Neonatology

Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy

Visit the Whitsett Lab.

Biography

Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.

Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.

Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.

Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.

Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.

Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.

MD: Columbia University, New York, NY, 1973.

Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6.

Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development.2010 Dec;137(23):3953-63.

Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304.

Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010 Nov 15;347(2):301-14.

Perl AK, Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir Crit Care Med. 2010 Sep 24.

Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2010 Sep 20.

Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13.

Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451.

Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61.

Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.

Division Director

James M. Greenberg, MD Co-Director, Perinatal Institute 513-636-3149 james.greenberg@cchmc.org

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James M. Greenberg, MD

Co-Director, Perinatal Institute

Director, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-803-0968

Email james.greenberg@cchmc.org

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Clinical Interests

Neonatal chronic lung disease; late preterm infant

MD: University of Illinois College of Medicine, Chicago, IL, 1977-1981.

Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, MN, 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1984.

Fellowship: Immunology/Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal/Perinatal Medicine, 1989.

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.

Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.

Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.

Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.

Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.

Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.

Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.

Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.

Faculty

Shawn K. Ahlfeld, MD 513-803-7723 shawn.ahlfeld@cchmc.org

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Shawn K. Ahlfeld, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7723

Email shawn.ahlfeld@cchmc.org

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Clinical

Neonatal-perinatal medicine; bronchopulmonary dysplasia

Research

Neonatal lung injury, development, and repair; neonatal lung mesenchymal development; biomarkers of neonatal lung injury; animal models of bronchopulmonary dysplasia

Biography

As a neonatal fellow and junior faculty, Dr. Ahlfeld has evaluated the role of matricellular proteins in saccular and early alveolar lung development. He and his team has determined that hyperoxia exposure resulted in the mis-expression of the Transforming Growth Factor Beta (TGFβ)-responsive extracellular matrix protein, periostin, during critical periods of saccular-alveolar lung development. Periostin proved to be a novel marker for both normal myofibroblastic activity during alveolarization and abnormal myofibroblastic persistence during late fibrotic stages of lung injury.

Under a scholar grant through the Prematurity and Respiratory Outcomes Program (PROP), they have demonstrated, for the first time, that plasma periostin levels in extremely premature infants during the first weeks of age correlate with the development and severity of BPD. Their investigations into TGFβ superfamily signaling during saccular and alveolar lung development, as well as its role in BPD pathogenesis, are ongoing.

Contrary to the prevailing notion of up-regulation, TGFβ extracellular signaling ligands, intracellular signaling messengers, and down-stream signaling targets are all down-regulated during early hyperoxic lung injury. They have determined that TGFβ down-regulation coincides with a period of saccular-alveolar lung development that is critical for development of distal lung complexity and function. The down-regulation of TGFβ signaling during this critical window of lung development occurs well before the up-regulation of TGFβ signaling associated with chronic hyperoxic lung injury that they and others have described.

Additionally, his team has identified that a second matricellular protein, TGFβ-induced protein (TGFBI), is a novel extracellular matrix protein mis-expressed by neonatal hyperoxia and vital for normal alveolar development.

Their findings have provided new mechanistic targets in BPD pathogenesis and have challenged the paradigm related to the role of TGFβ up-regulation in neonatal lung injury.

MD: Indiana University School of Medicine, Indianapolis, IN, 2005.

Residency: Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Fellowship: Neonatal-Perinatal Medicine, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.

Certification: General Pediatrics, 2008; Neonatal and Perinatal Medicine, 2012.

Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ. Initial suppression of transforming growth factor-β signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia. Am J Pathol. 2016.

Goss KN, Tepper RS, Lahm T, Ahlfeld SK. Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia. Am J Respir Cell Mol Biol. 2015;53(6):902-6.

Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, *Ahlfeld SK, *Lahm T. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L797-806. (* co-senior authorship).

Assaf SJ, Chang DV, Tiller CJ, Kisling JA, Case J, Mund JA, Slaven JE, Yu Z, Ahlfeld SK, Poindexter B, Haneline LS, Ingram DA, Tepper RS. Lung Parenchymal Development in Premature Infants without Bronchopulmonary Dysplasia. Pediatr Pulmonol. 2015;50(12):1313-9.

Beam K, Aliaga S, Ahlfeld S, Cohen-Wolkowiez M, Smith P, Laughon M. A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants. J Perinatol. 2014;34(9):705-10.

Ahlfeld SK, Gao Y, Conway SJ, Tepper RS. Relationship of Structural to Functional Impairment during Alveolar-Capillary Membrane Development. Am J Pathol. 2015;185(4):913-9.

Ahlfeld SK, Conway SJ. Assessment of Inhibited Alveolar-Capillary Membrane Structural Development and Function in Bronchopulmonary Dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100(3):168-79.

Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW, Conway SJ. Periostin down-regulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol. 2013;97(6):373-85.

Ahlfeld SK, Conway SJ. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2012;94(1):3-15.

Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011;186(8):4959-66.

Henry T. Akinbi, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-8915 henry.akinbi@cchmc.org

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Henry T. Akinbi, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8915

Fax 513-636-7868

Email henry.akinbi@cchmc.org

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Clinical

Neonatal infections; blood transfusions

Research

Role of lysozyme in airway host defense

MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.

Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.

Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.

Certification: General Pediatrics, 1991; Recertification, 1998; Newborn Medicine, 1995; Recertification, 2002.

McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14.

Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35.

Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9.

Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.

Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52.

Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83.

Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.

Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.

Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26

Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.

Jennifer M. Brady, MD Attending Neonatologist, Division of Neonatology and Pulmonary Biology 513-517-0023 jennifer.handzel@cchmc.org

Tanya E. Cahill, MD Director, High-Risk Clinic tanya.cahill@cchmc.org

DonnaMaria E. Cortezzo, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-4232 donnamaria.cortezzo@cchmc.org

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DonnaMaria E. Cortezzo, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Attending Palliative Care, Pain Management

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Anesthesiology

Phone 513-803-4232

Email donnamaria.cortezzo@cchmc.org

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MD: University of Connecticut School of Medicine, Farmington, CT, 2008.

Residency: Pediatrics, University of Connecticut School of Medicine, Farmington, CT, 2011.

Fellowship: Neonatology, University of Connecticut School of Medicine, Farmington, CT, 2014.

Fellowship: Hospice and Palliative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Certification: Pediatrics, 2011.

Cortezzo DE, Sanders MR, Brownell E, Moss K. End-of-Life Care in the Neonatal Intensive Care Unit: Experiences of Staff and Parents. Am J Perinatol. 2014 Dec 17.

