Urology

Clinical

Kidney stones; ESWL; genitourinary surgery; clinical trials

Research

Bladder organogenesis; tissue engineering of bladder matrix

Biography

Pramod P. Reddy, MD, is a pediatric and fetal urologist at Cincinnati Children's Hospital Medical Center and the Cincinnati Fetal Center. His special interests include kidney stones, ESWL, genitourinary surgery, and clinical trials.

MBBS: Nagarjuna University, Guntur, India, 1990.

Residency: Albany Medical Center, Albany, NY.

Fellowship: The Hospital For Sick Children, Toronto, ON, Canada.

Certification: American Board of Urology, 2001.

Reddy PP, Defoor WR. Ureteroscopy: The standard of care in the management of upper tract urolithiasis in children. Indian J Urol. 2010 Oct;26(4):555-63.

Ivancić V, Defoor W, Jackson E, Alam S, Minevich E, Reddy P, Sheldon C. Progression of renal insufficiency in children and adolescents with neuropathic bladder is not accelerated by lower urinary tract reconstruction. J Urol. 2010 Oct;184(4 Suppl):1768-74.

DeFoor WR, Jackson E, Minevich E, Caillat A, Reddy P, Sheldon C, Asplin J. The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology. 2010 Jul;76(1):242-5.

Traxel E, DeFoor W, Reddy P, Sheldon C, Minevich E. Risk factors for urinary tract infection after dextranomer/hyaluronic acid endoscopic injection. J Urol. 2009 Oct;182(4 Suppl):1708-12.

DeFoor WR, Heshmat S, Minevich E, Reddy P, Koyle M, Sheldon C. Long-term outcomes of the neobladder in pediatric continent urinary reconstruction. J Urol. 2009 Jun;181(6):2689-93; discussion 2693-4.

Reddy PP, Borgstein NG, Nijman RJ, Ellsworth PI. Long-term efficacy and safety of tolterodine in children with neurogenic detrusor overactivity. J Pediatr Urol. 2008 Dec;4(6):428-33.

DeFoor W, Clark C, Jackson E, Reddy P, Minevich E, Sheldon C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008 Oct;180(4 Suppl):1705-8; discussion 1708.

Heshmat S, DeFoor W, Minevich E, Reddy P, Reeves D, Sheldon C. Use of customized MIC-KEY gastrostomy button for management of MACE stomal complications. Urology. 2008 Nov;72(5):1026-9.

DeFoor W, Minevich E, Jackson E, Reddy P, Clark C, Sheldon C, Asplin J. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008 Jun;179(6):2369-72.

Reddy PP. Recent advances in pediatric uroradiology. Indian J Urol. 2007 Oct;23(4):390-402.

Faculty

William R. DeFoor Jr., MD, MPH Director, Clinical Research

is a pediatric urologist conducting a multi-institutional clinical trial to assess outcomes in vesico-ureteral reflux. Other studies include outcomes in neurogenic bladder (NGB), urinary biomarkers in ureteropelvic junction obstruction, complications of clean intermittent catheterization, urinary metabolic evaluations in bariatric patients, and UTI prevention with gentamicin bladder irrigations.

513-636-4975 pedsurology@cchmc.org

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William R. DeFoor Jr., MD, MPH

Director, Clinical Research

Academic Affiliations

Associate Professor, UC Department of Surgery

Phone 513-636-4975

Fax 513-636-6753

Email pedsurology@cchmc.org

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Clinical & Research Interests

Clinical

Complex genitourinary reconstruction; clinical outcomes research; clinical trials; urolithiasis; uro-oncology; laparoscopic-assisted; robotic-assisted surgery; vesicoureteral reflux

Research

Modulation of apoptosis in cryptorchidism (undescended testes) with anti-oxidant pharmacotherapy; pediatric urologic surgical outcomes analysis using an evidence based medicine approach

BS: Georgia Institute of Technology, Atlanta, GA, 1991.

Fulbright Fellowship: Universite' Rene' Descartes, Paris, France, 1992.

MD: University of Kentucky, Lexington, KY, 1996.

