Tourette Syndrome and Tic Disorder Clinic

Visit the Gilbert / Wu / Pedapati Lab.

Clinical

Movement disorders; Tourette's syndrome; Sydenham's chorea; kernicterus; dystonia; ataxia; clinical research; transcranial magnetic stimulation

Research

Clinical trials in Tourette's syndrome and associated ADHD; epidemiology of Tourette's syndrome and PANDAS; clinical effectiveness of multi-drug treatments in Tourette's syndrome; transcranial magnetic stimulation in Tourette's syndrome and pediatric movement disorders; functional neurosurgery for pediatric dystonia

Biography

Donald Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert did his pediatrics and neurology training at John Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in clinical research design and statistical analysis from the University of Michigan.

At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette's syndrome. Dr. Gilbert directs the Transcranial Magnetic Stimulation Laboratory at Cincinnati Children's.

BA: Princeton University, Princeton, NJ, 1987.

MD: University of Michigan School of Medicine, Ann Arbor, MI, 1993.

MS: University of Michigan, Ann Arbor, MI, 2003.

Pediatrics, Child Neurology Residency: Johns Hopkins School of Medicine, Baltimore, MD, 1998.

Certification: Board Certified in Neurology with Special Competence in Child Neurology, 2010; Board eligible in Pediatrics.

Appointment: Professor of Pediatric Neurology.

View PubMed Publications

Hong YH, Wu SW, Pedapati EV, Horn PS, Huddleston DA, Laue CS, Gilbert DL. Safety and Tolerability of Theta Burst Stimulation versus Single and Paired Pulse Transcranial Magnetic Stimulation: A Comparative Study of 164 Pediatric Subjects. Frontiers in Neuroscience. 2015. doi: 10.3389/fnhum.2015.00029

Dietrich A, Fernandez TV, King RA, State MW, Tischfield JA, Hoekstra PJ, Heiman GA, and the TIC Genetics Collaborative Group. The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette Syndrome: objectives and methods. Eur Child Adolesc Psychiatry, 2014. DOI 10.1007/s00787-014-0543-x

Gilbert DL, Budman CL, Singer HS, Kurlan R, Chipkin RE. A D1 Receptor Antagonist, Ecopipam, for treatment of tics in Tourette Syndrome. Clinical Neuropharmacology, 2014. 37:26-30.

Chen TH, Wu SW, Dixon S, Shahana N, Huddleston DA, Sarvis AR, Sallee FR, Gilbert DL. Motor Cortex Physiology and Stop Signal Reaction Times as Predictors and Correlates of Atomoxetine Responses in Children with ADHD. Journal of Child Neurology, 2014. 29:1672-9. DOI: 10.1177/0883073813513333.

Wu SW, Maloney T, Gilbert DL, Dixon SG, Horn PS, Huddleston DA, Eaton K, Vannest J. Functional MRI-navigated Repetitive Transcranial Magnetic Stimulation of Supplementary Motor Area in Chronic Tic Disorders. Brain Stimulation. 2014. 7: 212-218.

Gilbert DL, Patterson MC, Pugh JA, Ridel KR, Reynolds TQ, Valencia I. Views of Recently First-Certified US Child Neurologists on Their Residency Training. Journal of Child Neurology, 2013. 28 (3): 332-339. doi 10.1177/0883073812473644.

Wu SW, Shahana N, Huddleston DA, Gilbert DL. Effects of 30 Hz Theta Burst Transcranial Magnetic Stimulation on the primary motor cortex. Journal of Neuroscience Methods, 2012; 208: 161-164.

Wu SW, Gilbert DL, Shahan N, Huddleston DA, Mostofsky SH. Transcranial Magnetic Stimulation Measures in Attention Deficit/Hyperactivity Disorder. Pediatric Neurology, 2012; 47: 177-185. Doi: 10.1016/j.pediatricneurol.2012.06.0003.

Wu SW, Shahana N, Huddleston DA, Lewis AN, Gilbert DL. Safety and Tolerability of Theta Burst Stimulation in Children. Developmental Medicine and Child Neurology. 2012, 54 (7): 636-639. Doi: 10.111/j.1469-8749.2012.04300.x.

Edden RAE, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH. Reduced GABA concentration in Attention Deficit/Hyperactivity Disorder. Archives of General Psychiatry. 2012; 69: 750-753. PMID: 22752239.

