Prasad Lab

Publications

Ailabouni, AS; Halpin, K; Boone, EC; Gaedigk, A; Nadai, T; Irie, K; Mizuno, T; Leeder, JS; Prasad, B. Interindividual variability in metformin pharmacokinetics in pediatric patients. Pediatric Research. 2026.

Subash, S; Ahire, D; Jones, RS; Ma, B; Tian, Y; Wang, T; Khojasteh, SC; Murray, BP; Stresser, DM; Taub, M; Prasad, B. Protein Abundance of Hydrolytic Drug Metabolizing Enzymes in Different Tissues and across Species. Journal of Medicinal Chemistry. 2026.

Gadara, D; Singh, DK; Subash, S; Yue, G; Ahire, D; Bohl, C; Czerwinski, M; Helmstetter, S; Heyward, S; Jones, RS; Stresser, DM; Taub, ME; Wang, T; Prasad, B. Characterization of Lysosomal Hydrolases and Transporters and Their Age-Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs. Clinical Pharmacology and Therapeutics. 2026.

Prasad, B. Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics-Based Biomarkers. Clinical and Translational Science. 2026; 19(5):e70591.

Kuo-Esser, L; Vijaywargi, G; Prasad, B; Thakur, A; Aliabouni, AS; Halpin, K; Paine, M. Metabolite Panel for Estimation of Glomerular Filtration Rate (Abstract ID: 226554) Journal of Pharmacology and Experimental Therapeutics. 2026; 393(5):104160.

Shaffer, G; Singh, DK; Subash, S; Prasad, B. Proteomic Characterization of Human Kinases Across Tissue Types: Implications for Kinase Activated Drugs (Abstract ID: 225691) Journal of Pharmacology and Experimental Therapeutics. 2026; 393(5):104195.

Yee, SW; Prasad, B; Kusuhara, H; Kimoto, E. Integrating renal transporter biomarkers into drug development: Discovery, clinical assessment, and precision medicine. Drug Metabolism and Pharmacokinetics. 2026; 67:101515.

Cleary, Y; Prasad, B; Ogungbenro, K; Gertz, M; Galetin, A. Population Physiologically-Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease. CPT: Pharmacometrics and Systems Pharmacology. 2026; 15(2):e70174.

Gooden, F; Meier, BD; Shaffer, GD; Gibson, K; Toren, P; Punt, NC; Subash, S; Singh, DK; Prasad, B; Ramsey, LB; Taylor, ZL. Pharmacogenetic hSLCO1B1*14-Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response. Clinical and Translational Science. 2026; 19(1):e70449.

Baker, BH; Kruger, L; Prasad, B; Macdonald, JW; Bammler, TK; Konwar, C; Kobor, MS; Bush, NR; Lewinn, KZ; Zhao, Q; Paquette, AG; Sathyanarayana, S. Placental proteomic signatures of preterm birth, gestational age, and birthweight. BMC Pregnancy and Childbirth. 2025; 26(1):50.

Prasad, B. Promise of Quantitative Proteomics in the Qualification of New Approach Methodologies. Clinical Pharmacology and Therapeutics. 2025; 118(6):1273-1275.

Subash, S; Singh, DK; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Smith, BJ; Prasad, B. Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation. Molecular Pharmaceutics. 2025; 22(12):7359-7370.

Singh, DK; Ahire, D; Jones, RS; Kikuchi, R; Ma, B; Tian, Y; Wang, T; Zubair, F; Heyward, S; Khojasteh, SC; Stresser, DM; Taub, M; Zientek, M; Prasad, B. Protein Abundance of Clinically Relevant Drug-Metabolizing Hydrolases in Human Liver and Intestine by Targeted versus Global Proteomics Approaches: A Comparative Study. Journal of Proteome Research. 2025; 24(11):5683-5695.

Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Denton, TT; Clarke, JD; Paine, MF; Prasad, B. From Discovery to Translation: Endogenous Substrates of OAT1 and OAT3 as Clinical Biomarkers for Renal Secretory Function. Clinical Pharmacology and Therapeutics. 2025; 118(3):693-704.

Bachhav, N; Subash, S; Ahire, D; Singh, DK; Prasad, B. Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs). Biochemical Pharmacology. 2025; 239:117044.

Bachhav, N; Singh, DK; Shaffer, G; Amory, JK; Prasad, B. Curcumin enhances the oral bioavailability of testosterone by inhibiting its intestinal metabolism. Drug Metabolism And Disposition. 2025; 53(9):100144.

