Cardiomyopathy

Biomarkers for post-transplant lymphoproliferative disorder in children. Site investigator. National Institute of Allergy and Infectious Diseases. 2015 - present.

Richard J. Czosek, MD 513-636-2237

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Richard J. Czosek, MD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-2237

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Clinical Interests

Electrophysiology

BS: University of Georgia, 1997.

MD: Medical College of of Georgia, 2001.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center. Cincinnati, OH.

Cardiology Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Fellowship Subspecialty Training: Pediatric Pacing and Electrophysiology, Boston Children's Hospital, Boston, MA.

Walsh MA, Grenier MA, Jefferies JL, Towbin JA, Lorts A, Czosek RJ. Conduction Abnormalities in Pediatric Patients with Restrictive Cardiomyopathy. Circ Heart Fail. 2012 Mar 1;5(2):267-73.

Walsh MA, Anderson JB, Knilans TK, Cottrill CM, Czosek RJ. Ventricular "Oversensing" in a Biventricular Pacemaker. Pacing Clin Electrophysiol. 2012 Aug;35(8):1014-7.

Czosek RJ, Meganathan K, Anderson JB, Knilans TK, Marino BS, Heaton PC. Cardiac rhythm devices in the pediatric population: Utilization and complications. Heart Rhythm. 2012 Feb;9(2):199-208.

Czosek RJ, Anderson JB, Marino BS, Mellion K, Knilans TK. Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation. Pacing Clin Electrophysiol. 2011;34:555-562.

Czosek RJ, Haaning A, Ware SM. A mouse model of conduction system patterning abnormalities in heterotaxy syndrome. Pediatr Res. 2010;68:275-280.

Czosek RJ, Atallah J, Emani S, Hasan B, del Nido P, Berul CI. Electrical dyssynchrony and endocardial fibroelastosis resection in the rehabilitation of hypoplastic left cardiac syndrome. Cardiol Young. 2010;20:516-52.

Czosek RJ, Anderson JB, Cao J, Knilans TK. Assessment of t-wave oversensing in an infant with an implanted defibrillator. Heart Rhythm. 2010;7:1516-1517

Czosek RJ, Anderson J, Marino BS, Connor C, Knilans TK. Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults. Pacing Clin Electrophysiol. 2010;33:1304-131.

Czosek RJ, Anderson J, Connor C, Knilans T. Nodoventricular pathway associated with twin AV nodes: Complexity of ablation in single ventricle physiology. J Cardiovasc Electrophysiol. 2010;21:936-939.

Czosek RJ, Berul CI. Congenital long-QT syndrome concealed by hypercalcemia in Williams syndrome. J Cardiovasc Electrophysiol. 2008;19:1322-1324.

Lisa M. Dodd, MSSW, LISW Social Worker, Heart Institute 513-636-0328 lisa.dodd@cchmc.org

John L. Jefferies, MD, MPH, FAAP, FACC Co-Director, Advanced Heart Failure and Cardiomyopathy 513-803-1675 john.jefferies@cchmc.org

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John L. Jefferies, MD, MPH, FAAP, FACC

Co-Director, Advanced Heart Failure and Cardiomyopathy

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-1675

Email john.jefferies@cchmc.org

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Clinical

Advanced heart failure; cardiomyopathy; mechanical circulatory support and transplant

Research

Heritable causes of vascular disease; novel drug therapies for advanced heart failure; novel gene discovery in cardiomyopathy; characterization and management of left ventricular noncompaction (LVNC); early diagnosis and management of chemotherapy induced cardiotoxicity.

Biography

Dr. Jefferies, a professor of pediatric cardiology and adult cardiovascular diseases within the University of Cincinnati College of Medicine, is the director of Advanced Heart Failure / Cardiomyopathy in the Heart Institute at Cincinnati Children's Hospital Medical Center.

He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 120 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.

His current research interests include heritable causes of cardiovascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.

He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organizations, including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association. He is the lead editor for two textbooks that focus on the management of heart disease in children and young adults entitled “Heart Failure in the Child and Young Adult: From Bench to Bedside” and “Cardioskeletal Myopathies in Children and Young Adults.”

BS: University of Tennessee, Knoxville, TN, 1992.

MD: University of Tennessee, Knoxville, TN, 1996.

Residency: University of Kentucky, Lexington, KY, 2000.

MPH: University of Kentucky, Lexington, KY, 2001.

Fellowship: Baylor College of Medicine, Houston, TX, 2006.

Certification: Pediatrics, Internal Medicine, Cardiology, Advanced Heart Failure, Cardiac Transplant.

