Chen Lab

Publications

Shin, SY; Chen, J; Krentsis, IM; Reisner, Y; Abrencillo, R; Hussain, R; Wu, D; Karmouty-Quintana, H. From Epithelium to Therapy: Transitional Cells in Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2025; 72:472-483.

Gerner-Mauro, KN; Ellis, LV; Wang, G; Nayak, R; Lwigale, PY; Poché, RA; Chen, J. Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung. Development (Cambridge). 2025; 152:dev204346.

Kim, B; Huang, Y; Ko, KP; Zhang, S; Zou, G; Zhang, J; Kim, MJ; Little, D; Ellis, LV; Paschini, M; Jun, S; Park, KS; Chen, J; Kim, C; Park, JI. PCLAF-DREAM drives alveolar cell plasticity for lung regeneration. Nature Communications. 2024; 15:9169.

Hassan, D; Chen, J. CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair. Nature Communications. 2024; 15:4148.

Han, G; Sinjab, A; Rahal, Z; Lynch, AM; Treekitkarnmongkol, W; Liu, Y; Serrano, AG; Feng, J; Liang, K; Khan, K; Wistuba, II; Chen, J; Wang, L; Kadara, H. An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature. 2024; 627:656-663.

Hutchison, V; Lynch, A; Gutierrez-Gamez, AM; Chen, J. Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. The Journal of Cell Biology. 2024; 223:e202305086.

Wang, Y; Kulkarni, VV; García, JP; Leiva-Juárez, MM; Goldblatt, DL; Gulraiz, F; Ellis, LV; Chen, J; Longmire, MK; Donepudi, SR; Lorenzi, PL; Wang, H; Wong, LJ; Tuvim, MJ; Evans, SE. Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation. Editor, Guillard T. PLoS Pathogens. 2023; 19:e1011138.

Xia, S; Ellis, LV; Winkley, K; Menden, H; Mabry, SM; Venkatraman, A; Louiselle, D; Gibson, M; Grundberg, E; Chen, J; Sampath, V. Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasia. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2023; 324:L123-L140.

Corkins, ME; Achieng, MA; DeLay, BD; Krneta-Stankic, V; Cain, MP; Walker, BL; Chen, J; Lindström, NO; Miller, RK. A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron. Kidney International. 2023; 103:77-86.

Dickey, BF; Chen, J; Peebles, RS. Airway Mucus Dysfunction in COVID-19. American Journal of Respiratory and Critical Care Medicine. 2022; 206:1304-1306.

Hernandez, BJ; Cain, MP; Lynch, AM; Flores, JR; Tuvim, MJ; Dickey, BF; Chen, J. Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection. American Journal of Respiratory Cell and Molecular Biology. 2022; 67:389-401.

Han, G; Sinjab, A; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Parra, ER; Swisher, S; Cascone, T; Sepesi, B; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract 2126: Single-cell sequencing of early-stage lung adenocarcinomas reveals prominent intratumoral heterogeneity and epithelial plasticity programs. Cancer Research. 2022; 82:2126.

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Moghaddam, SJ; Fujimoto, J; Chen, J; Edwards, M; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract 1586: An emerging role for inflammation-associated alveolar intermediate cells in early phenotypic development of KRAS -mutant lung adenocarcinoma. Cancer Research. 2022; 82:1586.

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Moghaddam, SJ; Fujimoto, J; Chen, J; Edwards, M; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract PR006: An emerging role for inflammation-associated alveolar intermediate cells in early phenotypic development of KRAS -mutant lung adenocarcinoma. Cancer Research. 2022; 82:pr006.

Narvaez Del Pilar, O; del Pilar, ON; Garay, MJ G; Gacha Garay, MJ; Chen, J. Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts. Development (Cambridge). 2022; 149:dev200081.

Little, DR; Lynch, AM; Yan, Y; Akiyama, H; Kimura, S; Chen, J. Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nature Communications. 2021; 12:2509.

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hara, K; Brennan, PM; Dang, M; Hao, D; Wang, R; Dai, E; Dejima, H; Stevenson, CS; Spira, A; Wang, L; Kadara, H. Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing. Cancer Discovery. 2021; 11:2506-2523.

Vila Ellis, L; Chen, J. A cell-centric view of lung alveologenesis. Developmental Dynamics. 2021; 250:482-496.

Ellis, LV; Lin Kong, CS; Chen, J. Endothelial cells in the lung. ERS Monograph. 2021; 2021:144-157.

Han, G; Sinjab, A; Hara, K; Treekitkarnmongkol, W; Brennan, P; Chang, K; Bogatenkova, E; Sanchez-Espiridion, B; Behrens, C; Solis, LM; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers. 2021; 13:1250.