Wells Lab

Publications

Sertorio, M; Perentesis, JP; Vatner, RE; Mascia, AE; Zheng, Y; Wells, SI. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International Journal of Particle Therapy. 2019; 5:40-48.

Toptan, T; Brusadelli, MG; Turpin, B; Witte, DP; Surralles, J; Velleuer, E; Schramm, M; Dietrich, R; Brakenhoff, RH; Moore, PS; Chang, Y; Wells, SI. Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. Editor, Toland AE. PloS one. 2018; 13:e0209235.

Zhao, X; Brusadelli, MG; Sauter, S; Kovacic, MB; Zhang, W; Romick-Rosendale, LE; Lambert, PF; Setchell, KD R; Wells, SI. Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells. Clinical Cancer Research. 2018; 24:2700-2709.

Matrka, MC; Cimperman, KA; Haas, SR; Guasch, G; Ehrman, LA; Waclaw, RR; Komurov, K; Lane, A; Wikenheiser-Brokamp, KA; Wells, SI. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. Editor, Grosveld GC. PLoS Genetics. 2018; 14:e1007227.

Khoury, R; Sauter, S; Kovacic, MB; Nelson, AS; Myers, KC; Mehta, PA; Davies, SM; Wells, SI. Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know. Viruses-Basel. 2018; 10:E47.

Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI. The nuclear DEK interactome supports multi-functionality. Proteins: Structure, Function, and Bioinformatics. 2018; 86:88-97.

Matrka, MC; Watanabe, M; Muraleedharan, R; Lambert, PF; Lane, AN; Romick-Rosendale, LE; Wells, SI. Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. Editor, Singh PK. PloS one. 2017; 12:e0177952.

Smith, EA; Kumar, B; Komurov, K; Smith, SM; Brown, NV; Zhao, S; Kumar, P; Teknos, TN; Wells, SI. DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma. Oncotarget. 2017; 8:23414-23426.

Smith, EA; Gole, B; Willis, NA; Soria, R; Starnes, LM; Krumpelbeck, EF; Jegga, AG; Ali, AM; Guo, H; Meetei, AR; Daniel, JA; Scully, R; Wiesmueller, L; Wells, SI. DEK is required for homologous recombination repair of DNA breaks. Scientific Reports. 2017; 7:44662.

Chlon, TM; Ruiz-Torres, S; Maag, L; Mayhew, CN; Wikenheiser-Brokamp, KA; Davies, SM; Mehta, P; Myers, KC; Wells, JM; Wells, SI. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem Cell Reports. 2016; 6:44-54.

Vicente-Muñoz, S; Davis, JC; Lane, A; Lane, AN; Waltz, SE; Wells, SI. Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes. Frontiers in Oncology. 2024; 14:1382986.

Bartlett, AL; Wagner, JE; Jones, B; Wells, S; Sabulski, A; Fuller, C; Davies, SM. Fanconi anemia neuroinflammatory syndrome: brain lesions and neurologic injury in Fanconi anemia. Blood Advances. 2024; 8:3027-3037.

Bedard, MC; Chihanga, T; Carlile, A; Jackson, R; Brusadelli, MG; Lee, D; VonHandorf, A; Rochman, M; Dexheimer, PJ; Chalmers, J; Lambert, PF; Adam, M; Steven Potter, S; Wells, SI. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nature Communications. 2023; 14:1975.

Marion, W; Koppe, T; Chen, CC; Wang, D; Frenis, K; Fierstein, S; Sensharma, P; Aumais, O; Peters, M; Ruiz-Torres, S; Ebert, BL; Starczynowski, D; da Rocha, EL; Rowe, RG. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia. 2023; 37:1698-1708.

Nguyen, HT; Tang, W; Webster, AL H; Whiteaker, JR; Chandler, CM; Errazquin, R; Roohollahi, K; Fritzke, M; Hoskins, EE; Jonlin, E; Garcia-Escudero, R; Wells, SI; Smogorzewska, A; Monnat, RJ. Fanconi anemia-isogenic head and neck cancer cell line pairs: A basic and translational science resource. International Journal of Cancer. 2023; 153:183-196.

Hunt, BG; Davis, JC; Fox, LH; Vicente-Muñoz, S; Lester, C; Wells, SI; Waltz, SE. RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. Oncogene: Including Oncogene Reviews. 2023; 42:1716-1727.

