Neonatology

Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy

Visit the Whitsett Lab.

Biography

Dr. Whitsett's laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. They identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. They identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. They produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. They have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. They utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models.

Dr. Whitsett has a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and has contributed to the direct training of more than 80 graduate or post-graduate students in his laboratory. The scope of his work is represented in several recent reviews. Initial discoveries from his laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD.

MD: Columbia University, New York, NY, 1973.

Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

Davies ER, Kelly JFC, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. JCI Insight. 2016;1:e87632.

Ustiyan V, Zhang Y, Perl A-KT, Whitsett JA, Kalin TV, Kalinichenko VV. ß-Catenin and Kras/Foxm1 Signaling Pathway are Critical to Restrict Sox9 in Basal Cells During Pulmonary Branching Morphogenesis. Dev Dyn. 2016;245:590-604.

Guo M, Wang H, Potter SS, Whitsett JA, Xu Y. SINCERA: A pipeline for single-cell RNA-Seq profiling analysis. PLoS Comput Biol. 2015;11:e1004575.

Kamath-Rayne BD, Du Y, Hughes M, Wagner EA, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8:67.

Du Y, Guo M, Whitsett JA, Xu Y. ‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70:1092-1094.

Snowball J, Ambalavanan M, Whitsett J, Sinner D. Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015;405:56-70.

Wakata K, Tsuchiya T, Tomoshige K, Takagi K, Yamasaki N, Matsumoto K, Miyazaki T, Nanashima A, Whitsett JA, Maeda Y, Nagayasu T. A favorable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B. BMJ Open. 2015;5:e008366.

Ishida N, Fukazawa T, Maeda Y, Yamatsuji T, Kato K, Matsumoto K, Shimo T, Takigawa N, Whitsett JA, Naomoto Y. A novel P13K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with a MEK inhibitor. Exp Cell Res. 2015;335:197-206.

Rajavelu P, Chen G, Xu Y, Kitzmiller JA, Korfhagen TR, Whitsett JA. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015;125:2021-2031.

Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D. Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015;401:264-275.

Grants

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Jan 2012-Dec 2016. U01HL110964.

Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Apr 2013-Mar 2018. 2 R01HL095580.

Omics of Lung Diseases. Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Sep 2013-May 2018. K12 HL119686.

“Lung Map” Atlas Research Center. Multiple Principal Investigators. National Institutes Health/National Heart, Lung, and Blood Institute. Jun 2014-Apr 2019. U01 HL122642.

Editing Alveolar Progenitor Cells for Correction of Monogenic Disease. Program Director/Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Sep 2016-Aug 2023. U01 HL134745.

Role of EMC3/TMEM111 in Alveolar Epithelial Cell Function. Program Director/Principal Investigator. National Institutes Health/National Heart, Lung, and Blood Institute. Apr 2017-Mar 2022. R01 HL136722.

Division Director

James M. Greenberg, MD Co-Director, Perinatal Institute 513-636-3149 james.greenberg@cchmc.org

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James M. Greenberg, MD

Co-Director, Perinatal Institute

Director, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-803-0968

Email james.greenberg@cchmc.org

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Neonatal chronic lung disease; late preterm infant

Biography

Dr. Greenberg is a nationally recognized leader in neonatal-perinatal medicine. He serves as director of the Division of Neonatology for Cincinnati Children's Hospital Medical Center leading one of the largest comprehensive clinical and academic programs for newborn care in the United States. Dr. Greenberg has been division director since 2003, and has been an active clinician, researcher and teacher at Cincinnati Children's Hospital Medical Center for more than 22 years. In 2009, he was appointed associate director of the Perinatal Institute at Cincinnati Children’s and became co-director in 2011.

His research activities include developmental biology of the lung, neonatal chronic lung disease, neonatal epidemiology, and prevention of preterm birth. Dr. Greenberg partners with Cincinnati Children's faculty and regional leaders to lead community health initiatives to reduce preterm birth and eliminate infant mortality. He has authored more than 30 original research articles; and six book chapters in the textbook of Pediatrics, Maternal-Fetal Medicine, and Pulmonology.

As medical director for Regional Newborn Services and division director, Dr. Greenberg led the dramatic growth of the neonatology clinical program from 12 faculty physicians providing care at two neonatal intensive care units (NICUs) to more than 50 physicians providing newborn care at 13 regional hospitals including the five NICUs. The Division of Neonatology now has over 120,000 patient encounters per year. In addition to caring for all of the Level III and Level II intensive care nursery patients in the region, division physicians also see more than 18,000 normal newborns every year. The Newborn Intensive Care at Cincinnati Children’s represents the hub of the neonatology clinical program. This NICU has over 750 admissions per year and focuses its activities on caring for infants with complex medical and surgical problems. All patients requiring surgery, surgical subspecialty care, complex radiographic imaging, or comprehensive diagnostic services are managed at the Cincinnati Children's Hospital Medical Center NICU.

In addition to the clinical program, the Division of Neonatology has an active research program. The division is one of the 22 NICHD Neonatal Research Network Centers. Extramural grant funding for the division in fiscal year 2015 was in excess of $10 million. Division research programs span basic, translational, and clinical endeavors.

The division also has an active quality improvement program focusing on outcomes in varied clinical settings ranging from improving reliability of delivery room thermal stability to reduction of central-line-associated blood stream infections in the NICU.

MD: University of Illinois College of Medicine, Chicago, IL, 1977-1981.

Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, MN, 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1984.

Fellowship: Immunology/Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal/Perinatal Medicine, 1989.

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.

Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.

Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.

Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.

Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.

Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.

Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.

Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.

Faculty

Shawn K. Ahlfeld, MD Attending Neonatologist, Perinatal Institute 513-803-7723 shawn.ahlfeld@cchmc.org

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Shawn K. Ahlfeld, MD

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7723

Email shawn.ahlfeld@cchmc.org

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Clinical

Neonatal-perinatal medicine; bronchopulmonary dysplasia

Research

Neonatal lung injury, development, and repair; neonatal lung mesenchymal development; biomarkers of neonatal lung injury; animal models of bronchopulmonary dysplasia

Biography

As a neonatal fellow and junior faculty, Dr. Ahlfeld has evaluated the role of matricellular proteins in saccular and early alveolar lung development. He and his team has determined that hyperoxia exposure resulted in the mis-expression of the Transforming Growth Factor Beta (TGFβ)-responsive extracellular matrix protein, periostin, during critical periods of saccular-alveolar lung development. Periostin proved to be a novel marker for both normal myofibroblastic activity during alveolarization and abnormal myofibroblastic persistence during late fibrotic stages of lung injury.

Under a scholar grant through the Prematurity and Respiratory Outcomes Program (PROP), they have demonstrated, for the first time, that plasma periostin levels in extremely premature infants during the first weeks of age correlate with the development and severity of BPD. Their investigations into TGFβ superfamily signaling during saccular and alveolar lung development, as well as its role in BPD pathogenesis, are ongoing.

Contrary to the prevailing notion of up-regulation, TGFβ extracellular signaling ligands, intracellular signaling messengers, and down-stream signaling targets are all down-regulated during early hyperoxic lung injury. They have determined that TGFβ down-regulation coincides with a period of saccular-alveolar lung development that is critical for development of distal lung complexity and function. The down-regulation of TGFβ signaling during this critical window of lung development occurs well before the up-regulation of TGFβ signaling associated with chronic hyperoxic lung injury that they and others have described.

Additionally, his team has identified that a second matricellular protein, TGFβ-induced protein (TGFBI), is a novel extracellular matrix protein mis-expressed by neonatal hyperoxia and vital for normal alveolar development.

Their findings have provided new mechanistic targets in BPD pathogenesis and have challenged the paradigm related to the role of TGFβ up-regulation in neonatal lung injury.

MD: Indiana University School of Medicine, Indianapolis, IN, 2005.

Residency: Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Fellowship: Neonatal-Perinatal Medicine, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Certification: General Pediatrics, 2008; Neonatal and Perinatal Medicine, 2012.

Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ. Initial suppression of transforming growth factor-β signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia. Am J Pathol. 2016.

Goss KN, Tepper RS, Lahm T, Ahlfeld SK. Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia. Am J Respir Cell Mol Biol. 2015;53(6):902-6.

Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, *Ahlfeld SK, *Lahm T. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L797-806. (* co-senior authorship).

Assaf SJ, Chang DV, Tiller CJ, Kisling JA, Case J, Mund JA, Slaven JE, Yu Z, Ahlfeld SK, Poindexter B, Haneline LS, Ingram DA, Tepper RS. Lung Parenchymal Development in Premature Infants without Bronchopulmonary Dysplasia. Pediatr Pulmonol. 2015;50(12):1313-9.

Beam K, Aliaga S, Ahlfeld S, Cohen-Wolkowiez M, Smith P, Laughon M. A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants. J Perinatol. 2014;34(9):705-10.

Ahlfeld SK, Gao Y, Conway SJ, Tepper RS. Relationship of Structural to Functional Impairment during Alveolar-Capillary Membrane Development. Am J Pathol. 2015;185(4):913-9.

Ahlfeld SK, Conway SJ. Assessment of Inhibited Alveolar-Capillary Membrane Structural Development and Function in Bronchopulmonary Dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100(3):168-79.

Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW, Conway SJ. Periostin down-regulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol. 2013;97(6):373-85.

Ahlfeld SK, Conway SJ. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2012;94(1):3-15.

Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011;186(8):4959-66.

Henry T. Akinbi, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-8915 henry.akinbi@cchmc.org

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Henry T. Akinbi, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Member, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8915

Fax 513-636-7868

Email henry.akinbi@cchmc.org

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Clinical

Neonatal infections; blood transfusions

Research

Pharmacokinetis/pharmacodynamics of psychotropic medications in neonates; role of lysozyme in airway host defense

MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.

Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.

Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.

Certification: General Pediatrics, 1991; Recertification, 1998; Newborn Medicine, 1995; Recertification, 2002.

Danilov SM, Lünsdorf H, Nesterovitch AB, Epshtein Y, Letsiou E, Akinbi HT, Kryukova OV, Piegeler T, Golukhova EZ, Schwartz DE, Dull RO, Minshall RD, Kost OA, Garcia JGN. Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding. Scientific Reports. 2016.

Isemann B, Mueller E, Narendran V, Akinbi H. Impact of early sodium supplementation on hyponatremia and growth in premature infants: a randomized controlled trial. Journal of Parenteral and Enteral Nutrition. 2016;40(3):342-9.

Hall ES, Isemann BT, Wexelblatt SL, Meinzen-Derr J, Wiles JR, Harvey S, Akinbi HT. A cohort comparison of buprenorphine versus methadone treatment for neonatal abstinence syndrome. J Pediatr. 2016 Mar;170:39-44.e1.

Wiles JR, Isemann B, Mizuno T, Tabangin ME, Ward LP, Akinbi H, Vinks AA. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. J Pediatr. 2015 Dec;167(6):1214-20.e3.

Coya JM, Akinbi HT, Sáenz A, Yang L, Weaver TE, Casals C. Natural anti-infective pulmonary proteins: In vivo cooperative action of surfactant protein SP-A and the lung antimicrobial peptide SP-BN. J Immunol. 2015 Aug 15;195(4):1628-36.

Wiles JR, Isemann B, Ward LP, Vinks AA, Akinbi H. Current management of neonatal abstinence syndrome. J Pediatr. 2014 Sep;165(3):440-6.

