Clinical Trials / Research Studies
Clinical Trials / Research Studies

Study for Children and Teens 10 to 17 Years Old with Complex Regional Pain Syndrome and Their Parent

Why are we doing this research?

Cincinnati Children's is conducting a research study, sometimes known as a clinical study, to learn how emotions, thoughts and interactions with family and friends affect the recovery from Complex Regional Pain Syndrome (CRPS).

Who can participate?

Children and teens 10 to 17 years old who have CRPS and a parent may be eligible to participate.


  • Bones - Joints - Muscles

What will happen in the study?

This study involves up to three visits on separate days, lasting about 3 hours each. The first visit will take place at the same time the child/teen with CRPS is visiting for treatment. The second visit will be scheduled after treatment ends. The third visit will be scheduled 6 months after treatment ends. Here are some of the things that will happen in this study:

Children and teens with CRPS will:

  • Complete questionnaires about your feelings, relationship with your parents, your health, your CRPS and your CRPS treatments
  • Complete tasks which include listening to different sounds, looking at checkerboard images, and doing movements with your fingers
  • Be placed in a machine called an MRI to view your brain. The machine is like a giant tube which is open at both ends. You will be in that tube for one-and-a-half hours. Pillows will be used to keep your head still. We will take several breaks, but you will need to stay in the tube during these breaks.
  • Provide a urine sample to test for drugs. Your doctor and parent will be informed if the test result is positive.
  • Complete a pregnancy test if you are a sexually active female. Your doctor and parent will be informed if the test result is positive

Parents will complete a series of questionnaires during each visit that ask about your feelings, your relationship with your child, your health, your child’s pain condition and your child’s overall health.

What are the good things that can happen from this research?

Being in this study may not help participants. We hope the information learned from this study will eventually help children and teens with CRPS.

What are the bad things that can happen from this research?

This study has minimal risks as there are no known long-term effects of MRI procedures on the body. Any possible risks and discomforts will be discussed with participants and parents interested in learning more about the study.

Will you/your child be paid to be in this research study?

Families will receive up to $420 for 3 visits.


Contact Us.Pain Research Center
Cincinnati Children’s Hospital Medical Center
3333 Burnet Ave.
Cincinnati, OH 45229-3039

Study Doctor

Contact Us.Robert C. Coghill, PhD
Pain Research Center
Cincinnati Children’s Hospital Medical Center