Gebelein Lab

Publications

Solano, AF; Preusse, K; Cain, B; Hotz, R; Gavini, P; Yuan, Z; Bowen, B; Maco, G; Neal, H; Gagliani, EK; Southgate, L; Kovall, RA; Kopan, R; Gebelein, B. Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver syndrome. Journal of Clinical Investigation. 2025; 135(23).

Cain, B; Yuan, Z; Thoman, E; Kovall, RA; Gebelein, B. The ALX4 dimer structure provides insight into how disease alleles impact function. Nature Communications. 2025; 16(1):4800.

Tweedie, L; Riccetti, MR; Cain, B; Qin, S; Salomone, J; Webb, JA; Riesenberg, A; Ehrman, LA; Waclaw, RR; Kovall, RA; Gebelein, B; Campbell, K. Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects. Disease Models & Mechanisms. 2025; 18(2).

Webb, JA; Farrow, E; Cain, B; Yuan, Z; Yarawsky, AE; Schoch, E; Gagliani, EK; Herr, AB; Gebelein, B; Kovall, RA. Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface. Nucleic Acids Research (NAR). 2024; 52(13):7987-8002.

Salomone, J; Farrow, E; Gebelein, B. Homeodomain complex formation and biomolecular condensates in Hox gene regulation. Seminars in Cell and Developmental Biology. 2024; 152-153:93-100.

Cain, B; Webb, J; Yuan, Z; Cheung, D; Lim, H-W; Kovall, RA; Weirauch, MT; Gebelein, B. Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data. Nucleic Acids Research (NAR). 2023; 51(12):6055-6072.

Gagliani, EK; Gutzwiller, LM; Kuang, Y; Odaka, Y; Hoffmeister, P; Hauff, S; Turkiewicz, A; Harding-Theobald, E; Dolph, PJ; Borggrefe, T; Oswald, F; Gebelein, B; Kovall, RA. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. PLoS Genetics. 2022; 18(8):e1010335.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; Potter, SS; Waclaw, R; Campbell, K; Nakafuku, M. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development. 2022; 149(5).

Neilson, DE; Zech, M; Hufnagel, RB; Slone, J; Wang, X; Homan, S; Gutzwiller, LM; Leslie, EJ; Leslie, ND; Xiao, J; Eckenweiler, M; Winkelmann, J; Gilbert, DL; Huang, T. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Movement Disorders. 2022; 37(2):375-383.