Cortezzo, DE, Sanders, MR, Brownell, E, Moss K. Neonatologists’ Perspectives of Palliative and End-of-Life Care Neonatal Intensive Care Units. J Perinatol. 2013 Sept;33(9):731-5.

Black EP, Wei J, Atluri S, Cortezzo DE, Koziol-Dube K, Hoover DG, Setlow P. Analysis of factors influencing the rate of germination of spores of Bacillus subtilis by very high pressure. J Appl Microbiol. 2007 Jan;102(1):65-76.

Atluri S, Ragkousi K, Cortezzo DE, Setlow P. Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction of this cooperativity by alterations in the GerB receptor. J Bacteriol. 2006 Jan;188(1):28-36.

Black EP, Koziol-Dube K, Guan D, Wei J, Setlow B, Cortezzo DE, Hoover DG, Setlow P. Factors influencing germination of Bacillus subtilis spores via activation of nutrient receptors by high pressure. Appl Environ Microbiol. 2005 Oct;71(10):5879-87.

Cortezzo DE, Setlow P. Analysis of factors that influence the sensitivity of spores of Bacillus subtilis to DNA damaging chemicals. J Appl Microbiol. 2005 Mar;98(3):606-17.

Cortezzo DE, Koziol-Dube K, Setlow B, Setlow P. Treatment with oxidizing agents damages the inner membrane of spores of Bacillus subtilis and sensitizes spores to subsequent stress. J Appl Microbiol. 2004 Oct;97(4):838-52.

Jacobs ME, Cortezzo DE, Klobutcher LA. Assessing the effectiveness of coding and non-coding regions in antisense ribosome inhibition of gene expression in Tetrahymena. J Eukaryot Microbiol. 2004 Sep-Oct;51(5):536-41.

Cortezzo DE, Setlow B, Setlow P. Analysis of the action of compounds that inhibit the germination of spores of Bacillus species. J Appl Microbiol. 2004 Apr;96(4):725-41.

Michael W. Crossman, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology 859-301-3850 michael.crossman@cchmc.org

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Michael W. Crossman, MD, PhD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 859-301-3850

Fax 859-301-2066

Email michael.crossman@cchmc.org

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Clinical Interests

Intestinal function and host-microbial interactions; bioethics and neonatal palliative care

PhD: Biochemistry, St. Louis University, St. Louis, MO, 1985.

MD: St. Louis University, St. Louis, MO, 1986.

Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.

Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.

Certification: Neonatal - Perinatal Medicine, 1995, 2003.

Horacio S. Falciglia, MD horacio.falciglia@cchmc.org

Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.

Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12.

Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.

Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.

Jay H. Dritz, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-4830 jay.dritz@cchmc.org

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Horacio S. Falciglia, MD

Academic Affiliation

Professor Emeritus, UC Department of Pediatrics

Fax 513-872-4979

Email horacio.falciglia@cchmc.org

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Clinical

Meconium aspiration syndrome; pathophysiology

Research

Relationship of selenium status to sepsis in extremely premature infants

Biography

Horacio Falciglia, MD, serves as the director of the Vermont Oxford Database, where he finds his work both challenging and interesting. This work allows the division to compare local (Cincinnati) neonatal outcomes, morbidities, and mortality in premature infants under 1500 grams with 600 other NICUs in the US and abroad. Dr. Falciglia also enjoys sharing years of clinical experience with new graduates and students as he teaches medical students and residents at the bedside. Dr. Falciglia's past research on meconium aspiration has been exciting and rewarding, and his research is leading to the understanding of the pathophysiology of this complex disease. The incidence of this disease has been drastically reduced through research and improved perinatal care.

MD: University of Buenos Aires, Argentina, 1967.

Residency: Pediatrics, Lincoln Hospital, Albert Einstein College, 1973.

Fellowship: Neonatology, New York University, Bellevue Hospital, 1976.

Certification: General pediatrics.

Falciglia H. Exchange-Transfusion in Newborn Infants. Book Chapter, Ed Panamericana, 2007;7:113-140.

Falciglia HS, Johnson JR, Sullivan J, Hall CF, Miller JD, Riechmann GC, Falciglia GA. Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia. Am J Perinatol. 2003 Feb;20(2):97-107.

Falciglia HS, Henderschott C, Potter P, Helmchen R. Does DeLee suction at the perineum prevent meconium aspiration syndrome? Am J Obstet Gynecol. 1992 Nov;167(5):1243-9.

Falciglia HS. Failure to prevent meconium aspiration syndrome. Obstet Gynecol. 1988 Mar;71(3 Pt 1):349-53.

Neera K. Goyal, MD, MSc Attending Physician, Division of Hospital Medicine 513-803-7836

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Neera K. Goyal, MD, MSc

Attending Physician, Division of Hospital Medicine

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7836

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Clinical

Hospital medicine; level 1 and level 2 nursery care

Research

Perinatal health services; home visiting; preterm birth

Biography

As a Robert Wood Johnson Foundation Clinical Scholar at the University of Pennsylvania (2009-2011), Dr. Goyal studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, as well as the impact of discharge timing on readmission risk. She also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development.

She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of Hospital Medicine. In 2012 she received the BIRCWH K12 Award to evaluate the role of community-based home visiting to improve pregnancy and infant health outcomes. Currently, Dr. Goyal is studying programmatic effects on health care utilization in ED and primary care settings for full term and preterm infants.

BA: Emory University, Atlanta, GA, 2001.

MD: University of Texas Southwestern Medical Center in Dallas, Dallas, TX, 2005.

MSc: Health Policy Research, University of Pennsylvania, Philadelphia, PA, 2011.

Residency: Children's Hospital of Philadelphia, Philadelphia, PA, 2008.

View PubMed Publications.

Moyer LB, Goyal NK, Meinzen-Derr JK, Ward LP, Rust CL, Wexelblatt SL, Greenberg JM. Factors Associated with Readmission in Late-Preterm Infants: A Matched Case Control Study. Hosp Pediatr. 2014 Sep;4(5):298-304.

Simpson E, Goyal NK, Dhepyasuwan N, Flaherman V, Chung EK, Von Kohorn I, Burgos A, Taylor J. Prioritizing a Research Agenda: A Delphi Study of the Better Outcomes through Research for Newborns (BORN) Network. Hosp Pediatr. 2014 Jul;4(4):195-202.

Goyal NK, Hall ES, Ammerman RT, Meinzen-Derr JK, Jones DE, Short JA, Van Ginkel JB. Association of maternal and community factors with enrollment in home visiting among at-risk, first time mothers. Am J Public Health. 2014 Feb;104 Suppl 1:S144-51.