View PubMed Publications

Towbin JA, Lorts A, Jefferies JL. Left ventricular noncompaction cardiomyopathy. Lancet. 2015;Apr 9. Epub ahead of print.

McCullough PA, Jefferies JL. Novel Markers And Therapies For Patients With Acute Heart Failure And Renal Dysfunction. Am J Med. 2015 Mar;128(3):312.e1-22.

Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.

Raman SV, Hor KN, Halnon NJ, Kissel JT, He X, Tran T, Smart S, McCarthy B, Taylor MD, Jefferies JL, Rafael-Fortney JA, Lowe J, Roble SL, Cripe LH. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Feb;14(2):153-61.

Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205.

Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.

Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.

Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.

Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.

Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62.

Angela Lorts, MD Director, Ventricular Assist Device Program 513-803-4580 angela.lorts@cchmc.org

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Angela Lorts, MD

Director, Ventricular Assist Device Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-4580

Fax 513-636-3952

Email angela.lorts@cchmc.org

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Clinical

Advanced heart failure; cardiopulmonary bypass mediated myocardial dysfunction; novel uses of pediatric VADs; cardiomyopathy; mechanical circulatory support and transplant

Research

Myocardial remodeling

MD: Creighton University Medical School, Omaha, NE, 1998.

Residency: The Children’s Hospital, Denver, CO, 2001.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004; University of Michigan Medical Center, Ann Arbor, MI, 2006.

Certifications: American Board of Pediatrics, 2001; American Board of Pediatrics, Sub-Board of Pediatric Cardiology, 2004; American Board of Pediatrics, Sub-Board of Pediatric Critical Care, 2006.

View PubMed Publications

Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet. 2015 Apr 9.

Benoit S, Antommaria AH, Weidner N, Lorts A. Difficult decision: what should we do when a VAD-supported child experiences a severe stroke? Pediatr Transplant. 2015 Mar;19(2):139-43.

Zafar F, Castleberry C, Khan MS, Mehta V, Bryant R 3rd, Lorts A, Wilmot I, Jefferies JL, Chin C, Morales DL. Pediatric heart transplant waiting list mortality in the era of ventricular assist devices. J Heart Lung Transplant. 2015 Jan;34(1):82-8.

Thomas TO, Chandrakasan S, O'Brien M, Jefferies JL, Ryan TD, Wilmot I, Baker ML, Madueme PC, Morales D, Lorts A. The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease. Pediatr Transplant. 2015 Feb;19(1):E15-8.

Thomas TO, Jefferies JL, Lorts A, Anderson JB, Gao Z, Benson DW, Hor KN, Cripe LH, Urbina EM. Autonomic dysfunction: a driving force for myocardial fibrosis in young Duchenne muscular dystrophy patients? Pediatr Cardiol. 2015 Mar;36(3):561-8.

Friess MR, Marino BS, Cassedy A, Wilmot I, Jefferies JL, Lorts A. Health-related quality of life assessment in children followed in a cardiomyopathy clinic. Pediatr Cardiol. 2015 Mar;36(3):516-23.

Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DL. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO J. 2015 Jan-Feb;61(1):8-14.

Moore RA, Madueme PC, Lorts A, Morales DL, Taylor MD. Virtual implantation evaluation of the total artificial heart and compatibility: Beyond standard fit criteria. J Heart Lung Transplant. 2014 Nov;33(11):1180-3.

Lorts A, Zafar F, Adachi I, Morales DL. Mechanical assist devices in neonates and infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2014;17(1):91-5.

Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DL. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with duchenne muscular dystrophy: lessons learned from the first applications. ASAIO J. 2014 Mar-Apr;60(2):246-8.

Thomas D. Ryan, MD, PhD Heart Failure, Transplant, VAD Physician 513-803-2913 thomas.ryan@cchmc.org

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Thomas D. Ryan, MD, PhD

Heart Failure, Transplant, VAD Physician

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2913

Email thomas.ryan@cchmc.org

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Clinical

Cardiomyopathy; advanced heart failure; heart transplantation; mechanical circulatory support and transplant

Research

Development of cardiomyopathy in at risk populations, including Duchenne muscular dystrophy and other genetic cardiomyopathies, and anthracycline exposure.

Biography

Thomas D Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in biological sciences.

In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his pediatric cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation, and mechanical circulatory support.

BS: Wichita State University, Wichita, KS, 1996.

PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.

MD: University of Alabama at Birmingham, Birmingham, AL, 2005.

Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.

Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.

Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.

