Lymphoma Research Studies

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Non-Hodgkin Relapse / Refractory

ADVL1412: A Phase 1/2 Study of Nivolumab in Children, Adolescents, and Young Adults With Recurrent or Refractory Solid Tumors as a Single Agent and in Combination With Ipilimumab

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Lymphoma Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Sarcoma Ewing Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase I/II trial studies the side effects and best dose of nivolumab when given with or without ipilimumab to see how well they work in treating younger patients with solid tumors or sarcomas that have come back (recurrent) or do not respond to treatment (refractory). Monoclonal ...More

ADVL1414: A Phase 1 Study of Selinexor (KPT-330, IND#125052), a Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors.

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Craniopharyngioma, Brain Spinal Other ATRT, Brain Spinal Other All Other, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Kidney Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Lymphoma Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other All Other, Adult - Neuroblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: The investigators will conduct a phase 1 trial of Selinexor in children with recurrent or refractory solid tumors, including CNS tumors using the Rolling Six design. The aims of the trial will be to establish the maximum tolerated pediatric doses of tablet formulation; to investigate ...More

ADVL1513: A Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor DIPG Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other All Other, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Kidney Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Lymphoma Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other All Other, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase I trial studies the side effects and best dose of entinostat in treating pediatric patients with solid tumors that have come back or have not responded to treatment. Entinostat may block some of the enzymes needed for cell division and it may help to kill tumor cells. DETAILED D ...More

ADVL1621: A Phase I/II Study of Pembrolizumab (MK-3475) in Children with advanced melanoma or a PD-L1 positive advanced, relapsed or refractory solid tumor or lymphoma (KEYNOTE-051)

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumors - All Other, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Hodgkin Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This is a 2-part study of pembrolizumab (MK-3475) in pediatric participants who have either advanced melanoma or a programmed cell death ligand 1 (PD-L1)-positive advanced, relapsed or refractory solid tumor or lymphoma. Part 1 will find the maximum tolerated dose (MTD)/maximum administered ...More

ANHL1522: A Pilot Study of Rituximab (RTX) and Third Party Latent Membrane Protein (LMP)-Specific Cytotoxic T-Lymphocytes in Pediatric Solid Organ Recipients (SOT) With EBV-Positive CD20-Positive Post-Transplant Lymphoproliferative Disease (PTLD)

  • Conditions: Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse

PURPOSE: This pilot clinical trial studies how rituximab and latent membrane protein (LMP)-specific T-cells work in treating pediatric solid organ recipients with Epstein-Barr virus-positive, cluster of differentiation (CD)20-positive post-transplant lymphoproliferative disorder. Monoclonal antibodi ...More

APEC1621: Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders

  • Conditions: Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Germ Cell Tumor, Brain Spinal Other All Other, Adult - Brain Spinal Other All Other, Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Adult - Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Adult - Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Adult - Liver Relapse - Refractory, Kidney Relapse - Refractory, Adult - Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Solid Tumors - All Other

PURPOSE: This screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/o ...More

CLDK378X2103: A Phase I, Open-Label, Dose Escalation Study of LDK378 in Pediatric Patients with Malignancies that have a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK).

  • Conditions: Lymphoma Non Hodgkin Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory

CLDK378X2103: A Phase I, Open-Label, Dose Escalation Study of LDK378 in Pediatric Patients with Malignancies that have a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK).  ...More

CPX-MA-1201: A Phase I/Pilot Study of CPX-351 for Children, Adolescents and Young Adults with Recurrent or Refractory Hematologic Malignancies.

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Leukemia ALL Relapse, Leukemia AML Relapse, Adult - Leukemia AML Relapse, Adult - Leukemia ALL Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Hodgkin Relapse

  PURPOSE: The purpose of this study is to test the safety of a study drug called CPX-351. This drug has been tested in adults but not yet in children and adolescents. This study tests different doses of the drug to see which dose is safer in children and adolescents. Patients who have blood ca ...More

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To learn more about available lymphoma clinical trials, contact us at cancer@cchmc.org or 513-636-2799.