Prasad Lab

Publications

Bachhav, N; Subash, S; Ahire, D; Singh, DK; Prasad, B. Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs). Biochemical Pharmacology. 2025; 239:117044.

Panipinto, PM; Yue, GE; Prasad, B; Ahmed, S. Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1. American Journal of Physiology: Cell Physiology. 2025; 329:C500-C512.

Gu, W; Langlois, AW R; Giratallah, H; Claw, KG; Prasad, B; Thummel, KE; Tyndale, RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacology Research and Perspectives. 2025; 13:e70149.

Ailabouni, AS; Singh, DK; Thakur, A; Boone, EC; Gaedigk, A; Paine, MF; Prasad, B. Quantitative Contributions of Hepatic and Renal Organic Cation Transporters to the Clinical Pharmacokinetic Cimetidine-Metformin Interaction. Clinical Pharmacology and Therapeutics. 2025; 118:343-354.

Li, Y; Yabut, J; Zhang, Z; Fauty, S; Houle, R; Miller, H; Zhang, NR; Shin, MK; Rosahl, TW; Zhou, HH; Prasad, B; Unadkat, JD; Chu, X. Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs. Drug metabolism and disposition: the biological fate of chemicals. 2025; 53:100101.

Davydov, DR; Ponraj, K; Davydova, N; Singh, DK; Prasad, B. A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. The Biochemical journal. 2025; 482:839-857.

Subash, S; Ahire, D; Jones, R; Ma, B; Tian, Y; Murray, B; Stresser, D; Taub, M; Prasad, B. Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species. Drug Metabolism and Pharmacokinetics. 2025; 61:101350.

Thakur, A; Singh, DK; Lynch, KD; Kis, E; Gáborik, Z; Clarke, JD; Paine, MF; Prasad, B. Identification and validation of selective endogenous substrates of organic anion transporter 1 (OAT1) versus OAT3 using metabolomics and in-vitro mechanistic studies. Drug Metabolism and Pharmacokinetics. 2025; 61:101454.

Prasad, B. Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling. Drug Metabolism and Pharmacokinetics. 2025; 61:101072.

Thakur, A; Subash, S; Ahire, D; Prasad, B. Characterization of age-dependent abundance of drug transporter proteins and conjugating enzymes in human hepatocytes: Implication for pediatric drug dosing. Drug Metabolism and Pharmacokinetics. 2025; 61:101453.

Bachhav, N; Prasad, B. Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach. Drug Metabolism and Pharmacokinetics. 2025; 61:101301.

Singh, D; Ahire, D; Jones, R; Ma, B; Yu, T; Murray, B; Smith, B; Zientek, M; Heyward, S; Prasad, B. The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver. Drug Metabolism and Pharmacokinetics. 2025; 61:101127.

Saponjac, VT; Sun, R; Zheng, Z; Chen, J; Srinual, S; Prasad, B; Singh, DK; Hu, M; Singh, R. Influence of locally bioavailable herbal components on the regulation of gut homoeostatis via expression of intestinal drug metabolizing enzymes and transporters in irinotecan-induced intestinal injury model. Drug Metabolism and Pharmacokinetics. 2025; 61:101335.

Gaither, KA; Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Clarke, J; Prasad, B. Confounding Effect of Phenol Red on OAT- and OATP-Mediated Transporter Assays: Implications for Accuracy and Translatability of In Vitro Data (Abstract ID: 168143). The Journal of pharmacology and experimental therapeutics. 2025; 392:101704.

Ailabouni, A; Prasad, B. Organic cation transporters 2: Structure, regulation, functions, and clinical implications. Drug metabolism and disposition: the biological fate of chemicals. 2025; 53:100044.

Vijaywargi, G; Ailabouni, AS; Neogi, AG; Halpin, KL; Paine, M; Prasad, B. Identification of Potential Pre-Dose Endogenous Metabolic Features Associated with Metformin Plasma Exposure in Healthy Adults and Pediatric Patients (Abstract ID: 167055). The Journal of pharmacology and experimental therapeutics. 2025; 392:101700.