Ailabouni, AS; Singh, DK; Thakur, A; Boone, EC; Gaedigk, A; Paine, MF; Prasad, B. Quantitative Contributions of Hepatic and Renal Organic Cation Transporters to the Clinical Pharmacokinetic Cimetidine-Metformin Interaction. Clinical Pharmacology and Therapeutics. 2025; 118(2):343-354.

Panipinto, PM; Yue, GE; Prasad, B; Ahmed, S. Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1. American Journal of Physiology - Cell Physiology. 2025; 329(2):C500-C512.

Gu, W; Langlois, AWR; Giratallah, H; Claw, KG; Prasad, B; Thummel, KE; Tyndale, RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacology Research & Perspectives. 2025; 13(4):e70149.

Li, Y; Yabut, J; Zhang, Z; Fauty, S; Houle, R; Miller, H; Zhang, NR; Shin, MK; Rosahl, TW; Zhou, HH; Prasad, B; Unadkat, JD; Chu, X. Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs. Drug Metabolism And Disposition. 2025; 53(7):100101.

Davydov, DR; Ponraj, K; Davydova, N; Singh, DK; Prasad, B. A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. Biochemical Journal. 2025; 482(12):839-857.

Subash, S; Ahire, D; Jones, R; Ma, B; Tian, Y; Murray, B; Stresser, D; Taub, M; Prasad, B. Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species. Drug Metabolism and Pharmacokinetics. 2025; 61:101350.

Thakur, A; Subash, S; Ahire, D; Prasad, B. Characterization of age-dependent abundance of drug transporter proteins and conjugating enzymes in human hepatocytes: Implication for pediatric drug dosing. Drug Metabolism and Pharmacokinetics. 2025; 61:101453.

Thakur, A; Singh, DK; Lynch, KD; Kis, E; Gáborik, Z; Clarke, JD; Paine, MF; Prasad, B. Identification and validation of selective endogenous substrates of organic anion transporter 1 (OAT1) versus OAT3 using metabolomics and in-vitro mechanistic studies. Drug Metabolism and Pharmacokinetics. 2025; 61:101454.

Singh, D; Ahire, D; Jones, R; Ma, B; Yu, T; Murray, B; Smith, B; Zientek, M; Heyward, S; Prasad, B. The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver. Drug Metabolism and Pharmacokinetics. 2025; 61:101127.

Bachhav, N; Prasad, B. Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach. Drug Metabolism and Pharmacokinetics. 2025; 61:101301.

Prasad, B. Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling. Drug Metabolism and Pharmacokinetics. 2025; 61:101072.

Saponjac, VT; Sun, R; Zheng, Z; Chen, J; Srinual, S; Prasad, B; Singh, DK; Hu, M; Singh, R. Influence of locally bioavailable herbal components on the regulation of gut homoeostatis via expression of intestinal drug metabolizing enzymes and transporters in irinotecan-induced intestinal injury model. Drug Metabolism and Pharmacokinetics. 2025; 61:101335.

Ailabouni, A; Prasad, B. Organic cation transporters 2: Structure, regulation, functions, and clinical implications. Drug Metabolism And Disposition. 2025; 53(3):100044.

Vijaywargi, G; Ailabouni, AS; Neogi, AG; Halpin, KL; Paine, M; Prasad, B. Identification of Potential Pre-Dose Endogenous Metabolic Features Associated with Metformin Plasma Exposure in Healthy Adults and Pediatric Patients (Abstract ID: 167055) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101700.

Gaither, KA; Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Clarke, J; Prasad, B. Confounding Effect of Phenol Red on OAT- and OATP-Mediated Transporter Assays: Implications for Accuracy and Translatability of In Vitro Data (Abstract ID: 168143) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101704.

Naji-Talakar, S; Singh, DK; Paine, M; Prasad, B. Diclofenac Glucuronidation and Oxidation Are Inhibited by Curcumin Standard and Supplements (Abstract ID: 167709) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101701.

Shaffer, G; Prasad, B. Investigation of Interindividual Variability of Drug Metabolizing Kinases in Human Hepatocytes: Influence of Age, Sex, and Race (Abstract ID: 161579) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101673.

Venkatachalapathy, P; Singh, DK; Thakur, A; Prasad, B. Identification of Potential Endogenous Substrates of Cytochrome P450 Enzymes Using an Optimized Metabolomics-Based Approach (Abstract ID: 161986) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101676.

