Nichols Lab

Publications

Al-Qazazi, R; Emon, IM; Potus, F; Martin, AY; Lima, PDA; Vlasschaert, C; Ott, BP; Chen, K-H; Wu, D; Dasgupta, A; Zhu, N; Shen, Y; Rauh, MJ; Archer, SL. Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension. European Heart Journal. 2026; 47(33):4658-4675.

Karnes, JH; Bao, C; Liang, S; Thayer, T; Zagorski, J; Naidu, SR; West, JD; Schwantes-An, T-H; Khajouei, E; Banerjee, K; Nichols, WC; Chu, A; Tang, H; Desai, AA. Variation in SNX29 and Acute Vasodilator Response in Pulmonary Arterial Hypertension. Circulation Research. 2026; 139(2):e327117.

Byrd, CE; Schramm, JE; Yang, J; Barnes, AE; Griffiths, M; Nichols, WC; Ivy, DD; Austin, ED; Everett, AD. The Role of the Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension. Pulmonary Circulation. 2026; 16(2):e70323.

Yuguchi, E; Trinh, N; Robertson, HK; Nichols, WC; Alotaibi, M. D106-25 Specialized Pro-Resolving Mediators as Potential Mediators of Smoking-Associated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.5906.

Robertson, HK; Fernandes, TM; Nichols, WC; Alotaibi, M. C64-15 Specialized Pro-resolving Mediators Are Associated With Superior Right Ventricle Function in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.5832.

Gomez-Arroyo, J; Houweling, A; Bogaard, HJ; Aman, J; Kitzmiller, J; Dooijes, D; Aldred, M; Gräf, S; Rhodes, CJ; Chung, WK; Whitsett, JA; Martin, LJ; Kalinichenko, V; Nichols, WC. Association of FOXF1 Genomic Variants With Children and Adults With Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a3275-a3275.

Yuguchi, E; Gurholt, I; Robertson, HK; Yang, J; Papamatheakis, DG; Poch, DS; Nichols, WC; Pauciulo, MW; Kim, NH; Fernandes, TM; Alotaibi, M. Comparative Metabolomic and Molecular Profiles in Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a7248-a7248.

Robertson, HK; Wang, C; Nichols, WC; Pauciulo, MW; Fernandes, TM; Alotaibi, M. Sex-specific Differences in Eicosanoid and Bioactive Lipid Metabolites and Their Associations With Hemodynamic Parameters in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a7247-a7247.

Byrd, CE; Schramm, JE; Yang, J; Barnes, AE; Griffiths, M; Ambade, AS; Rosen, DT; Cubero Salazar, IM; Simpson, CE; Tedford, RJ; Austin, ED; Hassoun, PM; Damico, RL; Everett, AD. Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension. Pulmonary Circulation. 2025; 15(2):e70067.

Hindmarch, CCT; Potus, F; Al-Qazazi, R; Ott, BP; Nichols, WC; Rauh, MJ; Archer, SL. Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype. Comprehensive Physiology. 2025; 15(2):e70011.

Harvey, LD; Alotaibi, M; Tai, Y-Y; Tang, Y; Kim, H-JJ; Kelly, NJ; Sun, W; Woodcock, C-SC; Arshad, S; Culley, MK; Bertero, T; Benza, RL; Jain, M; Chan, SY. Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension. Science. 2025; 387(6732):eadn7277.

Griffiths, M; Simpson, CE; Yang, J; Vaidya, D; Nies, MK; Brandal, S; Damico, R; Hassoun, P; Ivy, DD; Austin, ED; Benza, RL; Nichols, WC; Manlhiot, C; Everett, AD. Equivalency of Multiple Biomarkers to Clinical Pulmonary Arterial Hypertension Survival Risk Models. Chest. 2024; 166(6):1511-1531.

Petrow, E; Feng, C; Frazer-Abel, A; Marangoni, RG; Lutz, K; Nichols, WC; Holers, VM; Ritchlin, C; White, RJ; Korman, BD. Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH). Seminars in Arthritis and Rheumatism. 2024; 69:152554.

