardes, EE; Aronow, BJ; Jegga, AG. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Research. 2009; 37:W305-W311.

Chen, J; Xu, H; Aronow, BJ; Jegga, AG. Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics. 2007; 8.

Yang, Z; Shikany, A; Ni, Y; Zhang, G; Weaver, KN; Chen, J. Using deep learning and electronic health records to detect Noonan syndrome in pediatric patients. Genetics in Medicine. 2022.

Weaver, KN; Chen, J; Shikany, A; White, PS; Prada, CE; Gelb, BD; Cnota, JF. Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis. Circulation: Genomic and Precision Medicine. 2022; 15.

Li, Q; Li, Y; Huang, W; Wang, X; Liu, Z; Chen, J; Fan, Y; Peng, T; Sadayappan, S; Wang, Y; et al. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in Immunology. 2022; 13.

Chen, J; Navais, PS; Xu, H; Flatley, C; Bacelis, J; Monangi, N; Kacerovsky, M; Hallman, M; Teramo, K; Lawlor, D; et al. Interrogating the causal effects of maternal circulating CRP on gestational duration and birth weight. 2022.

Sole-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; LaBella, A; Westergaard, D; Bacelis, J; et al. Genetic effects on the timing of parturition and links to fetal birth weight. 2022.

Mu, X; Fan, H; Wang, P; Li, Y; Domenico, K; Li, Q; Wang, X; Essandoh, K; Chen, J; Peng, T; et al. Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal. Molecular Therapy. 2021; 29:1294-1311.

Li, Y; Deng, S; Wang, X; Huang, W; Chen, J; Robbins, N; Mu, X; Essandoh, K; Peng, T; Jegga, AG; et al. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular Research. 2021; 117:890-902.

Chen, J; Bacelis, J; Sole-Navais, P; Srivastava, A; Juodakis, J; Rouse, A; Hallman, M; Teramo, K; Melbye, M; Feenstra, B; et al. Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs. PLoS Medicine. 2020; 17.

Srivastava, A; Juodakis, J; Sole-Navais, P; Chen, J; Bacelis, J; Teramo, K; Hallman, M; Njølstad, P; Evans, D; Jacobsson, B; et al. Haplotype-based heritability estimations reveal gestational duration as a maternal trait and fetal size measurements at birth as fetal traits in human pregnancy. 2020.

Deng, S; Essandoh, K; Wang, X; Li, Y; Huang, W; Chen, J; Peng, J; Jiang, D; Mu, X; Wang, C; et al. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox Biology. 2020; 32.

Chen, J; Bacelis, J; Navais, PS; Srivastava, A; Juodakis, J; Rouse, A; Hallman, M; Teramo, K; Melbye, M; Feenstra, B; et al. Haplotype genetic score analysis in 10,734 mother/infant pairs reveals complex maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes and adult phenotypes. 2019.

Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Novel phenotype-disease matching tool for rare genetic diseases. Genetics in Medicine. 2019; 21:339-346.

Dorn, LE; Lasman, L; Chen, J; Xu, X; Hund, TJ; Medvedovic, M; Hanna, JH; van Berlo, JH; Accornero, F. The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy. Circulation. 2019; 139:533-545.

Chen, J; Galvez-Peralta, M; Zhang, X; Deng, J; Liu, Z; Nebert, DW. In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Scientific Reports. 2018; 8.

Peng, J; Li, Y; Wang, X; Deng, S; Holland, J; Yates, E; Chen, J; Gu, H; Essandoh, K; Mu, X; et al. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination. Cell Reports. 2018; 23:3607-3620.

Wang, Y; Arora, K; Yang, F; Shin, W; Chen, J; Kihara, D; Naren, A; Jegga, A. PP-2, a src-kinase inhibitor, is a potential corrector for F508del-CFTR in cystic fibrosis. 2018.

Alexander, J; Teague, AM; Chen, J; Aston, CE; Leung, Y; Chernausek, S; Simmons, RA; Pinney, SE. Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS ONE. 2018; 13.