The Cincinnati Pediatric Research Group (CPRG) is a regional practice-based research network. Founded in 1996, the CPRG provides an infrastructure to catalyze community-academic partnerships by regularly eliciting the needs and interests of physicians in community practices and cultivating academic partners with shared goals on prioritized topics. Half of the pediatric practices in the Greater Cincinnati Region have participated in a research or quality improvement project in the past decade. Projects span a wide range of topics, including ADHD, obesity, asthma, pneumonia, and many others.

The CPRG is supported by Cincinnati Children's Hospital Medical Center, the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program (1UL1TR001425), as well as grants from various funding agencies. The CPRG is a participating member of the Collaborative Ohio Inquiry Network (COIN), a network of practice-based research networks located throughout Ohio funded by the Agency for Healthcare Research and Quality (AHRQ). Through COIN, the CPRG has regular meetings with networks based in Cleveland, Columbus, and Rootstown to facilitate collaborative research and information sharing for the benefit of Ohio's children.