Gaither, KA; Yue, G; Singh, DK; Trudeau, J; Ponraj, K; Davydova, NY; Lazarus, P; Davydov, DR; Prasad, B. Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver. Journal of Xenobiotics. 2025; 15(1).

Ailabouni, AS; Vijaywargi, G; Subash, S; Singh, DK; Gaborik, Z; Prasad, B. Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker? Metabolites. 2025; 15(2).

Lapehn, S; Nair, S; Firsick, EJ; Macdonald, J; Thoreson, C; Litch, JA; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. A transcriptomic comparison of in vitro models of the human placenta. Placenta. 2025; 159:52-61.

Granados, JC; Cheung, KWK; Prasad, B. Editorial: Diverse functions of drug transporters. Frontiers in Pharmacology. 2025; 16:1697775.

Coates, S; Bardhi, K; Prasad, B; Lazarus, P. Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics. 2024; 16(12).

Thakur, A; Subash, S; Ahire, D; Prasad, B. Developmental Expression of Drug Transporters and Conjugating Enzymes Involved in Enterohepatic Recycling: Implication for Pediatric Drug Dosing. Clinical Pharmacology and Therapeutics. 2024; 116(6):1615-1626.

Ponraj, K; Gaither, KA; Kumar Singh, D; Davydova, N; Zhao, M; Luo, S; Lazarus, P; Prasad, B; Davydov, DR. Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline. Biochemical Pharmacology. 2024; 230(Pt 1):116569.

Subash, S; Prasad, B. Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver. Drug Metabolism And Disposition. 2024; 52(12):1363-1372.

Prasad, B; Al-Majdoub, ZM; Wegler, C; Rostami-Hodjegan, A; Achour, B. Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook. Drug Metabolism And Disposition. 2024; 52(11):1208-1216.

Singh, DK; Ahire, D; Davydov, DR; Prasad, B. Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics. Drug Metabolism And Disposition. 2024; 52(11):1152-1160.

Parvez, MM; Thakur, A; Mehrotra, A; Stancil, S; Pearce, RE; Basit, A; Leeder, JS; Prasad, B. Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling. Clinical Pharmacology and Therapeutics. 2024; 116(4):1090-1099.

Ikumawoyi, VO; Lynch, KD; Iverson, DT; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Microcystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells. Toxicon. 2024; 249:108072.

Lapehn, S; Nair, S; Fisick, E; Macdonald, JW; Thoreson, C; Litch, J; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. Transcriptomic comparison of in vitro models of the human placenta. Placenta. 2024; 154:e22.

Bachhav, N; Singh, DK; Blithe, DL; Lee, MS; Prasad, B. Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17. Pharmaceutics. 2024; 16(8).

Subash, S; Ahire, D; Patel, M; Shaikh, S; Singh, DK; Deshmukh, S; Prasad, B. Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs. Pharmaceutical Research. 2024; 41(8):1621-1630.

Thakur, A; Yue, G; Ahire, D; Mettu, VS; Al Maghribi, A; Ford, K; Peixoto, L; Leeder, JS; Prasad, B. Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans? Clinical Pharmacology and Therapeutics. 2024; 116(1):235-246.

Subash, S; Singh, DK; Ahire, D; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Zubair, F; Smith, BJ; Heyward, S; Leeder, JS; Prasad, B. Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism. Molecular Pharmaceutics. 2024; 21(6):2740-2750.

Bachhav, N; Singh, DK; Blithe, D; Lee, M; Prasad, B. Biotransformation Pathways of 11β-Methyl-19-Nortestosterone and Its Prodrugs: Mechanistic In vitro Studies Unveils Involvement of Polymorphic Intestinal UGT2B17. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:38.

Ailabouni, A; Thakur, A; Singh, DK; Paine, MF; Prasad, B. Predicting contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction using a mechanistic PBPK model. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:442.

Gaither, K; Singh, DK; Yue, GE; Trudeau, J; Ponraj, K; Lazarus, P; Davydov, DR; Prasad, B. Interplay of Alcohol Intake, Smoking, and Sex on the Protein Abundance of Hepatic Drug Metabolizing Enzymes and Transporters in Humans. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:237.

Ponraj, K; Gaither, K; Singh, DK; Prasad, B; Davydov, DR. Non-additivity of the functional properties of P450 enzymes in the human drug-metabolizing ensemble revealed in a study with a series of individual microsomal preparations. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:40.

Thakur, A; Singh, DK; Kis, E; Gáborik, Z; Paine, MF; Prasad, B. De Novo Identification and Validation of Human Endogenous Biomarkers of Renal Organic Anion Transporters for Predicting Interindividual Variability. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:433-434.

