Filippi Lab
Publications and Grants

Publications

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26:420-430.e6.

Filippi, M. Neutrophil transendothelial migration: updates and new perspectives. Blood. 2019; 133:2149-2158.

Filippi, M; Ghaffari, S. Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Blood. 2019; 133:1943-1952.

Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M. p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Nature Communications. 2017; 8.

Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M. The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Journal of Experimental Medicine. 2014; 211:1741-1758.

Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M. p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Leukemia. 2013; 27:2209-2219.

Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood. 2012; 120:3563-3574.

Szczur, K; Zheng, Y; Filippi, M. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood. 2009; 114:4527-4537.

Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood. 2009; 114:3557-3566.

Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood. 2006; 108:4205-4213.

Chowdhury, CS; Wareham, E; Xu, J; Kumar, S; Kofron, M; Lakshmikanthan, S; Chrzanowska, M; Filippi, MD. Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo. Frontiers in Immunology. 2022; 13.

Nasr, W; Filippi, MD. Acquired and hereditary bone marrow failure: A mitochondrial perspective. Frontiers in Oncology. 2022; 12.

Bartram, J; Filippi, MD. The new metabolic needs of hematopoietic stem cells. Current Opinion in Hematology. 2022; 29:188-193.

Javier, J; Hinge, A; Bartram, J; Xu, J; Filippi, MD. Transforming growth factor-β signaling modifies the hematopoietic acute inflammatory response to drive bone marrow failure. Haematologica. 2022; 107:1323-1334.

Filippi, M. Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food. 2022; 4.

Filippi, MD. Asymmetric division: the choice of fate for huHSCs. Blood. 2022; 139:1930-1932.

Niederkorn, M; Ishikawa, C; M. Hueneman, K; Bartram, J; Stepanchick, E; R. Bennett, J; E. Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; et al. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36:438-451.

Young, K; Eudy, E; Bell, R; Loberg, MA; Stearns, T; Sharma, D; Velten, L; Haas, S; Filippi, MD; Trowbridge, JJ. Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. 2021; 28:1473-1482.e7.

Filippi, MD. Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division. Experimental Hematology. 2021; 96:27-34.

Tackenberg, H; Möller, S; Filippi, MD; Laskay, T. The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria. Frontiers in Immunology. 2021; 12.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Tackenberg, H; Moeller, S; Filippi, M; Laskay, T. The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions. Frontiers in Immunology. 2020; 11.

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26:420-430.e6.

Hinge, AS; Filippi, MD. Single-Cell Assays Using Hematopoietic Stem and Progenitor Cells. Methods in Molecular Biology. 2019; 2029:147-160.

Filippi, M. Neutrophil transendothelial migration: updates and new perspectives. Blood. 2019; 133:2149-2158.

Filippi, M; Ghaffari, S. Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Blood. 2019; 133:1943-1952.

Hu, P; Nebreda, AR; Hanenberg, H; Kinnebrew, GH; Ivan, M; Yoder, MC; Filippi, M; Broxmeyer, HE; Kapur, R. P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim. Nature Communications. 2018; 9.

Funding Support

Regulation of Neutrophil Migration and Polarity
1R01 HL090676-02
(PI – Filippi)
03/01/10-02/28/15 4.2 calendar months
National Institutes of Health (NIH)
Total direct cost $1,250,000

 

1R21 HL104458-02
(PI – Filippi)
08/01/10-07/31/13 2.4 calendar months
National Institutes of Health (NIH)
Total direct cost $1,250,000

 

Center for Excellence in Molecular Hematology
1P30 DK090971
(PI – Zheng)
Co-Director – Xenotransplant and Transgenic Mouse Core
9/30/10-06/30/15 0.6 calendar months
National Institutes of Health (NIH)
Total direct cost $3,572,110

 

Role of Cytomegalovirus Latency in Atherosclerosis
1R01 AI087683
(PI – Cardin)      
8/01/12-7/31/16 0.36 calendar months
National Institutes of Health (NIH)
Total direct cost $1,250,000

 

Innovation Fund Award
(PI – Zheng)
8/01/12-7/31/14
Cincinnati Children's Hospital Medical Center
$100,000 per year

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