Whitsett Lab

Publications from the Whitsett Lab

2015

Lange, A.W., Sridharan, A., Xu, Y., Stripp, B.R., Perl, A-K. and Whitsett, J.A. Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015 Feb;7(1):35-47.

Metzakopian, E., Bouhali, K., Alvarez-Saavedra, M., Whitsett, J.A., Picketts, D.J. and Ang, S-L. Genome- wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development. 2015 Apr 1;142(7):1315-24.

Xia, H., Ren, X., Bolte, C.S., Ustiyan, V., Zhang, Y., Shah, T.A., Kalin, T.V., Whitsett, J.A. and Kalinichenko, V.V. Foxm1 regulates resolution of hyperoxic lung injury in newborns. Am J Respir Cell Mol Biol. 2015 May;52(5):611-21.

Snowball, J., Ambalavanan, M., Cornett, B., Lang, R., Whitsett, J. and Sinner, D. Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015 May 15;401(2):264-75.

Rajavelu, P., Chen, G., Xu, Y., Kitzmiller, J.A., Korfhagen, T.R. and Whitsett, J.A. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015 May 1;125(5):2021-31.

Ishida, N., Fukazawa, T., Maeda, Y., Yamatsuji, T., Kato, K., Matsumoto, K., Shimo, T., Takigawa, N., Whitsett, J.A. and Naomoto, Y. A novel P13K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with a MEK inhibitor. Exp Cell Res. 2015 Apr 1. pii: S0014-4827(15)00113-5.

Wakata, K., Tsuchuya, T., Tomoshige, K., Takagi, K., Yamasaki, N., Matsumoto, K., Miyazaki, T., Nanashima, A., Whitsett, J.A., Maeda, Y. and Nagayasu, T. A favorable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B. BMJ Open. In press.

Du Y. Guo, M., Whitsett, J. and Xu, Y. “LungGENS:” A web-based tool for mapping single cell gene expression in the developing lung. Thorax. In press.

Snowball, J., Ambalavanan, M., Whitsett, J. and Sinner, D. Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. In press.

Liao, Y., Liu, C., Whitsett, J.A., Zheng, Y., Jiang, W., Akunuru, S., Sur, I. and Wan, H. KLF5 inhibits epithelial polarity through suppression of RICH2 during respiratory tube morphogenesis. Submitted for publication.

Davies, E.R., Kelly, J.F., Howarth, P.H., Holgate, S.T., Davies, D.E., Whitsett, J.A. and Haitchi, H.M. The asthma susceptibility gene ADAM33 promotes structural remodeling to augment airway inflammation and bronchial hyperresponsiveness. Submitted for publication.

Guo, M., Wang, H., Whitsett, J.A. and Xu, Y. SINCERA: A pipeline for single-cell RNA-Seq profiling analysis. Submitted for publication.

Kamath-Rayne, B.D., Venkatasubramanian, M., Wagner, E., Hughes, M., DeFranco, E.A., Muglia, L.J., Whitsett, J., Xu, Y. and Salomonis, N. Lineage Profiler: Accurate multi-lineage classification from cell-free RNA. Submitted for publication.

2014

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Zhou, J., Qu, Z, Yan, S., Sun, F., Whitsett, J.A., Shapiro, S.D. and Xiao, G. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene. 2014 Oct 6. [Epub ahead of print]

Chen, G., Korfhagen, T.R., Karp, C.L., Impey, S., Xu, Y., Randell, S.H., Kitzmiller, J., Maeda, Y., Haitchi, H.M., Sridharan, A., Senft, A.P. and Whitsett, J.A. FOXA3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Am J Respir Crit Care Med. 2014 Feb 1;189(3):301-13.

Lange, A.W., Haitchi, H.M., Le Cras, T.D., Sridharan, A., Xu, Y., Wert, S.E., James, J., Udell, N., Thurner, P.J. and Whitsett, J.A. Sox17 is required for normal pulmonary vascular morphogenesis. Dev Biol. 2014 Mar 1;387(1):109-20.

Hamvas, A., Deterding, R., Balch, W.E., Schwartz, D.A., Albertine, K.H., Whitsett, J.A., Cardoso, W.V., Kotton, D.N., Kourembanas, S. and Hagood, J.S. Diffuse lung disease in children: Summary of a scientific conference. Pediatr Pulmonol. 2014 Apr;49(4):400-9.

Bridges, J.P., Schehr, A., Wang, Y., Huo, L., Besnard, V., Ikegami, M., Whitsett, J.A. and Xu, Y. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One. 2014 May 7;9(5):e91376.

Cheng, X-H., Black, M., Ustiyan, V., Le, T., Fulford, L., Sridharan, A., Medvedovic, M., Kalinichenko, V.V., Whitsett, J.A. and Kalin, T.V. SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. PLoS Genet. 2014 Sep 25;10(9):e1004656.

McCauley, H.A., Liu, C-Y., Attia, A.C., Wikenheiser-Brokamp, K.A., Zhang, Y., Whitsett, J.A. and Guasch, G. TGFß signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development. 2014 Dec;141(23):4628-39.

2013

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Ren, X., Shah, T.A., Ustiyan, V., Zhang, Y., Shinn, J., Chen, G., Whitsett, J.A., Kalin, T.V. and Kalinichenko, V.V. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol. 2013 Jan;33(2):371-86.

Wan, H., Liu, C., Wert, S.E., Wei, X., Liao, Y., Zheng, Y. and Whitsett, J.A. CDC42 is required for structural patterning of the lung during development. Dev Biol. 2013 Feb 1;374(1):46-57.

Balli, D., Ustiyan, V., Zhang, Y., Wang, I-C., Masino, A.J., Ren, X., Whitsett, J.A., Kalinichenko, V.V. and Kalin, T.V. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J. 2013 Jan 23;32(2):231-44.

