Nicole M. Brown, MD
Attending Physician, Adult Congenital Heart Disease
Attending Physician, Adult Congenital Heart Disease
Director, Cardiovascular Genetics Clinic
Director, Adult Congenital Heart Disease Fellowship Program
Director, Center for Maternal Cardiac Care-Adult Congenital Heart Disease (Good Samaritan Hospital)
Attending Physician, Pediatric Pulmonary Hypertension
Assistant Professor, UC Department of Pediatrics
Dr. Brown is a native of Louisville, KY and later graduated Summa Cum Laude from the University of Dayton with a degree in Biochemistry. Following completion of her medical degree at University of Cincinnati College of Medicine, she stayed in Cincinnati for a combined residency in Internal Medicine and Pediatrics. Dr. Brown then completed her Pediatric Cardiology Fellowship at Children’s Hospital of Pittsburgh of UPMC before returning to Cincinnati once again to be the first Adult Congenital Heart Disease Fellow here. She has been on faculty at CCHMC ever since and participates in a variety of clinical, educational, and research activities within the Heart Institute at CCHMC as well as at several neighboring hospitals.
Dr. Brown serves as an attending cardiologist for the Adult Congenital Heart Disease (ACHD), Cardiovascular Genetics, and Pediatric Pulmonary Hypertension teams. She is director of the Cardiovascular Genetics Clinic as well as the ACHD Fellowship Program. Additionally, she is director of ACHD for the Center for Maternal Cardiac Care (CMCC) at TriHealth. Dr. Brown’s primary clinical interests include all forms of congenital heart disease, management of pregnancy in the setting of cardiovascular disease, pulmonary hypertension, and genetically-mediated aortic disease. Her research interests have thus far focused on obstacles to the care of ACHD patients and cardiovascular complications of Turner syndrome.
BS: Biochemistry, University of Dayton, Dayton, OH, 2002.
MD: University of Cincinnati, Cincinnati, OH, 2006.
Residency: Internal Medicine/Pediatrics, UC Medical Center and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2010.
Fellowship: Pediatric Cardiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, 2013.
Advanced Fellowship: Adult Congenital Heart Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.
Certifications: Internal Medicine-ABIM, 2010; General Pediatrics-ABP, 2010; Pediatric Cardiology-ABP, 2014; Adult Congenital Heart Disease-ABIM, 2015.
Pater C, Brown NM, Goldstein BH. Far From the Septum: Transcatheter Cardioform Septal Occluder Device Closure of a Descending Aortic Pseudoaneurysm Late After Interrupted Aortic Arch Repair. JACC Cardiovasc Interv. 2017.
Gravholt CH et al. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol. 2017;177(3):G1-G70.
Verhoeven PA, Learn CP, Brown NM, Goldstein BH. Noninfective Transcatheter Pulmonary Valve Thrombosis: A Rare Cause of Post-Implantation Pulmonary Valve Obstruction. JACC Cardiovasc Interv. 2017;10(13):e119-e122.
Brown N, Veldtman G, Morales DLS, Learn C. Ruptured Non-Coronary Sinus of Valsalva Aneurysm Causing Right Heart Failure. Congenit Cardiol Today. 2014;12:1–9.
Brown NM, Maul TM, Reed H, Clayton S, Cook SC. Obstacles Encountered in Developing an Adult Congenital Heart Disease Program. Am J Cardiol. 2013;112:1953–7.
Andrew M. Crean, BM, MRCP, FRCR
Professor, UC Department of Internal Medicine
Andrew M. Crean, BM, MRCP, FRCR, is a staff cardiologist with an interest in inherited & congenital cardiac conditions. He is the director of the center for advanced cardiac imaging.
Dr. Crean was hired by the University of Cincinnati Medical Center in January 2017 as a professor of Medicine (Cardiology) and Radiology, and a staff cardiologist in Inherited and Congenital Cardiovascular Conditions. He also holds the Sanghvi Endowed Chair in Cardiovascular Imaging at the University of Cincinnati Medical Center.
Dr. Crean was previously employed at Toronto General Hospital where he was a staff cardiologist and staff radiologist specializing in hypertrophic cardiomyopathy and ACHD.
MPH: Epidemiology, Harvard University, Cambridge, MA, 2019.
MPhil: University of Cambridge, Cambridge, UK, 2003.
MSc: The University of Edinburgh, Edinburgh, UK, 1999.
Bachelor of Medicine: University of Southampton, Southampton, UK, 1992.