Wiles JR, Leslie N, Knilans TK, Akinbi H. Prolonged QTc Interval in Association with Medium-chain Acyl-coenzyme A Dehydrogenase Deficiency. Pediatrics. 2014;133(6):e1-e6.

Monangi N, Slaughter J, Smith C, Dawodu A, Akinbi HT. Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay. Arch Dis Child Fetal Neonatal Ed. 2014;99(2):F166-8.

Glasser SW, Maxfield MD, Ruetschilling TL, Akinbi HT, Baatz JE, Kitzmiller JA, Page K, Xu Y, Bao EL, Korfhagen TR. Persistence of LPS induced lung inflammation in surfactant protein C deficient mice. Am J Respir Cell Mol Biol. 2013;49(5):845-54.

Dawodu A, Akinbi HT. Vitamin D nutrition in pregnancy: Current opinion. Int J Womens Health. 2013;24;5:333-43.

Maria E. Barnes-Davis, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-0093 maria.barnes@cchmc.org

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Maria E. Barnes-Davis, MD, PhD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0093

Email maria.barnes@cchmc.org

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Clinical

Neonatology

Research

Functional neuroimaging (fMRI, MEG, EEG); neurodevelopmental outcomes of extremely preterm children; language; sleep and learning disorders

Biography

Dr. Barnes-Davis, MD, PhD's, work during medical and graduate school led to presentations at national and international conferences, peer-reviewed publications, and a predoctoral training fellowship (F30) from the NIMH. Publications in residency included continuing work in Pediatric Brain Sciences as well as beginning to contribute to the scientific literature in Neonatology. She believes her graduate education and research background in neurodevelopmental outcomes and her training in neonatal-perinatal medicine uniquely qualify her to investigate the neurocognitive sequelae of children born preterm. Her scholarly project, “Multimodal Neuroimaging of Language Networks in Childhood: Impact of Prematurity” allowed her to study the feasibility of integrating multiple noninvasive neuroimaging methods, leveraging the relative strengths of each modality, to comprehensively characterize the distributed neural substrate of gross language functioning among those born at a healthy term gestation and those born preterm.

Dr. Barnes-Davis, MD, PhD's, long-term goal is to understand the neural substrate of language dysfunction in the preterm brain with the aspiration of developing interventions in the NICU and beyond to ameliorate these later impairments. She's discovered that language network connectivity as seen on fMRI and MEG differs in preterm children compared to term controls, and that atypical connectivity correlates with poor performance on standardized assessments of language and cognition. Taken together, her current experiments provide the first multimodal study of the development of language networks in the preterm versus term brain. They help elucidate the relationship between structure and function in the pediatric brain, investigate the possibility of alternate compensatory networks, determine feasibility of the protocol in a school-aged preterm population, and provide pilot data needed to pursue large-scale prospective and predictive studies for NICU graduates.

Clinical Fellowship: Neonatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2014-2017.

Residency: Pediatrics, Mount Sinai Medical Center, New York, NY, 2011-2014.

MD: University of Louisville, Louisville, KY, 2011.

PhD: University of Louisville, Louisville, KY, 2009.

MA: University of Louisville, Louisville, KY, 2006.

BA: Brown University, Providence, RI, 2003.

Weintraub AS, Blanco V, Barnes ME, Green RS. Impact of Renal Function and Protein Intake on Blood Urea Nitrogen in Preterm Infants in the First Three Weeks of Life. Journal of Perinatology. 2015;35:52–56.

Barnes ME, Gozal D, Molfese DL. Attention in Children with Obstructive Sleep Apnea: An Event-Related Potentials Study. Sleep Medicine. 2012;13(4):368-77.

Barnes ME, Huss E, Garrod KN, Van Raay E, Dayyat E, Gozal D, Molfese DL. Impairments in Attention in Occasionally Snoring Children: An Event-Related Potential Study. Developmental Neuropsychology. 2009;34(5):629-649.

Ivanenko A, Barnes ME, Crabtree VM, Gozal D. Psychiatric Symptoms in Children with Insomnia Referred to a Pediatric Sleep Medicine Center. Sleep Medicine. 2004;5:253-259.

Book Chapters:

Molfese D, Molfese V, Barnes ME, Warren CG, Molfese P. Familial Predictors of Dyslexia--Evidence from Preschool Children with and Without Familial Dyslexia Risk. In Berninger V, Reid G, Siegel L, Fawcett A, (Eds.) Handbook of Dyslexia. New York: Sage Publications. 2008.

Grants

Multimodal Neuroimaging of Language Networks in Childhood: Impact of Prematurity. Principal Investigator. Strauss Fellowship Award from Cincinnati Children’s Hospital Medical Center Office of Pediatric Clinical Fellowships & Office of Postdoctoral Affairs. 2016-2017.

Jennifer M. Brady, MD Attending Neonatologist, Division of Neonatology and Pulmonary Biology 513-517-0023 jennifer.handzel@cchmc.org

Tanya E. Cahill, MD Clinical Neonatologist, Division of Neonatology 513-636-3882 tanya.cahill@cchmc.org

DonnaMaria E. Cortezzo, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-4232 donnamaria.cortezzo@cchmc.org

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DonnaMaria E. Cortezzo, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Attending Palliative Care, Pain Management
Member, Perinatal Institute
Member, Palliative Care

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Anesthesiology

Phone 513-803-4232

Email donnamaria.cortezzo@cchmc.org

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Clinical

Neonatology; perinatal palliative care; neonatal palliative care; neonatal pain management; congenital anomalies

Research

Neonatal pain management; neonatal palliative care; perinatal palliative care

Biography

DonnaMaria Cortezzo, MD, is a neonatologist and pediatric palliative care provider. She has a specific interest in the assessment and management of pain and sedation in the neonatal period. She also has a specialized interest in neonatal/perinatal palliative care. This has led her work with multiple divisions within the hospital to improve the experience of and care provided to families with a pregnancy complicated by a life-limiting diagnosis.

Dr. Cortezzo is a practicing neonatologist who attends at Cincinnati Children’s Hospital Medical Center NICU and St. Elizabeth’s NICU. She is also part of the Fetal Care Center and consults on women who present to the center for evaluation. She is also a pediatric palliative care provider at Cincinnati Children’s Hospital Medical Center and a provider for Starshine, the hospital’s home hospice and palliative care program.

MD: University of Connecticut School of Medicine, Farmington, CT, 2008.

Residency: Pediatrics, University of Connecticut School of Medicine, Farmington, CT, 2011.

Fellowship: Neonatology, University of Connecticut School of Medicine, Farmington, CT, 2014.

Fellowship: Hospice and Palliative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Certifications: Pediatrics, 2011; Neonatal-Perinatal Medicine, 2016; Hospice and Palliative Medicine, 2015.

Cortezzo DE, Carter B. Avery’s Disease of the Newborn. In Palliative Care (10th edition). Elsevier, Philadelphia, PA. 2016.

Cortezzo DE, Sanders MR, Brownell E, Moss K. End-of-Life Care in the Neonatal Intensive Care Unit: Experiences of Staff and Parents. Am J Perinatol. 2015 Jul;32(8):713-24.

Cortezzo, DE, Sanders, MR, Brownell, E, Moss K. Neonatologists’ Perspectives of Palliative and End-of-Life Care Neonatal Intensive Care Units. J Perinatol. 2013 Sept;33(9):731-5.

Black EP, Wei J, Atluri S, Cortezzo DE, Koziol-Dube K, Hoover DG, Setlow P. Analysis of factors influencing the rate of germination of spores of Bacillus subtilis by very high pressure. J Appl Microbiol. 2007 Jan;102(1):65-76.

Atluri S, Ragkousi K, Cortezzo DE, Setlow P. Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction of this cooperativity by alterations in the GerB receptor. J Bacteriol. 2006 Jan;188(1):28-36.

Black EP, Koziol-Dube K, Guan D, Wei J, Setlow B, Cortezzo DE, Hoover DG, Setlow P. Factors influencing germination of Bacillus subtilis spores via activation of nutrient receptors by high pressure. Appl Environ Microbiol. 2005 Oct;71(10):5879-87.

Cortezzo DE, Setlow P. Analysis of factors that influence the sensitivity of spores of Bacillus subtilis to DNA damaging chemicals. J Appl Microbiol. 2005 Mar;98(3):606-17.

Cortezzo DE, Koziol-Dube K, Setlow B, Setlow P. Treatment with oxidizing agents damages the inner membrane of spores of Bacillus subtilis and sensitizes spores to subsequent stress. J Appl Microbiol. 2004 Oct;97(4):838-52.

Jacobs ME, Cortezzo DE, Klobutcher LA. Assessing the effectiveness of coding and non-coding regions in antisense ribosome inhibition of gene expression in Tetrahymena. J Eukaryot Microbiol. 2004 Sep-Oct;51(5):536-41.

Cortezzo DE, Setlow B, Setlow P. Analysis of the action of compounds that inhibit the germination of spores of Bacillus species. J Appl Microbiol. 2004 Apr;96(4):725-41.

Jay H. Dritz, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-4830 jay.dritz@cchmc.org

Kevin R. Dufendach, MD, MS Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-7018 kevin.dufendach@cchmc.org

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Kevin R. Dufendach, MD, MS

Attending Neonatologist, Neonatology and Pulmonary Biology

Clinical Informaticist, Division of Biomedical Informatics

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Biomedical Informatics

Phone 513-636-7018

Email kevin.dufendach@cchmc.org

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Clinical

Neonatology

Research

Clinical informatics; user-centered design; human-computer interaction; quality improvement; novel software development

Biography

Kevin Dufendach, MD, MS, is an assistant professor in the divisions of Neonatology and Pulmonary Biology and Biomedical Informatics. His research focuses on user-centered design of electronic health record system software. Specifically, he is interested in incorporating human factors principles into the design of human-computer interfaces to better improve information communication for both provider-facing as well as patient-facing applications. Dr. Dufendach’s current research seeks to improve parental engagement in the neonatal intensive care unit through a neonatal-specific inpatient portal application.

BA: Mathematics and Chemistry, Taylor University, Upland, IN, 2006.

MD: Mayo Clinic College of Medicine, Rochester, MN, 2010.

Residency: Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, 2013.

Fellowship: Neonatal and Perinatal Medicine, Vanderbilt University Medical Center, Nashville, TN, 2016.

MS: Biomedical Informatics, Vanderbilt University, Nashville, TN, 2016.

Certification: American Board of Pediatrics, 2013.

Dufendach KR, Lehmann CU. Topics in Neonatal Informatics: Essential Functionalities of the Neonatal Electronic Health Record. NeoReviews. 2015;16(12):e668-73.

Dufendach KR, Eichenberger JA, McPheeters ML, Temple MW, Bhatia HL, Alrifai MW, Potter SA, Weinberg ST, Johnson KB, Lehmann CU. Core Functionality in Pediatric Electronic Health Records. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Apr. Report No.: 15-EHC014-EF. AHRQ Comparative Effectiveness Technical Briefs.

Elizabeth M. Enlow, MD, MS Attending Neonatologist, Perinatal Institute 513-636-5470 elizabeth.enlow@cchmc.org

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Elizabeth M. Enlow, MD, MS

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-5470

Email elizabeth.enlow@cchmc.org

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Clinical

Neonatology; health care justice; access to care; family centered care

Research

Neonatology; social determinants of health; health disparities; health literacy; community engaged research; mixed methods research; perinatal outcomes; medical home

Biography

Dr. Enlow seeks to understanding the intersection of health and society throughout her medical training and career. At the University of Arizona, where she graduated in the top two of her medical school class, she was active in many organizations seeking equity in health care. As a pediatric resident at Stanford University, she participated in the Stanford Advocacy Track and led a research study examining the experiences of low-income, mostly Latino, families as they transitioned from the NICU to home.