Steve W. Wu, MD Medical Director, Dystonia Clinic 513-636-4222 steve.wu@cchmc.org

High Res

Steve W. Wu, MD

Medical Director, Dystonia Clinic

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4222

Email steve.wu@cchmc.org

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Clinical & Research Interests

Visit the Gilbert / Wu / Pedapati Lab.

Clinical

Pediatric neurology with specialty in pediatric movement disorder; botulinum toxin (Botox) injection for dystonia, spasticity, tics; deep brain stimulation (DBS)

Research

Neuroplasticity; movement disorders; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS)

Biography

Dr. Steve Wu is a pediatric neurologist with interests in children with movement disorders. Drs. Wu, Gilbert (Neurology) and Vadivelu (Neurosurgery) also work together in the Dystonia/Deep Brain Stimulation Clinic to care for children/adolescents with dystonia and complex movement disorders.

Dr. Wu’s research interest focuses on movement disorders and neuroplasticity of the brain. Dr. Wu collaborates with Dr. Donald Gilbert in the Transcranial Magnetic Stimulation Lab at Cincinnati Children’s Hospital Medical Center.

BA: University of California, Berkeley, CA, 1997.

MD: Vanderbilt University, Nashville, TN, 2003.

Residency: Pediatrics and Pediatric Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2003-2008.

Fellowship: Pediatric Movement Disorders, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2009.

Pedapati EV, Gilbert DL, Horn PS, Huddleston DA, Laue CS, Shahana N, Wu SW. Effect of 30 Hz Theta Burst Transcranial Magnetic Stimulation on the Primary Motor Cortex in Children and Adolescents. Front Hum Neurosci. 2015;9:91.

Wu SW, Gilbert DL. Measuring neuroplasticity in children using brain stimulation (Commentary). Dev Med Child Neurol. 2015.

Hong YH, Wu SW, Pedapati EV, Horn PS, Huddleston DA, Laue CS, Gilbert DL. Safety and Tolerability of Theta Burst Stimulation versus Single and Paired Pulse Transcranial Magnetic Stimulation: A Comparative Study of 165 Pediatric Subjects. Front Hum Neurosci. 2015.

Chen TH, Wu SW, Dixon S, Shahana N, Huddleston DA, Sarvis AR, Sallee FR, Gilbert DL. Reduced short interval cortical inhibition correlates with atomoxetine response in children with attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2014;29:1672-9.

Wu SW, Maloney T, Gilbert DL, Dixon SG, Horn PS, Huddleston DA, Eaton K, Vannest J. Functional MRI-navigated Repetitive Transcranial Magnetic Stimulation over Supplementary Motor Area in Chronic Tic Disorders. Brain Stimulation. 2014;7(2):212–218.

Hedera P, Xiao J, Puschmann A, Momčilović D, Wu SW, LeDoux MS. Novel PRRT2 mutation in an African-American family with paroxysmal kinesigenic dyskinesia. BMC Neurology. 2012;12:93.

Klotz J, Johnson M, Wu SW, Isaacs KM, Gilbert DL. Relationship between Reaction Time Variability and Motor Skill Development in ADHD. Child Neuropsychology. 2012;18:576-585.

Wu SW, Gilbert DL, Shahana N, Huddleston DA, Mostofsky SH. Transcranial Magnetic Stimulation Measures in Attention-Deficit/Hyperactivity Disorder. Pediatric Neurology. 2012;47:177-185.

Wu SW, Shahana N, Huddleston DA, Gilbert DL. Effects of 30 Hz Theta Burst Transcranial Magnetic Stimulation on the Primary Motor Cortex. Journal of Neuroscience Methods. 2012;208:161-164.

Wu SW, Shahana N, Huddleston DA, Lewis AN, Gilbert DL. Safety and Tolerability of Theta-Burst Transcranial Magnetic Stimulation in Children. Developmental Medicine and Child Neurology. 2012;54:636-639.

Staff

Tara D. Lipps, MSN, APRN, CNP Certified Nurse Practitioner, Movement Disorder Clinic and Tourette's Syndrome Clinic, Division of Neurology 513-636-4222 tara.lipps@cchmc.org

Tara D. Lipps, MSN, APRN, CNP

Certified Nurse Practitioner, Movement Disorder Clinic and Tourette's Syndrome Clinic, Division of Neurology

Certified Nurse Practitioner, General Neurology Clinic, Division of Neurology

Academic Affiliation

Phone 513-636-4222

Fax 513-636-3980

Email tara.lipps@cchmc.org

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Clinical & Research Interests