Shaffer, G; Prasad, B. Investigation of Interindividual Variability of Drug Metabolizing Kinases in Human Hepatocytes: Influence of Age, Sex, and Race (Abstract ID: 161579). The Journal of pharmacology and experimental therapeutics. 2025; 392:101673.

Venkatachalapathy, P; Singh, DK; Thakur, A; Prasad, B. Identification of Potential Endogenous Substrates of Cytochrome P450 Enzymes Using an Optimized Metabolomics-Based Approach (Abstract ID: 161986). The Journal of pharmacology and experimental therapeutics. 2025; 392:101676.

Naji-Talakar, S; Singh, DK; Paine, M; Prasad, B. Diclofenac Glucuronidation and Oxidation Are Inhibited by Curcumin Standard and Supplements (Abstract ID: 167709). The Journal of pharmacology and experimental therapeutics. 2025; 392:101701.

Gaither, KA; Yue, G; Singh, DK; Trudeau, J; Ponraj, K; Davydova, NY; Lazarus, P; Davydov, DR; Prasad, B. Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver. Journal of Xenobiotics. 2025; 15:20.

Ailabouni, AS; Vijaywargi, G; Subash, S; Singh, DK; Gaborik, Z; Prasad, B. Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?. Metabolites. 2025; 15:80.

Lapehn, S; Nair, S; Firsick, EJ; MacDonald, J; Thoreson, C; Litch, JA; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. A transcriptomic comparison of in vitro models of the human placenta. Placenta. 2025; 159:52-61.

Coates, S; Bardhi, K; Prasad, B; Lazarus, P. Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics. 2024; 16:1599.

Thakur, A; Subash, S; Ahire, D; Prasad, B. Developmental Expression of Drug Transporters and Conjugating Enzymes Involved in Enterohepatic Recycling: Implication for Pediatric Drug Dosing. Clinical Pharmacology and Therapeutics. 2024; 116:1615-1626.

Subash, S; Prasad, B. Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver. Drug metabolism and disposition: the biological fate of chemicals. 2024; 52:1363-1372.

Ponraj, K; Gaither, KA; Kumar Singh, D; Davydova, N; Zhao, M; Luo, S; Lazarus, P; Prasad, B; Davydov, DR. Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline. Biochemical Pharmacology. 2024; 230:116569.

Singh, DK; Ahire, D; Davydov, DR; Prasad, B. Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics. Drug metabolism and disposition: the biological fate of chemicals. 2024; 52:1152-1160.

Prasad, B; Al-Majdoub, ZM; Wegler, C; Rostami-Hodjegan, A; Achour, B. Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook. Drug metabolism and disposition: the biological fate of chemicals. 2024; 52:1208-1216.

Ikumawoyi, VO; Lynch, KD; Iverson, DT; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Microcystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells. Toxicon. 2024; 249:108072.

Parvez, MM; Thakur, A; Mehrotra, A; Stancil, S; Pearce, RE; Basit, A; Leeder, JS; Prasad, B. Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling. Clinical Pharmacology and Therapeutics. 2024; 116:1090-1099.

Lapehn, S; Nair, S; Fisick, E; MacDonald, JW; Thoreson, C; Litch, J; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. Transcriptomic comparison of in vitro models of the human placenta. Placenta. 2024; 154:e22.

Bachhav, N; Singh, DK; Blithe, DL; Lee, MS; Prasad, B. Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17. Pharmaceutics. 2024; 16:1032.

Subash, S; Ahire, D; Patel, M; Shaikh, S; Singh, DK; Deshmukh, S; Prasad, B. Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs. Pharmaceutical Research. 2024; 41:1621-1630.

Thakur, A; Yue, G; Ahire, D; Mettu, VS; Al Maghribi, A; Ford, K; Peixoto, L; Leeder, JS; Prasad, B. Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans?. Clinical Pharmacology and Therapeutics. 2024; 116:235-246.

Subash, S; Singh, DK; Ahire, D; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Zubair, F; Smith, BJ; Heyward, S; Leeder, JS; Prasad, B. Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism. Molecular Pharmaceutics. 2024; 21:2740-2750.