She continued in this line of research as a neonatology fellow at The Children's Hospital of Philadelphia. She lead research exploring the effect of continuity of care in infancy on early childhood outcomes as well as the impact of health literacy of parents of premature infants on health care utilization after NICU discharge. She was awarded a nationally competitive NSRA Ruth L Kirschstein T32 training grant. This award allowed her to complete a Masters of Health Policy Research at the University of Pennsylvania where she completed additional training in health policy research methodology and biostatistics. Her thesis project explored the experiences of low-income mothers in the first 30 days after NICU discharge. As a faculty member at Cincinnati Children's Hospital Medical Center within the UC Department of Pediatrics, she is interested in further elucidating the barriers parents face after NICU discharge, including the role of health literacy, and understanding the complex mechanism by which social determinants influence perinatal outcomes.

MD: University of Arizona, Tucson, AZ, 2009.

Residency: Pediatrics, Stanford University, Palo Alto, CA, 2012.

Fellowship: Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2015.

MS: Masters of Science in Health Policy Research, Philadelphia, PA, 2016.

Certification: Pediatrics 2012, Neonatology, 2016.

Horacio S. Falciglia, MD horacio.falciglia@cchmc.org

Lorch SA, Enlow E. The Role of Social Determinants in Explaining Racial/Ethnic Disparities in Perinatal Outcomes. Pediatr Res. 2016 Jan;79(1-2):141-7.

Enlow E, Herbert SL, Jovel IJ, Lorch SA, Anderson C, Chamberlain LJ. Neonatal intensive care unit to home: the transition from parent and pediatrician perspectives, a prospective cohort study. J Perinatol. 2014;34(10):761-766.

Gray M, Kovatis KZ, Stuart T, Enlow E, Itkin M, Keller MS, French HM. Treatment of congenital pulmonary lymphangiectasia using ethiodized oil lymphangiography. J Perinatol. 2014;34(9):720-2.

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Horacio S. Falciglia, MD

Academic Affiliation

Professor Emeritus, UC Department of Pediatrics

Fax 513-872-4979

Email horacio.falciglia@cchmc.org

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Clinical

Meconium aspiration syndrome; pathophysiology

Research

Relationship of selenium status to sepsis in extremely premature infants

Biography

Horacio Falciglia, MD, serves as the director of the Vermont Oxford Database, where he finds his work both challenging and interesting. This work allows the division to compare local (Cincinnati) neonatal outcomes, morbidities, and mortality in premature infants under 1500 grams with 600 other NICUs in the US and abroad. Dr. Falciglia also enjoys sharing years of clinical experience with new graduates and students as he teaches medical students and residents at the bedside. Dr. Falciglia's past research on meconium aspiration has been exciting and rewarding, and his research is leading to the understanding of the pathophysiology of this complex disease. The incidence of this disease has been drastically reduced through research and improved perinatal care.

MD: University of Buenos Aires, Argentina, 1967.

Residency: Pediatrics, Lincoln Hospital, Albert Einstein College, 1973.

Fellowship: Neonatology, New York University, Bellevue Hospital, 1976.

Certification: General pediatrics.

Falciglia H. Exchange-Transfusion in Newborn Infants. Book Chapter, Ed Panamericana, 2007;7:113-140.

Falciglia HS, Johnson JR, Sullivan J, Hall CF, Miller JD, Riechmann GC, Falciglia GA. Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia. Am J Perinatol. 2003 Feb;20(2):97-107.

Falciglia HS, Henderschott C, Potter P, Helmchen R. Does DeLee suction at the perineum prevent meconium aspiration syndrome? Am J Obstet Gynecol. 1992 Nov;167(5):1243-9.

Falciglia HS. Failure to prevent meconium aspiration syndrome. Obstet Gynecol. 1988 Mar;71(3 Pt 1):349-53.

Beth E. Haberman, MD Senior Medical Director, Neonatal Services 513-636-5465 beth.haberman@cchmc.org

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Beth E. Haberman, MD

Senior Medical Director, Neonatal Services

Medical Director, Newborn Intensive Care Unit (NICU)

Medical Director, Neonatal Transport Program

Associate Director, High-Risk Infant Follow-Up Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-5465

Fax 513-636-5846

Email beth.haberman@cchmc.org

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CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs

Biography

Dr. Haberman currently serves as senior medical director for the level IV Newborn Intensive Care Unit at Cincinnati Children's. Her focus is on operations of the NICU, quality improvement and patient safety. She is also the neonatal medical director for the Transport Team. Dr. Haberman’s clinical interests focus on care of babies born with congenital diaphragmatic hernia and post-discharge NICU follow up of neonates and infants with complex medical needs. She attends clinically in the NICU at Cincinnati Children's and in the Cincinnati regional community nurseries.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.

MD: University of Louisville, Louisville, KY, 1993.

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.

Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.

Crystal D. Hill, MD Attending Neonatologist, Neonatology and Pulmonary Biology 614-636-5470 crystal.hill@cchmc.org

Steven B. Hoath, MD 513-803-0960 steven.hoath@cchmc.org

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Steven B. Hoath, MD

Academic Affiliations

Emeritus, UC Department of Pediatrics

Phone 513-803-0960

Fax 513-803-0969

Email steven.hoath@cchmc.org

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Clinical

Human skin development; multiple roles of the skin in neonatal care; new perspectives on the skin as a sensory interface; role of the skin as an accessible environmental interface which complements ‘internal’ medicine; evidence-based organizational change in healthcare delivery to newborns; interface between medicine and nursing; focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.

Research

Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery.

Biography

Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.

He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of seven international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.

He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on five patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.

Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.

Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.

Residency: University of California, Los Angeles, 1977-79.

Internship: Harbor-UCLA Medical Center, 1976-1977.

MD: University of California, Los Angeles, CA, 1976.

Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.

Baccalaureate: Stanford University, Biology & German Studies, 1972.

Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.

Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.

Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.

Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.

Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.

Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.

Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.

Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.

Melissa House, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-517-0079 melissa.house@cchmc.org

Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology 513-636-8563 alan.jobe@cchmc.org

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Alan H. Jobe, MD, PhD

Director, Division of Perinatal Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8563

Fax 513-636-8691

Email alan.jobe@cchmc.org

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Clinical Interests

Clinical trials in neonatology; bronchopulmonary dysplasia

Research Interests

Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

Biography

Dr. Jobe is a neonatologist and professor of pediatrics at Cincinnati Children’s. His research contributions include studies of surfactant metabolism, the hormonal regulation of lung maturation, mechanisms of lung injury with mechanical ventilation, and neonatal resuscitation. He has been chair of the NICHD Neonatal Research Network Steering Committee and chair of the NICHD Global Research Network Steering Committee. He has a 26-year collaborative research project on fetal development with Professor John Newnham at the University of Western Australia. He remains actively involved with clinical and translational research to improve outcomes for infants. He was an associate editor for Journal of Pediatrics for 18 years. He presently is a consultant for the Bill and Melinda Gates Foundation for infant mortality. Noteworthy recognitions are the E. Mead Johnson Award for Pediatric Research, the Virginia Apgar Award from the AAP, and election to The US National Institute of Medicine.

MD: University of California, San Diego, CA, 1973.

PhD: University of California, San Diego, CA, 1973.

Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.

Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.

Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.

Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.

Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.

Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.

Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.

Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.

Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.

Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.

Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-3291 beth_ann.johnson@cchmc.org

Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-1606 beena.kamath-rayne@cchmc.org

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Beena D. Kamath-Rayne, MD, MPH

Attending Neonatologist, Neonatology and Pulmonary Biology

Global Health Center

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-1606

Fax 513-636-0171

Email beena.kamath-rayne@cchmc.org

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Research Interests

Perinatal epidemiology and public health; global health

Biography

Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal maturity, and biomarker discovery in amniotic fluid, with the hopes of developing less invasive tests of fetal maturity. She has a provisional patent for this work. She has received a BIRCWH K12, OMICS K12, and Perinatal Institute Pilot and Feasibility awards to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.

Dr. Kamath-Rayne is jointly appointed in Global Health and serves on the American Academy of Pediatrics Helping Babies Survive Planning Group. She is the associate editor for the 2nd Edition of Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and contributing editor to Essential Care for Small Babies and the Helping Mothers and Babies Survive Quality Improvement Workbook. She is collaborating on several research studies of HBB around the world. With Dr. Alan Jobe, she has served as a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide. Finally, she does research on educational outcomes of teaching neonatal resuscitation to pediatric residents.

MD: Georgetown University, Washington, DC, 2000.

Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2003.

Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2008.

MPH: Colorado School of Public Health, Aurora, CO, 2008.

Berkelhamer SK, Kamath-Rayne BD, Niermeyer S. Neonatal Resuscitation in Low-Resource Settings. Clin Perinatol. 2016;43(3):573-591.

Kamath-Rayne BD, Rozance PJ, Goldenberg RL, Jobe AH. Antenatal corticosteroids beyond 34 weeks: What do we do now? Am J Obstet Gynecol. 2016.

Kamath-Rayne BD, Du Y, Hughes M, Wagner E, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8(1):67.

Seto TL, Tabangin ME, Josyula S, Taylor KK, Vasquez JC, Kamath-Rayne BD. Educational outcomes of Helping Babies Breathe training at a community hospital in Honduras. Perspect Med Educ. 2015;4(5):225-32.

Kamath-Rayne BD, Griffin JB, Moran K, Jones B, Downs A, McClure EM, Goldenberg RL, Rouse D, Jobe AH. Resuscitation and obstetrical care to reduce intrapartum-related neonatal death: A MANDATE study. Matern Child Health J. 2015;12(Suppl 2):S13.

Hall ES, Folger AT, Kelly E, Kamath-Rayne BD. Impact of gestational age estimate method on the calculation of preterm birth rates. Matern Child Health J. 2014;18(3):755-62.

Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.

Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.

Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010.

Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.

Grants

Prediction of Fetal Maturity Using Novel Biomarkers from Cell Free Amniotic Fluid Transcriptome. Principal Investigator. National Institutes of Health OMICS K12. Nov 2014-Oct 2016.

Development of improved methods for predicting fetal maturity. Principal Investigator. Cincinnati Children’s Hospital Medical Center Shared Facilities Discovery Award. Dec 2015-Dec 2016.

Prediction of Fetal Maturity Using Novel Biomarkers from Cell- Free Amniotic Fluid Transcriptome. Principal Investigator. Cincinnati Children’s Hospital Medical Center--Center for Pediatric Genomics Pilot Grant. Jul 2016-Jun 2017.

Retention of neonatal resuscitation skills in pediatric residents. Principal Investigator. Perinatal Institute Pilot and Feasibility Grant. Jul 2015-Jun 2017.

Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-0478 heather.kaplan@cchmc.org

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Heather C. Kaplan, MD, MSCE

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0478

Fax 513-636-0171

Email heather.kaplan@cchmc.org

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Research Interests

Understanding variations in evidence-based care practices across hospitals; examining strategies for increasing the implementation of evidence into practice in perinatal care; using a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.

Biography

Heather C. Kaplan, MD, MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and has formed collaborative relationships with obstetrical and neonatal care providers across the state.

Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.

BA: Washington University, St. Louis, MO.

MD: Northwestern University, Chicago, IL.

Residency: Children's National Medical Center, Washington, DC.

Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA.

MSCE: University of Pennsylvania, Philadelphia, PA.

Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.

Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.

Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.

Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.

Alan P. Kenny, MD, PhD 513-803-2224 alan.kenny@cchmc.org

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Alan P. Kenny, MD, PhD

Attending Neonatologist, Perinatal Institute
Member, Division of Neonatology
Member, Division of Pulmonary Biology

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-2224

Fax 513-636-7868

Email alan.kenny@cchmc.org

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Clinical

Neonatal care; neonatal lung disease; neonatal malformations and anomalies

Research

Lung progenitor development; stem cell differentiation; fetal malformations

Biography

Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?

These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.

MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.

PhD: Biology.

Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.

Agricola ZN, Jagpal AK, Allbee AW, Prewitt AR, Shifley ET, Rankin SA, Zorn AM, Kenny AP. Identification of Genes Specific to Migrating Primitive Myeloid Lineage in Xenopus laevis. Developmental Dynamics. 2016;245(1):47-55.

Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure of Protein Related to DAN and Cerberus (PRDC): Insights into the Mechanism of BMP Antagonism. Structure. 2013 Aug 6;21(8):1417-29.

Kenny AP, Tabangin M, Hall E, Woodrooffe K, Lai W, Meinzen-Derr J, Hopkin RJ, Greenberg JM. Cincinnati Regional Incidence, Morbidity, and Mortality of Neonatal Foregut Defects and High Coincidence with Cardiovascular Malformations. Journal of Neonatal Biology. 2013;2:1-7.

Shifley ET, Kenny AP, Rankin SA, Zorn AM. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Developmental Biology. 2012;12(27).

Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Developmental Cell. 2012;23(2):292-304.

Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center 513-636-2995 paul.kingma@cchmc.org

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Paul S. Kingma, MD, PhD

Neonatal Director, Cincinnati Fetal Center

Member, Perinatal Institute
Member, Division of Neonatology
Member, Division of Pulmonary Biology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-2995

Fax 513-636-7868

Email paul.kingma@cchmc.org

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Clinical

Neonatology; fetal care; neonatal care of infants with congenital malformations including congenital diaphragmatic hernia, tracheal-esophageal defects and gastroschisis

Research

Innate immune systems; surfactant protein D; Neonatal lung growth; genetic basis of congenital malformations

Biography

Paul S. Kingma, MD, PhD, serves as an attending physician in the Cincinnati Children’s NICU and as neonatal director of the Cincinnati Fetal Center. Dr Kingma leads several basic science and translation research projects that focus on four primary goals.

The first goal is to improve our understanding of pathogenesis of congenital diaphragmatic hernia (CDH). To this end, Dr. Kingma’s laboratory is developing novel methods for measuring lung injury in CHD infants and he has advanced the use of airway pressure release ventilation as a method of reducing lung injury in infants with CDH. In addition, as part of a collaboration with Dr. Jason Woods, Dr. Kingma is using novel MRI-based methods to measure lung growth and function in CDH infants.

The second goal is to improve our understanding of the formation, repair and prognosis of tracheal esophageal (TE) defects. Dr. Kingma is using novel MRI techniques for evaluating tracheal and esophageal morphology in infants with TE defects. In addition, Dr. Kingma is leading an effort to gather detailed anatomic, genetic and clinical outcome data on a large cohort of patients with TE defects in order enhance diagnosis, predict patients at risk for complications, and ultimately improve treatment.

The third goal is to develop effective clinical management strategies to prevent and treat intestinal dysfunction and feeding intolerance in infants with gastroschisis. Dr. Kingma is currently leading a Gerber Foundation funded study that is using MRI to quantify intestinal factors that lead to enteral feeding intolerance.

The final goal of is to improve our understanding of the molecular pathogenesis of neonatal lung injury. Specifically, Dr. Kingma is evaluating the role of the Surfactant Protein D (SP-D) and the pulmonary innate immune system. In addition, Dr. Kingma is part of a Cincinnati Children's collaboration that is developing SP-D as a therapeutic agent designed to improve surfactant function and reduce lung injury in premature infants.

BS: Calvin College, MI, 1992.

MD: Vanderbilt University, TN, 2000.

PhD: Vanderbilt University, TN, 2000.

Residency: Cincinnati Children's Hospital Medical Center, 2003.

Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

Fu T, Kingma PS. Diagnosing Infection in a Neonate Using Whole-Body Screening Magnetic Resonance Imaging. Pediatrics. 2016.

Higano N, Hahn A, Tkach J, Cao X, Walkup L, Thomen R, Merhar S, Kingma P, Fain S, Woods J. Retrospective Respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magnetic Resonance in Medicine. 2016.

Coleman A, Phithakwatchara N, Shaaban A, Keswani S, Kline-Fath B, Kingma P, Haberman B, Lim FY. Fetal lung growth represented by longitudinal changes in MRI-derived fetal lung volume parameters predicts survival in isolated left-sided congenital diaphragmatic hernia. Prenat Diagn. 2015;35(2):160-6.

Lynema S, Marmer D, Hall E, Meinzen-Derr, J, Kingma PS. Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care. Am J Perinatology. 2015;32(4):331-6.

Landis MW, Butler D, Lim FY, Keswani SG, Frischer JS, Haberman BE, Kingma PS. Octreotide for chylous effusions in congenital diaphragmatic hernia. J Pediatr Surg. 2013;48(11):2226-9.

Wetzel EA, Kingma PS. Subgaleal hemorrhage in a neonate with Factor X deficiency following a non-traumatic cesarean section. J Perinatol. 2012;32(4):304-5.

Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012;47(1):57-62.

King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011;46(11):1142-5.

Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011;46(6):1165-71.

King BA, Kingma PS. Surfactant Protein D deficiency increases lung injury during endotoxemia. Am J Respir Cell Mol Bio. 2011;44(5):709-15.

Tom R. Korfhagen, MD, PhD Attending Physician, Perinatal Institute, Neonatology and Pulmonary Biology 513-636-8920 tom.korfhagen@cchmc.org

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Tom R. Korfhagen, MD, PhD

Attending Physician, Perinatal Institute, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8920

Fax 513-636-7868

Email tom.korfhagen@cchmc.org

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Clinical

Newborn Care Associates; NICU Follow up Clinic

Research

Lung protection from injury

BA: University of Cincinnati, Cincinnati, OH, 1972.

PhD: University of Cincinnati, Cincinnati, OH, 1977.

MD: University of Cincinnati, Cincinnati, OH, 1981.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.

Fellowship: Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director); Infectious Diseases, Massachusetts General Hospital, Boston, MA.

Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.

Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.

Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.

Yutaka Maeda, DVM, PhD 513-803-5066 yutaka.maeda@cchmc.org

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Yutaka Maeda, DVM, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-5066

Email yutaka.maeda@cchmc.org

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Specialties

Lung cancer; asthma

Biography

Dr. Maeda and his team have determined the mechanism of mucus production in asthma and lung cancers and identified potential therapeutic targets to control hyper-secreting mucus and lung tumor growth.

DVM: Hokkaido University, Sapporo, Japan, 1997.

PhD: University of California, Riverside, CA, 2002.

Tomoshige K, Guo M, Tsuchiya T, Fukazawa T, Fink-Baldauf IM, Stuart WD, Naomoto Y, Nagayasu T, Maeda Y. An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo. Oncogene. 2018.

Guo M, Tomoshige K, Meister M, Muley T, Fukazawa T, Tsuchiya T, Karns R, Warth A, Fink-Baldauf IM, Nagayasu T, Naomoto Y, Xu Y, Mall MA, Maeda Y. Gene signature driving invasive mucinous adenocarcinoma of the lung. EMBO Mol Med. 2017;9(4):462-481.

Fukazawa T*, Guo M, Ishida N, Yamatsuji T, Takaoka M, Yokota E, Haisa M, Miyake N, Ikeda T, Okui T, Takigawa N, Maeda Y*, Naomoto Y. SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma. Scientific reports. 2016;6:20113. *co-corresponding author.

Wakata K, Tsuchiya T, Tomoshige K, Takagi K, Yamasaki N, Matsumoto K, Miyazaki T, Nanashima A, Whitsett JA, Maeda Y*, Nagayasu T*. A favourable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B. BMJ open. 2015;5(7):e008366. *co-corresponding author.

Ishida N, Fukazawa T, Maeda Y, Yamatsuji T, Kato K, Matsumoto K, Shimo T, Takigawa N, Whitsett JA, Naomoto Y. A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor. Experimental cell research. 2015;335(2):197-206.

Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA. Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. American journal of respiratory and critical care medicine. 2014;189(3):301-13.

Hao H*, Maeda Y*, Fukazawa T, Yamatsuji T, Takaoka M, Bao XH, Matsuoka J, Okui T, Shimo T, Takigawa N, Tomono Y, Nakajima M, Fink-Baldauf IM, Nelson S, Seibel W, Papoian R, Whitsett JA, Naomoto Y. Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. PloS one. 2013;8(8):e71093. *co-first author.

Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. The Journal of clinical investigation. 2012;122(12):4388-400.

Whitsett JA, Haitchi HM, Maeda Y. Intersections between pulmonary development and disease. American journal of respiratory and critical care medicine. 2011;184(4):401-6.

Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. American journal of respiratory and critical care medicine. 2011;184(4):421-9.

Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship 513-803-0022

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Kristin R. Melton, MD

Associate Program Director, Neonatal-Perinatal Medicine Fellowship

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0022

Fax 513-636-7868

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Clinical

Congenital malformations

Research

Craniofacial malformations; somitogenesis

Biography

Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.

Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.

Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital Medical Center. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.

BA: Washington University, St. Louis, MO, 1991.

MD: University of Nebraska, Omaha, NE, 1995.

Residency: Children's Mercy Hospital, Kansas City, MO, 1998.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001.

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.

Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.

Nagendra K. Monangi, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-3982 nagendra.monangi@cchmc.org

Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU 513-803-0961 vivek.narendran@cchmc.org

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Vivek Narendran, MD, MRCP, MBA

Medical Director, University of Cincinnati Medical Center NICU

Medical Director, Cincinnati Perinatal Outreach Project

Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital

Member, Perinatal Institute

Member, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-0961

Fax 513-803-0969

Email vivek.narendran@cchmc.org

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Clinical

Non-invasive ventilation of the preterm infant; surfactant trials; business case for quality improvements

Research

Innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface

MBBS: Bangalore Medical College, Bangalore, India, 1985.

MD/DNB: JN Medical College, Belgaum, India, 1990.

Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.

Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.

Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1996, 1998-2000.

Credentials: Pediatrics, 1998 & 2008; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.

Seto TL, Tabangin ME, Dawodu A, Steinhoff M, Narendran V. Racial disparities in cord blood vitamin D levels and its association with small for gestational age infants. J Perinatol. 2016 Aug;36(8):623-8.

Isemann B, Mueller EW, Narendran V, Akinbi H. Impact of Early Sodium Supplementation on Hyponatremia and Growth in Premature Infants: A Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2016 Mar;40(3):342-9.

Hall ES, Lang MD, Levin L, Narendran V. Variation in Neonatal Inpatient Charges at the State and Local Level. Hospital Topics. 2015;93(2):27-35.

