Miles Lab

Publications

Miles, LA; Bowman, RL; Merlinsky, TR; Csete, IS; Ooi, AT; Durruthy-Durruthy, R; Bowman, M; Famulare, C; Patel, MA; Mendez, P; Carroll, MP; Meyer, SE; Viny, AD; Levine, RL. Single-cell mutation analysis of clonal evolution in myeloid malignancies. Nature. 2020; 587:477-482.

Miles, LA; Burga, LN; Gardner, EE; Bostina, M; Poirier, JT; Rudin, CM. Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. The Journal of Clinical Investigation. 2017; 127:2957-2967.

Krishnan, A; Miles, LA; Challen, GA. Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis. Experimental Hematology. 2025; 148:104816.

Goda, C; Kulkarni, R; Bustos, Y; Li, W; Rudich, A; Balcioglu, O; Chidester, S; Urs, AP; Karunasiri, M; Al-Marrawi, Y; Viny, AD; Miles, LA; Miller, KE; Dorrance, AM. Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia. Leukemia. 2025; 39:51-63.

Bowman, RL; Dunbar, AJ; Mishra, T; Xiao, W; Waarts, MR; Maestre, IF; Eisman, SE; Cai, L; Mowla, S; Shah, N; Miles, LA; Ferrell, PB; Trowbridge, JJ; Levine, RL. In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy. Cancer Cell. 2024; 42:1955-1969.e7.

Lee, D; Abu-Shihab, Y; Nicolet, D; Mrózek, K; Routbort, M; Patel, KP; Walker, CJ; Buss, J; Stiff, A; Laganson, A; Blachly, JS; Loghavi, S; Eisfeld, A; Miles, LA. BRAF-Mutated Acute Myeloid Leukemia (AML) Represents a Prognostically Poor Subgroup Enriched for Myelodysplasia-Related Subtypes and Distinct from Other RAS Pathway Mutant AML. Blood. 2024; 144:2921.

Stiff, A; Fornerod, M; Kain, BN; Nicolet, D; Kelly, BJ; Miller, KE; Mrózek, K; Boateng, I; Bollas, A; Garfinkle, EA R; Salomonis, N; Grimes, HL; Mardis, ER; Eisfeld, AK. Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia. Nature Genetics. 2024; 56:2434-2446.

Waarts, MR; Mowla, S; Boileau, M; Martinez Benitez, AR; Sango, J; Bagish, M; Fernández-Maestre, I; Shan, Y; Eisman, SE; Park, YC; Butler, JM; Cai, SF; Bowman, RL; Levine, RL. CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells. Cancer Discovery. 2024; 14:1860-1878.

Schwede, M; Jahn, K; Kuipers, J; Miles, LA; Bowman, RL; Robinson, T; Furudate, K; Uryu, H; Tanaka, T; Sasaki, Y; Levine, R; Beerenwinkel, N; Takahashi, K; Majeti, R. Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity. Leukemia. 2024; 38:1501-1510.

Abu-Shihab, Y; Nicolet, D; Mrózek, K; Routbort, M; Patel, KP; Walker, CJ; Buss, J; Stiff, A; Laganson, A; DiNardo, CD; Blachly, JS; Miles, LA; Eisfeld, A; Loghavi, S. BRAF-Mutated Acute Myeloid Leukemia (AML) Represents a Distinct, Prognostically Poor Subgroup Enriched in Myelodysplasia-Related (MR-)AML. Blood. 2023; 142:1575.

Li, J; Malouf, C; Miles, LA; Willis, MB; Pietras, EM; King, KY. Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells. Experimental Hematology. 2023; 127:8-13.

Robinson, TM; Bowman, RL; Persaud, S; Liu, Y; Neigenfind, R; Gao, Q; Zhang, J; Sun, X; Miles, LA; Cai, SF; Dogan, A; Roshal, M; Levine, RL; Xiao, W. Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia. Science Advances. 2023; 9:eadg0488.

Schwede, M; Jahn, K; Miles, LA; Bowman, RL; Kuipers, J; Robinson, TM; Ediriwickrema, A; Gentles, AJ; Levine, R; Beerenwinkel, N; Takahashi, K; Majeti, R. Abstract A49: Characterizing the order of mutation acquisition in acute myeloid leukemia using large-scale single-cell sequencing. Blood Cancer Discovery. 2023; 4:a49.

Gurska, LM; Okabe, R; Schurer, A; Tong, MM; Soto, M; Choi, D; Ames, K; Glushakow-Smith, S; Montoya, A; Tein, E; Levine, RL; Goel, S; Halmos, B; Gritsman, K. Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms. Clinical Cancer Research. 2023; 29:943-956.

Stahl, M; Derkach, A; Farnoud, N; Bewersdorf, JP; Robinson, T; Famulare, C; Cho, C; Devlin, S; Menghrajani, K; Patel, MA; Papaemmanuil, E; Tallman, MS; Roshal, M; Goldberg, AD. Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. American Journal of Hematology. 2023; 98:79-89.

SanMiguel, JM; Eudy, E; Loberg, MA; Miles, LA; Stearns, T; Mistry, JJ; Rauh, MJ; Levine, RL; Trowbridge, JJ. Cell origin-dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy. Blood Advances. 2022; 6:3666-3677.

Miles, LA; Bowman, RL; Delgaudio, N; Robinson, T; Carroll, MP; Meyer, SE; Levine, RL. Clonotype-Immunophenotype Relationships in TET2 and IDH-Mutant Myeloid Transformation. Blood. 2021; 138:373.

Bowman, RL; Mishra, T; Eisman, SE; Cai, L; Xiao, W; Waarts, MR; Sanchez Vela, P; Fernández-Maestre, I; Csete, IS; Potts, CR; Jenkins, MT; Miles, LA; Trowbridge, JJ; Ferrell, PB; Levine, RL. Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation. Blood. 2021; 138:2220.

Luu, AP; Yao, Z; Ramachandran, S; Azzopardi, SA; Miles, LA; Schneider, WM; Hoffmann, HH; Bozzacco, L; Garcia, G; Gong, D; Poirier, JT; Macdonald, MR; Rice, CM; Li, MM H. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses-Basel. 2021; 13:2113.

Bowman, R; Mishra, T; Miles, L; Levine, R. 3004 – GENETIC APPROACHES FOR MODELING SUBCLONAL MUTATIONS IN ACUTE MYELOID LEUKEMIA. Experimental Hematology. 2021; 100:s45.

Levine, R; Bowman, B; Miles, L; Waarts, M. 1008 – ROLE OF SEQUENTIAL MUTATIONAL ACQUISITION IN CLONAL HEMATOPOIESIS AND EVOLUTION TO AML. Experimental Hematology. 2021; 100:s20.

Suehnholz, SP; Kundra, R; Zhang, H; Smith, S; Nissan, M; Yao, Y; LaFave, L; Gala, K; Miles, L; Arcila, ME; Gao, J; Solit, D; Schultz, N; Chakravarty, D. Abstract 99: Evolution of OncoKB, a precision oncology knowledgebase. Cancer Research. 2021; 81:99.

Jayawardena, N; Miles, LA; Burga, LN; Rudin, C; Wolf, M; Poirier, JT; Bostina, M. N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection. Viruses-Basel. 2021; 13:769.

Hoffmann, HH; Schneider, WM; Rozen-Gagnon, K; Miles, LA; Schuster, F; Razooky, B; Jacobson, E; Wu, X; Yi, S; Rudin, CM; MacDonald, MR; McMullan, LK; Poirier, JT; Rice, CM. TMEM41B Is a Pan-flavivirus Host Factor. Cell. 2021; 184:133-148.e20.