Singh, DK; Ailabouni, A; Thakur, A; Paine, MF; Prasad, B. Deconvoluting the Global Metabolomic Changes Caused by a Complex Clinical Pharmacokinetic Cimetidine-Metformin Interaction Involving Organic Cation Transporters. The Journal of pharmacology and experimental therapeutics. 2024; 389:233.

Ailabouni, A; Thakur, A; Singh, DK; Paine, MF; Prasad, B. Predicting contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction using a mechanistic PBPK model. The Journal of pharmacology and experimental therapeutics. 2024; 389:442.

Gaither, K; Singh, DK; Yue, GE; Trudeau, J; Ponraj, K; Lazarus, P; Davydov, DR; Prasad, B. Interplay of Alcohol Intake, Smoking, and Sex on the Protein Abundance of Hepatic Drug Metabolizing Enzymes and Transporters in Humans. The Journal of pharmacology and experimental therapeutics. 2024; 389:237.

Thakur, A; Singh, DK; Kis, E; Gáborik, Z; Paine, MF; Prasad, B. De Novo Identification and Validation of Human Endogenous Biomarkers of Renal Organic Anion Transporters for Predicting Interindividual Variability. The Journal of pharmacology and experimental therapeutics. 2024; 389:433-434.

Harding, C; Yue, GE; Prasad, B. Quantitative Proteomics of Human Urine-Isolated Extracellular Vesicles Reveals Significant and Reproducible Enrichment of EV Markers and Renal Drug-Interacting Proteins. The Journal of pharmacology and experimental therapeutics. 2024; 389:437.

Bachhav, N; Singh, DK; Blithe, D; Lee, M; Prasad, B. Biotransformation Pathways of 11β-Methyl-19-Nortestosterone and Its Prodrugs: Mechanistic In vitro Studies Unveils Involvement of Polymorphic Intestinal UGT2B17. The Journal of pharmacology and experimental therapeutics. 2024; 389:38.

Ponraj, K; Gaither, K; Singh, DK; Prasad, B; Davydov, DR. Non-additivity of the functional properties of P450 enzymes in the human drug-metabolizing ensemble revealed in a study with a series of individual microsomal preparations. The Journal of pharmacology and experimental therapeutics. 2024; 389:40.

Ikumawoyi, V; Lynch, KD; Iverson, DT; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Microcystin-LR activates MAPKs and alters the phosphoproteome in human HepaRG cells. The Journal of pharmacology and experimental therapeutics. 2024; 389:18.

Gaither, K; Singh, DK; Yue, G; Trudeau, J; Davydova, N; Davydov, DR; Lazarus, P; Prasad, B. Quantitative proteomics identifies significant changes in the abundance and composition of hepatic drug metabolizing enzymes in heavy alcohol drinkers. Drug Metabolism and Pharmacokinetics. 2024; 55:100926.

Subash, S; Ahire, D; Patel, M; Shaikh, S; Deshmukh, S; Prasad, B. Relative expression versus activity factor (ref vs. raf) to estimate fractional contribution of individual UGT isoforms (FGLUC) in drug glucuronidation. Drug Metabolism and Pharmacokinetics. 2024; 55:100811.

Thakur, A; Singh, DK; Paine, MF; Prasad, B. Novel metabolomics approach to identify biomarkers of organic anion renal transporters. Drug Metabolism and Pharmacokinetics. 2024; 55:100805.

Ahire, D; Mariasoosai, C; Naji-Talakar, S; Natesan, S; Prasad, B. Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches. Drug Metabolism and Pharmacokinetics. 2024; 55:100955.

Prasad, B. What is new in LC-MS proteomics: Techniques and applications in IVIVE and precision medicine. Drug Metabolism and Pharmacokinetics. 2024; 55:100563.

Bachhav, N; Gaither, K; Singh, D; Prasad, B. Can LS180 cells predict metabolism and drug-drug interaction potential of UGT2B17 substrates?. Drug Metabolism and Pharmacokinetics. 2024; 55:100917.

Alade, AN; Claw, KG; McDonald, MG; Prasad, B; Rettie, AE; Thummel, KE. Cytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity. ACS Pharmacology and Translational Science. 2024; 7:716-732.