Residency: Medical University of South Carolina, Charleston, SC, 2001.

Fellowship: Cincinnati Children's Hospital, Cincinnati, OH, 2003.

MPH: Harvard University, Boston, Massachusetts, School of Public Health, 2005.

DeFoor, WR, et al. The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology. 2010 Jul;76(1):242-5.

DeFoor WR, et al. Long-Term Outcomes of the Neobladder in Pediatric Continent Urinary Reconstruction. J Urol. 2009;181:2689-94.

Traxel E, DeFoor WR, et al. Multivariate analysis of risk factors for urinary tract infections after endoscopic injection of dextranomer-hyaluronic acid. J Urol. 2009;182 (4 Suppl): 1708-12.

DeFoor WR, Tobias N. Simple behavioral modification may be effective first-line treatment in resolution of nocturnal enuresis. J Pediatrics. 2009;155(5):760.

Heshmat S, DeFoor WR, et al. The use of customized Mic-Key gastrostomy button for the management of the MACE stomal complications. Urology. 2008;72(5):1026-9.

DeFoor WR, et al. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008;179(6):2369-72.

DeFoor WR, et al. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008;180(4 Suppl):1705-8; discussion 1708.

Elizabeth C. Jackson, MD Director, Healthy Bladder Clinic

has clinical research in types of bedwetting alarms that are useful for nocturnal enuresis, in outcomes of neurogenic bladder, and in the relationship of obesity and kidney stones as well as industry sponsored research in anticholinergics for neurogenic bladder.

513-636-4975 pedsurology@cchmc.org

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Elizabeth C. Jackson, MD

Director, Healthy Bladder Clinic

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4975

Fax 513-636-6753

Email pedsurology@cchmc.org

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Specialties

Functional bladder disorders; neurogenic bladder; urolithiasis

Biography

Elizabeth C. Jackson, MD, is a pediatric nephrologist recognized in the need for bladder management. Dr. Jackson has recently discontinued her inpatient nephrology role and is currently focused on outpatient lower urinary tract management. She is the director of the Healthy Bladder Clinic at Cincinnati Children's. The Healthy Bladder Clinic cares for children with functional lower urinary tract disorders. There are more than 1200 visits per year to this clinic.

MD: University of Virginia, Charlottesville, VA, 1978.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA, 1981.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1984.

Certification: Pediatrics, 1983; Pediatric Nephrology, 1985.

DeFoor WR, Jackson E, Minevich E, Caillat A, Reddy P, Sheldon C, Asplin J. The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology. 2010 Jul;76(1):242-5.

DeFoor W, Clark C, Jackson E, Reddy P, Minevich E, Sheldon C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008 Oct;180(4 Suppl):1705-8; discussion 1708.

DeFoor W, Minevich E, Jackson E, Reddy P, Clark C, Sheldon C, Asplin J. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008 Jun;179(6):2369-72.

DeFoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Erhard M, Minevich E. Urinary metabolic evaluations in normal and stone forming children. J Urol. 2006 Oct;176(4 Pt 2):1793-6.

Defoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Minevich E. Results of a prospective trial to compare normal urine supersaturation in children and adults. J Urol. 2005 Oct;174(4 Pt 2):1708-10.

Jensen S, Jackson EC, Riley L, Reddy S, Goebel J. Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation -- 4-year experience at a moderate-volume center. Pediatr Transplant. 2003 7:119-124.

Strife CF, Prada AL, Clardy CW, Jackson E, Forristal J. Autoantibody to complement neoantigens in membranoproliferative glomerulonephritis. J Pediatr. 1990 May;116(5):S98-102.

Eugene Minevich, MD, FACS, FAAP Surgical Director, Stone Center

513-636-4975 pedsurology@cchmc.org

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Eugene Minevich, MD, FACS, FAAP

Surgical Director, Stone Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4975

Email pedsurology@cchmc.org

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Specialties

Complex genitourinary reconstruction; microscopic hypospadias; endoscopic treatment of vesicoureteral reflux; urolithiasis; ESWL

Traxel E, DeFoor W, Reddy P, Sheldon C, Minevich E. Risk factors for urinary tract infection after dextranomer/hyaluronic acid endoscopic injection. J Urol. 2009 Oct;182(4 Suppl):1708-12.