Visscher M, Narendran V. Ontogeny of skin. Advances in Wound Care Review (New Rochelle). 2014 Apr 1;3(4):291-303.

Chinta R, Rao MB, Narendran V, Malla G, Joshi M. Economic recession and headache related hospital admissions. Hospital Topics. 2013 Apr-Jun;91(2):37-42.

Donovan EF, Sparling K, Lake MR, Narendran V, Rose B et al. The investment case for preventing NICU associated infections. Am J Perinatol. 2013 Mar;30(3):179-84.

Downes K, Meinzen-Derr J, Narendran V, Akinbi H. The lost art of intubation: Assessing opportunities for residents to perform neonatal intubation. J Perinatol. 2012 Dec;32(12):927-32.

Visscher M, Taylor T, Narendran V. Neonatal intensive care practices and the influence on skin condition. J Eur Acad Dermatol Venereol. 2013 Apr;27(4):486-93.

Thomas C, Hoath SB, Narendran V. Neurodevelopmental outcomes of ELBW infants ventilated with continuous positive airway pressure vs mechanical ventilation. Indian Journal of Pediatrics. 2012;79(2):218-223.

Shah TA, Meinzen-Derr J, Steichen J, Yolton K, Narendran V, Schibler KR. Hospital and neurodevelopmental outcomes of extremely low-birth weight infants with necrotizing enterocolitis and spontaneous intestinal perforation. J Perinatol. 2012 Jul;32(7):552-8.

Amy T. Nathan, MD Medical Director, Neonatology and Pulmonary Biology 513-803-0909 amy.nathan@cchmc.org

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Amy T. Nathan, MD

Medical Director, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0909

Email amy.nathan@cchmc.org

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Clinical

Necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care

Research

Immune modulation of lung injury and inflammation

Biography

Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

MD: Yale University School of Medicine, New Haven, CT, 1998.

Residency: University of North Carolina, Chapel Hill, NC, 1998-2002.

Fellowship: University of North Carolina, Chapel Hill, NC, 2002-2005.

Certification: Pediatrics 2001; Neonatology, 2008.

Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.

Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.

Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.

Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.

Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.

Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.

Nehal A. Parikh, DO, MS Attending Neonatologist, Perinatal Institute 513-636-7584 nehal.parikh@cchmc.org

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Nehal A. Parikh, DO, MS

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7584

Email nehal.parikh@cchmc.org

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Clinical

Evidence-based and family-centered care of very premature infants and term infants with asphyxia/neonatal encephalopathy; critically-ill newborns

Research

Early diagnosis of perinatal brain injury/delayed brain development; early detection and prevention of neurodevelopmental disabilities

Visit the Parikh Lab.

Biography

Dr. Nehal Parikh’s singular goal is to prevent neurodevelopmental disabilities. Following rigorous training in translational research and clinical trials, he embarked on studies of etiology, prediction and prevention of neurodevelopmental disabilities in high-risk newborns. He has led or co-led several cohort studies of advanced brain MRI in very preterm infants, clinical trials of neuroprotective therapies in high-risk newborns, and the development of the NICHD NRN Extremely Preterm Birth Outcomes prognostic calculator and website. Increased survival of extremely preterm infants has contributed to a higher prevalence of survivors with motor, cognitive, and behavioral/psychiatric abnormalities. Accurate diagnosis of these abnormalities takes 2 to 3 years. These early years are when the brain is most active in building its wiring system and optimally receptive to change and healing. Thus, when the diagnosis is delayed by up to 3 years, we are losing precious time. Newer approaches to diagnosis, prediction and prevention of developmental disabilities are urgently needed to improve the long-term quality of life of high-risk newborns.

The Parikh lab employs advanced brain MRI tools such as volumetric, diffusion, and functional MRI for early identification of biomarkers of brain injury/delayed development that are predictive of disabilities in individual high-risk neonates/infants. The lab’s current focus is to understand the nature of the commonly encountered diffuse white matter abnormalities and to develop early prognostic models of motor, cognitive, and behavioral abnormalities in a geographic cohort of 500 very preterm infants. This important step will facilitate risk stratification, soon after birth, to design clinical trials of targeted neuroprotective interventions during the critical window of the first 3 years after birth when brain plasticity is at its peak.

DO: NY College of Osteopathic Medicine of NY Institute of Technology, Long Island, NY, 1996.

Residency: Pediatrics, Winthrop University Hospital of SUNY Stony Brook, Long Island, NY, 1999.

Fellowship: Neonatology, Thomas Jefferson University of Jefferson Medical College, Philadelphia, PA, 2002.

MS: Translational/Clinical Research, University of Texas Medical School at Houston, Houston, TX, 2007.

Certification: Pediatrics, 1996.

Certification: Neonatology, 2003.

He L, Li H, Holland SK, Yuan W, Altaye M, Parikh NA. Early prediction of cognitive deficits in very preterm infants using functional connectome data in an artificial neural network framework. Neuroimage: Clinical. 2018;18:290-297.

Laptook AR, Shankaran S, Tyson JE, Munoz B, Bell EF, Goldberg RN, Parikh NA, et al. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017;318(16):1550-1560.

Parikh, NA. Advanced Neuroimaging and its Role in Predicting Neurodevelopmental Outcomes in Very Preterm Infants. Seminars in Perinatology. 2016;40(8):530-541.

He L, Parikh NA. Brain Functional Network Connectivity Development in Very Preterm Infants: The First Six Months. Early Human Development. 2016;98:29-35.

Pogribna U, Burson K, Lasky RE, Narayana PA, Evans PW, Parikh NA. Role of Diffusion Tensor Imaging (DTI) as an Independent Predictor of Cognitive and Language Development in Extremely Preterm Infants. Am J of Neuroradiol. 2014;35(4):790-796.

Kaur S, Powell S, He L, Pierson C, Parikh NA. Reliability and repeatability of quantitative tractography methods for mapping structural white matter connectivity in preterm and term infants at term-equivalent age. PLoS One. 2014;9(1):e85807.

Parikh NA, He L, Bonfante-Mejia E, Hochhauser L, Evans P, Burson K, Kaur S. Automatically Quantified Diffuse Excessive High Signal Intensity on MRI Predicts Cognitive Development in Preterm Infants. Pediatr Neurol. 2013;49(6):424-30.

Parikh NA, Lasky RE, Kennedy KA, McDavid G, Tyson JE. Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants. PLoS ONE. 2013;8(5):e62804.

Parikh NA, Kennedy KA, Lasky RE, McDavid G, Tyson JE. Pilot Randomized Trial of Hydrocortisone in Ventilator-Dependent Extremely Preterm Infants: Effects on Regional Brain Volumes. J Pediatr. 2012;162(4):685-690.

Yu X, Zhang Y, Lasky RE, Datta S, Parikh NA, Narayana PA. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One. 2010;5(11):e13874.

Grants

Mihaela Pavlicev, PhD mihaela.pavlicev@cchmc.org

A New Model to Identify Preterm Neonates at High-Risk for Cognitive Deficits. Principal Investigator. National Institutes of Health / National Institute of Neurological Disorders and Stroke. Apr 2016-Jan 2022. R01-NS094200.

Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers. Principal Investigator. National Institutes of Health/ National Institute of Neurological Disorders and Stroke. Oct 2016-Sep 2021. R01-NS096037.

High Res

Mihaela Pavlicev, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Email mihaela.pavlicev@cchmc.org

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Research Interests

The structure of genotype-phenotype map; evolutionary history of female reproductive biology

Visit the Pavlicev Lab.

Biography

Dr. Pavlicev received a PhD in ecology from the University of Vienna in 2003. After PhD she trained in molecular phylogenetics at the Natural History Museum in Vienna, primarily working on phylogenetics of lizards and birds. During subsequent postdoctoral training in quantitative genetics, she worked on the structure and evolution of the genotype-to-phenotype map, first at Washington University in St. Louis, and later at the Center for Ecological and Evolutionary Synthesis at the University of Oslo, Norway. She subsequently spent a year at Konrad Lorenz Institute for Evolution and Cognition in Altenberg near Vienna and combined writing with teaching at the Department of Theoretical Biology, University of Vienna. She joined faculty at Cincinnati Children’s in the summer of 2013.

Dr. Pavlicev`s work focuses on understanding the patterns of phenotypic variation and its underlying genetics in the context of past evolution (see Publications). These approaches have fairly recently become used to understand human detrimental variation, i.e., disease, in a field commonly referred to as evolutionary medicine. Dr. Pavlicev`s lab focuses on the evolution of female reproduction and specifically pregnancy, in order to address the causes for the prevalence of premature births in human population.

PhD: University of Vienna, Austria, 2003.

Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).

Pavličev M, Wagner GP, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta; inferring the cell communication network of the maternal-fetal interface. Genome Research. 2017;27(3):349-361.

Pavličev M, Norwitz E. Human parturition: nothing more than delayed menstruation. Reproductive Sciences. 2017;25(2):166-173.

Mitteroecker P, Huttegger SM, Fischer B, Pavličev M. Reply to Grossman: The role of natural selection for the increase of Caesarean section rates. PNAS. 2017;114(8):E1305-E1305.

Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, Pavličev M, Schlosser G, Widder S, Laubichler MD, Wagner GP. Evolution of sister cell types by individuation. Nature Reviews Genetics. 2016.

Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Emera D, Lynch V, Ott T, Pavličev M, Wagner GP. The transcriptomic evolution of mammalian pregnancy: gene expression innovations in endometrial stromal fibroblasts. Genome biology and evolution. 2016.

Pavličev M, Wagner GP. The evolutionary origin of female orgasm. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2016;326(6):326-337.

Mitteroecker P, Cheverud JM, Pavličev M. Multivariate Analysis of Genotype–Phenotype Association. Genetics. 2016;202(4):1345-1363.

Pavličev M, Cheverud JM. Constraints Evolve: Context-Dependency of Gene Effects Allows Evolution of Pleiotropy. Annual Review of Ecology, Evolution, and Systematics. 2015;46(1).

Pavličev M, Hiratsuka K, Swaggart KA, Dunn C, Muglia LJ. Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome biology and evolution. 2015;7(4):1082-1097.

Swaggart K, Pavličev M, Muglia LJ. Genomics of Preterm Birth. In: Perspective on Human Reproductive and Newborn Medicine, ed: Norwitz E, Bianchi D. Cold Spring Harbor Perspective. 2015.

Brenda Poindexter, MD, MS Director of Clinical and Translational Research, Perinatal Institute 513-803-9029 brenda.poindexter@cchmc.org

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Brenda Poindexter, MD, MS

Director of Clinical and Translational Research, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-9029

Email brenda.poindexter@cchmc.org

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Clinical

Neonatology; clinical and translational research

Research

Nutrition in neonates

Biography

Dr. Brenda Poindexter is the director of Clinical and Translational Research for the Perinatal Institute. She has been a PI for the Eunice Kennedy Shriver NICHD Neonatal Research Network for more than 10 years and has devoted her career to the conduct of both observational and interventional trials in newborn infants. Her primary research interests relate to the role of early nutrition on growth and developmental outcomes in premature infants.

Dr. Poindexter completed residency in pediatrics at Cincinnati Children’s and then fellowship training in neonatal-perinatal medicine at Indiana University. Research training during fellowship began in the laboratory of Dr. Scott Denne, where she received the SPR Fellow’s Clinical Research Award and the Midwest SPR Kenny Trainee Investigator Award for her work related to amino acid metabolism. She was also mentored by Dr. James Lemons as her focus expanded to multicenter clinical trials. While at IU, she also earned a master’s degree in clinical research.