Balijepalli, P; Yue, G; Prasad, B; Meier, KE. Global Proteomics Analysis of Lysophosphatidic Acid Signaling in PC-3 Human Prostate Cancer Cells: Role of CCN1. International Journal of Molecular Sciences. 2024; 25:2067.

Ailabouni, AS; Mettu, VS; Thakur, A; Singh, DK; Prasad, B. Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats. Drug metabolism and disposition: the biological fate of chemicals. 2024; 52:86-94.

Ahire, D; Mariasoosai, C; Naji-Talakar, S; Natesan, S; Prasad, B. Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches. Journal of Chemical Information and Modeling. 2024; 64:483-498.

Chatterjee, S; Annaert, P; Prasad, B. Chapter 8 Application of in vitro models for pediatric translational research. Essentials of Translational Pediatric Drug Development. : Elsevier; Elsevier; 2024.

Singh, DK; Basit, A; Rettie, AE; Alade, N; Thummel, K; Prasad, B. Characterization of Gla proteoforms and non-Gla peptides of gamma carboxylated proteins: Application to quantification of prothrombin proteoforms in human plasma. Analytica Chimica Acta. 2023; 1284:341972.

Urbaniak, A; Thummel, KE; Alade, AN; Rettie, AE; Prasad, B; De Nicolò, A; Martin, JH; Sheppard, DN; Jarvis, MF. Experimental pharmacology in precision medicine. Pharmacology Research and Perspectives. 2023; 11:e01147.

Thakur, A; Saradhi Mettu, V; Singh, DK; Prasad, B. Effect of probenecid on blood levels and renal elimination of furosemide and endogenous compounds in rats: Discovery of putative organic anion transporter biomarkers. Biochemical Pharmacology. 2023; 218:115867.

Vieira, LS; Zhang, Y; López Quiñones, AJ; Hu, T; Singh, DK; Stevens, J; Prasad, B; Park, JR; Wang, J. The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter. The Journal of pharmacology and experimental therapeutics. 2023; 387:239-248.

Chothe, PP; Arya, V; Prasad, B; Ramsden, D; Taskar, K. Innovations, Opportunities, and Challenges for Predicting Alteration in Drug-Metabolizing Enzyme and Transporter Activity in Specific Populations. Drug metabolism and disposition: the biological fate of chemicals. 2023; 51:1547-1550.

Sharma, S; Kogan, C; Varma, MV S; Prasad, B. Analysis of the interplay of physiological response to food intake and drug properties in food-drug interactions. Drug Metabolism and Pharmacokinetics. 2023; 53:100518.

Zubiaur, P; Soria-Chacartegui, P; Boone, EC; Prasad, B; Dinh, J; Wang, WY; Zugbi, S; Rodríguez-Lopez, A; González-Iglesias, E; Leeder, JS; Abad-Santos, F; Gaedigk, A. Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity. Clinical Pharmacology and Therapeutics. 2023; 114:1033-1042.

Subash, S; Singh, DK; Ahire, DS; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Smith, BJ; Heyward, S; Cronin, CN; Prasad, B. Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs. Drug metabolism and disposition: the biological fate of chemicals. 2023; 51:1362-1371.

Kruger, L; Lapehn, S; Paquette, A; Singh, DK; MacDonald, J; Bammler, TK; Enquobahrie, DA; Zhao, Q; Mozhui, K; Sathyanarayana, S; Prasad, B. Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics. Drug metabolism and disposition: the biological fate of chemicals. 2023; 51:1053-1063.

Davydova, NY; Hutner, DA; Gaither, KA; Singh, DK; Prasad, B; Davydov, DR. High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism. Biology. 2023; 12:1055.

Lynch, KD; Iverson, DT; Bachhav, NK; Call, MR; Yue, GE; Prasad, B; Clarke, JD. Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells. International Journal of Molecular Sciences. 2023; 24:11168.

Ahire, D; Heyward, S; Prasad, B. Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations. Clinical Pharmacology and Therapeutics. 2023; 114:161-172.