DeFoor WR, Heshmat S, Minevich E, Reddy P, Koyle M, Sheldon C. Long-term outcomes of the neobladder in pediatric continent urinary reconstruction. J Urol. 2009 Jun;181(6):2689-93; discussion 2693-4.

Minevich E. Genitourinary emergencies in children. Minerva Pediatr. 2009 Feb;61(1):53-65.

DeFoor W, Clark C, Jackson E, Reddy P, Minevich E, Sheldon C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008 Oct;180(4 Suppl):1705-8; discussion 1708.

Heshmat S, DeFoor W, Minevich E, Reddy P, Reeves D, Sheldon C. Use of customized MIC-KEY gastrostomy button for management of MACE stomal complications. Urology. 2008 Nov;72(5):1026-9.

DeFoor W, Minevich E, Jackson E, Reddy P, Clark C, Sheldon C, Asplin J. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008 Jun;179(6):2369-72.

Kitchens DM, DeFoor W, Minevich E, Reddy P, Polsky E, McGregor A, Sheldon C. End cutaneous ureterostomy for the management of severe hydronephrosis. J Urol. 2007 Apr;177(4):1501-4.

Kitchens DM, Minevich E, DeFoor WR, Reddy PP, Wacksman J, Koyle MA, Sheldon CA. Incontinence following bladder neck reconstruction--is there a role for endoscopic management? J Urol. 2007 Jan;177(1):302-5; discussion 305-6.

Paul H. Noh, MD, FACS, FAAP Director, Minimally Invasive Surgery

513-636-4975 pedsurology@cchmc.org

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Paul H. Noh, MD, FACS, FAAP

Director, Minimally Invasive Surgery

Academic Affiliations

Associate Professor, UC Department of Surgery

Phone 513-636-4975

Fax 513-636-6753

Email pedsurology@cchmc.org

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Clinical Interests

Minimally invasive laparoscopic-assisted surgery; robotic-assisted surgery; prenatal evaluation; fetal care; UTIs

BS: Pennsylvania State University, State College, PA.

MD: Jefferson Medical College, Philadelphia, PA.

Internship: Tufts-New England Medical Center, Boston, MA, 1999-2000.

Residency: Tufts-New England Medical Center, Boston, MA, 2000-2004.

Fellowship: Children's Hospital of Pittsburgh, Pittsburgh, PA, 2004-2005.

Certification: American Board of Urology, Subspecialty Certification in Pediatric Urology - American Board of Urology.

Traxel EJ, Minevich EA, Noh PH. A review: the application of minimally invasive surgery to pediatric urology: upper urinary tract procedures. Urology. 2010 Jul;76(1):122-33.

Traxel EJ, Minevich EA, Noh PH. A review: the application of minimally invasive surgery to pediatric urology: lower urinary tract reconstructive procedures. Urology. 2010 Jul;76(1):115-20.

Chacko JK, Noh P, Barthold JS, Figueroa TE, Gonzalez R. Latrogenic ureteral injury after laparoscopic cholecystectomy in a 13-year-old boy. J Pediatr Urol. 2008 4(4):322-4.

Neheman A, Noh PH, Piaggio L, González R. The role of laparoscopic surgery for urinary tract reconstruction in infants weighing less than 10 kg: a comparison with open surgery. J Pediatr Urol. 2008 Jun;4(3):192-6.

Wang Y, Barthold J, Figueroa E, González R, Noh PH, Wang M, Manson J. Analysis of five single nucleotide polymorphisms in the ESR1 gene in cryptorchidism. Birth Defects Res A Clin Mol Teratol. 2008 Jun;82(6):482-5.

Neheman A, Noh PH, Brenn R, González R. Laparoscopic urinary tract surgery in infants weighing 6 kg or less: perioperative considerations and comparison to open surgery. J Urol. 2008 Apr;179(4):1534-8.