BSc: Molecular Medicine, University of Southampton, Southampton, UK, 1991.
Fellowship: Clinical Lecturer in Adult Congenital Heart Disease, Leeds General Infirmary, Leeds, UK, 2007-2008.
Fellowship: Senior Registrar in Adult Congenital Heart Disease Royal Brompton & St Thomas’ Hospitals, London, UK, 2007.
Residency: Junior Registrar in Adult Cardiology & Cardiac MRI, Leeds General Infirmary, Leeds, UK, 2005–2007.
Fellowship: Cardiac MRI & CT, Toronto General Hospital, Toronto, Canada, 2004–2005.
Residency: Junior Registrar in Adult Cardiology, Leeds General Infirmary, UK, 2003–2004.
Fellow: Cardiac Imaging (MRI, CT, Echo, Nuclear, Cath) Papworth Hospital, Cambridge, UK, 2001–2003.
Residency: Specialist Registrar in Diagnostic Radiology, Royal Infirmary of Edinburgh, Scotland, UK, 1997–2000.
Junior Resident: Senior House Officer, Cardiology, Anesthesia and intensive care, Clinical oncology, HIV and AIDS, 1994–1997.
Certifications: MRCP, 1996; FRCR, 2001; Cardiac MR, 2005; Cardiac CT, 2005; CCST (Radiology), 2002; CCST (Cardiology), 2008; ECFMG, 2013; USMLE, 2014.
View PubMed Publications
Keir M, Spears D, Caldarone C, Crean AM. Proving the innocence of a "malignant" coronary artery: Calling dobutamine stress CT for the defence. J Cardiovasc Comput Tomogr. 2017 Jan - Feb;11(1):68-69.
Winther S, Williams L, Keir M, Connelly K, Bradley T, Rakowski H, Crean AM. Cardiovascular Magnetic Resonance Provides Evidence of Abnormal Myocardial Strain and Primary Cardiomyopathy in Marfan syndrome. Open Heart. 2016.
Noiseux N, Mansour S, Weisel R, Stevens LM, Der Sarkissian S, Tsang K, Crean AM, Larose E, Li SH, Wintersperger B, Vu MQ, Prieto I, Li RK, Roy DC, Yau TM. The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2016 Dec;152(6):1582-1588.e2.
Shah A, Keir M, Ducas R, Crean AM. Uric acid bladder stones in congenital cyanotic heart disease. Lancet. 2016 Oct 15;388(10054):1921.
Chih S, Alba C, Manlhiot C, Fan S, Ross H, Crean AM. Perfusion Cardiac Magnetic Resonance Imaging as a Rule-Out Test for Cardiac Allograft Vasculopathy. Am J Transplant. 2016 Oct;16(10):3007-3015.
Deva DP, Hanneman K, Li Q, Ng MY, Wasim S, Morel C, Iwanochko RM, Thavendiranathan P, Crean AM. Cardiovascular magnetic resonance demonstration of the spectrum of morphological phenotypes and patterns of myocardial scarring in Anderson-Fabry disease. J Cardiovasc Magn Reson. 2016 Mar 31;18(1):14.
Williams LK, Chan RH, Carasso S, Durand M, Misurka J, Crean AM, Ralph-Edwards A, Gruner C, Woo A, Lesser JR, Maron BJ, Maron MS, Rakowski H. Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy. Biomed Res Int. 2015;2015:481245.
Keir M, Wald RM, Roche SL, Oechslin EN, Horlick E, Osten MD, Benson LN, Hickey EJ, Crean AM. Does a dedicated subspecialty ACHD coronary clinic result in greater consistency in approach and reduced loss to follow-up? An evaluation of the first 3 years of the Toronto Congenital Coronary Clinic for Adults. Progress in Pediatric Cardiology. 2015.
Han BK, Rigsby CK, Leipsic J, Bardo D, Abbara S, Ghoshhajra B, Lesser JR, Raman SV, Crean AM, Nicol ED, Siegel MJ, Hlavacek A. Computed Tomography Imaging in Patients with Congenital Heart Disease, Part 2: Technical Recommendations. An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the Society of Pediatric Radiology (SPR) and the North American Society of Cardiac Imaging (NASCI). J Cardiovasc Comput Tomogr. 2015 Nov-Dec;9(6):493-513.
Weissler-Snir A, Crean AM, Rakowski H. The role of imaging in the diagnosis and management of hypertrophic cardiomyopathy. Expert Rev Cardiovasc Ther. 2015 Nov 14:1-24.
