My areas of research include neuroscience, pain research and sensory neuron biology.
Our lab is investigating the mechanisms of sensory neuron sensitization with a particular emphasis on nociceptive processing. We seek to understand pain processing better to develop proper treatments.
Pain is a significant health issue that affects a large number of people worldwide. The mechanisms by which pain develops in children may be distinct from adults and influenced by non-neuronal communication. While we know a great deal of information about the role of nociceptors in the development of pain states, we do not have a comprehensive understanding of how distinct subtypes of sensory fibers modulate pain across the lifespan under different injury conditions.
Some of our discoveries include finding that peripheral growth hormone (GH) signaling to neurons not only modulates normal sensory development, but exogenous GH may also be used as a potential therapy for pediatric pain. We have obtained a U.S. patent to develop this technology. We also found that distinct growth factor signaling pathways have the ability to modulate both muscle pain and cardiovascular reflexes after ischemic injury to the periphery.
I am the recipient of numerous awards from the National Institutes of Health (NIH) that support my research that began as early as my pre-doctoral training (2006). I am also a Rita Allen Foundation Scholar (2012) and was named a Cincinnati Children's Trustee Scholar in 2013. I am an associate editor for the journals Pain and Molecular Pain and a reviewer for more than 30 other peer-reviewed journals. I have been a researcher for more than 20 years and began my work at Cincinnati Children's in 2011.
My accomplishments, awards and recognitions include:
I’m a member of the Society for Neuroscience, the US Association for the Study of Pain, the International Association for the Study of Pain and the Special Interest Group on Pain in Childhood.
MS: Neuroscience, University of Pittsburgh, Pittsburgh, PA, 2003.
PhD: Neurobiology, University of Pittsburgh, Pittsburgh, PA, 2006.
Postdoctoral Training: University of Pittsburgh, Pittsburgh, PA, 2006-2010.
Neuroscience; pain research; sensory neuron biology
Anesthesia, Neuromuscular Development
Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence. Canadian Journal of Pain. 2022; 6:85-107.
Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021; 41:4410-4427.
A dual role for peripheral GDNF signaling in nociception and cardiovascular reflexes in the mouse. Proceedings of the National Academy of Sciences of USA. 2020; 117:698-707.
A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature Medicine. 2018; 24:338-351.
Peripheral Mechanisms of Ischemic Myalgia. Frontiers in Cellular Neuroscience. 2017; 11:419.
Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming. 2023; 4:2023.02.13.528015.
Developmental impact of peripheral injury on neuroimmune signaling. Brain, Behavior, and Immunity. 2023; 113:156-165.
Role Of T-Cell Mobilizing Chemokine, Ccl27A, In Muscle Hypersensitivity After Repetitive Ischemia With Reperfusion Injury. Pain Forum. 2023; 24:7-8.
Sensory Neuron-Derived CCL2 Corresponds To Inflammation In Ulcerative Colitis. Pain Forum. 2023; 24:1.