Piaggio LA, Franc-Guimond J, Noh PH, Wehry M, Figueroa TE, Barthold J, González R. Transperitoneal laparoscopic pyeloplasty for primary repair of ureteropelvic junction obstruction in infants and children: comparison with open surgery. J Urol. 2007 Oct;178(4 Pt 2):1579-83.

Piaggio LA, Noh PH, González R. Reoperative laparoscopic pyeloplasty in children: comparison with open surgery. J Urol. 2007 May;177(5):1878-82.

Davies B, Noh P, Smaldone MC, Ranganathan S, Docimo SG. Paratesticular rhabdomyoma in a young adult: case study and review of the literature. J Pediatr Surg. 2007 42(4):E5-7.

Stein RJ, Matoka DJ, Noh PH, Docimo SG. Spontaneous perforation of congenital bladder diverticulum. Urology. 2005 Oct;66(4):881.

Joo-Seop Park, PhD

is interested in understanding how progenitor cells maintain their multi-potent status and how they differentiate into different types of cells during organogenesis of the mammalian kidney and bladder. His lab studies transcriptional and epigenetic controls of cis-regulatory modules that act downstream of various signaling pathways.

Visit the Park Lab.

513-803-7871 pedsurology@cchmc.org

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Joo-Seop Park, PhD

Academic Affiliations

Assistant Professor, UC Department of Surgery

Phone 513-803-7871

Email pedsurology@cchmc.org

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Research Interests

Molecular biology; genetics.

Visit the Park Lab.

Biography

Joo-Seop Park, PhD, is an assistant professor in the Divisions of Pediatric Urology and Developmental Biology at Cincinnati Children's Hospital Medical Center. He received his bachelor's in pharmacy from Seoul National University in Seoul, South Korea. He subsequently studied the regulation of gene transcription with Dr. Jeffrey W. Roberts at Cornell University in Ithaca, NY where he obtained his doctorate in molecular biology and genetics in 2004. Dr. Park then went on to postdoctoral training with Dr. Andrew P. McMahon at Harvard University where he was awarded fellowships from the National Kidney Foundation and the Charles King Trust to study mammalian kidney development.

Dr. Park is interested in understanding how progenitor cells maintain their multi-potent status and how they differentiate into different types of cells during organogenesis of the mammalian kidney and bladder. His lab studies transcriptional and epigenetic controls of cis-regulatory modules that act downstream of various signaling pathways.

PhD: Molecular Biology, Cornell University.

Brunskill EW, Park JS, Chung E, Chen F, Magella B, Potter SS. Single cell dissection of early kidney development: multilineage priming. Development. 2014;141, 3093-3101.

Xu J, Liu H, Park JS, Lan Y, Jiang R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014;141, 1442-1452.

Wang J, Park JS, Wei Y, Rajurkar M, Cotton JL, Fan Q, Lewis BC, Ji H, Mao J. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPalpha function. Mol Cell. 2013;51, 211-225.

Park JS, Ma W, O'Brien LL, Chung E, Guo JJ, Cheng JG, Valerius MT, McMahon JA, Wong WH, McMahon AP. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012;23, 637-651.

Park JS, Valerius MT, McMahon AP. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007;134, 2533-2539.

Park JS, Roberts JW. Role of DNA bubble rewinding in enzymatic transcription termination. Proc Natl Acad Sci U S A. 2006;103, 4870-4875.

Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental cell. 2005;9, 283-292.

Roberts J, Park, JS. Mfd, the bacterial transcription repair coupling factor: translocation, repair and termination. Current opinion in microbiology. 2004;7, 120-125.

Park JS, Marr MT, Roberts JW. E. coli Transcription repair coupling factor (Mfd protein) rescues arrested complexes by promoting forward translocation. Cell. 2002;109, 757-767.

Curtis A. Sheldon, MD Founding Director, Urogenital Center

513-636-4975 pedsurology@cchmc.org

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Curtis A. Sheldon, MD

Founding Director, Urogenital Center

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4975

Fax 513-636-6753

Email pedsurology@cchmc.org

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Clinical Interests

Complex genitourinary reconstructive surgery; renal transplantation; hypospadias

MD: University of California, San Diego School of Medicine, La Jolla, CA, 1972 to 1976.

