Wells Lab
Publications

Publications

Zhao, X; Brusadelli, MG; Sauter, S; Butsch Kovacic, M; Zhang, W; Romick-Rosendale, LE; Lambert, PF; Setchell, KDR; Wells, SI. Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells. Clinical Cancer Research. 2018; 24(11):2700-2709.

Matrka, MC; Cimperman, KA; Haas, SR; Guasch, G; Ehrman, LA; Waclaw, RR; Komurov, K; Lane, A; Wikenheiser-Brokamp, KA; Wells, SI. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS Genetics. 2018; 14(3):e1007227.

Khoury, R; Sauter, S; Butsch Kovacic, M; Nelson, AS; Myers, KC; Mehta, PA; Davies, SM; Wells, SI. Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know. Viruses. 2018; 10(1).

Sertorio, M; Perentesis, JP; Vatner, RE; Mascia, AE; Zheng, Y; Wells, SI. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International Journal of Particle Therapy. 2018; 5(1):40-48.

Toptan, T; Brusadelli, MG; Turpin, B; Witte, DP; Surrallés, J; Velleuer, E; Schramm, M; Dietrich, R; Brakenhoff, RH; Moore, PS; Chang, Y; Wells, SI. Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. PLoS ONE. 2018; 13(12):e0209235.

Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI. The nuclear DEK interactome supports multi-functionality. Proteins: Structure, Function and Bioinformatics. 2018; 86(1):88-97.

Smith, EA; Kumar, B; Komurov, K; Smith, SM; Brown, NV; Zhao, S; Kumar, P; Teknos, TN; Wells, SI. DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma. Oncotarget. 2017; 8(14):23414-23426.

Smith, EA; Gole, B; Willis, NA; Soria, R; Starnes, LM; Krumpelbeck, EF; Jegga, AG; Ali, AM; Guo, H; Meetei, AR; Daniel, JA; Scully, R; Wiesmüller, L; Wells, SI. DEK is required for homologous recombination repair of DNA breaks. Scientific Reports. 2017; 7:44662.

Matrka, MC; Watanabe, M; Muraleedharan, R; Lambert, PF; Lane, AN; Romick-Rosendale, LE; Wells, SI. Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. PLoS ONE. 2017; 12(5):e0177952.

Chlon, TM; Ruiz-Torres, S; Maag, L; Mayhew, CN; Wikenheiser-Brokamp, KA; Davies, SM; Mehta, P; Myers, KC; Wells, JM; Wells, SI. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem Cell Reports. 2016; 6(1):44-54.

Johnstone, ME; Leck, AL; Lange, TE; Wilcher, KE; Shephard, MS; Paranjpe, A; Schutte, S; Wells, SI; Kappes, F; Salomonis, N; Privette Vinnedge, LM. DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications. Life Science Alliance. 2025; 8(9).

Ruffolo, B; Vicente-Muñoz, S; Mehta, KY; Rivera-Cruz, CM; Zhao, X; Romick, L; Setchell, KDR; Lane, A; Wells, SI. The Fanconi Anemia Pathway Inhibits mTOR Signaling and Prevents Accelerated Translation in Head and Neck Cancer Cells. Cancers. 2025; 17(15).

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood advances. 2025; 9(8):1927-1939.

Bedard, MC; Rivera-Cruz, CM; Chihanga, T; Vonhandorf, A; Tang, AL; Zender, C; Weirauch, MT; Ferris, R; Wise-Draper, TM; Adam, M; Wells, SI. A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers. Viruses. 2025; 17(4).

Bartlett, AL; Wagner, JE; Jones, B; Wells, S; Sabulski, A; Fuller, C; Davies, SM. Fanconi anemia neuroinflammatory syndrome: brain lesions and neurologic injury in Fanconi anemia. Blood advances. 2024; 8(12):3027-3037.

Vicente-Muñoz, S; Davis, JC; Lane, A; Lane, AN; Waltz, SE; Wells, SI. Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes. Frontiers in Oncology. 2024; 14:1382986.

Marion, W; Koppe, T; Chen, C-C; Wang, D; Frenis, K; Fierstein, S; Sensharma, P; Aumais, O; Peters, M; Ruiz-Torres, S; Ebert, BL; Starczynowski, D; Da Rocha, EL; Rowe, RG. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia. 2023; 37(8):1698-1708.

Nguyen, HT; Tang, W; Webster, ALH; Whiteaker, JR; Chandler, CM; Errazquin, R; Roohollahi, K; Fritzke, M; Hoskins, EE; Jonlin, E; Garcia-Escudero, R; Wells, SI; Smogorzewska, A; Monnat, RJ. Fanconi anemia-isogenic head and neck cancer cell line pairs: A basic and translational science resource. International Journal of Cancer. 2023; 153(1):183-196.

Hunt, BG; Davis, JC; Fox, LH; Vicente-Muñoz, S; Lester, C; Wells, SI; Waltz, SE. RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. Oncogene. 2023; 42(21):1716-1727.

Bedard, MC; Chihanga, T; Carlile, A; Jackson, R; Brusadelli, MG; Lee, D; Vonhandorf, A; Rochman, M; Dexheimer, PJ; Chalmers, J; Lambert, PF; Adam, M; Steven Potter, S; Wells, SI. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nature Communications. 2023; 14(1):1975.

Webster, ALH; Sanders, MA; Patel, K; Dietrich, R; Noonan, RJ; Lach, FP; White, RR; Goldfarb, A; Hadi, K; Edwards, MM; Singh, B; Kutler, DI; Campbell, PJ; Smogorzewska, A. Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer. Nature. 2022; 612(7940):495-502.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; Romick-Rosendale, LE; Wells, SI. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14(8).

Silva De Araujo, BE; Velleuer, E; Dietrich, R; Pomjanski, N; De Santana Almeida Araujo, IK; Schlensog, M; Wells, SI; Dorsman, JC; Schramm, M. Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept. Clinical and Experimental Dental Research. 2022; 8(1):108-116.

Roohollahi, K; De Jong, Y; Pai, G; Zaini, MA; De Lint, K; Sie, D; Rooimans, MA; Rockx, D; Hoskins, EE; Ameziane, N; Wolthuis, R; Joenje, H; Wells, SI; Dorsman, J. BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia. Scientific Reports. 2022; 12(1):45.

Vicente-Muñoz, S; Hunt, BG; Lange, TE; Wells, SI; Waltz, SE. NMR-based metabolomic analysis identifies RON-DEK-β-catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival. PLoS ONE. 2022; 17(9):e0274128.

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