Whitsett Lab

Publications

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10.

Thebaud, B; Goss, KN; Laughon, M; Whitsett, JA; Abman, SH; Steinhorn, RH; Aschner, JL; Davis, PG; McGrath-Morrow, SA; Soll, RF; et al. Bronchopulmonary dysplasia. Nature Reviews Disease Primers. 2019; 5.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Du, Y; Clair, GC; Al Alam, D; Danopoulos, S; Schnell, D; Kitzmiller, JA; Misra, RS; Bhattacharya, S; Warburton, D; Mariani, TJ; et al. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2019; 317:L347-L360.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99:513-554.

Gokey, JJ; Snowball, J; Sridharan, A; Speth, JP; Black, KE; Hariri, LP; Perl, AT; Xu, Y; Whitsett, JA. MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation. JCI insight. 2018; 3.

Tang, X; Snowball, JM; Xu, Y; Na, C; Weaver, TE; Clair, G; Kyle, JE; Zink, EM; Ansong, C; Wei, W; et al. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Journal of Clinical Investigation. 2017; 127:4314-4325.

Gray, J; Oehrle, K; Worthen, G; Alenghat, T; Whitsett, J; Deshmukh, H. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Science Translational Medicine. 2017; 9.

Whitsett, JA; Morrisey, EE. INFLAMMATION. Modulating pulmonary inflammation. Science. 2016; 351:662-663.

Gaddis, N; Fortriede, J; Guo, M; Bardes, EE; Kouril, M; Tabar, S; Burns, K; Ardini-Poleske, ME; Loos, S; Schnell, D; et al. LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung. American Journal of Respiratory Cell and Molecular Biology. 2022.

Karolak, JA; Welch, CL; Mosimann, C; Bzdega, K; West, JD; Montani, D; Eyries, M; Mullen, MP; Abman, SH; Prapa, M; et al. Molecular Function and Contribution of TBX4 in Development and Disease. American Journal of Respiratory and Critical Care Medicine. 2022.

Huang, Y; Whitsett, J; Naren, A. 667 Endoplasmic reticulum membrane protein complex is required for cystic fibrosis transmembrane conductance regulator biogenesis and activation in vivo. Journal of Cystic Fibrosis. 2022; 21:s364-s365.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; et al. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14.

Clair, G; Bramer, LM; Misra, R; McGraw, MD; Bhattacharya, S; Kitzmiller, JA; Feng, S; Danna, VG; Bandyopadhyay, G; Bhotika, H; et al. Proteomic Analysis of Human Lung Development. American Journal of Respiratory and Critical Care Medicine. 2022; 205:208-218.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Kingma, PS; Guiot, N; Whitsett, JA. Pulmonary Collectins☆. Encyclopedia of Respiratory Medicine. 2022.

Boat, TF; Whitsett, JA. How Can the Pediatric Community Enhance Funding for Child Health Research?. JAMA Pediatrics. 2021; 175:1212-1214.

Kolesnichenko, OA; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:473-488.

Sun, YL; Hurley, K; Villacorta-Martin, C; Huang, J; Hinds, A; Gopalan, K; Caballero, IS; Russo, SJ; Kitzmiller, JA; Whitsett, JA; et al. Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:442-460.

Gokey, JJ; Snowball, J; Sridharan, A; Sudha, P; Kitzmiller, JA; Xu, Y; Whitsett, JA. YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1. iScience. 2021; 24.

Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Bui, LT; Winters, NI; Chung, M; Joseph, C; Gutierrez, AJ; Habermann, AC; Adams, TS; Schupp, JC; Poli, S; Peter, LM; et al. Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Nature Communications. 2021; 12.

Li, E; Ustiyan, V; Wen, B; Kalin, GT; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Developmental Dynamics. 2021; 250:1001-1020.

Rindler, TN; Brown, KM; Stockman, CA; van Lieshout, LP; Martin, EP; Weaver, TE; Zacharias, WJ; Wootton, SK; Whitsett, JA; Bridges, JP. Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:118-121.

Jiang, M; Fang, Y; Li, Y; Huang, H; Wei, Z; Gao, X; Sung, HK; Hu, J; Qiang, L; Ruan, J; et al. VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway. Developmental Cell. 2021; 56:1646-1660.e5.

Whitsett, JA; Jobe, AH. Commentary on the Truncated Splice Variant of the GM-CSF Receptor Beta-Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns. Neonatology. 2021; 118:194-197.

He, H; Snowball, J; Sun, F; Na, CL; Whitsett, JA. IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis. JCI insight. 2021; 6.

Muus, C; Luecken, MD; Eraslan, G; Sikkema, L; Waghray, A; Heimberg, G; Kobayashi, Y; Vaishnav, ED; Subramanian, A; Smillie, C; et al. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine. 2021; 27:546-559.

Wu, G; Lee, YY; Gulla, EM; Potter, A; Kitzmiller, J; Ruben, MD; Salomonis, N; Whitsett, JA; Francey, LJ; Hogenesch, JB; et al. Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease. eLife. 2021; 10.

Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; et al. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Du, Y; Ouyang, W; Kitzmiller, JA; Guo, M; Zhao, S; Whitsett, JA; Xu, Y. Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:146-149.

Bernardes, JP; Mishra, N; Tran, F; Bahmer, T; Best, L; Blase, JI; Bordoni, D; Franzenburg, J; Geisen, U; Josephs-Spaulding, J; et al. Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. Immunity. 2020; 53:1296-1314.e9.

Kang, MH; van Lieshout, LP; Xu, L; Domm, JM; Vadivel, A; Renesme, L; Muhlfeld, C; Hurskainen, M; Mizikov, I; Pei, Y; et al. A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency. Nature Communications. 2020; 11.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Wang, A; Chiou, J; Poirion, OB; Buchanan, J; Valdez, MJ; Verheyden, JM; Hou, X; Kudtarkar, P; Narendra, S; Newsome, JM; et al. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. eLife. 2020; 9.

