Physicians and researchers at Cincinnati Children’s participate in numerous clinical and laboratory research projects designed to improve the lives of patients and find new therapies to treat bone marrow failure syndromes.

In our laboratories, we are working to:

  • Investigate molecular mechanism of bone marrow failure
  • Find new biomarkers for prognosis of Shwachman-Diamond syndrome
  • Explore longitudinal changes in blood that predict bone marrow failure in patients with Fanconi anemia
  • Learn more about clinical and genetic changes of dyskeratosis congenita (a disease that leads to failure of the bone marrow)

Our physicians also partner with other researchers throughout the world to further the understanding and treatment of these diseases. For instance, our team participates in the Severe Chronic Neutropenia International Registry, which monitors the clinical course, treatment and outcomes of patients with severe chronic neutropenia (SCN). We also participate in the Diamond Blackfan Anemia Registry, the Dyskeratosis Congenita Registry, and the Shwachman-Diamond Syndrome Registry, for which Stella Davies and Richard Harris serve as principal investigators.