Hall ES, Goyal NK*, Ammerman RT, Miller MM, Jones DE, Short JA, Van Ginkel JB. Development of a linked perinatal data resource from state administrative and community-based program data. Matern Child Health J. 2014 Jan;18(1):316-25.

Goyal NK, Hall ES, Meinzen-Derr JK, Kahn RS, Short JA, Van Ginkel JB, Ammerman RT. Dosage effect of prenatal home visiting on pregnancy outcomes in at-risk, first-time mothers. Pediatrics. 2013 Nov;132 Suppl 2:S118-25.

Goyal NK, Teeters A, Ammerman RT. Home Visiting and Outcomes of Preterm Infants: A Systematic Review. Pediatrics. 2013 Sep;132(3):502-16.

Goyal N, Zubizarreta JR, Small DS, Lorch SA. Length of stay and readmission among late preterm infants: an instrumental variable approach. Hosp Pediatr. 2013 Jan;3(1):7-15.

Goyal NK, Fiks AG, Lorch SA. Persistence of underweight status among late preterm infants. Arch Pediatr Adolesc Med. 2012 May;166(5):424-30.

Goyal NK, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.

Goyal NK, Fiks AG, Lorch SA. Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics. 2011 Oct;128(4):e830-8.

Beth E. Haberman, MD Senior Medical Director, Neonatal Services 513-636-5465 beth.haberman@cchmc.org

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Beth E. Haberman, MD

Senior Medical Director, Neonatal Services

Medical Director, Newborn Intensive Care Unit (NICU)

Medical Director, Neonatal Transport Program

Associate Director, High-Risk Infant Follow-Up Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-5465

Fax 513-636-5846

Email beth.haberman@cchmc.org

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Clinical Interests

CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.

MD: University of Louisville, Louisville, KY, 1993.

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.

Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.

Crystal D. Hill, MD Attending Neonatologist, Neonatology and Pulmonary Biology 614-636-5470 crystal.hill@cchmc.org

Steven B. Hoath, MD 513-803-0960 steven.hoath@cchmc.org

High Res

Steven B. Hoath, MD

Academic Affiliations

Emeritus, UC Department of Pediatrics

Phone 513-803-0960

Fax 513-803-0969

Email steven.hoath@cchmc.org

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Clinical

Human skin development; multiple roles of the skin in neonatal care; new perspectives on the skin as a sensory interface; role of the skin as an accessible environmental interface which complements ‘internal’ medicine; evidence-based organizational change in healthcare delivery to newborns; interface between medicine and nursing; focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.

Research

Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery.

Biography

Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.

He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of seven international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.

He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on five patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.

Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.

Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.

Residency: University of California, Los Angeles, 1977-79.

Internship: Harbor-UCLA Medical Center, 1976-1977.

MD: University of California, Los Angeles, CA, 1976.

Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.

Baccalaureate: Stanford University, Biology & German Studies, 1972.

Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.

Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.

Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.

Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.

Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.

Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.

Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.

Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.

Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.

Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology 513-636-8563 alan.jobe@cchmc.org

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Alan H. Jobe, MD, PhD

Director, Division of Perinatal Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8563

Fax 513-636-8691

Email alan.jobe@cchmc.org

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Clinical Interests

Clinical trials in neonatology; bronchopulmonary dysplasia

Research Interests

Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

MD: University of California, San Diego, CA, 1973.

PhD: University of California, San Diego, CA, 1973.

Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.

Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.

Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.

Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.

Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.

Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.

Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.

Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.

Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.

Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.

Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-3291 beth_ann.johnson@cchmc.org

Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education 513-636-3879 suhas.kallapur@cchmc.org

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Suhas G. Kallapur, MD

Director, Neonatology Continuing Medical Education

Global Health Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3879

Fax 513-636-7868

Email suhas.kallapur@cchmc.org

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Clinical

Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity

Research

Visit the Kallapur Lab.

MBBS: University of Bombay, India, 1984.

DCH: College of Physicians and Surgeons, Bombay, India, 1986.

MD, Pediatrics: University of Bombay, India, 1986.

Residency: University of Bombay, India, 1984-87.

Residency: Children's Hospital of Michigan, Detroit, MI, 1988-90.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1990-1993.

Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18.

Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.

Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151.

Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010 Sep;68(3):210-5.

Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis. Pediatr Res. 2010 May 28.

Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5.

Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124.

Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5.

Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7.

Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.

Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-1606 beena.kamath-rayne@cchmc.org

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Beena D. Kamath-Rayne, MD, MPH

Attending Neonatologist, Neonatology and Pulmonary Biology

Global Health Center

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-1606

Fax 513-636-0171

Email beena.kamath-rayne@cchmc.org

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Research Interests

Perinatal epidemiology and public health; global health

Biography

Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal maturity, and biomarker discovery in amniotic fluid, with the hopes of developing less invasive tests of fetal maturity. She has received a BIRCWH K12 OMICS K12, and Perinatal Institute Pilot and Feasibility awards to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.

Dr. Kamath-Rayne is jointly appointed in Global Health and serves on the American Academy of Pediatrics Helping Babies Survive Planning Group. She is the associate editor for the 2nd Edition of Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and contributing editor to Essential Care for Small Babies. She is collaborating on several research studies of HBB around the world. With Dr. Alan Jobe, she has served as a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide. Finally, she does research on educational outcomes of teaching neonatal resuscitation to pediatric residents.

MD: Georgetown University, Washington, DC, 2000.

Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2003.

Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2008.

MPH: Colorado School of Public Health, Aurora, CO, 2008.

Kamath-Rayne BD, Du Y, Hughes M, Wagner E, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8(1):67.

Seto TL, Tabangin ME, Josyula S, Taylor KK, Vasquez JC, Kamath-Rayne BD. Educational outcomes of Helping Babies Breathe training at a community hospital in Honduras. Perspect Med Educ. 2015;4(5):225-32.

Kamath-Rayne BD, Griffin JB, Moran K, Jones B, Downs A, McClure EM, Goldenberg RL, Rouse D, Jobe AH. Resuscitation and obstetrical care to reduce intrapartum-related neonatal death: A MANDATE study. Matern Child Health J. 2015;12(Suppl 2):S13.

Kamath-Rayne BD, Habli M, Rodriguez Z, Wu M, Gresh J, DeFranco EA. Antenatal exposure to sulindac and risk of necrotizing enterocolitis. Am J Obstet Gynecol. 2015 Jan;212(1):96.e1-7.

Hall ES, Folger AT, Kelly E, Kamath-Rayne BD. Impact of gestational age estimate method on the calculation of preterm birth rates. Matern Child Health J. 2014;18(3):755-62.

Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: An evaluation of neonatal outcomes. Obstet Gynecol. 2012;119(5):909-916.

Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.

Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.

Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010.

Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.

Grants

Prediction of Fetal Maturity Using Novel Biomarkers from Cell Free Amniotic Fluid Transcriptome. Principal Investigator. National Institutes of Health OMICS K12. Nov 2014-Oct 2016.

Retention of neonatal resuscitation skills in pediatric residents. Principal Investigator. Perinatal Institute Pilot and Feasibility Grant. Jul 2015-Jun 2017.

Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-0478 heather.kaplan@cchmc.org

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Heather C. Kaplan, MD, MSCE

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0478

Fax 513-636-0171

Email heather.kaplan@cchmc.org

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Research Interests

Understanding variations in evidence-based care practices across hospitals; examining strategies for increasing the implementation of evidence into practice in perinatal care; using a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.

Biography

Heather C. Kaplan, MD, MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and has formed collaborative relationships with obstetrical and neonatal care providers across the state.

Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.

BA: Washington University, St. Louis, MO.

MD: Northwestern University, Chicago, IL.

Residency: Children's National Medical Center, Washington, DC.

Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA.

MSCE: University of Pennsylvania, Philadelphia, PA.

Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.

Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.

Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.

Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.

Alan P. Kenny, MD, PhD 513-803-2224 alan.kenny@cchmc.org

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Alan P. Kenny, MD, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-2224

Fax 513-636-7868

Email alan.kenny@cchmc.org

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Clinical

Neonatal care; neonatal lung disease; neonatal malformations and anomalies

Research

Lung progenitor development; stem cell differentiation; fetal malformations

Biography

Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?

These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.

MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.

PhD: Biology.

Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.

Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.

Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.

Kenny A. Vitamin A for prevention of bronchopulmonary dysplasia. Preemie Press. Local news brief for Good Samaritan Hospital. 2007.

Angerer LM, Kenny AP, Newman LA, Angerer RC. Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Signal Transduction Wiley Interscience, New York. 2007 7(2), 174-178.

Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center 513-636-2995 paul.kingma@cchmc.org

Thomas R. Korfhagen, MD, PhD Attending Pediatrician, Neonatology and Pulmonary Biology 513-636-7216 thomas.korfhagen@cchmc.org

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Thomas R. Korfhagen, MD, PhD

Attending Pediatrician, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7216

Fax 513-636-7868

Email thomas.korfhagen@cchmc.org

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Clinical

Care of high-risk infants; pediatric patients with complex, long term medical problems

Research

Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.

BA: University of Cincinnati, Cincinnati, OH, 1972.

PhD: University of Cincinnati, Cincinnati, OH, 1976.

MD: University of Cincinnati, Cincinnati, OH, 1981.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director).

Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.

Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.

Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.

Yutaka Maeda, DVM, PhD 513-636-3322 yutaka.maeda@cchmc.org

Yutaka Maeda, DVM, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3322

Email yutaka.maeda@cchmc.org

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Specialties

Lung cancer; asthma

DVM: Hokkaido University, Sapporo, Japan, 1997.

PhD: University of California, Riverside, CA, 2002.

Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest. 2012 Dec 3;122(12):4388-400.

Whitsett JA, Haitchi HM, Maeda Y. Intersections between pulmonary development and disease. Am J Respir Crit Care Med. 2011 Aug 15;184(4):401-6.

Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med. 2011 Aug 15;184(4):421-9.

Fukazawa T, Maeda Y, Matsuoka J, Ono T, Mominoki K, Yamatsuji T, Shigemitsu K, Morita I, Murakami I, Tanaka H, Durbin ML, Naomoto Y. Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer. Anticancer Res. 2010 Dec;30(12):4925-35.

Han S, Fukazawa T, Yamatsuji T, Matsuoka J, Miyachi H, Maeda Y, Durbin M, Naomoto Y. Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. PLoS One. 2010 Nov 4;5(11):e13834.

Fukazawa T, Maeda Y, Matsuoka J, Yamatsuji T, Shigemitsu K, Morita I, Faiola F, Durbin ML, Soucek L, Naomoto Y. Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. Anticancer Res. .2010 Oct;30(10):4193-200.

Fukazawa T, Matsuoka J, Yamatsuji T, Maeda Y, Durbin ML, Naomoto Y. Adenovirus-mediated cancer gene therapy and virotherapy (Review). Int J Mol Med. 2010 Jan;25(1):3-10.

Fukazawa T, Maeda Y, Matsuoka J, Tanaka N, Tanaka H, Durbin ML, Naomoto Y. Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system. Int J Cancer. 2009 Oct 15;125(8):1975-84.

Fukazawa T, Matsuoka J, Naomoto Y, Maeda Y, Durbin ML, Tanaka N. Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy. Cancer Res. 2008 Sep 1;68(17):7120-9.

Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship 513-803-0022

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Kristin R. Melton, MD

Associate Program Director, Neonatal-Perinatal Medicine Fellowship

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0022

Fax 513-636-7868

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Clinical

Congenital malformations

Research

Craniofacial malformations; somitogenesis

Biography

Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.

Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.

Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital Medical Center. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.

BA: Washington University, St. Louis, MO, 1991.

MD: University of Nebraska, Omaha, NE, 1995.

Residency: Children's Mercy Hospital, Kansas City, MO, 1998.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001.

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.

Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.

Nagendra K. Monangi, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-803-3982 nagendra.monangi@cchmc.org

Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU 513-803-0961 vivek.narendran@cchmc.org

High Res

Vivek Narendran, MD, MRCP, MBA

Medical Director, University of Cincinnati Medical Center NICU

Medical Director, Cincinnati Perinatal Outreach Project

Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-0961

Fax 513-803-0969

Email vivek.narendran@cchmc.org

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Clinical

Non-invasive ventilation of the preterm infant; business case for quality improvements

Research

Interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface

MBBS: Bangalore Medical College, Bangalore, India, 1985.

MD/DNB: JN Medical College, Belgaum, India, 1990.

Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.

Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.

Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1996, 1998-2000.

Credentials: Pediatrics, 1998; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Feb 14.

Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.

Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.

Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep;25(9):608-11.

Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol. 2005 Jul;25(7):440-6. Review.

Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec;191(6):2090-6.

Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9.

Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review.

Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.

Amy T. Nathan, MD Medical Director, Neonatology and Pulmonary Biology 513-803-0909 amy.nathan@cchmc.org

High Res

Amy T. Nathan, MD

Medical Director, Neonatology and Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0909

Email amy.nathan@cchmc.org

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Clinical

Necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care

Research

Immune modulation of lung injury and inflammation

Biography

Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

MD: Yale University School of Medicine, New Haven, CT, 1998.