Singh, DK; Ailabouni, A; Thakur, A; Paine, MF; Prasad, B. Deconvoluting the Global Metabolomic Changes Caused by a Complex Clinical Pharmacokinetic Cimetidine-Metformin Interaction Involving Organic Cation Transporters. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:233.

Harding, C; Yue, GE; Prasad, B. Quantitative Proteomics of Human Urine-Isolated Extracellular Vesicles Reveals Significant and Reproducible Enrichment of EV Markers and Renal Drug-Interacting Proteins. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:437.

Ikumawoyi, V; Lynch, KD; Iverson, DT; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Microcystin-LR activates MAPKs and alters the phosphoproteome in human HepaRG cells. Journal of Pharmacology and Experimental Therapeutics. 2024; 389:18.

Thakur, A; Singh, DK; Paine, MF; Prasad, B. Novel metabolomics approach to identify biomarkers of organic anion renal transporters. Drug Metabolism and Pharmacokinetics. 2024; 55:100805.

Prasad, B. What is new in LC-MS proteomics: Techniques and applications in IVIVE and precision medicine. Drug Metabolism and Pharmacokinetics. 2024; 55:100563.

Ahire, D; Mariasoosai, C; Naji-Talakar, S; Natesan, S; Prasad, B. Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches. Drug Metabolism and Pharmacokinetics. 2024; 55:100955.

Subash, S; Ahire, D; Patel, M; Shaikh, S; Deshmukh, S; Prasad, B. Relative expression versus activity factor (ref vs. raf) to estimate fractional contribution of individual UGT isoforms (FGLUC) in drug glucuronidation. Drug Metabolism and Pharmacokinetics. 2024; 55:100811.

Gaither, K; Singh, DK; Yue, G; Trudeau, J; Davydova, N; Davydov, DR; Lazarus, P; Prasad, B. Quantitative proteomics identifies significant changes in the abundance and composition of hepatic drug metabolizing enzymes in heavy alcohol drinkers. Drug Metabolism and Pharmacokinetics. 2024; 55:100926.

Bachhav, N; Gaither, K; Singh, D; Prasad, B. Can LS180 cells predict metabolism and drug-drug interaction potential of UGT2B17 substrates? Drug Metabolism and Pharmacokinetics. 2024; 55:100917.

Alade, AN; Claw, KG; Mcdonald, MG; Prasad, B; Rettie, AE; Thummel, KE. Cytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity. ACS Pharmacology and Translational Science. 2024; 7(3):716-732.

Balijepalli, P; Yue, G; Prasad, B; Meier, KE. Global Proteomics Analysis of Lysophosphatidic Acid Signaling in PC-3 Human Prostate Cancer Cells: Role of CCN1. International Journal of Molecular Sciences. 2024; 25(4).

Ahire, D; Mariasoosai, C; Naji-Talakar, S; Natesan, S; Prasad, B. Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches. Journal of Chemical Information and Modeling. 2024; 64(2):483-498.

Ailabouni, AS; Mettu, VS; Thakur, A; Singh, DK; Prasad, B. Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats. Drug Metabolism And Disposition. 2024; 52(2):86-94.

Annaert, P; Chatterjee, S; Prasad, B. Chapter 8 Application of in vitro models for pediatric translational research. In: Essentials of Translational Pediatric Drug Development. Elsevier; 2024:155-188.

Singh, DK; Basit, A; Rettie, AE; Alade, N; Thummel, K; Prasad, B. Characterization of Gla proteoforms and non-Gla peptides of gamma carboxylated proteins: Application to quantification of prothrombin proteoforms in human plasma. Analytica Chimica Acta. 2023; 1284:341972.

Sharma, S; Kogan, C; Varma, MVS; Prasad, B. Analysis of the interplay of physiological response to food intake and drug properties in food-drug interactions. Drug Metabolism and Pharmacokinetics. 2023; 53:100518.

Thakur, A; Saradhi Mettu, V; Singh, DK; Prasad, B. Effect of probenecid on blood levels and renal elimination of furosemide and endogenous compounds in rats: Discovery of putative organic anion transporter biomarkers. Biochemical Pharmacology. 2023; 218:115867.

Vieira, LS; Zhang, Y; López Quiñones, AJ; Hu, T; Singh, DK; Stevens, J; Prasad, B; Park, JR; Wang, J. The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter. Journal of Pharmacology and Experimental Therapeutics. 2023; 387(3):239-248.

