Mathieu performed his PhD research at the National Institute of Health and Medical Research in the Division of Immunology and Genetics of Parasitic Diseases, in Marseille, France. While there, he studied the human immune response to schistosomiasis, and genetic susceptibility to severe forms of the disease (liver fibrosis).
In 2012, Mathieu moved to Cincinnati Children’s to explore hematopoietic stem cell and immune deficiencies in the childhood disorder Fanconi anemia disease in the laboratory of Dr. Qishen Pang. His work demonstrated that the deregulation of WNT signaling in Fanconi deficient B cells leads to an impairment of cellular differentiation into plasma cells.
In 2015 Mathieu moved to the laboratory of Dr. Susanne Wells to spearhead basic research studies in the new Proton Therapy Center in collaboration with the Heidelberg Ion Beam Therapy Center (HIT, Germany, and Dr. Amir Abdollahi). There is a major gap between our sophisticated understanding of proton beam physics in clinical applications and a paucity of data on the molecular, cellular and tissue responses to radiation. The goal of Mathieu’s initiative is to bridge this gap, with the short term goal of leveraging novel transcriptomic and metabolomic profiling data into proton therapy biomarkers and treatment sensitizers.