Residency: University of North Carolina, Chapel Hill, NC, 1998-2002.

Fellowship: University of North Carolina, Chapel Hill, NC, 2002-2005.

Certification: Pediatrics 2001; Neonatology, 2008.

Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.

Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.

Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.

Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.

Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.

Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.

Nehal A. Parikh, DO, MS Attending Neonatologist, Perinatal Institute 513-636-7584 nehal.parikh@cchmc.org

Nehal A. Parikh, DO, MS

Attending Neonatologist, Perinatal Institute

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7584

Email nehal.parikh@cchmc.org

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Clinical

Evidence-based and family-centered care of very premature infants and term infants with asphyxia/neonatal encephalopathy; critically-ill newborns

Research

Early diagnosis of perinatal brain injury/delayed brain development; prediction and prevention of neurodevelopmental disabilities

Biography

Dr. Nehal Parikh’s singular goal is to prevent neurodevelopmental disabilities. Following rigorous training in translational research and clinical trials, he embarked on studies of etiology, prediction and prevention of neurodevelopmental disabilities in high-risk newborns. He has led or co-led several cohort studies of advanced brain MRI in very preterm infants, clinical trials of neuroprotective therapies in high-risk newborns, and the development of the NICHD NRN Extremely Preterm Birth Outcomes prognostic calculator and website. Increased survival of extremely preterm infants has contributed to a higher prevalence of survivors with motor, cognitive, and behavioral/psychiatric abnormalities. Accurate diagnosis of these abnormalities takes 2 to 3 years. These early years are when the brain is most active in building its wiring system and optimally receptive to change and healing. Thus, when the diagnosis is delayed by up to 3 years, we are losing precious time. Newer approaches to diagnosis, prediction and prevention of developmental disabilities are urgently needed to improve the long-term quality of life of high-risk newborns.

The Parikh lab employs advanced brain MRI tools such as volumetric, diffusion, and functional MRI for early identification of biomarkers of brain injury/delayed development that are predictive of disabilities in individual high-risk neonates/infants. The lab’s current focus is to understand the nature of the commonly encountered diffuse white matter abnormalities and to develop early prognostic models of motor, cognitive, and behavioral abnormalities in a geographic cohort of 500 very preterm infants. This important step will facilitate risk stratification, soon after birth, to design clinical trials of targeted neuroprotective interventions during the critical window of the first 3 years after birth when brain plasticity is at its peak.

DO: NY College of Osteopathic Medicine of NY Institute of Technology, Long Island, NY, 1996.

Residency: Pediatrics, Winthrop University Hospital of SUNY Stony Brook, Long Island, NY, 1999.

Fellowship: Neonatology, Thomas Jefferson University of Jefferson Medical College, Philadelphia, PA, 2002.

MS: Translational/Clinical Research, University of Texas Medical School at Houston, Houston, TX, 2007.

Certification: Pediatrics, 1996.

Certification: Neonatology, 2003, 2010.

Parikh, NA. Advanced Neuroimaging and its Role in Predicting Neurodevelopmental Outcomes in Very Preterm Infants. Seminars in Perinatology. 2016.

He L, Parikh NA. Brain Functional Network Connectivity Development in Very Preterm Infants: The First Six Months. Early Human Development. 2016;98:29-35.

Pogribna U, Burson K, Lasky RE, Narayana PA, Evans PW, Parikh NA. Role of Diffusion Tensor Imaging (DTI) as an Independent Predictor of Cognitive and Language Development in Extremely Preterm Infants. Am J of Neuroradiol. 2014;35(4):790-796.

Kaur S, Powell S, He L, Pierson C, Parikh NA. Reliability and repeatability of quantitative tractography methods for mapping structural white matter connectivity in preterm and term infants at term-equivalent age. PLoS One. 2014;9(1):e85807.

Parikh NA, He L, Bonfante-Mejia E, Hochhauser L, Evans P, Burson K, Kaur S. Automatically Quantified Diffuse Excessive High Signal Intensity on MRI Predicts Cognitive Development in Preterm Infants. Pediatr Neurol. 2013;49(6):424-30.

Parikh NA, Lasky RE, Kennedy KA, McDavid G, Tyson JE. Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants. PLoS ONE. 2013;8(5):e62804.

Parikh NA, Kennedy KA, Lasky RE, McDavid G, Tyson JE. Pilot Randomized Trial of Hydrocortisone in Ventilator-Dependent Extremely Preterm Infants: Effects on Regional Brain Volumes. J Pediatr. 2012;162(4):685-690.

Yu X, Zhang Y, Lasky RE, Datta S, Parikh NA, Narayana PA. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One. 2010;5(11):e13874.

Tyson JE, Parikh NA, Langer J, Green C, Higgins R, for the NICHD Neonatal Research Network. Intensive Care for Extreme Prematurity – Moving Beyond Gestational Age. N Engl J Med. 2008;358(16):1672-81.

Parikh NA, Lasky RE, Kennedy KA, Moya FR, Hochhauser L, Romo S, Tyson JE. Postnatal Dexamethasone Therapy and Cerebral Tissue Volumes in Extremely Low Birth Weight Infants. Pediatrics. 2007;119(2):265-272.

Grants

Mihaela Pavlicev, PhD mihaela.pavlicev@cchmc.org

A New Model to Identify Preterm Neonates at High-Risk for Cognitive Deficits. Principal Investigator. National Institutes of Health / National Institute of Neurological Disorders and Stroke. Apr 2016-Jan 2021.

Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers. Principal Investigator. National Institutes of Health/ National Institute of Neurological Disorders and Stroke. Oct 2016-Sep 2021.

High Res

Mihaela Pavlicev, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Email mihaela.pavlicev@cchmc.org

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Research Interests

Visit the Pavlicev Lab.

PhD: University of Vienna, Austria, 2003.

Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).

Pavličev M, Wagner GP. A model of developmental evolution: selection, pleiotropy, compensation. TrEE. 2012;27: 316-322.

Pavličev M, Hansen TF. Genotype-phenotype maps maximizing evolvability: modularity revisited. Evolutionary Biology. 2011;38: 371-389.

Pavličev M, Norgard EA, Fawcett GL, Cheverud JM. Evolution of pleiotropy: Epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. J. Experimental Zoology B. 2011;316B: 371-385.

Pavličev M, Wagner GP, Cheverud JM. Evolution of adaptive phenotypic variation patterns by direct selection on evolvability. Proc. Roy. Soc. 2011;278: 1903-1912.

Pavličev M, Le Rouzic AP, Wagner GP, Cheverud JM, Hansen TF. Directionality of epistasis in a murine intercross population. Genetics. 2010;185:1489-1505.