Ailabouni, A; Mettu, V; Singh, DK; Thakur, A; Prasad, B. Identification of endogenous biomarkers of renal organic cation transporters in rats by global metabolomics analysis. The Journal of pharmacology and experimental therapeutics. 2023; 385:577.

Singh, D; Mettu, VS; Thakur, A; Ailabouni, A; Prasad, B. High-Resolution Mass Spectrometry Coupled with XCMS Online for High-throughput Detection and Identification of Drug Metabolites. The Journal of pharmacology and experimental therapeutics. 2023; 385:182.

Thakur, A; Singh, DK; Paine, M; Prasad, B. Identification of Putative Novel Biomarkers of Organic Anion Transporter 1 and 3 for the Prediction of Transporter-Mediated Drug-Drug Interactions. The Journal of pharmacology and experimental therapeutics. 2023; 385:187-188.

Basit, A; Amory, JK; Mettu, VS; Li, CY; Heyward, S; Jariwala, PB; Redinbo, MR; Prasad, B. Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition. Drug metabolism and disposition: the biological fate of chemicals. 2023; 51:427-435.

Sharma, S; Singh, DK; Mettu, VS; Yue, G; Ahire, D; Basit, A; Heyward, S; Prasad, B. Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling. Molecular Pharmaceutics. 2023; 20:1737-1749.

Ahire, D; Patel, M; Deshmukh, SV; Prasad, B. Quantification of Accurate Composition and Total Abundance of Homologous Proteins by Conserved-Plus-Surrogate Peptide Approach: Quantification of UDP Glucuronosyltransferases in Human Tissues. Drug metabolism and disposition: the biological fate of chemicals. 2023; 51:285-292.

Sharma, S; Mettu, VS; Prasad, B. Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats. Pharmaceutics. 2023; 15:542.

Kruger, L; Yue, G; Paquette, A; Sathyanarayana, S; Enquobahrie, DA; Bammler, TK; MacDonald, J; Zhao, Q; Prasad, B. An optimized proteomics-based approach to estimate blood contamination and cellular heterogeneity of frozen placental tissue. Placenta. 2023; 131:111-118.

Sharma, S; Ahire, D; Basit, A; Lajoie, M; Wang, C; Lee, MS; Blithe, DL; Amory, JK; Singh, DK; Heyward, S; Prasad, B. Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver. Drug metabolism and disposition: the biological fate of chemicals. 2022; 50:1493-1500.

Aliwarga, T; Dinh, JC; Heyward, S; Prasad, B; Gharib, SA; Lemaitre, RN; Sotoodehnia, N; Totah, RA. Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation. International Journal of Molecular Sciences. 2022; 23:12433.

Katti, N; Paprocki, E; Amory, JK; Prasad, B. Can analysis of serum androgens aid in the diagnosis of polycystic ovary syndrome (PCOS) in adolescents?. Expert Review of Endocrinology and Metabolism. 2022; 17:375-381.

Chu, X; Prasad, B; Neuhoff, S; Yoshida, K; Leeder, JS; Mukherjee, D; Taskar, K; Varma, MV S; Zhang, X; Yang, X; Galetin, A. Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clinical Pharmacology and Therapeutics. 2022; 112:501-526.

Kruger, L; Yue, G; Mettu, VS; Paquette, A; Sathyanarayana, S; Prasad, B. Differential proteomics analysis of JEG-3 and JAR placental cell models and the effect of androgen treatment. The Journal of Steroid Biochemistry and Molecular Biology. 2022; 222:106138.

Ahire, D; Kruger, L; Sharma, S; Mettu, VS; Basit, A; Prasad, B. Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine. Pharmacological Reviews. 2022; 74:769-796.

Naji‐Talakar, S; Kruger, L; Prasad, B. Effect of acetaminophen treatment on endocrine pathways in placenta: Proteomics investigation in JEG‐3 cell model. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022; 36.

Sharma, S; Mettu, VS; Ahire, D; Basit, A; Lajoie, M; Lee, MS; Blithe, DL; Amory, JK; Wang, C; Prasad, B. Poor and variable oral bioavailability of dimethandrolone (DMA), an investigational male hormonal contraceptive, is likely associated with UGT2B17 mediated first‐pass metabolism. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022; 36.