Dr. Poindexter is also an experienced clinician and teacher. She currently serves on the AAP Committee on Fetus and Newborn and the American Board of Pediatrics Neonatal Subboard. She was co-editor of the recently updated Nutritional Care of Preterm Infants, a textbook that is a practical resource for practicing neonatologists, dietitians, and nurses in neonatal intensive care units all over the world.

Dr. Poindexter has served as president of the Midwest Society for Pediatric Research and currently serves on the SPR Council representing Neonatology.

MD: Medical College of Ohio, Toledo, OH, 1990.

MS: Indiana University, Indianapolis, IN, 2004.

Residency: Cincinnati Children's Medical Hospital Center, Cincinnati, OH, 1993.

Fellowship: Indiana University School of Medicine, Indianapolis, IN, 1997.

Certification: General Pediatrics 1993; Neonatal and Perinatal Medicine, 1997.

Ahlfeld SK, Davis SD, Kelley KJ, Poindexter BB. Early Elevation of Plasma Periostin Is Associated with Chronic Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1430-1433.

Navarrete CT, Wrage LA, Carlo WA, Walsh MC, Rich W, Gantz MG, Das A, Schibler K, Newman NS, Piazza AJ, Poindexter BB, Shankaran S, Sánchez PJ, Morris BH, Frantz ID 3rd, Van Meurs KP, Cotten CM, Ehrenkranz RA, Bell EF, Watterberg KL, Higgins RD, Duara S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. J Pediatr. 2016 Sep;176:62-68.e4.

Phelps DL, Ward RM, Williams RL, Nolen TL, Watterberg KL, Oh W, Goedecke M, Ehrenkranz RA, Fennell T, Poindexter BB, Cotten CM, Hallman M, Frantz ID 3rd, Faix RG, Zaterka-Baxter KM, Das A, Ball MB, Lacy CB, Walsh MC, Carlo WA, Sánchez PJ, Bell EF, Shankaran S, Carlton DP, Chess PR, Higgins RD. Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2888-94.

Gonzalez D, Delmore P, Bloom BT, Cotten CM, Poindexter BB, McGowan E, Shattuck K, Bradford KK, Smith PB, Cohen-Wolkowiez M, Morris M, Yin W, Benjamin DK Jr, Laughon MM. Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2888-94.

Poindexter BB, Martin CR. Impact of Nutrition on Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec;42(4):797-806.

John H. Reuter, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology 513-862-2748 john.reuter@cchmc.org

Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center 513-636-3149 ward.rice@cchmc.org

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Ward R. Rice, MD, PhD

Medical Director, Newborn Services, St. Elizabeth Medical Center

Director, Neonatology Fellowship Training Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-636-7868

Email ward.rice@cchmc.org

Show All

Clinical

Hypotension in ELBW infants; EMR

Research

Processing of surfactant protein C

Biography

Ward R. Rice, MD, PhD, is the director of the Neonatology Fellowship Training Program and director of Newborn Services, St. Elizabeth Medical Center.

Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.

His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of surfactant protein C.

PhD: University of Chicago, Chicago, Illinois, 1972-76.

PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane."

MD: University of Chicago, Chicago, Illinois, 1972-78.

Internship: Duke University Medical Center, Durham, North Carolina, 1978-79.

Residency: Duke University Medical Center, Durham, North Carolina, 1979-81.

Fellowship Neonatology: University of Cincinnati College of Medicine, Children's Hospital Medical Center, 1981-83.

Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.

Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.

Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.

Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.

Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.

Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.

Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.

Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.

Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.

Stefanie Riddle, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-4830 stefanie.riddle@cchmc.org

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Stefanie Riddle, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4830

Email stefanie.riddle@cchmc.org

Show All

Clinical

Neonatology; fetal care; care of infants with congenital anomalies.

Research

Clinical outcomes of infants with congenital anomalies.

Biography

Dr. Riddle completed pediatric residency and neonatology fellowship at Cincinnati Children’s. She has a clinical and research interest in optimizing the post-natal care of neonates with congenital anomalies. As a fellow, she focused on understanding prematurity-related morbidities following fetal myelomeningocele repair. She also performed a cost analysis comparing the fetal repair strategy to traditional post-natal management. Currently, her work focuses on outcomes of patients with renal and genitourinary anomalies that lead to abnormal amniotic fluid volumes who are at high risk of pulmonary hypoplasia. She aims to better describe contemporary care of these patients to inform standard practice, as well as improve prenatal counseling for families.

MD: University of Alabama School of Medicine, Birmingham, AL, 2010.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

Fellowship: Neonatal-Perinatal Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

Certification: Pediatrics, 2013.

Jerod M. Rone, MD Medical Director, Kettering Medical Center NICU 513-636-7216 jerod.rone@cchmc.org

Kurt R. Schibler, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-3972 kurt.schibler@cchmc.org

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Kurt R. Schibler, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3972

Fax 513-636-7868

Email kurt.schibler@cchmc.org

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Clinical

Clinical trials; neonatal immune development

Research

Immune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity

MD: University of Cincinnati, Cincinnati, Ohio, 1984.

Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.

Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.

Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.

Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 Jan 20.

Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.

Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.

Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8.

Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16.

Book Chapters

Schibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.

Augusto F. Schmidt, MD, PhD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 augusto.schmidt@cchmc.org

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Augusto F. Schmidt, MD, PhD

Clinical Fellow, Neonatology and Pulmonary Biology

Academic Affiliation

Phone 513-636-4214

Email augusto.schmidt@cchmc.org

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Clinical

Neonatology; neonatal ventilation; antenatal steroids

Research

Fetal maturation induced by antenatal steroids; fetal brain development and injury; congenital diaphragmatic hernia

MD: Universidade Estadual de Campinas, Brazil, 2007.

PhD: Universidade Estadual de Campinas, Brazil, 2010.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

Certification: Pediatrics, 2013.

Schmidt AF, Kannan PS, Kemp MW, Kramer BW, Newnham JP, Jobe AH, Kallapur SG. Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung. Pediatr Res. 2014;76(5):441-447.

Schmidt AF, Rojas-Moscoso JA, Goncalves FL, Gallindo RM, Monica FZ, Antunes E, Figueira RL, Sbragia L. Increased contractility and impaired relaxation of the left pulmonar artery in a rabbit model of congenital diaphragmatic hernia. Pediatr Surg Int. 2013;29(5):489-494.

Schmidt AF, Goncalves FL, Regis AC, Gallindo RM, Sbragia L. Prenatal retinoic acid treatment improves lung vascularization and VEGF expression in CDH rat. Am J Obstet Gynecol. 2012;207(1):76.e25-32.

Schmidt AF, Goncalves FL, Nassr AC, Pereira LA, Farmer D, Sbragia L. Antenatal steroid and tracheal occlusion restore vascular endothelial growth factor receptors in congenital diaphragmatic hernia rat model. Am J Obstet Gynecol. 2010;203(2):184.e13-20.

Kristen Suhrie, MD Neonatologist, Perinatal Institute 513-636-4830 kristen.suhrie@cchmc.org

Daniel T. Swarr, MD 513-803-8396 daniel.swarr@cchmc.org

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Daniel T. Swarr, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-8396

Email daniel.swarr@cchmc.org

Show All

Clinical

Isolated and syndromic birth defects; bronchopulmonary dysplasia; pediatric lung diseases; general neonatology

Research

Early endoderm and lung development; epigenetic regulation of gene expression; long non-coding RNAs; Congenital lung malformations; TEF/EA; VACTERL

Biography

After finishing general pediatrics residency training at Baylor College of Medicine, Dr. Swarr completed a combined fellowship program at The Children’s Hospital of Philadelphia, which lead to Board certification in Neonatal-Perinatal Medicine and Medical Genetics & Genomics. As both a neonatologist and geneticist, Dr. Swarr is particularly interested in both isolated and syndromic birth defects impacting the health of newborn infants.

The goal of Dr. Swarr’s research is to improve our understanding of the etiology and pathogenesis of congenital malformations and pulmonary disease using a wide variety of tools from developmental biology, genetics and epigenetics. His laboratory is particularly interested in understanding epigenetic mechanisms by which gene expression is regulated during early endoderm and lung development, and how disruptions of these processes lead to neonatal disease. Current work seeks to define the role of long non-coding RNAs (lncRNAs) during lung development and lung epithelial repair after injury.

Dr. Swarr’s laboratory is also actively involved in “translating” findings from basic developmental biology to better understanding disorders of the esophagus, trachea, and lungs through a patient registry-biorepository established in collaboration with investigators at CCHMC and The Children’s Hospital of Philadelphia.

MD: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2007.

Residency: General Pediatrics, Baylor College of Medicine & Texas Children’s Hospital, Houston, TX, 2007-2010.

Fellowship: Combined Fellowship in Neonatal-Perinatal Medicine and Medical Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2010-2015.

Board Certifications: General Pediatrics, 2010; Medical Genetics & Genomics, 2015; Neonatal-Perinatal Medicine, 2016.

Swarr DT, Morrisey EE. Lung endoderm morphogenesis: gasping for form and function. Annu Rev Cell Dev Biol. 2015 Nov 13;31:553-73.

Luo M, Mulchandani S, Dubbs HA, Swarr DT, Pyle L, Zackai EH, Spinner NP, Conlin LK. Detection of mutually exclusive mosaicism in a girl with genotype-phenotype discrepancies. Am J Med Genet A. 2015 Dec;167A(12):3091-5.

Kruska P, Li D, Harr MH, Wilson NR, Swarr D, McCormick E, Chiavacci R, Li M, Johnson J, McDonald-McGinn D, Deardorff M, Falk MJ, Allanson J, Saadi I, Hakonarson H, Muenke M, Zackai EH. Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome. J Med Genet. 2015 Feb;52(2):104-10.

Herriges M*, Swarr DT*, Morley MP, Peng T, Stewart KM, Morrisey EE. Long non-coding RNAs are preferentially located near transcription factors and regulate lung development. Genes Dev. 2014 Jun 15;28(12):1363-79. *Co-first authors

Wenger TL, Gerdes J, Deardorff MA, Taub K, Swarr DT, Abend N. Telemedicine for genetic and neurologic evaluation of infants in the Neonatal Intensive Care Unit. J Perinatol. 2014 Mar;34(3):234-40.

Swarr DT, Khalek N, Treat J, Horton M, Riviere JB, Dobyns W, Zackai EH. Expanding the differential diagnosis of fetal hydrops: an unusual prenatal presentation of megalencephaly-capillary malformation syndrome. Prenat Diagn. 2013 Oct;33(10):1010-2.

Kalish JM, Conlin LK, Bhatti TR, Feret H, Harris MC, Izumi K, Mostoufi-Moab S, Saitta S, States LJ, Swarr DT, Wilkens AB, Zackai EH, Zelley K, Bartolomei MS, Nichols KE, Palladino AA, Spinner NB, Deardorff MA. Clinical presentation of three subjects with genome-wide paternal uniparental disomy. Am J Med Genet A. 2013 Mar;161(3):473-8.

Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz P, Garvin J, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Valenzuela Palafoll I, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Homing L, Lo I, Lam S, Gerychova R, Jezova M, Valaskova I, Fellman F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon L, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach J, Cole JS, Hamvas A, Prince L, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 June;34(6):801-11.

