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Research in this area focuses on identifying and manipulating stem cells to replace tissues damaged by disease and injury. It is estimated that many diseases could ultimately be treated with stem cell-based therapies.
Scientists here investigate new ways to use adult and embryonic stem cells to promote regeneration and to generate tissues for transplantation to cure childhood disease. The Cincinnati Children's Research Foundation has initiated a seven-year expansion project that includes a new state-of-the-art research building and a commitment to hire new faculty members that study stem cell biology.
Jose A. Cancelas Perez, MD, PhD, Associate Professor Cellular and molecular mechanisms of norm and cancer hematopoietic stem cells [Visit the Cancelas Lab]
Steve Danzer, PhD, Associate ProfessorMy laboratory focuses on elucidating the mechanisms by which epilepsy develops, with the ultimate goal of developing novel therapies to prevent or treat the disease. We are currently conducting studies on the roles of the mTOR signaling pathway and adult generated neurons in epilepsy. [Visit the Danzer Lab]
Tony De Falco, PhD, Assistant ProfessorThe De Falco lab is interested in uncovering the mechanisms underlying the differentiation of the fetal gonad, focusing on how myeloid cells (such as macrophages) and vasculature promote tissue remodeling during organogenesis. Additionally, we are investigating the roles of myeloid cells in regulating spermatogonial stem cell differentiation in the adult testis. [Visit the De Falco Lab]
Lee Grimes, PhD, ProfessorHematopoiesis, molecular biology, and molecular oncology including mouse modeling of hematopoiesis, myelopoiesis and leukemia. [Visit the Grimes Lab]
Stacey S. Huppert, PhD, Associate ProfessorIntercellular signaling pathways that regulate the patterning of liver architecture during development and regeneration. [Visit the Huppert Lab]
Rafi Kopan, PhD, ProfessorThe generation of different cell types and specialized organs. [Visit the Kopan Lab]
Qing Richard Lu, PhD, ProfessorTranscriptional and epigenetic control of glial development and brain tumor initiation [Visit Experimental Hematology]
Doug Millay, PhD, Assistant Professor We are interested in the mechanisms of cell-cell fusion, using skeletal muscle development and regeneration as a model system. [Visit the Millay Lab]
James C. Mulloy, PhD, ProfessorMolecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
Masato Nakafuku, MD, PhD, Professor Molecular control of neural stem cells in development and regeneration of mammalian central nervous system [Visit the Nakafuku Lab]
Satoshi Namekawa, PhD, Assistant ProfessorThe long-term goal of my research is to understand the mechanisms and evolution of epigenetic events during mammalian reproduction. We study epigenetic regulation of sex chromosomes during meiosis and the regulatory mechanisms in germline stem cells. [Visit Reproductive Sciences]
Yuya Ogawa, PhD, Assistant ProfessorMolecular mechanisms of long noncoding RNA-mediated epigenetic gene regulation during mammalian development; X-chromosome inactivation using ex vivo differentiation system with mouse ES cells. [Visit Reproductive Sciences]
Joo-Seop Park, PhD, Assistant ProfessorGene regulatory networks regulating stem/progenitor cells in development and disease. [Visit Urology]
Jim Wells, PhD, Professor Endoderm organogenesis and promoting the differentiation of embryonic stem cells into therapeutic endoderm derivatives. [Visit the Wells Lab]
Susanne Wells, PhD, ProfessorPapilloma virus and cervical cancer [Visit the Susanne Wells Lab]
Jeffrey A. Whitsett, MD, ProfessorOrgan morphogenesis, gene regulation, cell differentiation, respiratory disease [Visit the Whitsett Lab]
Chunyue Yin, PhD, Assistant ProfessorThe molecular and cellular mechanisms underlying liver development and disease pathogenesis using the zebrafish model organism. [Visit the Yin Lab]
Yi Zheng, PhD, Professor Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Zheng Lab]
Aaron Zorn, PhD, Professor Molecular mechanisms of endoderm organ development [Visit the Zorn Lab]
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