Chen Lab

Publications | Chen Lab

Chen, J; Bacelis, J; Sole-Navais, P; Srivastava, A; Juodakis, J; Rouse, A; Hallman, M; Teramo, K; Melbye, M; Feenstra, B; Williams, SM; Jacobsson, B; Muglia, LJ; Zhang, G. Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs. Editor, Tekola-Ayele F. PLoS Medicine. 2020; 17:e1003305.

Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Novel phenotype-disease matching tool for rare genetic diseases. Genetics in Medicine. 2019; 21:339-346.

Chen, J; Hu, Z; Phatak, M; Reichard, J; Freudenberg, JM; Sivaganesan, S; Medvedovic, M. Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. Editor, Morris Q. PLoS Computational Biology. 2013; 9:e1003198.

Chen, J; Aronow, BJ; Jegga, AG. Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics. 2009; 10:73.

Chen, J; Bardes, EE; Aronow, BJ; Jegga, AG. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Research (NAR). 2009; 37:W305-W311.

Chen, J; Xu, H; Aronow, BJ; Jegga, AG. Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics. 2007; 8:392.

Srivastava, AK; Juodakis, J; Sole-Navais, P; Chen, J; Bacelis, J; Teramo, K; Hallman, M; Njølstad, PR; Evans, DM; Jacobsson, B; Muglia, LJ; Zhang, G. Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes. Editor, Cordell HJ. PLoS Genetics. 2025; 21:e1011575.

Xu, H; Zhang, G; Chen, J. A novel method for cell deconvolution using DNA methylation in PCA space. BMC Genomics. 2024; 25:798.

Zhu, R; Zhang, Y; Wang, X; Liu, BD; Chowdhury, D; Li, Z; Pan, M; Peng, T; Chen, J; Huang, W; Zhan, L; Fan, GC. Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway. Molecular medicine (Cambridge, Mass.). 2024; 30:216.

Clark, J; Wunderlich, M; Chen, J; Starczynowski, D; Lee, L. Abstract A017: IGF2BP1 is essential for ETO2/GLIS2 leukemogenesis via stabilization of primitive myeloid transcriptional programs. Molecular Cancer Therapeutics. 2024; 23:a017.

Zhang, Y; Wang, X; Zhu, R; Sakabe, M; Chowdhury, D; Li, Z; Chen, J; Huang, W; Xin, M; Fan, G. Abstract 4118360: Lipocalin10 is Critical for Macrophage Efferocytosis to Repair Myocardial Ischemia/Reperfusion Injury. Circulation. 2024; 150:a4118360.

Herr, K; Lu, P; Diamreyan, K; Xu, H; Mendonca, E; Weaver, KN; Chen, J. Estimating prevalence of rare genetic disease diagnoses using electronic health records in a children's hospital. Human Genetics and Genomics Advances. 2024; 5:100341.

Wang, X; Du, W; Li, Y; Yang, HH; Zhang, Y; Akbar, R; Morgan, H; Peng, T; Chen, J; Sadayappan, S; Hu, YC; Fan, Y; Huang, W; Fan, GC. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI insight. 2024; 9:e173832.

Monangi, NK; Xu, H; Fan, YM; Khanam, R; Khan, W; Deb, S; Pervin, J; Price, JT; Kaur, L; Villar, J; Stringer, JS A; Ashorn, P; Zhang, G; Muglia, LJ. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. American Journal of Clinical Nutrition. 2024; 119:221-231.

Wang, L; Rossi, RM; Chen, X; Chen, J; Runyon, J; Chawla, M; Miller, D; Forney, C; Lynch, A; Zhang, X; Kottyan, LC; Weirauch, MT; Zhang, G; Muglia, LJ. A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth. BMC Medicine. 2023; 21:258.

Beaumont, RN; Flatley, C; Vaudel, M; Wu, X; Chen, J; Moen, GH; Skotte, L; Helgeland, Ø; Solé-Navais, P; Banasik, K; Johansson, S; Freathy, RM; Feenstra, B; Njølstad, PR. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics. 2023; 55:1807-1819.

