Clinical Trials

Liver / Kidney Research Studies

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Liver New Diagnosis

ADVL1622: Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Conditions: Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Tumor DIPG Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other All Other, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver New Diagnosis, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other All Other, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Liver New Diagnosis, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some o ...More

AHEP0731: Treatment of Children With All Stages of Hepatoblastoma With Temsirolimus (NSC#683864) Added to High Risk Stratum Treatment

Conditions: Liver New Diagnosis, Adult - Liver New Diagnosis

PURPOSE: This phase III trial studies the side effects and how well risk-based therapy works in treating younger patients with newly diagnosed liver cancer. Surgery, chemotherapy drugs (cancer fighting medicines), and when necessary, liver transplant, are the main current treatments for hepatoblasto ...More