Pavličev M, Cheverud JM, Wagner GP. Measuring morphological integration using eigenvalue variance. Evolutionary Biology. 2009;36:157-170.

Wagner GP, Kenney-Hunt JP, Pavličev M, Peck JR, Waxman D, and Cheverud JM. Pleiotropic scaling of gene effects and the "Cost of complexity". Nature. 2008;452: 470-472.

Pavličev M, Kenney-Hunt JP, Norgard AE, Roseman CC, Wolf J, and Cheverud JM. Genetic variation in pleiotropy: Differential epistasis as a source of variation in the allometric relationships between bone lengths and body weight. Evolution. 2008;62 (1): 199-213.

Wagner GP, Pavličev M, Cheverud JM. The road to modularity. Nature Reviews Genetics. 2007;8: 921- 931.

Brenda Poindexter, MD, MS Director of Clinical and Translational Research, Perinatal Institute 513-803-9029 brenda.poindexter@cchmc.org

John H. Reuter, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology 513-862-2748 john.reuter@cchmc.org

Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center 513-636-3149 ward.rice@cchmc.org

High Res

Ward R. Rice, MD, PhD

Medical Director, Newborn Services, St. Elizabeth Medical Center

Director, Neonatology Fellowship Training Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-636-7868

Email ward.rice@cchmc.org

Show All

Clinical

Hypotension in ELBW infants; EMR

Research

Processing of surfactant protein C

Biography

Ward R. Rice, MD, PhD, is the director of the Neonatology Fellowship Training Program and director of Newborn Services, St. Elizabeth Medical Center.

Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.

His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of surfactant protein C.

PhD: University of Chicago, Chicago, Illinois, 1972-76.

PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane."

MD: University of Chicago, Chicago, Illinois, 1972-78.

Internship: Duke University Medical Center, Durham, North Carolina, 1978-79.

Residency: Duke University Medical Center, Durham, North Carolina, 1979-81.

Fellowship Neonatology: University of Cincinnati College of Medicine, Children's Hospital Medical Center, 1981-83.

Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.

Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.

Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.

Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.

Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.

Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.

Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.

Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.

Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.

Jerod M. Rone, MD Medical Director, Kettering Medical Center NICU 513-636-7216 jerod.rone@cchmc.org

Kurt R. Schibler, MD Attending Neonatologist, Neonatology and Pulmonary Biology 513-636-3972 kurt.schibler@cchmc.org

High Res

Kurt R. Schibler, MD

Attending Neonatologist, Neonatology and Pulmonary Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3972

Fax 513-636-7868

Email kurt.schibler@cchmc.org

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Clinical

Clinical trials; neonatal immune development

Research

Immune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity

MD: University of Cincinnati, Cincinnati, Ohio, 1984.

Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.

Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.

Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.

Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.

Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.

Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8.

Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16.

Book Chapters

Schibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.

Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.

Kristen Suhrie, MD Neonatologist, Perinatal Institute 513-803-0274 kristen.suhrie@cchmc.org

Daniel T. Swarr, MD 513-803-8396 daniel.swarr@cchmc.org

Daniel T. Swarr, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-8396

Email daniel.swarr@cchmc.org

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Clinical

Isolated and syndromic birth defects; bronchopulmonary dysplasia; pediatric lung diseases; general neonatology

Research

Early endoderm and lung development; epigenetic regulation of gene expression; long non-coding RNAs; Congenital lung malformations; TEF/EA; VACTERL

Biography

After finishing general pediatrics residency training at Baylor College of Medicine, Dr. Swarr completed a combined fellowship program at The Children’s Hospital of Philadelphia, which lead to Board certification in Neonatal-Perinatal Medicine and Medical Genetics & Genomics. As both a neonatologist and geneticist, Dr. Swarr is particularly interested in both isolated and syndromic birth defects impacting the health of newborn infants.

The goal of Dr. Swarr’s research is to improve our understanding of the etiology and pathogenesis of congenital malformations and pulmonary disease using a wide variety of tools from developmental biology, genetics and epigenetics. His laboratory is particularly interested in understanding epigenetic mechanisms by which gene expression is regulated during early endoderm and lung development, and how disruptions of these processes lead to neonatal disease. Current work seeks to define the role of long non-coding RNAs (lncRNAs) during lung development and lung epithelial repair after injury.

Dr. Swarr’s laboratory is also actively involved in “translating” findings from basic developmental biology to better understanding disorders of the esophagus, trachea, and lungs through a patient registry-biorepository established in collaboration with investigators at CCHMC and The Children’s Hospital of Philadelphia.

MD: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2007.

Residency: General Pediatrics, Baylor College of Medicine & Texas Children’s Hospital, Houston, TX, 2007-2010.

Fellowship: Combined Fellowship in Neonatal-Perinatal Medicine and Medical Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2010-2015.

Board Certifications: General Pediatrics, 2010; Medical Genetics & Genomics, 2015; Neonatal-Perinatal Medicine, 2016.

Swarr DT, Morrisey EE. Lung endoderm morphogenesis: gasping for form and function. Annu Rev Cell Dev Biol. 2015 Nov 13;31:553-73.

Luo M, Mulchandani S, Dubbs HA, Swarr DT, Pyle L, Zackai EH, Spinner NP, Conlin LK. Detection of mutually exclusive mosaicism in a girl with genotype-phenotype discrepancies. Am J Med Genet A. 2015 Dec;167A(12):3091-5.

Kruska P, Li D, Harr MH, Wilson NR, Swarr D, McCormick E, Chiavacci R, Li M, Johnson J, McDonald-McGinn D, Deardorff M, Falk MJ, Allanson J, Saadi I, Hakonarson H, Muenke M, Zackai EH. Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome. J Med Genet. 2015 Feb;52(2):104-10.

Herriges M*, Swarr DT*, Morley MP, Peng T, Stewart KM, Morrisey EE. Long non-coding RNAs are preferentially located near transcription factors and regulate lung development. Genes Dev. 2014 Jun 15;28(12):1363-79. *Co-first authors

Wenger TL, Gerdes J, Deardorff MA, Taub K, Swarr DT, Abend N. Telemedicine for genetic and neurologic evaluation of infants in the Neonatal Intensive Care Unit. J Perinatol. 2014 Mar;34(3):234-40.

Swarr DT, Khalek N, Treat J, Horton M, Riviere JB, Dobyns W, Zackai EH. Expanding the differential diagnosis of fetal hydrops: an unusual prenatal presentation of megalencephaly-capillary malformation syndrome. Prenat Diagn. 2013 Oct;33(10):1010-2.