Gruschen R. Veldtman, FRCP, MBChB
Director of Adult Congenital Heart Disease
Director of Adult Congenital Heart Disease
Professor, UC Department of Pediatrics
General Pediatrics and Neonates, Royal Hospital for Sick Children, Glasgow, 1995.
Pediatric Cardiology, Leeds General Infirmary, 1999.
Fellowship: Adult Congenital Heart Disease, Toronto, 2000.
Research Fellowship: Hospital For Sick Children Toronto, 2001.
Fellowship: Adult Congenital Heart Disease, Mayo Clinic, 2002.
Fellowship: Pediatric Interventional Cardiology, 2003.
Gary D. Webb, MD
Professor Emeritus, UC Department of Internal Medicine
Beginning in 1980, Dr. Webb was co-director, and then director of the Toronto Congenital Cardiac Center for Adults, the first such ACHD clinic in the world. He was the founding president of the Canadian Adult Congenital Heart Network. He was the founding president of the International Society for Adult Congenital Heart Disease. He led the first articulation and publication of clinical guidelines for adult congenital heart patients. He has edited two major texts in the field of adult congenital heart disease.
While in Cincinnati, and with the support of the Heart Institute, he established the Adult Congenital Heart Learning Center, an online source of information intended primarily for providers, but also available to patients and families.
MD: McGill University, Montréal, Québec, Canada, 1967.
Residency: Internal medicine and cardiology, University of Toronto, Toronto Ontario, Canada.
Fellowship: Royal College of Physicians and Surgeons of Canada (Cardiology), 1972; Royal College of Physicians and Surgeons of Canada (Internal Medicine), 1972; Fellow of the American College of Cardiology, 1976.
Knowles R, Veldtman G, Hickey EJ, Bradley T, Gengsakul A, Webb GD, Williams WG, McCrindle BW. Functional Health Status of Adults with Tetralogy of Fallot: Marched Comparison with Healthy Siblings. Ann Thorac Surg. 2012 Jul;94(1):124-32.
The long road to better ACHD care
Congenital Heart Dis
. 2010 May-Jun;5(3):198-205.
Khairy P, Aboulhosn J, Gurvitz MZ, Opotowsky AR, Mongeon FP, Kay J, Valente AM, Earing MG, Lui G, Gersony DR, Cook S, Ting JG, Nickolaus MJ, Webb G, Landzberg MJ, Broberg CS; Alliance for Adult Research in Congenital Cardiology (AARCC). Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation. 2010 Aug 31;122(9):868-75.
Valente AM, Bhatt AB, Cook S, Earing MG, Gersony DR, Aboulhosn J, Opotowsky AR, Lui G, Gurvitz M, Graham D, Fernandes SM, Khairy P, Webb G, Gerhard-Herman M, Landzberg MJ; AARCC (Alliance for Adult Research in Congenital Cardiology) Investigators. The CALF (Congenital Heart Disease in Adults Lower Extremity Systemic Venous Health in Fontan Patients) study. J Am Coll Cardiol. 2010 Jul 6;56(2):144-50.
Silversides CK, Kiess M, Beauchesne L, Bradley T, Connelly M, Niwa K, Mulder B, Webb G, Colman J, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome. Can J Cardiol. 2010 Mar;26(3):e80-97.
Apitz C, Webb GD, Redington AN. Tetralogy of Fallot. Lancet. 2009 Oct;374(9699):1462-71.
Opotowsky AR, Siddiqi OK, Webb, GD. Trends in hospitalizations for adults with congenital heart disease in the US. J Am Coll Cardiol. 2009 Jul;54(5):460-7.
Schwerzmann M, Salehian O, Harris L, Siu SC, Williams WG, Webb GD, Colman JM, Redington A, Silversides CK. Ventricular arrhythmias and sudden death in adults after a Mustard operations for transposition of the great arteries. Eur Heart J. 2009 Aug;30(15):1873-9.
Hickey EJ, Veldtman G, Bradley TJ, Gengsakul A, Manlhiot C, Williams WG, Webb GD, McCrindle BW. Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades. European Journal of Cardio-thoracic Surgery. 2009 Jan;35(1):156-64.
Tzemos N, Silversides CK, Colman JM, Therrien J, Webb, GD, Mason J, Cocoara E, Sermer M, Siu SC. Late cardiac outcomes after pregnancy in women with congenital aortic stenosis. American Heart Journal. 2009;157(3):474-480.
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