Whitsett, JA; Glasser, SW. Targeting Gene Expression to the Lung. Gene Therapy for Diseases of the Lung. 2020.

Cohen, SA; Kingma, PS; Whitsett, JA; Goldbart, R; Traitel, T; Kost, J. SP-D loaded PLGA nanoparticles as drug delivery system for prevention and treatment of premature infant's lung diseases. International Journal of Pharmaceutics. 2020; 585.

Ziegler, CG K; Allon, SJ; Nyquist, SK; Mbano, IM; Miao, VN; Tzouanas, CN; Cao, Y; Yousif, AS; Bals, J; Hauser, BM; et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020; 181:1016-1035.e19.

Sungnak, W; Huang, N; Bécavin, C; Berg, M; Queen, R; Litvinukova, M; Talavera-López, C; Maatz, H; Reichart, D; Sampaziotis, F; et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine. 2020; 26:681-687.

Basil, MC; Katzen, J; Engler, AE; Guo, M; Herriges, MJ; Kathiriya, JJ; Windmueller, R; Ysasi, AB; Zacharias, WJ; Chapman, HA; et al. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020; 26:482-502.

Whitsett, JA; Zacharias, W; Swarr, D; Kalinichenko, VV. Chapter 67 Cell- and tissue-based therapies for lung disease. Principles of Tissue Engineering. 2020.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10.

Thebaud, B; Goss, KN; Laughon, M; Whitsett, JA; Abman, SH; Steinhorn, RH; Aschner, JL; Davis, PG; McGrath-Morrow, SA; Soll, RF; et al. Bronchopulmonary dysplasia. Nature Reviews Disease Primers. 2019; 5.

Sinner, DI; Carey, B; Zgherea, D; Kaufman, KM; Leesman, L; Wood, RE; Rutter, MJ; de Alarcon, A; Elluru, RG; Harley, JB; et al. Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1267-1281.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. Identification of the Lymphangioleiomyomatosis Cell and Its Uterine Origin. 2019.

Du, Y; Clair, GC; Al Alam, D; Danopoulos, S; Schnell, D; Kitzmiller, JA; Misra, RS; Bhattacharya, S; Warburton, D; Mariani, TJ; et al. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2019; 317:L347-L360.

Schmidt, AF; Kannan, PS; Bridges, JP; Filuta, A; Lipps, D; Kemp, M; Miller, LA; Kallapur, SG; Xu, Y; Whitsett, JA; et al. Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques. Scientific Reports. 2019; 9.

Taylor, DM; Aronow, BJ; Tan, K; Bernt, K; Salomonis, N; Greene, CS; Frolova, A; Henrickson, SE; Wells, A; Pei, L; et al. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell. 2019; 49:10-29.

Suhrie, K; Pajor, NM; Ahlfeld, SK; Dawson, DB; Dufendach, KR; Kitzmiller, JA; Leino, D; Lombardo, RC; Smolarek, TA; Rathbun, PA; et al. Neonatal Lung Disease Associated with TBX4 Mutations. Journal of Pediatrics. 2019; 206:286-292.e1.

Swarr, DT; Wert, SE; Whitsett, JA. Molecular Determinants of Lung Morphogenesis. Kendig's Disorders of the Respiratory Tract in Children. 2019.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99:513-554.

Swarr, DT; Wert, SE; Whitsett, JA. 2 Molecular Determinants of Lung Morphogenesis. Kendig's Disorders of the Respiratory Tract in Children. 2019.

Kyle, JE; Clair, G; Bandyopadhyay, G; Misra, RS; Zink, EM; Bloodsworth, KJ; Shukla, AK; Du, Y; Lillis, J; Myers, JR; et al. Cell type-resolved human lung lipidome reveals cellular cooperation in lung function. Scientific Reports. 2018; 8.

Whitsett, JA. Airway Epithelial Differentiation and Mucociliary Clearance. Annals of the American Thoracic Society. 2018; 15:S143-S148.

Bandyopadhyay, G; Huyck, HL; Misra, RS; Bhattacharya, S; Wang, Q; Mereness, J; Lillis, J; Myers, JR; Ashton, J; Bushnell, T; et al. Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2018; 315:L576-L583.

Gokey, JJ; Snowball, J; Sridharan, A; Speth, JP; Black, KE; Hariri, LP; Perl, AT; Xu, Y; Whitsett, JA. MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation. JCI insight. 2018; 3.

Zhang, C; D'Alessandro, A; Wellendorf, AM; Mohmoud, F; Serrano-Lopez, J; Perentesis, JP; Komurov, K; Alexe, G; Stegmaier, K; Whitsett, JA; et al. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia. Oncotarget. 2018; 9:29665-29679.

Moghieb, A; Clair, G; Mitchell, HD; Kitzmiller, J; Zink, EM; Kim, Y; Petyuk, V; Shukla, A; Moore, RJ; Metz, TO; et al. Time-resolved proteome profiling of normal lung development. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2018; 315:L11-L24.

Gokey, JJ; Sridharan, A; Xu, Y; Green, J; Carraro, G; Stripp, BR; Perl, AT; Whitsett, JA. Active epithelial Hippo signaling in idiopathic pulmonary fibrosis. JCI insight. 2018; 3.

Ding, J; Aronow, BJ; Kaminski, N; Kitzmiller, J; Whitsett, JA; Bar-Joseph, Z. Reconstructing differentiation networks and their regulation from time series single-cell expression data. Genome Research. 2018; 28:383-395.