Hindmarch, C; Potus, F; Al-Qazazi, R; Nichols, W; Pauciulo, M; Rauh, M; Archer, S. Abstract 4140468: Tet Methylcytosine Dioxygenase 2 mutation drives a global hypermethylation signature in patients with pulmonary arterial hypertension resulting in a common T cell phenotype. Circulation. 2024; 150(Suppl_1):a4140468-a4140468.

Emon, I; Al-Qazazi, R; Rauh, M; Vlasschaert, C; Ott, B; Mcnaughton, A; Potus, F; Pauciulo, M; Bick, A; Nichols, W; Chung, W; Archer, S. Abstract 4138731: Clonal Hematopoiesis of Indeterminant Potential is Associated with Pulmonary Arterial Hypertension. Circulation. 2024; 150(Suppl_1):a4138731-a4138731.

Byrd, C; Benza, R; Webb, A; Schramm, J; Yang, J; Griffiths, M; Brandal, S; Damico, R; Vaidya, D; Simpson, C; Hassoun, P; Everett, A; Austin, E; Martin, L. Abstract 4138019: eQTL Analysis of the PAH Biomarker CCN2 Identifies a Novel SNP that Associates with Survival. Circulation. 2024; 150(Suppl_1):a4138019-a4138019.

Hong, J; Medzikovic, L; Sun, W; Wong, B; Ruffenach, G; Rhodes, CJ; Brownstein, A; Liang, LL; Aryan, L; Li, M; Geraci, MW; Stearman, RS; Yang, X; Eghbali, M. Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. Circulation. 2024; 150(16):1268-1287.

Austin, ED; Aldred, MA; Alotaibi, M; Gräf, S; Nichols, WC; Trembath, RC; Chung, WK. Genetics and precision genomics approaches to pulmonary hypertension. European Respiratory Journal. 2024; 64(4).

Tang, H; Gupta, A; Morrisroe, SA; Bao, C; Schwantes-An, T-H; Gupta, G; Liang, S; Sun, Y; Chu, A; Luo, A; Duarte, JD; Nichols, WC; Garcia, JGN; Desai, AA. Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation. 2024; 150(4):302-316.

Gao, L; Skinner, J; Nath, T; Lin, Q; Griffiths, M; Damico, RL; Pauciulo, MW; Nichols, WC; Hassoun, PM; Everett, AD; Johns, RA. Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension. Respiratory Research. 2024; 25(1):235.

Tai, Y-Y; Yu, Q; Tang, Y; Sun, W; Kelly, NJ; Okawa, S; Zhao, J; Schwantes-An, T-H; Lacoux, C; Torrino, S; Nichols, WC; Desai, AA; Bertero, T; Chan, SY. Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. Science Translational Medicine. 2024; 16(729):eadd2029.

Welch, CL; Aldred, MA; Balachandar, S; Dooijes, D; Eichstaedt, CA; Gräf, S; Houweling, AC; Machado, RD; Pandya, D; Prapa, M; Shaukat, M; Southgate, L; Tenorio-Castano, J; Chung, WK. Defining the clinical validity of genes reported to cause pulmonary arterial hypertension. Genetics in Medicine. 2023; 25(11):100925.

Jose, A; Elwing, JM; Kawut, SM; Pauciulo, MW; Sherman, KE; Nichols, WC; Fallon, MB; Mccormack, FX. Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension. Communications Biology. 2023; 6(1):826.

Torres, G; Lancaster, AC; Yang, J; Griffiths, M; Brandal, S; Damico, R; Vaidya, D; Simpson, CE; Martin, LJ; Pauciulo, MW; Nichols, WC; Ivy, DD; Austin, ED; Hassoun, PM; Everett, AD. Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival. Pulmonary Circulation. 2023; 13(3):e12284.

Alotaibi, M; Liu, Y; Magalang, GA; Kwan, AC; Ebinger, JE; Nichols, WC; Pauciulo, MW; Jain, M; Cheng, S. Deriving Convergent and Divergent Metabolomic Correlates of Pulmonary Arterial Hypertension. Metabolites. 2023; 13(7).

