Jichao Chen Lab

Publications

Chaikof, EL; Chen, J; Gillette, MU; Boyer, LA; Deans, TL; Li, P; Hilton, IB; Daniels, K; Goyal, Y; Mei, Y; Davis, J; Gupta, K; Gao, XJ; Galloway, KE. Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems. Cell Systems. 2025; 16(12):101446.

Peng, F; Sinjab, A; Dai, Y; Treekitkarnmongkol, W; Yang, S; Gomez Bolanos, LI; Zhou, T; Chen, M; Serrano, AG; Krishna, A; Myers, J; Akdemir, K; Wang, L; Kadara, H. Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions. Cancer Cell. 2025.

Vila Ellis, L; Bywaters, JD; Ceas, A; Liu, Y; Sucre, JM; Chen, J. p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia. JCI Insight. 2025; 10(17).

Kong, CSL; V, M; Pantaleón-García, J; Evans, SE; Chen, J. Truncated NTRK2 is induced in CAP1 endothelial cells during mouse lung injury-repair. iScience. 2025; 28(7):112973.

Shin, SY; Chen, J; Milman Krentsis, I; Reisner, Y; Abrencillo, R; Hussain, R; Wu, D; Karmouty-Quintana, H. From Epithelium to Therapy: Transitional Cells in Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2025; 72(5):472-483.

Gerner-Mauro, KN; Vila Ellis, L; Wang, G; Nayak, R; Lwigale, PY; Poché, RA; Chen, J. Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung. Development. 2025; 152(8).

Kim, B; Huang, Y; Ko, K-P; Zhang, S; Zou, G; Zhang, J; Kim, MJ; Little, D; Ellis, LV; Paschini, M; Jun, S; Park, K-S; Chen, J; Kim, C; Park, J-I. PCLAF-DREAM drives alveolar cell plasticity for lung regeneration. Nature Communications. 2024; 15(1):9169.

Hassan, D; Chen, J. CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair. Nature Communications. 2024; 15(1):4148.

Han, G; Sinjab, A; Rahal, Z; Lynch, AM; Treekitkarnmongkol, W; Liu, Y; Serrano, AG; Feng, J; Liang, K; Khan, K; Wistuba, II; Chen, J; Wang, L; Kadara, H. An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature. 2024; 627(8004):656-663.

Hutchison, V; Lynch, A; Gutierrez-Gamez, AM; Chen, J. Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. Journal of Cell Biology. 2024; 223(1).

Wang, Y; Kulkarni, VV; Pantaleón García, J; Leiva-Juárez, MM; Goldblatt, DL; Gulraiz, F; Vila Ellis, L; Chen, J; Longmire, MK; Donepudi, SR; Lorenzi, PL; Wang, H; Wong, L-J; Tuvim, MJ; Evans, SE. Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation. PLoS Pathogens. 2023; 19(9):e1011138.

Han, G; Sinjab, A; Treekitkarnmongkol, W; Rahal, Z; Liu, Y; Serrano, AG; Feng, J; Liang, K; Khan, K; Lu, W; Stevenson, CS; Spira, A; Wang, L; Kadara, H. Abstract 113: An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Cancer Research. 2023; 83(7_Supplement):113-113.

Xia, S; Vila Ellis, L; Winkley, K; Menden, H; Mabry, SM; Venkatraman, A; Louiselle, D; Gibson, M; Grundberg, E; Chen, J; Sampath, V. Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasia. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2023; 324(2):L123-L140.

Corkins, ME; Achieng, M; Delay, BD; Krneta-Stankic, V; Cain, MP; Walker, BL; Chen, J; Lindström, NO; Miller, RK. A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron. Kidney International. 2023; 103(1):77-86.

Dickey, BF; Chen, J; Peebles, RS. Airway Mucus Dysfunction in COVID-19. American Journal of Respiratory and Critical Care Medicine. 2022; 206(11):1304-1306.

Hernandez, BJ; Cain, MP; Lynch, AM; Flores, JR; Tuvim, MJ; Dickey, BF; Chen, J. Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection. American Journal of Respiratory Cell and Molecular Biology. 2022; 67(3):389-401.

Han, G; Sinjab, A; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Parra, ER; Swisher, S; Cascone, T; Sepesi, B; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract 2126: Single-cell sequencing of early-stage lung adenocarcinomas reveals prominent intratumoral heterogeneity and epithelial plasticity programs. Cancer Research. 2022; 82(12_Supplement):2126-2126.

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Moghaddam, SJ; Fujimoto, J; Chen, J; Edwards, M; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract 1586: An emerging role for inflammation-associated alveolar intermediate cells in early phenotypic development of KRAS -mutant lung adenocarcinoma. Cancer Research. 2022; 82(12_Supplement):1586-1586.

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hao, D; Dai, E; Solis, LM; Moghaddam, SJ; Fujimoto, J; Chen, J; Edwards, M; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Abstract PR006: An emerging role for inflammation-associated alveolar intermediate cells in early phenotypic development of KRAS -mutant lung adenocarcinoma. Cancer Research. 2022; 82(10_Supplement):pr006-pr006.

Narvaez Del Pilar, O; Gacha Garay, MJ; Chen, J. Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts. Development. 2022; 149(6).

Sinjab, A; Han, G; Treekitkarnmongkol, W; Hara, K; Brennan, PM; Dang, M; Hao, D; Wang, R; Dai, E; Dejima, H; Stevenson, CS; Spira, A; Wang, L; Kadara, H. Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing. Cancer Discovery. 2021; 11(10):2506-2523.

Little, DR; Lynch, AM; Yan, Y; Akiyama, H; Kimura, S; Chen, J. Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nature Communications. 2021; 12(1):2509.

Vila Ellis, L; Shuet Lin Kong, C; Chen, J. Endothelial cells in the lung. ERS Monograph. 2021.

Vila Ellis, L; Chen, J. A cell-centric view of lung alveologenesis. Developmental Dynamics. 2021; 250(4):482-496.

Han, G; Sinjab, A; Hara, K; Treekitkarnmongkol, W; Brennan, P; Chang, K; Bogatenkova, E; Sanchez-Espiridion, B; Behrens, C; Solis, LM; Stevenson, CS; Spira, AE; Wang, L; Kadara, H. Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers. 2021; 13(6).