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Results (47)
A Next-Generation, Non-Viral, Non-Lipid Gene Therapy Platform for Cystic Fibrosis & Beyond
A novel non‑viral, non‑lipid delivery system enables safe transfer of large genetic payloads, avoiding key limits of current gene therapies and improving uptake using targeted siRNA or drug-based enhancers.
AERSMine: Clinical Pharmacology Discovery Platform
AERS Mine, A novel approach to clinical trial design, toxicology prediction, identifying polypharmacy confounders, and drug repurposing by datamining and synthesizing information from extensive drug, disease, and adverse effect databases
AI-Guided Intubation Coaching
AI-powered intubation coach provides real-time visual guidance to help clinicians secure the airway safely.
Autologous cell and gene therapy for Gaucher Disease
Therapy for neuronopathic Gaucher Disease using gene therapy and a specialized neuronal lineage iPS cell that facilitates entry to and engraftment in the brain.
Automated Risk Assessment (ARIA) for School Violence Prevention
An innovative AI-based system for early detection and prevention of school violence through automated risk assessment.
Biomarker Response Signatures of Children Receiving Infliximab for Crohn’s Disease
Plasma Proteomic Response Signature of Children Receiving Infliximab for Crohn’s Disease
Bivalent VLP Ebola Vaccine
Bi-valent spherical virus like particle (VLP) vaccine against Ebola virus.
Brain Function Mapping with Intracranial SEEG Using Event-related Spectral Modulations
This SEEG-based technique offers a safer, more precise method for functional brain mapping.
Combination Therapy for Leukemia and Solid Tumors
A pharmaceutical therapy that has demonstrated, in vivo, the ability to eliminate leukemic, lung adenocarcinoma and lung squamous carcinoma cells.
Comprehensive Method to Package mRNA Gene Therapies, Vaccines and Protein Replacement Therapies
Comprehensive method to package mRNA gene therapies, vaccines and protein replacement therapies
Controlled Aromatherapy System
Controlled aromatherapy system delivering precise metered doses of therapeutic essential oils through an automated platform.
Decode - An AI Prediction Model
Decode is an AI prediction model that integrates EHR, environmental and social data to predict crisis risk up to 12 months in advance.
Dosing Algorithm for Inhibitors of Complement-Mediated Activity
A validated algorithm to calculate when the next dose of an inhibitor of complement-mediated (C5) activity is required.
Elevated Oncostatin M Predicts Non-response to Anti-TNF Therapy
Oncostatin M biomarkers are associated with non-response to Infliximab therapy
FlightPlan -Visual Care Intelligence Software Platform
A cloud-based visual care intelligence platform transforming EHR data into visual timelines to enable proactive intervention.
Methods for treating inflammation and autoimmune disease.
Methods for treating inflammation and autoimmune disease.
Microbiota-derived retinoid boosts immunity
Probiotic bacteria strains increase infection resistance.
Model-Informed Precision Dosing Platform
Cloud-based, HIPAA-compliant clinical decision-support platform that brings pharmacometrics and model-informed precision dosing directly to the bedside.
Multi-Biomarker Panel for Reliable Detection of Septic Shock
A novel means to quickly and accurately predict the risk of death for both children and adults with septic shock.
Multi-Frequency Encoded Source Imaging
A new imaging technology to localize and visualize electrical and/or magnetic signals in two or more frequency ranges.
Non-Invasive Eosinophilic Gastritis Diagnostic
Non-Invasive Eosinophilic Gastritis Diagnostic
Norovirus P Particle Vaccine Development Platform
This technology utilizes the Norovirus P particle as a platform for the development of novel vaccines.
Novel DUSP1 and FLT3-JAK2-IKK1 Degraders for Treating Relapsed and Recurrent Leukemia
Next-generation orally bioavailable degrader programs targeting DUSP1 and NFKB1 suppress JAK-STAT and NFκB signaling to restore treatment sensitivity in relapsed and refractory leukemia and potentially other cancers.
Novel Small Molecule RAC-Pathway Inhibitor for the Treatment of Cancer
Our proprietary inhibitor binds to VAV3 thereby inhibiting the activation of RAC downstream of several oncogenes.
Peds Echo AI
The Pediatric Echo AI suite extracts key cardiac metrics directly from routine echo views enabling real-time assessment.
