A novel approach to clinical trial design, toxicology prediction, identifying polypharmacy confounders, and drug repurposing by datamining and synthesizing information from extensive drug, disease, and adverse effect databases
Therapy for neuronopathic Gaucher Disease using gene therapy and a specialized neuronal lineage iPS cell that facilitates entry to and engraftment in the brain.
Human Natural Killer cells expressing chimeric antigen receptor that targets aberrant immune system signaling that is involved in auto-antibody production associated with Systemic Lupus Erythematosus.
Cloud-based, HIPAA-compliant clinical decision-support platform that brings pharmacometrics and model-informed precision dosing directly to the bedside.
Quantitatively identifying diffuse white matter anomalies using MRI as a systematic approach provides early identification of the need for developmental deficit interventions in preterm infants.
Perforin inhibition during vaccination can improve vaccine success against a variety of infections and diseases for which sufficiently efficacious immune response has proven difficult
Pharmacologic and genetic inhibition of UBE2N suppresses the function and viability of MDS/AML cells lines and patient samples. A commercially available and a novel compound has been identified.
A newly established link between the mechanistic role of thrombin and fibrinogen and their contribution to AD provides a novel mechanism for oral treatment.