Ortega, R; Burbulla, L; Mileva, I; Taylor, G; Cuperlovic-Culf, M; Glickman, A; Pullman, M; Scherzer, C; Raymond, D; Miltenyi-Miltenberger, G; Obeid, L; Hannun, Y; Bennett, S; Saunders-Pullman, R. Peripheral Sphingolipids as Potential Biomarkers of Parkinson disease Including Sex-Related Differences (P3-11.007) Neurology. 2023; 100(17_supplement_2).

Sangam, S; Sun, X; Schwantes-An, T-H; Yegambaram, M; Lu, Q; Shi, Y; Cook, T; Fisher, A; Frump, AL; Coleman, A; Tang, H; Nichols, WC; Black, SM; Desai, AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. American Journal of Respiratory and Critical Care Medicine. 2023; 207(8):1055-1069.

Prohaska, CC; Zhang, X; Schwantes-An, T-HL; Stearman, RS; Hooker, S; Kittles, RA; Aldred, MA; Lutz, KA; Pauciulo, MW; Nichols, WC; Desai, AA; Gordeuk, VR; Machado, RF. RASA3 is a candidate gene in sickle cell disease-associated pulmonary hypertension and pulmonary arterial hypertension. Pulmonary Circulation. 2023; 13(2):e12227.

Torres, G; Yang, J; Griffiths, M; Brandal, S; Damico, R; Vaidya, D; Simpson, CE; Pauciulo, MW; Nichols, WC; Ivy, DD; Austin, ED; Hassoun, PM; Everett, AD. Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival. Pulmonary Circulation. 2023; 13(2):e12235.

Eichstaedt, CA; Belge, C; Chung, WK; Gräf, S; Grünig, E; Montani, D; Quarck, R; Tenorio-Castano, JA; Soubrier, F; Trembath, RC; Morrell, NW. Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH. European Respiratory Journal. 2023; 61(2).

Alotaibi, M; Shao, J; Pauciulo, MW; Nichols, WC; Hemnes, AR; Malhotra, A; Kim, NH; Yuan, JX-J; Fernandes, T; Kerr, KM; Long, T; Cheng, S; Chan, SY; Jain, M. Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023; 163(1):204-215.

Harbaum, L; Rhodes, CJ; Wharton, J; Lawrie, A; Karnes, JH; Desai, AA; Nichols, WC; Humbert, M; Montani, D; Girerd, B; Gräf, S; Pietzner, M; Morrell, NW; Wilkins, MR. Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2022; 205(12):1449-1460.

Simpson, CE; Griffiths, M; Yang, J; Nies, MK; Vaidya, D; Brandal, S; Martin, LJ; Pauciulo, MW; Lutz, KA; Coleman, AW; Nichols, WC; Everett, AD; Hassoun, PM; Damico, RL. COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study. ERJ Open Research. 2022; 8(2).

Toshner, M; Church, C; Harbaum, L; Rhodes, C; Villar Moreschi, SS; Liley, J; Jones, R; Arora, A; Batai, K; Desai, AA; Wilkins, MR; Gaine, S; Morrell, NW; Corris, PA. Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension. European Respiratory Journal. 2022; 59(3).

Pal, G; Mangone, G; Hill, EJ; Ouyang, B; Liu, Y; Lythe, V; Ehrlich, D; Saunders-Pullman, R; Shanker, V; Bressman, S; Foltynie, T; Hall, D; Corvol, J-C; Goetz, CG. Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers. Annals of Neurology. 2022; 91(3):424-435.

Griffiths, M; Yang, J; Vaidya, D; Nies, M; Brandal, S; Ivy, DD; Hickey, F; Wolter-Warmerdam, K; Austin, ED; Mullen, M; Hirsch, R; Yung, D; Nichols, WC; Everett, AD. Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension. Journal of Pediatrics. 2022; 241:68-76.e3.

Yang, J; Ambade, AS; Nies, M; Griffiths, M; Damico, R; Vaidya, D; Brandal, S; Pauciulo, MW; Lutz, KA; Coleman, AW; Nichols, WC; Austin, ED; Ivy, D; Hassoun, PM; Everett, AD. Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival. Pulmonary Circulation. 2022; 12(1):e12007.