View PubMed Publications

Ryan TD, Jefferies JL, Chin C, Sticka JJ, Taylor MD, Harris R, Moore J, Goodridge E, Mount L, Bolyard AA, Otto B, Jones A, Shimamura A, Davies S, Myers K. Abnormal circumferential strain measured by echocardiography is present in patients with shwachman-diamond syndrome despite normal shortening fraction. Pediatr Blood Cancer. 2015 Mar 2.

Ryan TD, Jefferies JL, Wilmot I. Managing heart failure in adults with congenital heart disease. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.

Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.

Dandoy CE, Davies SM, Hirsch R, Chima RS, Paff Z, Cash M, Ryan TD, Lane A, El-Bietar J, Myers KC, Jodele S. Abnormal echocardiography seven days after stem cell transplant may be an early indicator of thrombotic microangiopathy. Biol Blood Marrow Transplant. 2015 Jan;21(1):113-8.

Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DLSM. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO Journal. 2015 Jan-Feb;61(1):8-14.

Chin C, Ryan TD, Castleberry CD. Transplantation in the highly sensitized pediatric patient. Circulation. 2014 Jun 3;129:2313-19.

Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DLS. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with Duchenne muscular dystrophy: lessons learned from the first applications. ASAIO Journal. 2014 Mar-Apr;60(2):246-8.

Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.

Ryan TD, Ware SM, Lucky AW, Towbin JA, Jefferies JL, Hinton RB. Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa. Circ Heart Fail. 2012 Sep 1;5(5):e81-2.

Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.

David S. Spar, MD Pediatric Electrophysiologist, Heart Institute, Pediatric Cardiology 513-636-4432 david.spar@cchmc.org

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David S. Spar, MD

Pediatric Electrophysiologist, Heart Institute, Pediatric Cardiology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4432

Email david.spar@cchmc.org

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Clinical Interests

Electrophysiology; Cardiac Step-Down Unit

MD: University of Vermont College of Medicine, Burlington, VT, 2005.

Residency: Pediatrics, Yale-New Haven Children’s Hospital, New Haven, CT, 2008.

Fellowship: Pediatric Cardiology, Morgan Stanley Children’s Hospital, Columbia University, New York, NY, 2011.

Pediatric Electrophysiology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.

Spar DS, Anderson JB, Palumbo JS, Kukreja KU, Czosek RJ. Symptomatic Upper-Extremity Deep Venous Thrombosis After Pacemaker Placement in a Pediatric Patient: How to Treat?Pediatr Cardiol. 2012 May 23.

Spar DS, Silver ES, Hordof AJ, Liberman L. Relation of the utility of exercise testing for risk assessment in pediatric patients with ventricular preexcitation to pathway location. Am J Cardiol. 2012 Apr 1;109(7):1011-4.

Spar DS, Silver ES, Hordof AJ, Torres A, Liberman L. Coronary artery spasm during radiofrequency ablation of a left lateral accessory pathway. Pediatr Cardiol. 2010 Jul;31(5):724-7.

Erdem SR, Broxson CS, Erdem A, Spar DS, Williams RT, Tümer N. The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in rats. Neuropharmacology. 2002 Dec;43(8):1280-8.

Spar D, Macknin M. Use of letters and phone calls to encourage preparticipation Special Olympics physical examinations to be done in a medical home: a randomized, controlled trial. Clin Pediatr (Phila). 2001 Dec;40(12):685-7.

Shelly L. Stark, MSN, APRN, CNP Acute Care Pediatric Nurse Practitioner, Heart Failure/Cardiomyopathy/Transplant, Heart Institute 513-803-9011 shelly.stark@cchmc.org

BreAnn Taylor, PharmD, BCPS Clinical Pharmacy Specialist, Outpatient Cardiology, Division of Pharmacy 513-636-4292 breann.taylor@cchmc.org

Ivan Wilmot, MD Heart Failure, Transplant, Ventricular Assist Device Physician 513-803-2913 ivan.wilmot@cchmc.org

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Ivan Wilmot, MD

Heart Failure, Transplant, Ventricular Assist Device Physician

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2913

Email ivan.wilmot@cchmc.org

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Clinical

Advanced heart failure; transplantation; mechanical circulatory support and transplant; cardiomyopathy

Research

Care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant and mechanical circulatory support (MCS); advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.

Biography

Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor of Science in zoology.

In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.

His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).

BS: Louisiana State University, Baton Rouge, LA, 1998.

MD: Emory University School of Medicine, Atlanta, GA, 2002.

Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.

Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.

Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.

Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.