Hagan Lab

Publications

Hagan, T; Gerritsen, B; Tomalin, LE; Fourati, S; Mulè, MP; Chawla, DG; Rychkov, D; Henrich, E; Miller, HE R; Diray-Arce, J; et al. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nature Immunology. 2022; 23:1788-1798.

Arunachalam, PS; Scott, MK D; Hagan, T; Li, C; Feng, Y; Wimmers, F; Grigoryan, L; Trisal, M; Edara, VV; Lai, L; et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021; 596:410-416.

Hagan, T; Cortese, M; Rouphael, N; Boudreau, C; Linde, C; Maddur, MS; Das, J; Wang, H; Guthmiller, J; Zheng, NY; et al. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell. 2019; 178:1313-1328.e13.

Wimmers, F; Burrell, AR; Feng, Y; Zheng, H; Arunachalam, PS; Hu, M; Spranger, S; Nyhoff, LE; Joshi, D; Trisal, M; et al. Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell. 2023; 186:4632-4651.e23.

Luo, W; Adamska, JZ; Li, C; Verma, R; Liu, Q; Hagan, T; Wimmers, F; Gupta, S; Feng, Y; Jiang, W; et al. SREBP signaling is essential for effective B cell responses. Nature Immunology. 2023; 24:337-348.

Adamska, JZ; Verma, R; Gupta, S; Hagan, T; Wimmers, F; Floyd, K; Li, Q; Valore, EV; Wang, Y; Trisal, M; et al. Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2. Cell Reports. 2023; 42:112038.

Hagan, T; Gerritsen, B; Tomalin, LE; Fourati, S; Mulè, MP; Chawla, DG; Rychkov, D; Henrich, E; Miller, HE R; Diray-Arce, J; et al. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nature Immunology. 2022; 23:1788-1798.

Diray-Arce, J; Miller, HE R; Henrich, E; Gerritsen, B; Mulè, MP; Fourati, S; Gygi, J; Hagan, T; Tomalin, L; Rychkov, D; et al. The Immune Signatures data resource, a compendium of systems vaccinology datasets. Scientific Data. 2022; 9:635.

Fourati, S; Tomalin, LE; Mulè, MP; Chawla, DG; Gerritsen, B; Rychkov, D; Henrich, E; Miller, HE R; Hagan, T; Diray-Arce, J; et al. Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nature Immunology. 2022; 23:1777-1787.

Ozonoff, A; Schaenman, J; Jayavelu, ND; Milliren, CE; Calfee, CS; Cairns, CB; Kraft, M; Baden, LR; Shaw, AC; Krammer, F; et al. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022; 83:104208.

Shao, TY; Kakade, P; Witchley, JN; Frazer, C; Murray, KL; Ene, IV; Haslam, DB; Hagan, T; Noble, SM; Bennett, RJ; et al. Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity. Cell Reports. 2022; 39:110837.

Arunachalam, PS; Scott, MK D; Hagan, T; Li, C; Feng, Y; Wimmers, F; Grigoryan, L; Trisal, M; Edara, VV; Lai, L; et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021; 596:410-416.

Wimmers, F; Donato, M; Kuo, A; Ashuach, T; Gupta, S; Li, C; Dvorak, M; Foecke, MH; Chang, SE; Hagan, T; et al. The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination. Cell. 2021; 184:3915-3935.e21.

Arunachalam, PS; Wimmers, F; Mok, CK P; Perera, RA P M; Scott, M; Hagan, T; Sigal, N; Feng, Y; Bristow, L; Tsang, OT Y; et al. Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. Science. 2020; 369:1210-1220.

Hagan, T; Cortese, M; Rouphael, N; Boudreau, C; Linde, C; Maddur, MS; Das, J; Wang, H; Guthmiller, J; Zheng, NY; et al. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell. 2019; 178:1313-1328.e13.