Hagan Lab

Publications

Cortese, M; Hagan, T; Rouphael, N; Wu, SY; Xie, X; Kazmin, D; Wimmers, F; Gupta, S; van der Most, R; Coccia, M; Mulligan, MJ; Khurana, S; Golding, H; Pulendran, B. System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans. Nature Immunology. 2025; 26:116-130.

Hagan, T; Gerritsen, B; Tomalin, LE; Fourati, S; Mulè, MP; Chawla, DG; Rychkov, D; Henrich, E; Miller, HE R; Diray-Arce, J; Stuart, K; Togias, A; Tsang, JS; Suárez-Fariñas, M. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nature Immunology. 2022; 23:1788-1798.

Arunachalam, PS; Scott, MK D; Hagan, T; Li, C; Feng, Y; Wimmers, F; Grigoryan, L; Trisal, M; Edara, VV; Lai, L; Suthar, MS; Khatri, P; Nadeau, KC; Pulendran, B. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021; 596:410-416.

Hagan, T; Cortese, M; Rouphael, N; Boudreau, C; Linde, C; Maddur, MS; Das, J; Wang, H; Guthmiller, J; Zheng, NY; Alter, G; Khurana, S; Golding, H; Pulendran, B. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell. 2019; 178:1313-1328.e13.

Hu, M; Oliveira, AP B N; Fang, Z; Feng, Y; Miranda, M; Kowli, S; Arunachalam, PS; Vasudevan, G; Hui, HS Y; Grifoni, A; Hagan, T; Dhillon, G; Nicolls, MR; Pulendran, B. Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients. Cell Reports Medicine. 2025; 6:102050.

Cortese, M; Hagan, T; Rouphael, N; Wu, SY; Xie, X; Kazmin, D; Wimmers, F; Gupta, S; van der Most, R; Coccia, M; Mulligan, MJ; Khurana, S; Golding, H; Pulendran, B. System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans. Nature Immunology. 2025; 26:116-130.

Ozonoff, A; Jayavelu, ND; Liu, S; Melamed, E; Milliren, CE; Qi, J; Geng, LN; McComsey, GA; Cairns, CB; Baden, LR; Rogers, AJ; Artandi, M; Yendewa, G; Powell, DL. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nature Communications. 2024; 15:216.

Haslund-Gourley, BS; Woloszczuk, K; Hou, J; Connors, J; Cusimano, G; Bell, M; Taramangalam, B; Fourati, S; Mege, N; Bernui, M; Kojic, E; Chinthrajah, S; Ahuja, N; Rogers, AJ. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition. Nature Communications. 2024; 15:404.

Apps, R; Biancotto, A; Candia, J; Kotliarov, Y; Perl, S; Cheung, F; Farmer, R; Mulè, MP; Rachmaninoff, N; Chen, J; Dickler, HB; Germain, RN; Schwartzberg, PL; Tsang, JS. Acute and persistent responses after H5N1 vaccination in humans. Cell Reports. 2024; 43:114706.

Saha, I; Chawla, AS; Oliveira, AP B N; Elfers, EE; Warrick, K; Meibers, HE; Jain, VG; Hagan, T; Katz, JD; Pasare, C. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2401658121.

Rosenberg-Hasson, Y; Holmes, TH; Diray-Arce, J; Chen, J; Kellogg, R; Snyder, M; Becker, PM; Ozonoff, A; Rouphael, N; Reed, EF; Woodruff, PG; Prasad, P; Ghale, R; Lota, R. Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients. Journal of immunology (Baltimore, Md. : 1950). 2023; 211:1224-1231.

Wimmers, F; Burrell, AR; Feng, Y; Zheng, H; Arunachalam, PS; Hu, M; Spranger, S; Nyhoff, LE; Joshi, D; Trisal, M; Khurana, S; Khatri, P; Staat, MA; Pulendran, B. Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell. 2023; 186:4632-4651.e23.

Arunachalam, PS; Scott, MK D; Hagan, T; Li, C; Feng, Y; Wimmers, F; Grigoryan, L; Trisal, M; Edara, VV; Lai, L; Suthar, MS; Khatri, P; Nadeau, KC; Pulendran, B. Addendum: Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2023; 618:E18.

Luo, W; Adamska, JZ; Li, C; Verma, R; Liu, Q; Hagan, T; Wimmers, F; Gupta, S; Feng, Y; Jiang, W; Trisal, M; Subramaniam, S; Osborne, TF; Pulendran, B. SREBP signaling is essential for effective B cell responses. Nature Immunology. 2023; 24:337-348.

Adamska, JZ; Verma, R; Gupta, S; Hagan, T; Wimmers, F; Floyd, K; Li, Q; Valore, EV; Wang, Y; Trisal, M; Walkley, CR; Suthar, MS; Li, JB; Pulendran, B. Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2. Cell Reports. 2023; 42:112038.

Hagan, T; Gerritsen, B; Tomalin, LE; Fourati, S; Mulè, MP; Chawla, DG; Rychkov, D; Henrich, E; Miller, HE R; Diray-Arce, J; Stuart, K; Togias, A; Tsang, JS; Suárez-Fariñas, M. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nature Immunology. 2022; 23:1788-1798.

Diray-Arce, J; Miller, HE R; Henrich, E; Gerritsen, B; Mulè, MP; Fourati, S; Gygi, J; Hagan, T; Tomalin, L; Rychkov, D; Sekaly, R; Floratos, A; Kleinstein, SH; Suárez-Fariñas, M. The Immune Signatures data resource, a compendium of systems vaccinology datasets. Scientific Data. 2022; 9:635.

Fourati, S; Tomalin, LE; Mulè, MP; Chawla, DG; Gerritsen, B; Rychkov, D; Henrich, E; Miller, HE R; Hagan, T; Diray-Arce, J; Suárez-Fariñas, M; Pulendran, B; Kleinstein, SH; Sékaly, RP. Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nature Immunology. 2022; 23:1777-1787.

Ozonoff, A; Schaenman, J; Jayavelu, ND; Milliren, CE; Calfee, CS; Cairns, CB; Kraft, M; Baden, LR; Shaw, AC; Krammer, F; Ahuja, N; Rogers, AJ; Artandi, M; Siegel, SA R. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022; 83:104208.

Shao, TY; Kakade, P; Witchley, JN; Frazer, C; Murray, KL; Ene, IV; Haslam, DB; Hagan, T; Noble, SM; Bennett, RJ; Way, SS. Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity. Cell Reports. 2022; 39:110837.

Arunachalam, PS; Scott, MK D; Hagan, T; Li, C; Feng, Y; Wimmers, F; Grigoryan, L; Trisal, M; Edara, VV; Lai, L; Suthar, MS; Khatri, P; Nadeau, KC; Pulendran, B. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021; 596:410-416.

Wimmers, F; Donato, M; Kuo, A; Ashuach, T; Gupta, S; Li, C; Dvorak, M; Foecke, MH; Chang, SE; Hagan, T; Yosef, N; Utz, PJ; Khatri, P; Pulendran, B. The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination. Cell. 2021; 184:3915-3935.e21.