Clinical

Movement disorders and Tourette's syndrome; general neurology; epilepsy

Research

Movement disorders and Tourette's syndrome

Biography

Tara Lipps, MSN, APRN, CNP, began working in the Movement Disorder Clinic and Tourette's Syndrome Clinic within the Division of Neurology in 2001. She worked as a clinical nurse and research nurse for three years until transitioning to the role of nurse practitioner in 2004. She has helped to further develop the role of the nurse practitioner in a multi-disciplinary Movement Disorder Clinic and Tourette's Syndrome Clinic, presented on pediatric movement disorders and Tourette's Syndrome nationally and internationally, and has been involved as a sub-investigator on multiple clinical research studies on Tourette's Syndrome.

Tara has additional training in CBIT (Comprehensive Behavioral Intervention for Tics) as a clinical nurse practitioner (not as a psychologist or therapist)and is able to provide CBIT training to patients seen in the Tourette's Syndrome Clinic.

In addition, Tara spends part of her time working as a nurse practitioner in general neurology clinic seeing and treating patients with a variety of complex neurological conditions (since 2005).

MSN, CFNP: Northern Kentucky University, Highland Heights, KY.

RN, BSN: Northern Kentucky University, Highland Heights, KY.

Certification : CFNP (Certified Family Nurse Practitioner), AANP (American Academy of Nurse Practitioners), 2004.

Ricketts EJ, Gilbert DL, Zinner SH, Mink JW, Lipps TD, Wiegand GA, Vierhile AE, Ely LJ, Piacentini J, Walkup JT, Woods DW. Pilot Testing Behavior Therapy for Chronic Tic Disorders in Neurology and Developmental Pediatrics Clinics. J Child Neurol. 2016 Mar;31:444-450.

Ridel, Keith R, Lipps, Tara D, Gilbert, Donald L. The Prevalence of Neuropsychiatric Disorders in Sydenham's Chorea. Pediatric Neurology. 2009.

Gilbert DL, Zhang J, Lipps TD, Natarajan N, Brandyberry J, Wang Z, Sallee FR, Wassermann EM. Atomoxetine Treatment of ADHD in Tourette Syndrome: Reduction in Motor Cortex Inhibition Correlates with Clinical Improvement. Clinical Neurophysiology. 2007; 118:1835-1841.

Gilbert DL, Wang Z, Sallee FR, Ridel KR, Merhar S, Zhang J, Lipps TD, White C, Badreldin N, Wassermann EM. Dopamine transporter genotype influences the physiological response to medication in ADHD. Brain. 2006; 129:2038-2046.

Gilbert DL, Ridel KR, Sallee FR, Zhang J, Lipps T, Wassermann E. Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortex. Neuropsychopharmacology. 2006;31:442-449.

Gilbert DL, Lipps TD. Tourette Syndrome. Current Treatment Options in Neurology. 2005;7:211-219.

Gilbert DL, Sallee FR, Zhang J, Lipps T, Wassermann EM. TMS-evoked cortical inhibition, a consistent marker of ADHD scores in Tourette Syndrome. Biological Psychiatry. 2005.

Gilbert DL, Bansal AS, Sethuraman G, Huff T, Zhang J, Sallee FR, Wassermann EM. Association of Cortical Disinhibition with tic, ADHD, and OCD Severity in Tourette Syndrome. Movement Disorders. 2004;19:416-425.

Gilbert DL, Garvey M, Bansal AS, Huff T, Zhang J, Wassermann EM. Should Transcranial Magnetic Research in Children be Considered Minimal Risk? Clinical Neurophysiology. 2004; 18: 1730-1739.

Affiliates

Elana Harris, MD, PhD 513-636-2100 elana.harris@cchmc.org

Elana Harris, MD, PhD

Academic Affiliations

Assistant Professor, N/A

UC Department of Psychiatry and Behavioral Neuroscience

Phone 513-636-2100

Email elana.harris@cchmc.org

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Specialties

Conditions: anxiety disorders; obsessive compulsive disorder; Tourette syndrome; trichotillomania

Treatment modalities: habit reversal therapy; pharmacotherapy

MD: State University of New York, Downstate Medical Center.

PhD: Neural and Behavioral Science; State University of New York, Downstate Medical Center.

Internship: Pediatrics, Winthrop University Hospital, Mineola, NY.

Residency: Psychiatry, Johns Hopkins Hospital, Baltimore, MD.

Fellowship: Child and Adolescent Psychiatry, Johns Hopkins Hospital, Baltimore, MD.