Gebelein Lab

Kobia, FM; Preusse, K; Dai, Q; Weaver, N; Hass, MR; Chaturvedi, P; Stein, SJ; Pear, WS; Yuan, Z; Kovall, RA; et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biology. 2020; 18:e3000850-e3000850.

Elliott, KH; Chen, X; Salomone, J; Chaturvedi, P; Schultz, PA; Balchand, SK; Servetas, JD; Zuniga, A; Zeller, R; Gebelein, B; et al. Gli3 utilizes hand2 to synergistically regulate tissue-specific transcriptional networks. eLife. 2020; 9:1-33.

Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; et al. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9.

Roychoudhury, K; Salomone, J; Qin, S; Cain, B; Adam, M; Pottert, SS; Nakafuku, M; Gebelein, B; Campbell, K. Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Development (Cambridge). 2020; 147:dev185348-dev185348.

Zhang, X; McGrath, PS; Salomone, J; Rahal, M; McCauley, HA; Schweitzer, J; Kovall, R; Gebelein, B; Wells, JM. A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Developmental Cell. 2019; 50:367-380.e7.

Zandvakili, A; Uhl, JD; Campbell, I; Salomone, J; Song, YC; Gebelein, B. The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila. Developmental Biology. 2019; 445:226-236.

Zandvakili, A; Campbell, I; Gutzwiller, LM; Weirauch, MT; Gebelein, B. Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity. PLoS Genetics. 2018; 14:e1007289-e1007289.

Gu, Z; Kalamboglas, J; Yoshioka, S; Han, W; Li, Z; Kawasawa, YI; Pochareddy, S; Li, Z; Liu, F; Xu, X; et al. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Science. 2017; 357:400-404.

Wang, G; Gutzwiller, L; Li-Kroeger, D; Gebelein, B. A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes. PLoS Genetics. 2017; 13:e1006910-e1006910.

Kovall, RA; Gebelein, B; Sprinzak, D; Kopan, R. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 2017; 41:228-241.

Zandvakili, A; Gebelein, B. Mechanisms of specificity for hox factor activity. Journal of Developmental Biology. 2016; 4:16-16.

Uhl, JD; Zandvakili, A; Gebelein, B. A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes. PLoS Genetics. 2016; 12:e1005981-e1005981.