Nathanson J, Swarr DT, Singer A, Liu M, Chinn A, Jones W, Hurst J, Khalek N, Zackai E, Slavotinek A. Novel FREM1 mutations expand the phenotypic spectrum associated with Manitoba-Oculo-Tricho-Anal (MOTA) syndrome and Bifid Nose Renal Agenesis Anorectal Malformations (BNAR) syndrome. Am J Med Genet A. 2013 Mar;161(3):473-8.

Swarr DT, Bloom D, Lewis RA, Elenberg E, Friedman EM, Glotzbach C, Wissman SD, Shaffer LG, Potocki L. Potocki-Shaffer syndrome: comprehensive clinical assessment, review of the literature, and proposals for medical management. Am J Med Genet A. 2010 Mar;152A(3):565-72.

Laura P. Ward, MD, IBCLC Medical Director, Mercy Hospital Anderson Nurseries 513-803-0963 laura.ward@cchmc.org

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Laura P. Ward, MD, IBCLC

Medical Director, Mercy Hospital Anderson Nurseries

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0963

Fax 513-803-0969

Email laura.ward@cchmc.org

Show All

Clinical

Neonatology; quality improvement; breastfeeding; necrotizing enterocolitis

Research

Neonatal abstinence syndrome; breastfeeding

Biography

Dr. Ward graduated from St. Louis University School of Medicine in 1994. She went on to complete her residency in pediatrics and her fellowship in neonatology at the Children’s National Medical Center in Washington DC from 1994-2000.

Dr. Ward has been a neonatologist in the division since 2002, and attends at The University Hospital.

MD: St. Louis University School of Medicine, St. Louis, MO, 1994.

Residency: Pediatrics, Children’s National Medical Center, Washington DC, 1994-1997.

Fellowship: Neonatology, Children’s National Medical Center, Washington DC, 1997-2000.

Certifications: Pediatrics, 1997; Neonatology, 2003; International Board Certified Lactation Consultant, 2013.

Wiles JR, Isemann B, Tomoyuki M, Tabangin ME, Ward LP, Akinbi H, Vinks AA. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. J Pediatr. 2015;167(7):1214-1220.

Wexelblatt SL, Ward LP, Torok K, Tisdale E, Meinzen-Derr JK, Greenberg JM. Universal Maternal Drug Testing in a High-Prevalence Region of Prescription Opiate Abuse. J Pediatr. 2015;166(3):582-586.

Wiles JR, Isemann,B, Ward LP, Vinks AA, Akinbi H. Current Management of Neonatal Abstinence Syndrome Secondary to Intrauterine Opioid Exposure. J Pediatr. 2014;165(3):440-446.

Moyer LB, Goyal NK, Meinzen-Derr J, Ward LP, Rust CL, Wexelblatt SL, Greenberg JM. Factors Associated with Readmission in Late Preterm Infants: A Matched Case Control Study. Hosp Pediatr. 2014;4(5):298-304.

Delfosse NM, Ward LP, Lagomarcino AJ, Auer C, Smith C, Meinzen-Derr J, Valentine CV, Schibler KR, Morrow AL. Donor human milk largely replaces formula-feeding of preterm infants in two urban hospitals. J Perinatol. 2013;33(6):446-451.

Ward LP, Auer CA, Smith C, Schoettker PJ, Pruett R, Shah NY, Kotagal UR. The Human Milk Project: A Quality Improvement Initiative to Increase Human Milk Consumption in Very Low Birth Weight Infants. Breastfeed Med. 2012;7(4):234-240.

Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital 513-872-2748 kathy.wedig@cchmc.org

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Kathy E. Wedig-Stevie, MD

Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital

Neonatologist, Good Samaritan Hospital

Medical Director, Mercy Hospital Fairfield Nurseries

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-872-2748

Fax 513-872-4979

Email kathy.wedig@cchmc.org

Show All

Neonatal high risk infant follow up and developmental follow up; developmental and clinical follow up of preterm infants and children exposed to opioids in utero.

Biography

Dr. Wedig-Stevie was a graduate of the University of Cincinnati Medical School in 1978. She completed her residency in pediatrics at Cincinnati Children's Hospital Medical Center from 1978-1981 and completed her fellowship in neonatology at University Hospitals in Cleveland from 1981-1983.

She continued as a neonatologist at Good Samaritan Hospital in Cincinnati from 1983-1996. In 1996, she came to Cincinnati Children's as a neonatologist and has continued her work here ever since. At the same time, she has also been the associate professor of clinical pediatrics at the University of Cincinnati. Dr. Wedig-Stevie is the director of Cincinnati Children's Neonatal Followup at TriHealth and the co-founder of the Neonatal Abstinence Clinic at Cincinnati Children's.

MD: University of Cincinnati Medical School, Cincinnati, OH, 1978.

Residency: Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, 1978-1981.

Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, 1983.

Certifications: Pediatrics, 1983; Neonatology, 1983.

Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008 Jan;152(1):140, 140.e1.

Wedig KE, Kogan J, Schorry EK, Whitsett JA. Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4.

Scott L. Wexelblatt, MD Regional Director of Newborn Services, Perinatal Institute 513-803-0999 scott.wexelblatt@cchmc.org

High Res

Scott L. Wexelblatt, MD

Regional Director of Newborn Services, Perinatal Institute

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0999

Fax 513-803-2633

Email scott.wexelblatt@cchmc.org

Show All

Neonatal Abstinence Syndrome

Biography

Dr. Scott Wexelblatt is the regional medical director for newborn services for the Cincinnati region. He is an assistant professor in the Division of Neonatology, Perinatal Institute at Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine. He attended medical school at the University of Vermont, and completed his pediatric residency at Cincinnati Children’s Hospital Medical Center. He is a faculty member with the Ohio Perinatal Quality Collaborative (OPQC) on the Neonatal Abstinence Syndrome project.

MD: University of Vermont College of Medicine, Burlington, VT, 1996.

Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Certification: American Board of Pediatrics, 1999.

Hall ES, Wexelblatt SL, Greenberg JM. Self-Reported and Laboratory Evaluation of Late Pregnancy Nicotine Exposure and Drugs of Abuse. J Perinatol. 2016 Oct;36(10):814-8.

Hunter LL, Meinzen-Derr J, Wiley S, Horvath CL, Kothari R, Wexelblatt S. Influence of the WIC Program on Loss to Follow-Up for Newborn Hearing Screening. Pediatrics. 2016 Jul;138(1).

Goyal NK, Hall ES, Kahn RS, Wexelblatt SL, Greenberg JM, Samaan ZM, Brown CM. Care Coordination Associated with Improved Timing of Newborn Primary Care Visits.
Matern Child Health J. 2016 Sep;20(9):1923-32.

Hall ES, Meinzen-Derr J, Wexelblatt SL. Cohort analysis of a pharmacokinetic-modeled methadone weaning optimization for neonatal abstinence syndrome. J Pediatr. 2015 Dec;167(6):1221-5.e1.

Hall ES*, Wexelblatt SL*, Crowley M, Grow JL, Jasin LR, Klebanoff MA, McClead RE, Meinzen-Derr J, Mohan VK, Stein H, Walsh MC; OCHNAS Consortium. Implementation of a neonatal abstinence syndrome weaning protocol: A multicenter cohort study. Pediatrics. 2015 Oct;136(4):e803-10. *These authors contributed equally to this work.

Wexelblatt SL, Ward LP, Torok K, Tisdale E, Meinzen-Derr JK, Greenberg JM. Universal maternal drug testing in a high-prevalence region of prescription opiate abuse. Journal of Pediatrics. 2014;166(3):582–586.

Hall ES*, Wexelblatt SL*, Crowley M, Grow JL, Jasin LR, Klebanoff MA, McClead RE, Meinzen-Derr J, Mohan VK, Stein H, Walsh MC; OCHNAS Consortium. A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome. Pediatrics. 2014 Aug;134(2):e527-34. *These authors contributed equally to this work.

Winhusen T, Wilder C, Wexelblatt SL, Theobald J, Hall ES, Lewis D, Van Hook J, Marcotte M. Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. Contemporary Clinical Trials. 2014 Sep;39(1):158-65.

Moyer LB, Goyal NK, Meinzen-Derr J, Ward LP, Rust CL, Wexelblatt SL, Greenberg JM. Factors associated with readmission in late preterm infants: A matched case control study. Hospital Pediatrics. 2014;4:298.

William J. Zacharias, MD, PhD 513-636-2938 william.zacharias@cchmc.org

William J. Zacharias, MD, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Internal Medicine

Phone 513-636-2938

Email william.zacharias@cchmc.org

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MD: University of Michigan, Ann Arbor, MI, 2011.

PhD: University of Michigan, Ann Arbor, MI, 2011.

Residency: Hospital of the University of Pennsylvania, Philadelphia, PA.

Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.

Certifications: Internal Medicine; Pulmonary Medicine; Critical Care Medicine.

Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkahleel FA, Kong J, Zhou S, Cantu E, Morrisey EE. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature. 2018 Mar 8;555(7695):251-255.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na C-L, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Och M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10.

Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Morley MP, Morrisey EE. Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. Cell. 2017 Sep 7;170(6):1134-1148.e10.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS. Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075.

Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X, Gumucio DL. Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol. 2011 Jul 1;355(1):152-62.

Zacharias WJ, Madison BB, Walton KD, Li X, Kretovich K, Gumucio DL. Epithelial Hedgehog is an anti-inflammatory signal to the intestinal lamina propria. Gastroenterology. 2010 Jun;138(7):2368-77, 2377.e1-4.

Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison B, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz A, Kottmann AH, Gumucio DL. Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning. Gastroenterology. 2009 Aug;137(2):618-28.

Lees CW, Zacharias WJ, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Torkvist L, Kao J, Farrington S, Drummond HE, Ho GT, Arnott ID, Appelman HD, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SE, Gumucio DL, Satsangi J. Analysis of germline GLI1 variation implicates Hedgehog signaling in the regulation of intestinal inflammatory pathways. PLoS Med. 2008 Dec 9;5(12):e239.

Li X, Madison BB, Zacharias W, Kolterud A, States D, Gumucio DL. Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics. 2007 May 11;29(3):290-301.

Krause A, Zacharias W, Camarata T, Linkhart B, Law E, Lischke A, Miljan E, Simon HG. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev Biol. 2004 Sep 1;273(1):106-20.

Staff

Amil H. Allen, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 amil.allen@cchmc.org

Shreyas Arya, MBBS Clinical Fellow, Division of Neonatology and Pulmonary Biology 513-636-7216 shreyas.arya@cchmc.org

High Res

Shreyas Arya, MBBS

Clinical Fellow, Division of Neonatology and Pulmonary Biology

Phone 513-636-7216

Email shreyas.arya@cchmc.org

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Clinical

Neonatology and pulmonary biology

Research

Necrotizing enterocolitis; fetoplacental insufficiency

Biography

Shreyas Arya completed his pediatric residency training at the University of Texas Medical Branch, Galveston. He has interests in both basic science and clinical research. He was awarded the Arild E. Hansen Award for Outstanding resident research in recognition for his resident scholarly project looking at the outcomes of infants with fetoplacental insufficiency.

MD: Kasturba Medical College,Manipal University, Mangalore, India, 2012.

Residency: Pediatrics, University of Texas Medical Branch, Galveston, TX, 2016.

Dasgupta S, Arya S, Choudhary S, Jain SK. Amniotic fluid: Source of trophic factors for the developing intestine. World J Gastrointest Pathophysiol. 2016;7(1):38-47.

