Roskin Lab
Publications

Publications

Pham, TD; Chng, MHY; Roskin, KM; Jackson, KJL; Nguyen, KD; Glanville, J; Lee, J-Y; Engleman, EG; Boyd, SD. High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance. Mucosal Immunology. 2017; 10(6):1468-1479.

Ellebedy, AH; Jackson, KJL; Kissick, HT; Nakaya, HI; Davis, CW; Roskin, KM; Mcelroy, AK; Oshansky, CM; Elbein, R; Thomas, S; Mehta, AK; Thomas, PG; Boyd, SD; Ahmed, R. Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nature Immunology. 2016; 17(10):1226-1234.

Hoh, RA; Joshi, SA; Liu, Y; Wang, C; Roskin, KM; Lee, J-Y; Pham, T; Looney, TJ; Jackson, KJL; Dixit, VP; Jenks, J; Hamilton, RG; Nadeau, KC; Boyd, SD. Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. Journal of Allergy and Clinical Immunology. 2016; 137(1):157-167.

Collins, AM; Wang, Y; Roskin, KM; Marquis, CP; Jackson, KJL. The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains. Philosophical Transactions of the Royal Society of London. Biological Sciences. 2015; 370(1676).

Roskin, KM; Simchoni, N; Liu, Y; Lee, J-Y; Seo, K; Hoh, RA; Pham, T; Park, JH; Furman, D; Dekker, CL; Davis, MM; James, JA; Nadeau, KC; Cunningham-Rundles, C; Boyd, SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Science Translational Medicine. 2015; 7(302):302ra135.

Wang, C; Liu, Y; Cavanagh, MM; Le Saux, S; Qi, Q; Roskin, KM; Looney, TJ; Lee, J-Y; Dixit, V; Dekker, CL; Swan, GE; Goronzy, JJ; Boyd, SD. B-cell repertoire responses to varicella-zoster vaccination in human identical twins. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(2):500-505.

Jackson, KJL; Liu, Y; Roskin, KM; Glanville, J; Hoh, RA; Seo, K; Marshall, EL; Gurley, TC; Moody, MA; Haynes, BF; Koller, D; Davis, MM; Fire, AZ; Boyd, SD. Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host and Microbe. 2014; 16(1):105-114.

Wang, C; Liu, Y; Xu, LT; Jackson, KJL; Roskin, KM; Pham, TD; Laserson, J; Marshall, EL; Seo, K; Lee, J-Y; Dekker, CL; Davis, MM; Fire, AZ; Boyd, SD. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. Journal of Immunology. 2014; 192(2):603-611.

Parameswaran, P; Liu, Y; Roskin, KM; Jackson, KKL; Dixit, VP; Lee, J-Y; Artiles, KL; Zompi, S; Vargas, MJ; Simen, BB; Balmaseda, A; Boyd, SD; Harris, E; Fire, AZ. Convergent antibody signatures in human dengue. Cell Host and Microbe. 2013; 13(6):691-700.

Liao, H-X; Lynch, R; Zhou, T; Gao, F; Alam, SM; Boyd, SD; Fire, AZ; Roskin, KM; Schramm, CA; Zhang, Z; Korber, BTM; Kwong, PD; Mascola, JR; Haynes, BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013; 496(7446):469-476.

Gill, KK; Moore, C; Nwogu, O; Kroner, JW; Chang, W-C; Burkle, J; Virolainen, SJ; Stevens, ML; Baatyrbek, A; Miraldi, ER; Martin, LJ; Andorf, S; Khurana Hershey, GK; Roskin, KM. B-Cell Repertoire of Children With Atopic Dermatitis Exhibits Altered IgE Maturation Associated With Allergic Food Sensitization. Allergy. European Journal of Allergy and Clinical Immunology. 2025.

Peters, AL; Depasquale, EAK; Begum, G; Roskin, KM; Kotliar, M; Barski, A; Salomonis, N; Shi, T; Ranganathan, S; Woodle, ES; Hildeman, DA. Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells. American Journal of Transplantation. 2025; 25(11):2345-2360.

Roskin, KM; Meeds, HL; Krishnan, JM; Juhascik, M; Cafardi, JM; Brown, JL; Freiermuth, C; Lyons, MS; Sherman, KE; Blackard, JT. Single cell RNA transcriptome response to fentanyl use in persons with hepatitis C virus infection. Frontiers in Virology. 2025; 5:1585217.

Cowell, LG; Christley, S; Breden, F; Burns, KA; Corrie, BD; Lees, WD; Overton, JA; Peters, B; Richardson, E; Roskin, KM; Scheffer, L; Vita, R; Watson, CT; Yaari, G. The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community. Cell Systems. 2025; 16(9):101401.

Phelan, KJ; Roskin, KM; Burkle, JW; Chang, W-C; Martin, LJ; Biagini, JM; Satish, L; Haslam, DB; Spagna, D; Jenkins, S; Visness, CM; Altman, MC; Gern, JE; Khurana Hershey, GK. Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life. Journal of Allergy and Clinical Immunology. 2025; 156(3):640-650.

Zaslavsky, ME; Craig, E; Michuda, JK; Sehgal, N; Ram-Mohan, N; Lee, J-Y; Nguyen, KD; Hoh, RA; Pham, TD; Röltgen, K; Yang, S; Tibshirani, R; Kundaje, A; Boyd, SD. Disease diagnostics using machine learning of B cell and T cell receptor sequences. Science. 2025; 387(6736):eadp2407.