Webster, AL H; Sanders, MA; Patel, K; Dietrich, R; Noonan, RJ; Lach, FP; White, RR; Goldfarb, A; Hadi, K; Edwards, MM; Singh, B; Kutler, DI; Campbell, PJ; Smogorzewska, A. Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer. Nature. 2022; 612:495-502.

Roohollahi, K; de Jong, Y; Pai, G; Zaini, MA; de Lint, K; Sie, D; Rooimans, MA; Rockx, D; Hoskins, EE; Ameziane, N; Wolthuis, R; Joenje, H; Wells, SI; Dorsman, J. BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia. Scientific Reports. 2022; 12:45.

Vicente-Muñoz, S; Hunt, BG; Lange, TE; Wells, SI; Waltz, SE. NMR-based metabolomic analysis identifies RON-DEK-β-catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival. Editor, Samant R. PloS one. 2022; 17:e0274128.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; Romick-Rosendale, LE; Wells, SI. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14:2040.

Silva de Araujo, BE; Velleuer, E; Dietrich, R; Pomjanski, N; de Santana Almeida Araujo, IK; Schlensog, M; Wells, SI; Dorsman, JC; Schramm, M. Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept. Clinical and Experimental Dental Research. 2022; 8:108-116.

Ruiz-Torres, S; Lambert, PF; Wikenheiser-Brokamp, KA; Wells, SI. Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. Molecular Biology Reports: an international journal on molecular and cellular biology. 2021; 48:6213-6222.

Bedard, MC; de Alarcon, A; Kou, YF; Lee, D; Sestito, A; Duggins, AL; Brusadelli, M; Lane, A; Wikenheiser-Brokamp, KA; Wells, SI; Smith, DF. HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening. Cancers. 2021; 13:2556.

Sauter, SL; Zhang, X; Romick-Rosendale, L; Wells, SI; Myers, KC; Brusadelli, MG; Poff, CB; Brown, DR; Panicker, G; Unger, ER; Mehta, PA; Bleesing, J; Davies, SM; Kovacic, MB. Human Papillomavirus Oral- and Sero- Positivity in Fanconi Anemia. Cancers. 2021; 13:1368.

Ruiz-Torres, S; Brusadelli, MG; Witte, DP; Wikenheiser-Brokamp, KA; Sauter, S; Nelson, AS; Sertorio, M; Chlon, TM; Lane, A; Mehta, PA; Komurov, K; Kovacic, MB; Davies, SM; Wells, SI. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell Stem Cell. 2021; 28:424-435.e6.

Cunningham, S; McCauley, S; Vairamani, K; Speth, J; Girdhani, S; Abel, E; Sharma, RA; Perentesis, JP; Wells, SI; Mascia, A; Sertorio, M. FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cancers. 2021; 13:1-15.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; Perentesis, JP; Abdollahi, A; Zheng, Y; Wells, SI. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Bartlett, AL; Romick-Rosendale, L; Nelson, A; Abdullah, S; Luebbering, N; Bartlett, J; Brusadelli, M; Palumbo, JS; Lake, K; Litts, B; Lane, A; Myers, KC; Wells, SI; Davies, SM. Tryptophan metabolism is dysregulated in individuals with Fanconi anemia. Blood Advances. 2021; 5:250-261.

Bedard, MC; Brusadelli, MG; Carlile, A; Ruiz-Torres, S; Lodin, H; Lee, D; Kofron, M; Lambert, PF; Lane, A; Ameziane, N; Bahassi, EM; Wikenheiser-Brokamp, KA; de Alarcon, A; Smith, DF; Wells, SI. Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. Viruses-Basel. 2021; 13:68.

Marion, W; Boettcher, S; Ruiz-Torres, S; da Rocha, EL; Lundin, V; Morris, V; Chou, S; Zhao, AM; Kubaczka, C; Aumais, O; Ebert, BL; Wells, SI; Daley, GQ; Grant Rowe, R. An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation. Blood Advances. 2020; 4:4679-4692.

collaboration, fT B P; Staff, PN S E. Proceedings to the 58th Annual Conference of the Particle Therapy Cooperative Group (PTCOG58). International Journal of Particle Therapy. 2020; 6:45-491.

Nowrouzi, A; Sertorio, MG; Akbarpour, M; Knoll, M; Krunic, D; Kuhar, M; Schwager, C; Brons, S; Debus, J; Wells, SI; Wells, JM; Abdollahi, A. Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers. 2020; 12:E469.