Ahire, DS; Prasad, B. Proteomics‐informed physiologically‐based pharmacokinetic (PBPK) modeling revealed differential effects of UGT2B17 variability on the pharmacokinetics of diclofenac following intravenous and oral administration. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022; 36.

Thakur, A; Prasad, B. Assessing the Effect of Organic Anion Transporter Inhibition on Circulating Pyridoxic Acid, an Endogenous Transporter Biomarker, using Physiologically‐based Pharmacokinetic Modeling. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022; 36.

Li, X; Lim, JJ; Wang, K; Prasad, B; Bhatt, DK; Cui, JY; Lehmler, H. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environmental Toxicology and Pharmacology. 2022; 92:103854.

Kruger, L; Prasad, B. Effect of di‐ethylhexyl phthalate (DEHP) on androgen related proteins in JEG‐3 placental cells. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022; 36.

Balhara, A; Ladumor, MK; Nankar, RP; Syed, SD; Giri, S; Prasad, B; Singh, S. Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling. Pharmaceutical Research. 2022; 39:677-689.

Basit, A; Fan, PW; Khojasteh, SC; Murray, BP; Smith, BJ; Heyward, S; Prasad, B. Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species. Drug metabolism and disposition: the biological fate of chemicals. 2022; 50:197-203.

Ahire, D; Basit, A; Christopher, LJ; Iyer, R; Leeder, JS; Prasad, B. Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2022; 50:191-196.

Davydov, DR; Dangi, B; Yue, G; Ahire, DS; Prasad, B; Zgoda, VG. Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry. Biomolecules. 2022; 12:185.

Leeder, JS; Dinh, JC; Gaedigk, A; Staggs, VS; Prasad, B; Pearce, RE. Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver. Drug metabolism and disposition: the biological fate of chemicals. 2022; 50:24-32.

El-Boraie, A; Tanner, J; Zhu, AZ X; Claw, KG; Prasad, B; Schuetz, EG; Thummel, KE; Fukunaga, K; Mushiroda, T; Kubo, M; Benowitz, NL; Lerman, C; Tyndale, RF. Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes. Clinical and Translational Science. 2022; 15:204-220.

Prasad, B. Quantitative proteomics in drug discovery and development. Drug Discovery Today: Technologies. 2021; 40:27-28.

Davydov, DR; Prasad, B. Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism. Trends in Pharmacological Sciences. 2021; 42:988-997.

Singh, AK; Haque, M; Madarampalli, B; Shi, Y; Wildman, BJ; Basit, A; Khuder, SA; Prasad, B; Hassan, Q; Ahmed, S; Ouseph, MM. Ets-2 Propagates IL-6 Trans-Signaling Mediated Osteoclast-Like Changes in Human Rheumatoid Arthritis Synovial Fibroblast. Frontiers in Immunology. 2021; 12:746503.

Miller, L; Thompson, K; Pavlenco, C; Mettu, VS; Haverkamp, H; Skaufel, S; Basit, A; Prasad, B; Larsen, J. The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients. 2021; 13:3620.

Dangi, B; Davydova, NY; Maldonado, MA; Ahire, D; Prasad, B; Davydov, DR. Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics. Archives of Biochemistry and Biophysics. 2021; 708:108937.

Paquette, AG; MacDonald, J; Lapehn, S; Bammler, T; Kruger, L; Day, DB; Price, ND; Loftus, C; Kannan, K; Marsit, C; Enquobahrie, DA; Prasad, B; Karr, CJ; Sathyanarayana, S. A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape. Environmental Health Perspectives. 2021; 129:97003.

Parvez, MM; Basit, A; Jariwala, PB; Gáborik, Z; Kis, E; Heyward, S; Redinbo, MR; Prasad, B. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug metabolism and disposition: the biological fate of chemicals. 2021; 49:683-693.

Sharma, S; Prasad, B. Meta-Analysis of Food Effect on Oral Absorption of Efflux Transporter Substrate Drugs: Does Delayed Gastric Emptying Influence Drug Transport Kinetics?. Pharmaceutics. 2021; 13:1035.

