Give weekly adalimumab a chance before discontinuing it: a retrospective clinical and pharmacokinetic analysis in pediatric rheumatology. Arthritis Research & Therapy. 2025; 27(1):230.
IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope. Cancer Science. 2025; 116(12):3250-3265.
Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital. Clinical and Translational Science. 2025; 18(12):e70438.
Maternal Sirolimus Treatment Reverses Cardiac Rhabdomyoma-Induced Hydrops Fetalis in a Twin Gestation With Tuberous Sclerosis Complex. American Journal of Medical Genetics, Part A. 2025; 197(11):e64175.
Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease. Clinical Pharmacokinetics. 2025; 64(11):1669-1679.
Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft-Versus-Host Disease After Pediatric Liver Transplantation. Pediatric Transplantation. 2025; 29(7):e70187.
Belatacept Pharmacokinetic Analysis of Belatacept Early Steroid Withdrawal Trial (BEST) to Clinical Outcomes and Compared With Reported BENEFIT and BENEFIT-EXT Pharmacokinetic Analysis. Clinical Transplantation. 2025; 39(8):e70172.
Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. Journal of Applied Laboratory Medicine. 2025; 10(4):806-819.
Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing. Antibiotics. 2025; 14(6).
Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64(4):553-564.
Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients. Antimicrobial Agents and Chemotherapy. 2025; 69(3):e0122724.
AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31(Supplement_1):s59-s60.
Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40(2):513-521.
Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2025; 47(1):4-31.
Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. Clinical and Translational Science. 2025; 18(2):e70086.
AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168(3):s84-s85.
NUDT15 Genetic Polymorphism as a Risk Factor for Early Neutropenia During Valganciclovir Prophylaxis in Lung Transplant Patients. Transplant Infectious Disease. 2025; 27(6):e70108.
Pharmacokinetic Factors Associated With Early Meropenem Target Attainment in Pediatric Severe Sepsis. Pediatric Critical Care Medicine. 2024; 25(12):1103-1116.
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment. Journal of Intensive Care. 2024; 12(1):38.
Identifying optimal dosing strategies for meropenem in the paediatric intensive care unit through modelling and simulation. Journal of Antimicrobial Chemotherapy. 2024; 79(10):2668-2677.
Impact of fluid balance on beta-lactam antibiotics target attainment: Insights from a simulation-based meropenem study. International Journal of Antimicrobial Agents. 2024; 64(3):107267.
Recent Advances Addressing the Challenges of Precision Dosing. Clinical Pharmacology and Therapeutics. 2024; 116(3):527-530.
Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical Pharmacology and Therapeutics. 2024; 116(3):670-677.
Pharmacokinetic Factors Associated With Early Meropenem Target Attainment in Pediatric Severe Sepsis. Lippincott Williams & Wilkins. Aug 20, 2024.
Belatacept Removal by Plasmapheresis: Dose Adjustments and Clinical Recommendations. Transplantation Direct. 2024; 10(8):e1677.
Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug Metabolism And Disposition. 2024; 52(8):785-796.
Cystatin C Outperforms Creatinine in Predicting Cefepime Clearance in Pediatric Stem Cell Transplant Recipients. Transplantation and Cellular Therapy. 2024; 30(6):614.e1-614.e11.
Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results. Annals of the Child Neurology Society. 2024; 2(2):106-119.
Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2024; 46(3):291-308.
Potential treatment option of rivaroxaban for breastfeeding women: A case series. Thrombosis Research. 2024; 237:141-144.
958 ATTAINING EARLY ANTI-TNF EXPOSURE TARGETS IS ASSOCIATED WITH IMPROVED RATES OF ENDOSCOPIC HEALING AND TRANSMURAL HEALING IN CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166(5):s-226-s-227.
Ceftriaxone Pharmacokinetics and Pharmacodynamic Target Attainment for Three Pediatric Patients Receiving Continuous Kidney Replacement Therapy. Journal of Pediatric Pharmacology and Therapeutics. 2024; 29(2):180-187.
84 Using Opportunistic Sampling and Remnant Blood Samples to Develop Pediatric Pharmacokinetic Models to Inform Antidepressant Dosing. Journal of Clinical and Translational Science. 2024; 8(s1):22-23.
Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohn's disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA. BMJ Open. 2024; 14(3):e077193.
Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling. Pharmaceutics. 2024; 16(3).
Model-Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease. Clinical Pharmacology and Therapeutics. 2024; 115(2):239-247.
868: EARLY MEROPENEM CLEARANCE OF CRITICALLY ILL PATIENTS IN A PEDIATRIC INTENSIVE CARE UNIT. Critical Care Medicine. 2024; 52(1):s407-s407.
Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis-A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study). Journal of Clinical Trials. 2024; 14(4).
Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic Drug Monitoring. 2023; 45(6):832-836.
Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: Pharmacometrics and Systems Pharmacology. 2023; 12(12):1827-1845.
Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients. Clinical Pharmacokinetics. 2023; 62(11):1621-1637.
Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients. Clinical and Translational Science. 2023; 16(10):1768-1778.
Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. Journal of Antimicrobial Chemotherapy. 2023; 78(9):2140-2147.
Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2023; 29(8):1342-1346.
Model-Informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient With Posterior Reversible Encephalopathy Syndrome. Therapeutic Drug Monitoring. 2023; 45(3):376-382.
Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21(5):1338-1347.
347 DISEASE PROGRESSION PHARMACOKINETIC MODELING IMPROVES THE ACCURACY OF EARLY INFLIXIMAB CONCENTRATION TARGETS. Gastroenterology. 2023; 164(6):s-59.
714 INFLIXIMAB CLEARANCE IN RELATION TO DISEASE ACTIVITY DURING INDUCTION AND MAINTENANCE THERAPY OF ACUTE SEVERE AND AMBULATORY PEDIATRIC ULCERATIVE COLITIS. Gastroenterology. 2023; 164(6):s-150.
Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic Drug Monitoring. 2023; 45(2):143-150.
Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary Pharmacology and Therapeutics. 2023; 57(5):524-539.
610: RENAL IMPAIRMENT IS ASSOCIATED WITH HIGH CEFEPIME CONCENTRATIONS IN CRITICALLY ILL CHILDREN. Critical Care Medicine. 2023; 51(1):294-294.
38: CRITICALLY ILL CHILDREN WITH SEVERE SEPSIS OFTEN HAVE SUB-TARGET MEROPENEM LEVELS EARLY IN THERAPY. Critical Care Medicine. 2023; 51(1):19-19.
Pharmacokinetic-Guided Dosing to Maintain Therapeutic Tacrolimus Levels During Post-Kidney Transplant Erythrocytapheresis in a Patient With Sickle Cell Anemia. Journal of the American Society of Nephrology. 2022; 33(11S):840-840.
A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology and Therapeutics. 2022; 234:108045.
Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55(5):593-603.
REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Gastroenterology. 2022; 162(3):s100.
PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Gastroenterology. 2022; 162(3):s99-s100.
BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Gastroenterology. 2022; 162(3):s98-s99.
Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacology and Therapeutics. 2022; 111(2):496-508.
Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British Journal of Clinical Pharmacology. 2022; 88(4):1418-1426.
REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s100-s100.
PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s99-s100.
BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s98-s99.
Everolimus pharmacokinetics and exposure-response relationship in Japanese patients with advanced breast cancer. Frontiers in Pharmacology. 2022; 13:984002.