Personalized Pain Management Diagnostic
A method of identifying genetic variants that affect acute treatment for acute pain.
Polymer-based product streamlines population cell analysis
Single cell labeling method to aid in applied medicine and drug development
Predicting Preterm Infants' Cognitive and Language Outcomes
Quantitatively identifying diffuse white matter anomalies using MRI as a systematic approach provides early identification of the need for developmental deficit interventions in preterm infants.
Pseudotyped Lentiviral Vector for Duchenne Muscular Dystrophy (DMD)
Engineered lentiviral platforms leveraging Myomaker/Myomerger-mediated muscle targeting overcome key limitations, enabling delivery of large genetic payloads with the potential for reduced immunogenicity and repeat dosing in muscular dystrophies.
Rapid reliable method for collection of keratinocyte RNA and DNA samples from children.
Rapid reliable method for collection of keratinocyte RNA, DNA, microbiome, proteins, lipids, and metabolites.
Renal Activity Index in Lupus (RAIL) Urinary Biomarkers Predict Treatment Response
Noninvasive measures to accurately gauge lupus nephritis status activity and forecast response to therapy
Rotavirus Subunit Vaccine Based on Norovirus S Particle Platform
A non-replicating subunit Rotavirus vaccine was developed by using a novel S particle platform and displaying recombinant antigens.
SMART@Home Complex Home Care Platform
Children with medical complexity account for a significant portion of healthcare spending and most care occurs at home, with limitations in current digital tools.
Small Molecule Inhibitors for Treating Demyelinating Diseases
Small molecules, targeting HDAC3, enhance myelin repair in demyelinating diseases and injuries
Spherical implant to improve surgical outcomes for patients with esophageal Atresia
Spheric endo-luminal traction device helps improve surgical outcomes for individuals with long-gap esophageal atresia
Stem Cell & Organoid Medicine
Organoids provide an unprecedented opportunity to study human organ development and physiology, and investigate the cause of disease.
Synaptometric
Synaptometric uses translational EEG biomarkers to bridge preclinical and clinical development, helping reduce risk in CNS drug development programs.
TOPS is an online family problem-solving treatment for pediatric traumatic brain injury (TBI)
TOPS is an online family problem-solving treatment for pediatric traumatic brain injury (TBI)
Targeted inhibition of UBE2N as a therapeutic approach in myeloid malignancies
Pharmacologic and genetic inhibition of UBE2N suppresses the function and viability of MDS/AML cells lines and patient samples. A commercially available and a novel compound has been identified.
Targeting NTRK1 for Treatment of Allergic Inflammatory Conditions
Pharmacological targeting of NTRK1 using small molecule inhibitors may reduce allergic inflammation.
Therapeutic Inhibition of the WT1-MYCN-PLK1 Axis for Treatment of Idiopathic Pulmonary Fibrosis (IPF)
Repurposing Volasertib, a potent PLK1 inhibitor, as a treatment of Idiopathic Pulmonary Fibrosis
Therapeutic Prevention of Obesity in At-Risk Populations
A method to prevent or treat diet-induced obesity and/or the associated co-morbidities in an at-risk population.
Therapeutic Protein Delivery Across the Blood-Brain Barrier
A delivery mechanism which allows large molecule therapeutics to trancytose the blood-brain barrier for treatment of neurological disorders.
Thrombin Inhibitor as Novel Oral Treatment for Atopic Dermatitis
A newly established link between the mechanistic role of thrombin and fibrinogen and their contribution to AD provides a novel mechanism for oral treatment.
Urinary Protein Biomarker Assay for Idiopathic Nephrotic Syndrome
Biomarker panel for distinguishing idiopathic steroid resistant vs. steroid sensitive nephrotic syndrome.
Using Dantrolene to Treat Neuronopathic Gaucher Disease
Dantrolene is an antagonist of ryanodine receptors (Ryrs) and blocks Ryr-mediated endoplasmic reticulum calcium release. It is an FDA-approved drug.
Virtual Reality Surgical Simulation Suite (VR3S)
VR3S provides an interactive environment for surgeons to visualize, manipulate and plan complex repairs using patient-specific 3D models. Planning is enabled on-screen or in virtual reality, along with training and remote case consultation.
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