Madhuravasal Krishnan, J; Kong, L; Meeds, HL; Roskin, KM; Medvedovic, M; Sherman, KE; Blackard, JT. The synthetic opioid fentanyl increases HIV replication in macrophages. PLoS ONE. 2025; 20(2):e0298341.

Devore, SB; Schuetz, M; Alvey, L; Lujan, H; Ochayon, DE; Williams, L; Chang, WC; Filuta, A; Ruff, B; Kothari, A; Keles, S; Milner, JD; Supp, DM; Khurana Hershey, GK. Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease. Cell reports. 2024; 43(8):114589.

Bedolla, A; Wegman, E; Weed, M; Stevens, MK; Ware, K; Paranjpe, A; Alkhimovitch, A; Ifergan, I; Taranov, A; Peter, JD; Mcclain, L; Roskin, KM; Greig, NH; Luo, Y. Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice. Nature Communications. 2024; 15(1):5306.

Luebbering, N; Abdullah, S; Roskin, K; Webster, A; Blackard, JT; Odegard, E; Laskin, B; Seif, AE; Jodele, S; Davies, SM; Sabulski, A. Single Cell Rnaseq Identifies Chemokine Responses to BK Polyomavirus Infection and Novel Contribution of MAIT Cells. Transplantation and Cellular Therapy. 2024; 30(2):s84.

Abdullah, S; Leever, G; Langenberg, L; Luebbering, N; Roskin, K; Webster, A; Jodele, S; Davies, SM; Sabulski, A. Intra- and Inter-Organ Endothelial Cell Differences Contribute to TA-TMA through HMOX1, Hypoxia and Reactive Oxygen Species Signaling. Transplantation and Cellular Therapy. 2024; 30(2):s142.

Tsuda, S; Shichino, S; Tilburgs, T; Shima, T; Morita, K; Yamaki-Ushijima, A; Roskin, K; Tomura, M; Sameshima, A; Saito, S; Nakashima, A. CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing. Frontiers in Immunology. 2024; 15:1401738.

Krishnan, JM; Roskin, KM; Meeds, HL; Blackard, JT. Effect of fentanyl on HIV expression in peripheral blood mononuclear cells. Frontiers in Microbiology. 2024; 15:1463441.

Dexheimer, PJ; Pujato, M; Roskin, KM; Weirauch, MT. VExD: a curated resource for human gene expression alterations following viral infection. G3: Genes, Genomes, Genetics. 2023; 13(10).

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O'brien, E; Vancauwenbergh, B; Perentesis, J; Roskin, K; Kornblum, H; Plas, DR; Lu, QR. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports. 2023; 13(1):12433.

Shi, T; Burg, AR; Caldwell, JT; Roskin, KM; Castro-Rojas, CM; Chukwuma, PC; Gray, GI; Foote, SG; Alonso, JA; Cuda, CM; Shields, AR; Baker, BM; Woodle, ES; Hildeman, DA. Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. Journal of Clinical Investigation. 2023; 133(14).

Rossi, AP; Tremblay, S; Castro-Rojas, CM; Burg, AA; Roskin, KM; Gehman, JM; Rike-Shields, A; Alloway, RR; Brailey, P; Allman, D; Hildeman, DA; Woodle, ES. Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. American Journal of Transplantation. 2023; 23(6):759-775.

Williams, JG; Joshi, R; Haslam, D; Yehya, N; Jones, RL; Paranjpe, A; Pujato, M; Roskin, KM; Lahni, PM; Wong, HR; Varisco, BM. Multi-omic characterization of pediatric ARDS via nasal brushings. Respiratory Research. 2022; 23(1):181.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; Lu, R. Chromatin structure predicts survival in glioma patients. Scientific Reports. 2022; 12(1):8221.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; Lu, R. Chromatin structure predicts survival in glioma patients. Scientific Reports. 2022; 12(1).

Mcdaniel, MM; Chawla, AS; Jain, A; Meibers, HE; Saha, I; Gao, Y; Jain, V; Roskin, K; Way, SS; Pasare, C. Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science immunology. 2022; 7(67):eabk0182.

Chen, JA; Hou, Y; Roskin, KM; Arber, DA; Bangs, CD; Baughn, LB; Cherry, AM; Ewalt, MD; Fire, AZ; Fresard, L; Pearce, KE; Pitel, BA; Merker, JD; Gotlib, J. Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance. Blood advances. 2021; 5(17):3492-3496.

Yang, F; Nielsen, SCA; Hoh, RA; Röltgen, K; Wirz, OF; Haraguchi, E; Jean, GH; Lee, J-Y; Pham, TD; Jackson, KJL; Nadeau, KC; Niemann, CU; Parsonnet, J; Boyd, SD. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Science. 2021; 372(6543):738-741.

Wagar, LE; Salahudeen, A; Constantz, CM; Wendel, BS; Lyons, MM; Mallajosyula, V; Jatt, LP; Adamska, JZ; Blum, LK; Gupta, N; Robinson, WH; Boyd, SD; Kuo, CJ; Davis, MM. Modeling human adaptive immune responses with tonsil organoids. Nature Medicine. 2021; 27(1):125-135.

Shi, T; Roskin, K; Baker, BM; Woodle, ES; Hildeman, D. Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution. Frontiers in Immunology. 2021; 12:750754.

Varisco, B; Joshi, R; Jones, R; Paranjpe, A; Roskin, K; Yunger, T; Stoneman, E; Lahni, P; Wong, H; Williams, J. 1003: Nasal Transcriptomic and Serum Proteomic Identification of Three Pediatric ARDS Subtypes. Critical Care Medicine. 2021; 49(1):500-500.

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