Physicians and researchers at Cincinnati Children’s conduct numerous clinical research projects in hopes of improving the lives and prognosis for children with cancer, Fanconi anemia, immune deficiencies and other diseases.

In our laboratories, we are working to:

  • Understand the biology of blood stem cells
  • Understand the microenvironment in the bone marrow, and how it leads to pathological conditions, such as leukemia
  • Improve bone marrow transplant regimens (including how we screen and match donors with certain cellular characteristics) to improve outcomes from blood cell transplants
  • Identify new biomarkers to predict damage to kidneys after a bone marrow transplant
  • Understand genetic changes that happen in the blood stem cells to make them leukemic
  • Learn more about clinical and genetic changes of dyskeratosis congenita (a disease that leads to failure of the bone marrow)
  • Develop novel therapies for patients with hemophagocytic lymphohistiocytosis (HLH) using animal models
  • Develop new diagnostic tests for patents with X-linked lymphoproliferative (XLP) syndrome
  • Develop new drugs to improve blood stem cell mobilization so that blood stem cells can be harvested — and travel back to the bone marrow — efficiently. This is key to a successful transplant procedure.
  • Develop intervention strategies to improve quality of life for children who have received transplants

Our team includes some of the country’s most innovative laboratory researchers. Cincinnati Children’s scientists have made key discoveries about bone marrow transplantation, and they work closely with our physicians to speed advances from the laboratory to the clinic.