Bhargava V, DeLeon C, Arya S, Jain SK. Paradoxical Hypoxemia with Simultaneous Use of Pulmonary Vasodilators in a Case of PPHN. J Pediatr Child Care. 2015;1(2): 3.

Arya S, Richardson CJ, Jain S, Swischuck LE. Early Vitamin K Deficiency Bleeding in a Neonate Associated with Maternal Acute Fatty Liver of Pregnancy. AJP Rep. 2015;5(2):e193-5.

Michael A. Carl, MD Clinical Fellow, Division of Neonatology and Pulmonary Biology 513-803-7844 michael.carl@cchmc.org

High Res

Michael A. Carl, MD

Clinical Fellow, Division of Neonatology and Pulmonary Biology

Phone 513-803-7844

Email michael.carl@cchmc.org

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MD: Saint Louis University, St. Louis, MO, 2014.

Residency: Pediatrics, St. Louis Children's, Hospital/Washington University, St. Louis, MO, 2017.

Carl MA, Ndao IM, Springman AC, Manning SD, Johnson JR, Johnston BD, Burnham BD, Burnham C-A, Sodergren-Weinstock E, Weinstock GM, Wylie T, Mitreva M, Abubucker S, Zhou Y, Stevens H, Hall-Moore C, Julian S, Shaikh N, Warner BB, Tarr PI. Sepsis from the gut, the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections. Clin Infect Dis. 2014 May;58(9):1211-8.

Russell AB, Singh P, Bittnacher M, Bui NK, Hood RD, Carl MA, Agnello DM, Schwarz S, Goodlett DR, Vollmer W, Mougous JD. A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe. 2012 May 17;11(5):538-49.

Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD. Structural basis for type VI secretion effector recognition by a cognate immunity protein. PLoS Pathog. 2012;8(4):e1002613.

Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD. Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog. 2010 Aug 26;6(8):e1001068.

Hood RD, Singh P, Hsu F, Guvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD. A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe. 2010 Jan 21;7(1):25-37.

Korotkova N, Yarova-Yarovaya Y, Tchesnokova V, Yazvenko N, Carl MA, Stapleton AE, Moseley SL. Escherichia coli DraE adhesion-associated bacterial internalization by epithelial cells is promoted independently by decay-accelerating factor and carcinoembryonic antigen related cell adhesion molecule binding and does not require the DraD invasin. Infect Immun. 2008 Sep;76(9):3869-80.

Clara F. Chlon, MD Staff Physician, Neonatology and Pulmonary Biology 513-636-4214 clara.chlon@cchmc.org

Diane K. Donley, MD Staff Physician, Neonatology and Pulmonary Biology 513-636-5470 diane.donley@cchmc.org

Thomas J. Duggan, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-803-7844 thomas.duggan@cchmc.org

John Erickson, MD, PhD Clinical Fellow, Division of Neonatology and Pulmonary Biology 513-636-7997 john.erickson@cchmc.org

Ene Fairchild, MD, PhD Clinical Fellow, Neonatology and Pulmonary Biology 513-803-7844 ene.fairchild@cchmc.org

Heather Hammer, APRN Nurse Practitioner, Neonatology and Pulmonary Biology 859-301-2421 heather.hammer@cchmc.org

Jennifer B. Hardie, MD Staff Physician II, Division of General and Community Pediatrics 513-636-6487 jennifer.hardie@cchmc.org

Gayle Hertenstein, MSN, CNP Nurse Practitioner, Neonatology and Pulmonary Biology 513-636-3882 gayle.hertenstein@cchmc.org

Viral G. Jain, MD Clinical Fellow, Division of Neonatology and Pulmonary Biology 513-517-0090 viral.jain2@cchmc.org

High Res

Viral G. Jain, MD

Clinical Fellow, Division of Neonatology and Pulmonary Biology

Phone 513-517-0090

Email viral.jain2@cchmc.org

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Clinical

Neonatology; bioinformatics; early literacy; evidence based medicine

Research

Urogenital anomalies; endocrine disruptors; genetics of preterm birth

Biography

Viral G Jain, MD, completed his pediatric residency at Case Western Reserve University (MetroHealth) program, and is currently pursuing his Neonatology fellowship at Cincinnati Children’s Hospital Medical Center under Dr. Louis Muglia.

He has experience in both basic science as well as clinical research, and has published extensively in well-respected journals. His research focuses on identifying risk factors for urogenital developmental disorders in newborns and the role of steroid hormones in neonates. His research also focuses on understanding the inflammatory pathways involved in preterm birth, and the role of progesterone in preterm birth with the goal of developing better interventions to reduce preterm birth. He is also interested in exploring family’s contribution to young child’s learning, and is the founder of TinyVoices, a NICU Infant Reading program. He has also worked on developing a novel nanoparticle for treatment of retinoblastoma. Dr. Jain has strong interest in BioInformatics, and was the founding team member of a well-funded startup to connect sub-specialty services to underserved cities in India - which won numerous international awards for Healthcare Innovations.

He serves as the founder and co-editor of the AAP, Section on Neonatology Journal Club. He is an active member of the AAP-SoNPM Website Committee, American Medical Informatics Association and heads the AAP TECAN Research Section.

He is the winner of the AAP Marshall Klaus Research Award and the AAP Travel Grant award, 2017.

MBBS: Maharashtra State University of Health Sciences (MGM Medical College), Mumbai, India, 2011.

Residency: Pediatrics, Case Western Reserve University (MetroHealth) Program, Cleveland, OH, 2016.

Kong F, Liu Z, Jain VG, Shima K, Suzuki T, Muglia LJ, Bhattacharyya S. Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. The Journal of Immunology. 2017;199(10):3654-3667.

Singal AK, Jain VG, Ghazali Z, Shekhawat PS. Shorter Anogenital distance correlates with severity of hypospadias in pre-pubertal boys. Human Reproduction. 2016 Jul;31(7):1406-10.

Singal AK, Jain VG. Maternal and infant characteristics influencing the anogenital distance and penile length in newborns. Andrologia. 2016 Aug;48(6):708-13.

Singal AK, Dubey M, Jain V. Transverse preputial onlay island flap urethroplasty for single-stage correction of proximal hypospadias. World journal of urology. 2016 Jul;34(7):1019-24.

Jain V, Gulati R. Mirizzi syndrome – An uncommon Cause of obstructive jaundice in a child. Indian Pediatr. 2015 Jun 8;52(6):539.

Kalita D, Shome D, Jain VG, Chadha K, Bellare JR. In vivo intraocular distribution and safety of periocular nanoparticle carboplatin for treatment of advanced retinoblastoma in humans. American journal of ophthalmology. 2014;157(5):1109-1115.

Shome D, Kalita D, Jain V, Sarin R, Maru GB, Bellare JR. Carboplatin loaded polymethylmethacrylate nano-particles in an adjunctive role in retinoblastoma: An animal trial. Indian journal of ophthalmology. 2014;62(5):585-89.

Jain VG, Singal AK. Shorter anogenital distance correlates with undescended testis: a detailed genital anthropometric analysis in human newborns. Human reproduction. 2013;28(9):2343-2349.

Singal AK, Jain V, Dubey M, Deshpande P. Undescended testis and torsion: is the risk understated? Arch Dis Child. 2013 Jan;98(1):77-9.

Jain V, Singal AK, Ramu C, Raghunaathan KD. Superior mesenteric artery syndrome: a rare complication in a child with Marfan syndrome. Archives of disease in childhood. 2013;98(10):754-755.

Suyog Kamatkar, MD, MS Epi Fellow, Division of Neonatology and Pulmonary Biology 513-636-4830 suyog.kamatkar@cchmc.org

High Res

Suyog Kamatkar, MD, MS Epi

Fellow, Division of Neonatology and Pulmonary Biology

Academic Affiliation

Phone 513-636-4830

Email suyog.kamatkar@cchmc.org

Show All

Clinical

Neonatal Abstinence Syndrome; pharmacokinetics; pharmacodynamics; pharmacogenomics; neurodevelopmental outcomes of premature infants

Research

Pharmacogenomic analysis and PK/PD modeling of sublingual Buprenorphine in treatment of Neonatal Abstinence Syndrome

MBBS: Topiwala National Medical College, Mumbai, India.

MS: TH Chan School of Public Health, Harvard University.

Residency: Pediatrics, Indiana University Riley Children's Hospital, Indianapolis, IN.

Certification: Pediatrics, 2014.

Kamatkar S, Lee BT, Duggan MM, Keenan MT, Quinlan RM, Hergrueter CA, Hertl MC, Shin JH, Truppin NB, Chun YS. Commonwealth of Massachusetts Board of Registration in Medicine Expert Panel on immediate implant-based breast reconstruction following mastectomy for cancer. Journal of American College of Surgeons. 2011 Dec;213(6):800-5.

Kamatkar S, Zafar N, Iqbal A, Farez M, de Moya M. Meta-analysis: Intensive Insulin Therapy in Brain Injury. Journal of Neurotrauma. 2011 Jul;28(7):1307-17.

Kamatkar S, Njinimbam C. Anemia in a Term Newborn With Facial Anomalies. Neoreviews. 2015;16(12):e711–e713.

Kamatkar S. Dress Code: Story of conformity among medical professionals. Indian Academy of Pediatrics. 2007 July 1.

Book Chapter

Kamatkar S, Chloe A, Sharaya N, Huskins J, Ruhl L. Review of Rheumatic Heart Disease. Reference Manual for Moi Teaching and Referral Hospital, Eldoret, Kenya. 2012, September 1.

Jillian A. Klein, MD Staff Physician III, Division of General and Community Pediatrics 513-636-7722 jillian.klein@cchmc.org

Gregg A. Kottyan, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 gregg.kottyan@cchmc.org

Jennifer Lewis, MSN, APRN, CNP Nurse Practitioner, Neonatology and Pulmonary Biology 513-636-4830 jennifer.lewis@cchmc.org

M. Katherine Loudermilk, MD Pediatrician, Neonatology and Pulmonary Biology M.Katherine.Loudermilk@cchmc.org

Paige Marks, MD Pediatrician, Neonatology and Pulmonary Biology 513-736-2269 paige.marks@cchmc.org

Jennifer McAllister, MD, CLC Medical Director, West Chester Hopsital Special Care Nursery 513-517-0601 jennifer.mcallister@cchmc.org

High Res

Jennifer McAllister, MD, CLC

Medical Director, West Chester Hopsital Special Care Nursery

Medical Director, NICU Follow Up Clinic-NAS Clinic

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-517-0601

Email jennifer.mcallister@cchmc.org

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Clinical

Neonatal Abstinence Syndrome; newborn care; breastfeeding

Research

Follow up care of infants treated for Neonatal Abstinence Syndrome

Biography

Dr. McAllister is a pediatrician who has been with the Perinatal Institute since 2013. She is the co-medical director of the Neonatal Abstinence Clinic (NAS), and her research investigates the short and long term outcomes of babies diagnosed with NAS. She is interested in standardizing and optimizing care for newborns with NAS both inpatient and upon discharge from the hospital.

Additionally she is involved in resident education and has helped develop the newborn resident education curriculum.

MD: University of Toledo College of Medicine, Toledo, OH, 2007.

Residency: Pediatrics, University of Michigan Mott Children's Hospital, Ann Arbor, MI, 2010.

Certification: Pediatrics, 2010.