Lynn Lee Lab
Publications

Publications

Itskovich, SS; Gurunathan, A; Clark, J; Burwinkel, M; Wunderlich, M; Berger, MR; Kulkarni, A; Chetal, K; Venkatasubramanian, M; Salomonis, N; Kumar, AR; Lee, LH. MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. Nature Communications. 2020; 11(1):2369.

Lee, LH; Krupski, C; Clark, J; Wunderlich, M; Lorsbach, RB; Grimley, MS; Burwinkel, M; Nelson, A; Kumar, AR. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood advances. 2020; 4(4):717-727.

Lee, LH; Gasilina, A; Roychoudhury, J; Clark, J; Mccormack, FX; Pressey, J; Grimley, MS; Lorsbach, R; Ali, S; Bailey, M; Stephens, P; Ross, JS; Miller, VA; Nassar, NN; Kumar, AR. Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. JCI Insight. 2017; 2(3):e89473.

Bender, JD; Pommert, L; Backus, LR; Bidwell, A; Blank, C; Breese, EH; Burns, KC; Lane, A; Lee, LH; Mizukawa, B; Ryan, TD; Young, J; Absalon, M; Perentesis, JP. CPX-351 in High-Risk Relapsed Pediatric Acute Leukemia: Real-World Phase 1 Data Establishing the FDA-Approved Dose. Pediatric Blood and Cancer. 2026; 73(6):e70268.

Uible, EE; Choi, I; Clough, CA; Hassan, A; Anandappa, AJ; Fisher, J; Karki, B; Hueneman, K; Choi, K; Vick, EJ; Pasare, C; Cunningham, JT; Volk, AG; Starczynowski, DT. Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia. Cell Chemical Biology. 2026; 33(1):59-73.e10.

Mukhopadhyay, E; Lakes, N; Krishnamurthy, D; Tuazon, JA; Ohayon, DE; Ali, A; Seelamneni, H; Lee, LH; Hildeman, DA; Waggoner, SN. RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression. Journal of Immunology. 2025; 214(12):3218-3227.

Leblanc, FR; Breese, EH; Burns, KC; Chang, EK; Jones, LM; Lee, L; Mizukawa, B; Norris, RE; O'brien, MM; Phillips, CL; Perentesis, JP; Rubinstein, J; Pommert, L. Clinical outcomes of hypomethylating agents and venetoclax in newly diagnosed unfit and relapsed/refractory paediatric, adolescent and young adult acute myeloid leukaemia patients. British Journal of Haematology. 2024; 205(3):1055-1066.

Gracia-Maldonado, G; Clark, J; Burwinkel, M; Greenslade, B; Wunderlich, M; Salomonis, N; Leone, D; Gatti, E; Pierre, P; Kumar, AR; Lee, LH. LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for mixed lineage leukemia-rearranged acute leukemia. Haematologica. 2022; 107(4):803-815.

Muto, T; Guillamot, M; Yeung, J; Fang, J; Bennett, J; Nadorp, B; Lasry, A; Redondo, LZ; Choi, K; Gong, Y; Lujambio, A; Lowe, SW; Aifantis, I; Starczynowski, DT. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. 2022; 29(2):298-314.e9.

Lin, S; Larrue, C; Scheidegger, NK; Seong, BKA; Dharia, NV; Kuljanin, M; Wechsler, CS; Kugener, G; Robichaud, AL; Conway, AS; Wunderlich, M; Letai, A; Tamburini, J; Stegmaier, K. An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML. Cancer Discovery. 2022; 12(2):432-449.

Lin, S; Larrue, C; Scheidegger, NK; Seong, BKA; Dharia, NV; Wechsler, C; Kugener, G; Robinchaud, AL; Conway, A; Adane, B; Lee, L; Wunderlich, M; Tamburini, J; Stegmaier, K. An In Vivo CRISPR Screening Platform to Identify New Therapeutic Targets in AML. Blood. 2021; 138(Supplement 1):266.

Rubinstein, JD; Shah, R; Breese, EH; Burns, KC; Mangino, JL; Norris, RE; Lee, L; Mizukawa, B; O'brien, MM; Phillips, CL; Perentesis, JP; Pommert, L; Absalon, MJ. Treatment of posttransplant lymphoproliferative disorder with poor prognostic features in children and young adults: Short-course EPOCH regimens are safe and effective. Pediatric Blood and Cancer. 2021; 68(8):e29126.

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