Balhara, A; Basit, A; Argikar, UA; Dumouchel, JL; Singh, S; Prasad, B. Comparative Proteomics Analysis of the Postmitochondrial Supernatant Fraction of Human Lens-Free Whole Eye and Liver. Drug metabolism and disposition: the biological fate of chemicals. 2021; 49:592-600.

Fohner, AE; Dalton, R; Skagen, K; Jackson, K; Claw, KG; Hopkins, SE; Robinson, R; Khan, BA; Prasad, B; Schuetz, EG; Dillard, DA; Boyer, BB; Thummel, KE; Woodahl, EL. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clinical and Translational Science. 2021; 14:1292-1302.

Ahire, DS; Basit, A; Karasu, M; Prasad, B. Ultrasensitive Quantification of Drug-metabolizing Enzymes and Transporters in Small Sample Volume by Microflow LC-MS/MS. Journal of Pharmaceutical Sciences. 2021; 110:2833-2840.

Kumar, AR; Prasad, B; Bhatt, DK; Mathialagan, S; Varma, MV S; Unadkat, JD. In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach. Drug metabolism and disposition: the biological fate of chemicals. 2021; 49:470-478.

Sharma, S; Kogan, C; Prasad, B. Does fed‐state associated prolonged gastric emptying affect drug transport kinetics in intestine?. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Basit, A; Amory, J; Li, C; Mettu, V; Heyward, S; Jariwala, P; Redinbo, M; Prasad, B. Novel mechanisms of testosterone detoxification in UGT2B17 gene deletion carriers and androgen activation by gut microbiome. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Balhara, A; Basit, A; Argikar, U; Dumouchel, J; Singh, S; Prasad, B. Comparative Proteomics Analysis of the Post‐Mitochondrial Fraction (S9 Fraction) of Human Lens‐Free Whole Eye and Liver. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Ahire, D; Basit, A; Christopher, L; Iyer, R; Prasad, B. Inter‐individual variability and differential tissue abundance of mitochondrial amidoxime reducing component 1 (mARC1) enzyme in human. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Kruger, L; Paquette, A; Sathyanarayana, S; Enquobahrie, D; Prasad, B. Optimized Targeted Proteomics Methodology for Normalizing Tissue Protein Abundance Data in Analysis of Placental Markers. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Parvez, M; Basit, A; Jariwala, P; Gáborik, Z; Kis, E; Heyward, S; Redinbo, M; Prasad, B. Proteomics‐Informed Scaling of Irinotecan Metabolism, Transport, and Gut Microbial Activation Explain its Intestinal Toxicity after Intravenous Dose. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021; 35.

Naji-Talakar, S; Sharma, S; Martin, LA; Barnhart, D; Prasad, B. Potential implications of DMET ontogeny on the disposition of commonly prescribed drugs in neonatal and pediatric intensive care units. Expert Opinion on Drug Metabolism and Toxicology. 2021; 17:273-289.

Takahashi, RH; Achour, B; Prasad, B. Quantitative Determination of Cytochrome P450 Using LC-MS/MS. Cytochrome P450. : Springer Nature; Springer Nature; 2021.

Thakur, A; Parvez, MM; Leeder, JS; Prasad, B. Ontogeny of Drug-Metabolizing Enzymes. Methods in molecular biology (Clifton, N.J.). 2021; 2342:551-593.

Li, N; Kulkarni, P; Badrinarayanan, A; Kefelegn, A; Manoukian, R; Li, X; Prasad, B; Karasu, M; McCarty, WJ; Knutson, CG; Gupta, A. P-glycoprotein Substrate Assessment in Drug Discovery: Application of Modeling to Bridge Differential Protein Expression Across In Vitro Tools. Journal of Pharmaceutical Sciences. 2021; 110:325-337.

Sharma, P; Patel, N; Prasad, B; Varma, MV S. Pharmacokinetics: Theory and Application in Drug Discovery and Development. Drug Discovery and Development. : Springer Nature; Springer Nature; 2021.