Filippi Lab
Publications

Publications

Selected Publications

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; Mulloy, J; Kofron, M; Salomonis, N; Grimes, HL; Filippi, M-D. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26(3):420-430.e6.

Filippi, M-D. Neutrophil transendothelial migration: updates and new perspectives. Blood. 2019; 133(20):2149-2158.

Filippi, M-D; Ghaffari, S. Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Blood. 2019; 133(18):1943-1952.

Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M-D. p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Nature Communications. 2017; 8:14382.

Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M-D. The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Journal of Experimental Medicine (JEM). 2014; 211(9):1741-1758.

Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M-D. p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Leukemia. 2013; 27(11):2209-2219.

Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M-D. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood. 2012; 120(17):3563-3574.

Szczur, K; Zheng, Y; Filippi, M-D. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood. 2009; 114(20):4527-4537.

Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M-D. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood. 2009; 114(17):3557-3566.

Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M-D. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood. 2006; 108(13):4205-4213.

Wu, Q; Zhang, J; Kumar, S; Shen, S; Kincaid, M; Johnson, CB; Zhang, YS; Turcotte, R; Alt, C; Ito, K; Ito, K; Way, SS; Kofron, JM; Lucas, D. Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024; 627(8005):839-846.

Solomon, M; Song, B; Govindarajah, V; Good, S; Arasu, A; Hinton, EB; Thakkar, K; Bartram, J; Filippi, M-D; Cancelas, JA; Salomonis, N; Grimes, HL; Reynaud, D. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. Journal of Experimental Medicine (JEM). 2024; 221(1).

Filippi, M-D. The multifaceted role of mitochondria in HSC fate decisions: energy and beyond. Experimental Hematology. 2023; 128:19-29.

Treichel, S; Filippi, M-D. Linking cell cycle to hematopoietic stem cell fate decisions. Frontiers in Cell and Developmental Biology. 2023; 11:1231735.

Bartram, J; Filippi, M-D. The new metabolic needs of hematopoietic stem cells. Current Opinion in Hematology. 2022; 29(4):188-193.

Javier, J; Hinge, A; Bartram, J; Xu, J; Filippi, M-D. Transforming growth factor-β signaling modifies the hematopoietic acute inflammatory response to drive bone marrow failure. Haematologica. 2022; 107(6):1323-1334.

Filippi, M-D. Asymmetric division: the choice of fate for huHSCs. Blood. 2022; 139(13):1930-1932.

Niederkorn, M; Ishikawa, C; M Hueneman, K; Bartram, J; Stepanchick, E; R Bennett, J; E Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; Wunderlich, M; Perentesis, JP; M Chlon, T; Filippi, M-D; Starczynowski, DT. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36(2):438-451.

Filippi, M-D. Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food. Immunometabolism. 2022; 4(2).

Nasr, W; Filippi, M-D. Acquired and hereditary bone marrow failure: A mitochondrial perspective. Frontiers in Oncology. 2022; 12:1048746.

Chowdhury, CS; Wareham, E; Xu, J; Kumar, S; Kofron, M; Lakshmikanthan, S; Chrzanowska, M; Filippi, M-D. Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo. Frontiers in Immunology. 2022; 13:1061544.

Young, K; Eudy, E; Bell, R; Loberg, MA; Stearns, T; Sharma, D; Velten, L; Haas, S; Filippi, M-D; Trowbridge, JJ. Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. 2021; 28(8):1473-1482.e7.

Filippi, M-D. Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division. Experimental Hematology. 2021; 96:27-34.

Tackenberg, H; Möller, S; Filippi, M-D; Laskay, T. The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria. Frontiers in Immunology. 2021; 12:564720.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, M-D; Xin, M; Lu, QR; Geiger, H; Zheng, Y; Diaz-Meco, MT; Moscat, J; Cancelas, JA. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136(16):1824-1836.

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; Mulloy, J; Kofron, M; Salomonis, N; Grimes, HL; Filippi, M-D. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26(3):420-430.e6.

Tackenberg, H; Möller, S; Filippi, M-D; Laskay, T. The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions. Frontiers in Immunology. 2020; 11:1197.

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