Kalish JM, Conlin LK, Bhatti TR, Feret H, Harris MC, Izumi K, Mostoufi-Moab S, Saitta S, States LJ, Swarr DT, Wilkens AB, Zackai EH, Zelley K, Bartolomei MS, Nichols KE, Palladino AA, Spinner NB, Deardorff MA. Clinical presentation of three subjects with genome-wide paternal uniparental disomy. Am J Med Genet A. 2013 Mar;161(3):473-8.

Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz P, Garvin J, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Valenzuela Palafoll I, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Homing L, Lo I, Lam S, Gerychova R, Jezova M, Valaskova I, Fellman F, Afshar K, Giannoni E, Muehlethaler V, Liang J, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon L, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach J, Cole JS, Hamvas A, Prince L, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 June;34(6):801-11.

Nathanson J, Swarr DT, Singer A, Liu M, Chinn A, Jones W, Hurst J, Khalek N, Zackai E, Slavotinek A. Novel FREM1 mutations expand the phenotypic spectrum associated with Manitoba-Oculo-Tricho-Anal (MOTA) syndrome and Bifid Nose Renal Agenesis Anorectal Malformations (BNAR) syndrome. Am J Med Genet A. 2013 Mar;161(3):473-8.

Swarr DT, Bloom D, Lewis RA, Elenberg E, Friedman EM, Glotzbach C, Wissman SD, Shaffer LG, Potocki L. Potocki-Shaffer syndrome: comprehensive clinical assessment, review of the literature, and proposals for medical management. Am J Med Genet A. 2010 Mar;152A(3):565-72.

Laura P. Ward, MD 513-803-0963 laura.ward@cchmc.org

Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital 513-872-2748 kathy.wedig@cchmc.org

Scott L. Wexelblatt, MD Medical Director, Regional Newborn Services 513-803-2681 scott.wexelblatt@cchmc.org

Staff

Amil H. Allen, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 amil.allen@cchmc.org

Shreyas Arya, MBBS Clinical Fellow, Division of Neonatology and Pulmonary Biology 513-636-7216 shreyas.arya@cchmc.org

High Res

Shreyas Arya, MBBS

Clinical Fellow, Division of Neonatology and Pulmonary Biology

Phone 513-636-7216

Email shreyas.arya@cchmc.org

Show All

Clinical

Neonatology and pulmonary biology

Research

Necrotizing enterocolitis; fetoplacental insufficiency

Biography

Shreyas Arya completed his pediatric residency training at the University of Texas Medical Branch, Galveston. He has interests in both basic science and clinical research. He was awarded the Arild E. Hansen Award for Outstanding resident research in recognition for his resident scholarly project looking at the outcomes of infants with fetoplacental insufficiency.

MD: Kasturba Medical College,Manipal University, Mangalore, India, 2012.

Residency: Pediatrics, University of Texas Medical Branch, Galveston, TX, 2016.

Dasgupta S, Arya S, Choudhary S, Jain SK. Amniotic fluid: Source of trophic factors for the developing intestine. World J Gastrointest Pathophysiol. 2016;7(1):38-47.

Bhargava V, DeLeon C, Arya S, Jain SK. Paradoxical Hypoxemia with Simultaneous Use of Pulmonary Vasodilators in a Case of PPHN. J Pediatr Child Care. 2015;1(2): 3.

Arya S, Richardson CJ, Jain S, Swischuck LE. Early Vitamin K Deficiency Bleeding in a Neonate Associated with Maternal Acute Fatty Liver of Pregnancy. AJP Rep. 2015;5(2):e193-5.

Clara F. Chlon, MD Staff Physician, Neonatology and Pulmonary Biology 513-636-4214 clara.chlon@cchmc.org

Diane K. Donley, MD Staff Physician, Neonatology and Pulmonary Biology 513-636-5470 diane.donley@cchmc.org

Ting Ting Fu, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4830 tingting.fu@cchmc.org

Jennifer B. Hardie, MD Staff Physician II, Division of General and Community Pediatrics 513-636-6487 jennifer.hardie@cchmc.org

Gayle Hertenstein, MSN, CNP Nurse Practitioner, Neonatology and Pulmonary Biology 513-636-3882 gayle.hertenstein@cchmc.org

Melissa House, MD Clinical Fellow, Neonatalogy and Pulmonary Biology 513-517-0079 melissa.house@cchmc.org

Viral G. Jain, MD Clinical Fellow, Division of Neonatology and Pulmonary Biology viral.jain2@cchmc.org

High Res

Viral G. Jain, MD

Clinical Fellow, Division of Neonatology and Pulmonary Biology

Email viral.jain2@cchmc.org

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Clinical

Neonatology; bioinformatics; early literacy; evidence based medicine

Research

Urogenital anomalies; endocrine disruptors; genetics of preterm birth

Biography

Viral G Jain, MD, completed his pediatric residency at Case Western Reserve University (MetroHealth) program, and is currently pursuing his Neonatology fellowship at Cincinnati Children’s Hospital Medical Center under Dr. Louis Muglia. He has experience in both basic science as well as clinical research, and has published extensively in well-respected journals. His research focuses on identifying risk factors for urogenital developmental disorders in newborns, understanding genomics of preterm birth, and exploring a family’s contribution to a young child’s learning. He has also worked on developing a novel nanoparticle for treatment of retinoblastoma.

Dr. Jain also has strong interest in bioinformatics and was the founding team member of a well-funded startup to connect sub-specialty services to underserved cities in India, which won numerous international awards for healthcare innovations.

He also serves as the founder and co-editor of the AAP, Section on Neonatology Journal Club. He is an active member of the AAP-SoNPM Website Committee, American Medical Informatics Association; and WikiProject Medicine (WikiPedia).

MBBS: Maharashtra State University of Health Sciences (MGM Medical College), Mumbai, India, 2011.

Residency: Pediatrics, Case Western Reserve University (MetroHealth) Program, Cleveland, OH, 2016.

Singal AK, Jain VG, Ghazali Z, Shekhawat PS. Shorter Anogenital distance correlates with severity of hypospadias in pre-pubertal boys. Human Reproduction. 2016 Jul;31(7):1406-10.

Singal AK, Jain VG. Maternal and infant characteristics influencing the anogenital distance and penile length in newborns. Andrologia. 2016 Aug;48(6):708-13.

Singal AK, Dubey M, Jain V. Transverse preputial onlay island flap urethroplasty for single-stage correction of proximal hypospadias. World journal of urology. 2016 Jul;34(7):1019-24.