Bell, S.M., Zhang, L., Xu, Y., Besnard, V., Wert, S.E., Shroyer, N. and Whitsett, J.A. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39.

Taniguchi Ishikawa, E., Chang, K.H., Olsson, H.A., Ficker, A., Dunn, S.K., Madhu, M., Nayak, R., Sengupta, A., Whitsett, J.A., Grimes, H.L. and Cancelas, J.A. Kruppel-like-factor 5 (Klf-5) controls bone marrow lodging of hematopoietic stem cells and progenitors through Rab5-mediated active β₁-integrin expression. Nat Commun. 2013;4:1660.

Cornett, B., Snowball, J., Varisco, B.M., Lang, R., Whitsett J. and Sinner, D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev. Biol. 2013 Jul 1;379(1):38-52.

Marko, C.D., Menon, B.B, Chen, G., Whitsett, J.A., Clevers, H. and Gipson, I.K. Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. Am J Pathol. 2013 Jul;183(1):35-48.

Hao, H., Maeda, Y., Fukazawa, T., Yamatsuji, T., Bao, X-H., Matsuoka, J., Okui, T., Shimo, T., Takigawa, N., Tomono, Y., Nakajima, M., Fink-Baldauf, I.M., Nelson, S., Seibel, W., Papoian, R., Whitsett, J.A. and Namoto, Y. Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE. 2013 Aug 16;8(8):e71093.

Sun, X., Bartos, A., Whitsett, J.A. and Dey, S.K. Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses. Mol Endocrinol. 2013 Sep;27(9):1492-501.

Bridges, J.P., Ludwig, M-G., Mueller, M., Kinzel, B., Sato, A., Xu, Y., Whitsett, J.A. and Ikegami, M. Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57.

Tang, X., Liu, X.J., Tian, C., Su, Q., Lei, Y., Wu, Q., He, Y., Whitsett, J.A. and Luo, F. Foxa2 regulates leukotrienes to inhibit Th2-mediated pulmonary inflammation. Am J Respir Cell Mol Biol. 2013 Dec;49(6):960-70.

2012

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Varisco, B.M., Ambalavanan, N., Whitsett, J. A. and Hagood, J.S. Thy-1 signals through PPARg to promote lipofibroblast differentiation in the developing lung. Am. J. Respir. Cell Mol. Biol. 2012 Jun;46(6):765-72.

Plantier, L., Besnard, V., Xu, Y., Ikegami, M., Wert, S.E., Hunt, A.N., Postle, A.D. and Whitsett, J.A. Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity. J Biol Chem. 2012 Mar 23;287(13):10099-114.

Sun, X., Zhang, L., Xie, H., Wan, H., Magella, B., Whitsett, J.A. and Dey, S.K. Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation. Proc Natl Acad Sci. 2012 Jan 24;109(4):1145-50.

Metzakopian, E., Lin, W., Salmon-Divon, M., Dvinge, H., Andersson, E., Ericson, J., Perlmann, T., Whitsett, J.A., Bertone, P. and Ang, S-L. Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34.

Xu, Y., Wang, Y., Besnard, V., Ikegami, M., Wert, S.E., Heffner, C., Murray, S.A., Donahue, L.R. and Whitsett, J.A. Transcriptional programs controlling perinatal lung maturation. PLoS ONE. 2012;7(8):e37046.

Wang, I-C., Snyder, J., Zhang, Y., Lander, J., Nakafuku, Y., Lin, J., Chen, G., Kalin, T.V., Whitsett, J.A. and Kalinichenko, V.V. Foxm1 mediates cross talk between Kras/Mitogen-Activated Protein Kinase and Canonical Wnt Pathways during Development of Respiratory Epithelium. Mol. Cell Biol. 2012 Oct;32(19):3838-50.

Ustiyan, V., Wert, S.E., Ikegami, M., Kalin, T.V., Whitsett, J.A. and Kalinichenko, V.V. Foxm1 transcription factor is required for differentiation and maintenance of Clara cells in the conducting airways. Dev. Biol. 2012 Oct 15;370(2):198-212.

Sato, A., Xu, Y., Whitsett, J.A. and Ikegami, M. CCAAT/enhancer binding protein-a regulates protease/antiprotease balance required for the bronchiolar epithelium regeneration. Am J Respir Cell Mol Biol. 2012 Oct;47(4):454-63.

Korfhagen, T.R., Kitzmiller, J., Chen, G., Sridharan, A., Haitchi, H.M., Hegde, R.S., Divanovic, S., Karp, C.L. and Whitsett, J.A. SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci. 2012 Oct 9;109(41):16630-5.

Tkach, J.A., Hillman, N.H., Jobe, A.H., Loew, W., Pratt, R.G., Daniels, B.R., Kallapur, S.G., Kline-Fath, B.M., Merhar, S.L., Giaquinto, R.O., Winter, P.M., Li, Y., Ikegami, M., Whitsett, J.A. and Dumoulin, C.L. An MRI system for imaging neonates in the NICU: Initial feasibility study. Pediatr Radiol. 2012 Nov;42(11):1347-56.

Maeda, Y., Tsuchiya, T., Hao, H., Tompkins, D.H., Xu, Y., Mucenski, M.L., Du, L., Keiser, A.R., Fukazawa, T., Naomoto, Y. Nagayasu, T. and Whitsett, J.A. Kras^G12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest. 2012 Dec;122(12):4388-400.

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Jeffrey A. Whitsett, MD

Mailing Address:
Division of Pulmonary Biology
3333 Burnet Ave.
Cincinnati, OH 45229-3039

Phone: 513-803-2790
Email: jeff.whitsett@cchmc.org

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Publications from the Whitsett Lab

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