Chothe, PP; Arya, V; Prasad, B; Ramsden, D; Taskar, K. Innovations, Opportunities, and Challenges for Predicting Alteration in Drug-Metabolizing Enzyme and Transporter Activity in Specific Populations. Drug Metabolism And Disposition. 2023; 51(12):1547-1550.

Urbaniak, A; Thummel, KE; Alade, AN; Rettie, AE; Prasad, B; De Nicolò, A; Martin, JH; Sheppard, DN; Jarvis, MF. Experimental pharmacology in precision medicine. Pharmacology Research & Perspectives. 2023; 11(6):e01147.

Zubiaur, P; Soria-Chacartegui, P; Boone, EC; Prasad, B; Dinh, J; Wang, WY; Zugbi, S; Rodríguez-Lopez, A; González-Iglesias, E; Leeder, JS; Abad-Santos, F; Gaedigk, A. Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity. Clinical Pharmacology and Therapeutics. 2023; 114(5):1033-1042.

Subash, S; Singh, DK; Ahire, DS; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Smith, BJ; Heyward, S; Cronin, CN; Prasad, B. Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs. Drug Metabolism And Disposition. 2023; 51(10):1362-1371.

Kruger, L; Lapehn, S; Paquette, A; Singh, DK; Macdonald, J; Bammler, TK; Enquobahrie, DA; Zhao, Q; Mozhui, K; Sathyanarayana, S; Prasad, B. Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics. Drug Metabolism And Disposition. 2023; 51(8):1053-1063.

Davydova, NY; Hutner, DA; Gaither, KA; Singh, DK; Prasad, B; Davydov, DR. High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism. Biology. 2023; 12(8).

Lynch, KD; Iverson, DT; Bachhav, NK; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells. International Journal of Molecular Sciences. 2023; 24(13).

Ahire, D; Heyward, S; Prasad, B. Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations. Clinical Pharmacology and Therapeutics. 2023; 114(1):161-172.

Singh, D; Mettu, VS; Thakur, A; Ailabouni, A; Prasad, B. High-Resolution Mass Spectrometry Coupled with XCMS Online for High-throughput Detection and Identification of Drug Metabolites. Journal of Pharmacology and Experimental Therapeutics. 2023; 385:182.

Thakur, A; Singh, DK; Paine, M; Prasad, B. Identification of Putative Novel Biomarkers of Organic Anion Transporter 1 and 3 for the Prediction of Transporter-Mediated Drug-Drug Interactions. Journal of Pharmacology and Experimental Therapeutics. 2023; 385:187-188.

Ailabouni, A; Mettu, V; Singh, DK; Thakur, A; Prasad, B. Identification of endogenous biomarkers of renal organic cation transporters in rats by global metabolomics analysis. Journal of Pharmacology and Experimental Therapeutics. 2023; 385:577.

Basit, A; Amory, JK; Mettu, VS; Li, CY; Heyward, S; Jariwala, PB; Redinbo, MR; Prasad, B. Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition. Drug Metabolism And Disposition. 2023; 51(4):427-435.

Sharma, S; Singh, DK; Mettu, VS; Yue, G; Ahire, D; Basit, A; Heyward, S; Prasad, B. Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling. Molecular Pharmaceutics. 2023; 20(3):1737-1749.

Ahire, D; Patel, M; Deshmukh, SV; Prasad, B. Quantification of Accurate Composition and Total Abundance of Homologous Proteins by Conserved-Plus-Surrogate Peptide Approach: Quantification of UDP Glucuronosyltransferases in Human Tissues. Drug Metabolism And Disposition. 2023; 51(3):285-292.

Sharma, S; Mettu, VS; Prasad, B. Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats. Pharmaceutics. 2023; 15(2).

Kruger, L; Yue, G; Paquette, A; Sathyanarayana, S; Enquobahrie, DA; Bammler, TK; Macdonald, J; Zhao, Q; Prasad, B. An optimized proteomics-based approach to estimate blood contamination and cellular heterogeneity of frozen placental tissue. Placenta. 2023; 131:111-118.

Sharma, S; Ahire, D; Basit, A; Lajoie, M; Wang, C; Lee, MS; Blithe, DL; Amory, JK; Singh, DK; Heyward, S; Prasad, B. Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver. Drug Metabolism And Disposition. 2022; 50(12):1493-1500.

Aliwarga, T; Dinh, JC; Heyward, S; Prasad, B; Gharib, SA; Lemaitre, RN; Sotoodehnia, N; Totah, RA. Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation. International Journal of Molecular Sciences. 2022; 23(20).