Jain V, Gulati R. Mirizzi syndrome – An uncommon Cause of obstructive jaundice in a child. Indian Pediatr. 2015 Jun 8;52(6):539.

Kalita D, Shome D, Jain VG, Chadha K, Bellare JR. In vivo intraocular distribution and safety of periocular nanoparticle carboplatin for treatment of advanced retinoblastoma in humans. American journal of ophthalmology. 2014;157(5):1109-1115.

Shome D, Kalita D, Jain V, Sarin R, Maru GB, Bellare JR. Carboplatin loaded polymethylmethacrylate nano-particles in an adjunctive role in retinoblastoma: An animal trial. Indian journal of ophthalmology. 2014;62(5):585-89.

Jain VG, Singal AK. Shorter anogenital distance correlates with undescended testis: a detailed genital anthropometric analysis in human newborns. Human reproduction. 2013;28(9):2343-2349.

Singal AK, Jain V, Dubey M, Deshpande P. Undescended testis and torsion: is the risk understated? Arch Dis Child. 2013 Jan;98(1):77-9.

Jain V, Singal AK, Ramu C, Raghunaathan KD. Superior mesenteric artery syndrome: a rare complication in a child with Marfan syndrome. Archives of disease in childhood. 2013;98(10):754-755.

Reddy S, Jain V, Dubey M, Deshpande P, Singal AK. Local steroid therapy as the first‐line treatment for boys with symptomatic phimosis–a long‐term prospective study. Acta Paediatrica. 2012;101(3):e130-e133.

Suyog Kamatkar, MD, MS Epi Fellow, Division of Neonatology and Pulmonary Biology 513-636-4830 suyog.kamatkar@cchmc.org

High Res

Suyog Kamatkar, MD, MS Epi

Fellow, Division of Neonatology and Pulmonary Biology

Academic Affiliation

Phone 513-636-4830

Email suyog.kamatkar@cchmc.org

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Clinical

Neonatal Abstinence Syndrome; pharmacokinetics; pharmacodynamics; pharmacogenomics; neurodevelopmental outcomes of premature infants

Research

Pharmacogenomic analysis and PK/PD modeling of sublingual Buprenorphine in treatment of Neonatal Abstinence Syndrome

MBBS: Topiwala National Medical College, Mumbai, India.

MS: TH Chan School of Public Health, Harvard University.

Residency: Pediatrics, Indiana University Riley Children's Hospital, Indianapolis, IN.

Certification: Pediatrics, 2014.

Kamatkar S, Lee BT, Duggan MM, Keenan MT, Quinlan RM, Hergrueter CA, Hertl MC, Shin JH, Truppin NB, Chun YS. Commonwealth of Massachusetts Board of Registration in Medicine Expert Panel on immediate implant-based breast reconstruction following mastectomy for cancer. Journal of American College of Surgeons. 2011 Dec;213(6):800-5.

Kamatkar S, Zafar N, Iqbal A, Farez M, de Moya M. Meta-analysis: Intensive Insulin Therapy in Brain Injury. Journal of Neurotrauma. 2011 Jul;28(7):1307-17.

Kamatkar S, Njinimbam C. Anemia in a Term Newborn With Facial Anomalies. Neoreviews. 2015;16(12):e711–e713.

Kamatkar S. Dress Code: Story of conformity among medical professionals. Indian Academy of Pediatrics. 2007 July 1.

Book Chapter

Kamatkar S, Chloe A, Sharaya N, Huskins J, Ruhl L. Review of Rheumatic Heart Disease. Reference Manual for Moi Teaching and Referral Hospital, Eldoret, Kenya. 2012, September 1.

Jillian A. Klein, MD Staff Physician III, Division of General and Community Pediatrics 513-636-7722 jillian.klein@cchmc.org

Gregg A. Kottyan, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 gregg.kottyan@cchmc.org

Jennifer Lewis, MSN, APRN, CNP Nurse Practitioner, Neonatology and Pulmonary Biology 513-636-4830 jennifer.lewis@cchmc.org

M. Katherine Loudermilk, MD Pediatrician, Neonatology and Pulmonary Biology M.Katherine.Loudermilk@cchmc.org

Paige Marks, MD Pediatrician, Neonatology and Pulmonary Biology 513-736-2269 paige.marks@cchmc.org

Jennifer McAllister, MD Staff Physician, Neonatology and Pulmonary Medicine 513-803-4232 jennifer.mcallister@cchmc.org

Alisa O. McGill, MD Staff Physician, Neonatology and Pulmonary Biology alisa.mcgill@cchmc.org

Kera M. McNelis, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-517-0082 kera.mcnelis@cchmc.org

A photo of Shanmukha (Sai) Niranjan Mukthapuram.

Shanmukha Sai Niranjan Mukthapuram, MD Clinical Fellow, Division of Neonatology sai.mukthapuram@cchmc.org

Miriam Y. Peri, MD Staff Physician II, Neonatology and Pulmonary Biology miriam.peri@cchmc.org

Kathyrn P. Peterson, MD Pediatrician, Newborn Care Associates, Neonatology and Pulmonary Biology 513-636-3874 kathryn.peterson@cchmc.org

Lisa Marie Piwoszkin, DO Clinical Fellow, Neonatology and Pulmonary Biology 513-517-0091 lisa.piwoszkin@cchmc.org

Stefanie Riddle, MD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4830 stefanie.riddle@cchmc.org

Stefani Rojek, MSN, NNPBC, APRN Advanced Practice Registered Nurse, Neonatology and Pulmonary Biology 513-636-4466 stefani.rojek@cchmc.org

Deborah K. Rufner, MD Staff Physician, Neonatology and Pulmonary Biology 513-636-5470 deborah.rufner@cchmc.org

Heather R. Ryle, DNP, APRN, NNP-BC NICU APRN Program Lead, Neonatology and Pulmonary Biology 513-636-3409 heather.ryle@cchmc.org

Augusto F. Schmidt, MD, PhD Clinical Fellow, Neonatology and Pulmonary Biology 513-636-4214 augusto.schmidt@cchmc.org

High Res

Augusto F. Schmidt, MD, PhD

Clinical Fellow, Neonatology and Pulmonary Biology

Academic Affiliation

Phone 513-636-4214

Email augusto.schmidt@cchmc.org

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Clinical

Neonatology; neonatal ventilation; antenatal steroids

Research

Fetal maturation induced by antenatal steroids; fetal brain development and injury; congenital diaphragmatic hernia

MD: Universidade Estadual de Campinas, Brazil, 2007.

PhD: Universidade Estadual de Campinas, Brazil, 2010.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

Certification: Pediatrics, 2013.