Molecular and Developmental Biology Graduate Program

  • Stem Cell Biology

    Research in this area focuses on identifying and manipulating stem cells to replace tissues damaged by disease and injury.Research in this area focuses on identifying and manipulating stem cells to replace tissues damaged by disease and injury. It is estimated that many diseases could ultimately be treated with stem cell-based therapies. 

    Scientists here investigate new ways to use adult and embryonic stem cells to promote regeneration and to generate tissues for transplantation to cure childhood disease. The Cincinnati Children's Research Foundation has initiated a seven-year expansion project that includes a new state-of-the-art research building and a commitment to hire new faculty members that study stem cell biology.

    Faculty

    Steve Danzer, PhD.Steve Danzer, PhD, Assistant Professor
    My laboratory focuses on elucidating the mechanisms by which epilepsy develops, with the ultimate goal of developing novel therapies to prevent or treat the disease. We are currently conducting studies on the roles of the mTOR signaling pathway and adult generated neurons in epilepsy. [Visit the Danzer Lab]

    Tony De Falco, PhD.Tony De Falco, PhD, Assistant Professor
    The De Falco lab is interested in uncovering the mechanisms underlying the differentiation of the fetal gonad, focusing on how myeloid cells (such as macrophages) and vasculature promote tissue remodeling during organogenesis. Additionally, we are investigating the roles of myeloid cells in regulating spermatogonial stem cell differentiation in the adult testis. [Visit the De Falco Lab]

    Stacey S. Huppert, PhD.Stacey S. Huppert, PhD, Associate Professor
    Intercellular signaling pathways that regulate the patterning of liver architecture during development and regeneration. [Visit the Huppert Lab]

    Qing Richard Lu, PhD.Qing Richard Lu, PhD, Professor
    Transcriptional and epigenetic control of glial development and brain tumor initiation [Visit Experimental Hematology]

    James C. Mulloy, PhD.James C. Mulloy, PhD, Associate Professor
    Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]


    Masato Nakafuku, MD, PhD, Professor
    Molecular control of neural stem cells in development and regeneration of mammalian central nervous system [Visit the Nakafuku Lab]

    Satoshi Namekawa, PhD.Satoshi Namekawa, PhD, Assistant Professor
    The long-term goal of my research is to understand the mechanisms and evolution of epigenetic events during mammalian reproduction. We study epigenetic regulation of sex chromosomes during meiosis and the regulatory mechanisms in germline stem cells. [Visit Reproductive Sciences]

    Yuya Ogawa, PhD.Yuya Ogawa, PhD
    Molecular mechanisms of long noncoding RNA-mediated epigenetic gene regulation during mammalian development; X-chromosome inactivation using ex vivo differentiation system with mouse ES cells. [Visit Reproductive Sciences]

    Joo-Seop Park, PhD.Joo-Seop Park, PhD, Assistant Professor
    Gene regulatory networks regulating stem/progenitor cells in development and disease. [Visit Urology]


    Jim Wells, PhD.Jim Wells, PhD, Associate Professor
    Endoderm organogenesis and promoting the differentiation of embryonic stem cells into therapeutic endoderm derivatives. [Visit the Wells Lab

    Susanne Wells, PhD.Susanne Wells, PhD, Associate Professor
    Papilloma virus and cervical cancer [Visit the Susanne Wells Lab]


    Jeffrey A. Whitsett, MD.Jeffrey A. Whitsett, MD, Professor
    Organ morphogenesis, gene regulation, cell differentiation, respiratory disease [Visit the Whitsett Lab]


    Chunyue Yin, PhD.Chunyue Yin, PhD, Assistant Professor
    The molecular and cellular mechanisms underlying liver development and disease pathogenesis using the zebrafish model organism. [Visit the Yin Lab]

    Yi Zheng, PhD.Yi Zheng, PhD, Professor
    Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Zheng Lab