Residency: Urology, University of Minnesota, Minneapolis, MN, 1976 to 1981; General Surgery, University of Minnesota, Minneapolis, MN, 1981 to 1983.

Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1983 to 1985; Pediatric Urology, Hospital for Sick Children, Toronto, Canada, 1985 to 1986; Visiting Fellow, Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, PA, 1986.

Certification: Adult and Pediatric Urology, 1982; Surgery, 1985; Pediatric Surgery, 1988.

DeFoor WR, Jackson E, Minevich E, Caillat A, Reddy P, Sheldon C, Asplin J. The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology. 2010 Jul;76(1):242-5.

Traxel E, DeFoor W, Reddy P, Sheldon C, Minevich E. Risk factors for urinary tract infection after dextranomer/hyaluronic acid endoscopic injection. J Urol. 2009 Oct;182(4 Suppl):1708-12.

DeFoor WR, Heshmat S, Minevich E, Reddy P, Koyle M, Sheldon C. Long-term outcomes of the neobladder in pediatric continent urinary reconstruction. J Urol. 2009 Jun;181(6):2689-93.

DeFoor W, Clark C, Jackson E, Reddy P, Minevich E, Sheldon C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008 Oct;180(4 Suppl):1705-8.

Heshmat S, DeFoor W, Minevich E, Reddy P, Reeves D, Sheldon C. Use of customized MIC-KEY gastrostomy button for management of MACE stomal complications. Urology. 2008 Nov;72(5):1026-9.

Alam S, Sheldon C. Urological issues in pediatric renal transplantation. Curr Opin Urol. 2008 Jul;18(4):413-8.

DeFoor W, Minevich E, Jackson E, Reddy P, Clark C, Sheldon C, Asplin J. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008 Jun;179(6):2369-72.

Alam S, Levitt MA, Sheldon CA, Peña A. The posterior sagittal approach for recurrent genitourinary pathology. J Urol. 2007 Oct;178(4 Pt 2):1668-71

Alam S, Goebel J, Pacheco MC, Sheldon C. Papillary urothelial neoplasm of low malignant potential in a pediatric renal transplant recipient (PUNLMP): a case report. Pediatr Transplant. 2007 Sep;11(6):680-2.

Brian A. Vanderbrink, MD Urologist, Division of Urology

is an attending urologist who has strong interest in conducting clinical outcomes research, specifically in the area of lower urinary tract dysfunction. He works closely in collaboration with urology colleagues and the Colorectal Center to report and improve the urologic outcomes of patients with anorectal malformations. Reducing the incidence of urinary tract infection is another area of interest that includes examining the role innovative methods such as probiotics and hydrophilic catheters in small clinical trials.

513-636-4975 pedsurology@cchmc.org

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Brian A. Vanderbrink, MD

Urologist, Division of Urology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4975

Email pedsurology@cchmc.org

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Specialties

Reconstructive lower urinary tract surgery; neurogenic bladder; spina bifida

Biography

Dr. VanderBrink's career goal is to help children with congenital conditions that affect the urinary tract to achieve the best possible outcomes. This can mean different things to different families and he takes pride in listening to each individual family’s concerns while formulating a treatment plan. His main goals are to preserve kidney function, work towards urinary control and provide opportunities to become independent for their chronic condition.

Cincinnati Children’s is uniquely poised to be a global leader in the field of urology given its national and international prominence along with the wealth of institutional resources available. Dr. VanderBrink is proud to work with excellent clinical colleagues who share the same mission of delivering high-quality urologic care to the children they serve. He is committed to actively researching our outcomes during this process in order to improve them.

MD: Tufts University School of Medicine, Boston, MA, 2003.

Residency: North Shore LIJ Health System, New Hyde Park, NY, 2008.

Fellowship: James Whitcomb Riley Hospital for Children, Indianapolis, IN, 2010.

Certification: American Board of Urology, 2012.