A photo of Matthew N. Alder.

Instructor, UC Department of Pediatrics

513-636-4259

Board Certified

My Biography & Research

Biography

My interest in pediatric medicine began at a young age. I was quite ill as a child and became inspired by the physicians who cared for me.

During college, I realized I also enjoyed research. So, I decided to pursue a career that would combine research and patient care. I completed a fellowship in critical care and a PhD in microbiology and immunology.

Today, I work in the Pediatric Intensive Care Unit, where I continuously care for children who struggle to overcome sepsis. My research, which draws on my training in neutrophil biology, neutrophil heterogeneity and immunology in the critically ill, aims to understand why some kids quickly recover from sepsis while others do not.

I’ve received research funding from a variety of sources. This funding includes a K08 Mentored Clinical Scientist Development Award from the National Institute of General Medical Sciences and a Procter Scholar Award from Cincinnati Children’s.

Additional Languages

Mandarin

Clinical Interests

Pediatric critical care

Research Interests

Immunology; sepsis 

Academic Affiliation

Instructor, UC Department of Pediatrics

Clinical Divisions

Pediatric Intensive Care Unit PICU

Research Divisions

Critical Care

My Education

BA: Mandarin Chinese, University of Utah, Salt Lake City, UT, 2002.

MD, PhD: Microbiology and Immunology, University of Alabama, Birmingham, AL, 2009.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012.

Fellowship: Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

My Publications

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Kangelaris, KN; Clemens, R; Fang, X; Jauregui, A; Liu, T; Vessel, K; Deiss, T; Sinha, P; Leligdowicz, A; Liu, KD; et al. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2021; 320:L892-L902.

Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock. Kassam, AF; Levinsky, NC; Mallela, JP; Angel, K; Opoka, A; Lahni, P; Sahay, RD; Fei, L; Nomellini, V; Wong, HR; et al. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:216-223.

Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation. Stark, JE; Opoka, AM; Fei, L; Zang, H; Davies, SM; Wong, HR; Alder, MN. PLoS ONE. 2020; 15.

Pre-operative neutrophil-lymphocyte ratio predicts low cardiac output in children after cardiac surgery. Iliopoulos, I; Alder, MN; Cooper, DS; Villarreal, EG; Loomba, R; Sahay, RD; Fei, L; Steele, PE; Flores, S. Cardiology in the Young. 2020; 30:521-525.

Juvenile OLFM4-null mice are protected from sepsis. Stark, JE; Opoka, AM; Mallela, J; Devarajan, P; Ma, Q; Levinsky, NC; Stringer, KF; Wong, HR; Alder, MN. American Journal of Physiology - Renal Physiology. 2020; 318:F809-F816.

The olfactomedin-4 positive neutrophil has a role in murine intestinal ischemia/reperfusion injury. Levinsky, NC; Mallela, J; Opoka, AM; Harmon, K; Lewis, HV; Zingarelli, B; Wong, HR; Alder, MN. FASEB Journal. 2019; 33:13660-13668.

Soluble CD64 Is a Novel Marker of Steroid Refractory Acute Gastrointestinal Graft Versus Host Disease in Pediatric Allogeneic Hematopoietic Stem Cell Transplant. Loveless, M; Minar, P; Stark, J; Alder, MN; Luebbering, N; Myers, KC; Lake, KE; Litts, B; Davies, SM; Khandelwal, P. Biology of Blood and Marrow Transplantation. 2019; 25:s258-s259.

Olfactomedin 4 marks a subset of neutrophils in mice. Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Innate Immunity. 2019; 25:22-33.

280. Iliopoulos, I; Alder, M; Cooper, D; Loomba, R; Sahay, R; Fei, L; Opoka, A; Flores, S. Critical Care Medicine. 2019; 47.

The glucocorticoid receptor and cortisol levels in pediatric septic shock. Alder, MN; Opoka, AM; Wong, HR. Critical Care. 2018; 22.