Kruger, L; Yue, G; Mettu, VS; Paquette, A; Sathyanarayana, S; Prasad, B. Differential proteomics analysis of JEG-3 and JAR placental cell models and the effect of androgen treatment. Journal of Steroid Biochemistry and Molecular Biology. 2022; 222:106138.

Chu, X; Prasad, B; Neuhoff, S; Yoshida, K; Leeder, JS; Mukherjee, D; Taskar, K; Varma, MVS; Zhang, X; Yang, X; Galetin, A. Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clinical Pharmacology and Therapeutics. 2022; 112(3):501-526.

Katti, N; Paprocki, E; Amory, JK; Prasad, B. Can analysis of serum androgens aid in the diagnosis of polycystic ovary syndrome (PCOS) in adolescents? Expert Review of Endocrinology and Metabolism. 2022; 17(5):375-381.

Ahire, D; Kruger, L; Sharma, S; Mettu, VS; Basit, A; Prasad, B. Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine. Pharmacological Reviews. 2022; 74(3):769-796.

Ladumor, MK; Paudel, A; Modhave, D; Sharma, S; Balhara, A; Singh, DK; Ramalingam, M; Shah, R; Pavankumarraju, S; Kurmi, M; Mariappan, TT; Bhutani, H; Prasad, B. A Tribute to Professor Saranjit Singh - A Critical Thinker, Innovator, Mentor, and Educator. Journal of Pharmaceutical Sciences. 2022; 111(5):1224-1231.

Li, X; Lim, JJ; Wang, K; Prasad, B; Bhatt, DK; Cui, JY; Lehmler, H-J. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environmental Toxicology and Pharmacology. 2022; 92:103854.

Thakur, A; Prasad, B. Assessing the Effect of Organic Anion Transporter Inhibition on Circulating Pyridoxic Acid, an Endogenous Transporter Biomarker, using Physiologically‐based Pharmacokinetic Modeling. The FASEB Journal. 2022; 36(S1).

Ahire, DS; Prasad, B. Proteomics‐informed physiologically‐based pharmacokinetic (PBPK) modeling revealed differential effects of UGT2B17 variability on the pharmacokinetics of diclofenac following intravenous and oral administration. The FASEB Journal. 2022; 36(S1).

Kruger, L; Prasad, B. Effect of di‐ethylhexyl phthalate (DEHP) on androgen related proteins in JEG‐3 placental cells. The FASEB Journal. 2022; 36(S1).

Sharma, S; Mettu, VS; Ahire, D; Basit, A; Lajoie, M; Lee, MS; Blithe, DL; Amory, JK; Wang, C; Prasad, B. Poor and variable oral bioavailability of dimethandrolone (DMA), an investigational male hormonal contraceptive, is likely associated with UGT2B17 mediated first‐pass metabolism. The FASEB Journal. 2022; 36(S1).

Naji‐Talakar, S; Kruger, L; Prasad, B. Effect of acetaminophen treatment on endocrine pathways in placenta: Proteomics investigation in JEG‐3 cell model. The FASEB Journal. 2022; 36(S1).

Balhara, A; Ladumor, MK; Nankar, RP; Syed, SD; Giri, S; Prasad, B; Singh, S. Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling. Pharmaceutical Research. 2022; 39(4):677-689.

Basit, A; Fan, PW; Khojasteh, SC; Murray, BP; Smith, BJ; Heyward, S; Prasad, B. Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species. Drug Metabolism And Disposition. 2022; 50(3):197-203.

Ahire, D; Basit, A; Christopher, LJ; Iyer, R; Leeder, JS; Prasad, B. Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans. Drug Metabolism And Disposition. 2022; 50(3):191-196.

Davydov, DR; Dangi, B; Yue, G; Ahire, DS; Prasad, B; Zgoda, VG. Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry. Biomolecules. 2022; 12(2).

Leeder, JS; Dinh, JC; Gaedigk, A; Staggs, VS; Prasad, B; Pearce, RE. Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver. Drug Metabolism And Disposition. 2022; 50(1):24-32.

El-Boraie, A; Tanner, J-A; Zhu, AZX; Claw, KG; Prasad, B; Schuetz, EG; Thummel, KE; Fukunaga, K; Mushiroda, T; Kubo, M; Benowitz, NL; Lerman, C; Tyndale, RF. Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes. Clinical and Translational Science. 2022; 15(1):204-220.