Zhao, H; Wang, P; Wang, X; Du, W; Yang, HH; Liu, Y; Cui, SN; Huang, W; Peng, T; Chen, J; Ma, C; Fan, Y; Wang, C; Fan, GC. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular Research (CVR). 2023; 119:1981-1996.

Elliott, KH; Balchand, SK; Paese, CL B; Chang, CF; Yang, Y; Brown, KM; Rasicci, DT; He, H; Thorner, K; Chaturvedi, P; Murray, SA; Chen, J; Porollo, A; Peterson, KA; Brugmann, SA. Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. Development (Cambridge). 2023; 150:dev201237.

Solé-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; LaBella, AL; Westergaard, D; Bacelis, J; Freathy, RM; Johanson, S; Zhang, G; Jacobsson, B. Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics. 2023; 55:559-567.

Wunderlich, M; Clark, J; Chen, J; Lee, L. In Vivo Crispr Screening Identifies Novel Vulnerabilities in ETO2/GLIS2-rearranged Leukemia. Blood. 2022; 140:3431-3432.

Yang, Z; Shikany, A; Ni, Y; Zhang, G; Weaver, KN; Chen, J. Using deep learning and electronic health records to detect Noonan syndrome in pediatric patients. Genetics in Medicine. 2022; 24:2329-2337.

Weaver, KN; Chen, J; Shikany, A; White, PS; Prada, CE; Gelb, BD; Cnota, JF. Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis. Circulation: Genomic and Precision Medicine. 2022; 15:e003635.

Li, Q; Li, Y; Huang, W; Wang, X; Liu, Z; Chen, J; Fan, Y; Peng, T; Sadayappan, S; Wang, Y; Fan, GC. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in Immunology. 2022; 13:930397.

Chen, J; Navais, PS; Xu, H; Flatley, C; Bacelis, J; Monangi, N; Kacerovsky, M; Hallman, M; Teramo, K; Lawlor, D; Murray, J; Jacobsson, B; Muglia, L; Zhang, G. Interrogating the causal effects of maternal circulating CRP on gestational duration and birth weight. 2022; 2022.05.16.22275164.

Zhao, H; Wang, P; Wang, X; Li, Y; Li, Q; Chen, J; Ma, C; Wang, C; Fan, G. Abstract 386: Lipocalin 10 Protects Against Sepsis-triggered Vascular Leakage Through Activation Of The Ssh1-cofilin Signaling Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022; 42:a386.

Wunderlich, M; Chen, J; Sexton, C; Manning, N; Byerly, L; O’Brien, E; Perentesis, J; Mulloy, J; Mizukawa, B. PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets. 2022; 2022.01.31.478534.

Ninomiya, M; Inoue, J; Krueger, EW; Chen, J; Cao, H; Masamune, A; McNiven, MA. The Exosome-Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus. Hepatology Communications. 2021; 5:1238-1251.

Cao, H; Qiang, L; Chen, J; Johnson, KM; McNiven, MA; Razidlo, GL. Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells. Editor, Zech T. PloS one. 2021; 16:e0248111.

Mu, X; Fan, H; Wang, P; Li, Y; Domenico, K; Li, Q; Wang, X; Essandoh, K; Chen, J; Peng, T; Fan, GC. Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal. Molecular Therapy. 2021; 29:1294-1311.

Li, Y; Deng, S; Wang, X; Huang, W; Chen, J; Robbins, N; Mu, X; Essandoh, K; Peng, T; Jegga, AG; Rubinstein, J; Adams, DE; Wang, Y; Peng, J; Fan, GC. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular Research (CVR). 2021; 117:890-902.

Chen, J; Zhang, D; Qin, X; Owzar, K; McCann, JJ; Kastan, MB. DNA-Damage-Induced Alternative Splicing of p53. Cancers. 2021; 13:E251.