A photo of Matthew N. Alder.

Instructor, UC Department of Pediatrics

513-636-4259

Board Certified

My Biography & Research

Biography

My interest in pediatric medicine began at a young age. I was quite ill as a child and became inspired by the physicians who cared for me.

During college, I realized I also enjoyed research. So, I decided to pursue a career that would combine research and patient care. I completed a fellowship in critical care and a PhD in microbiology and immunology.

Today, I work in the Pediatric Intensive Care Unit, where I continuously care for children who struggle to overcome sepsis. My research, which draws on my training in neutrophil biology, neutrophil heterogeneity and immunology in the critically ill, aims to understand why some kids quickly recover from sepsis while others do not.

I’ve received research funding from a variety of sources. This funding includes a K08 Mentored Clinical Scientist Development Award from the National Institute of General Medical Sciences and a Procter Scholar Award from Cincinnati Children’s.

Additional Languages

Mandarin

Clinical Interests

Pediatric critical care

Research Interests

Immunology; sepsis 

Academic Affiliation

Instructor, UC Department of Pediatrics

Clinical Divisions

Pediatric Intensive Care Unit PICU

Research Divisions

Critical Care

My Education

BA: Mandarin Chinese, University of Utah, Salt Lake City, UT, 2002.

MD, PhD: Microbiology and Immunology, University of Alabama, Birmingham, AL, 2009.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012.

Fellowship: Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

My Publications

Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation. Stark, JE; Opoka, AM; Fei, L; Zang, H; Davies, SM; Wong, HR; Alder, MN. PLoS ONE. 2020; 15:e0233738-e0233738.

Pre-operative neutrophil-lymphocyte ratio predicts low cardiac output in children after cardiac surgery. Iliopoulos, I; Alder, MN; Cooper, DS; Villarreal, EG; Loomba, R; Sahay, RD; Fei, L; Steele, PE; Flores, S. Cardiology in the Young. 2020; 30:521-525.

Juvenile OLFM4-null mice are protected from sepsis. Stark, JE; Opoka, AM; Mallela, J; Devarajan, P; Ma, Q; Levinsky, NC; Stringer, KF; Wong, HR; Alder, MN. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2020; 318:F809-F816.

The olfactomedin-4 positive neutrophil has a role in murine intestinal ischemia/reperfusion injury. Levinsky, NC; Mallela, J; Opoka, AM; Harmon, K; Lewis, HV; Zingarelli, B; Wong, HR; Alder, MN. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:13660-13668.

Olfactomedin 4 marks a subset of neutrophils in mice. Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Innate Immunity. 2019; 25:22-33.

The glucocorticoid receptor and cortisol levels in pediatric septic shock. Alder, MN; Opoka, AM; Wong, HR. Critical Care (UK). 2018; 22.

Characterization of the Glucocorticoid Receptor in Children Undergoing Cardiac Surgery*. Flores, S; Cooper, DS; Opoka, AM; Iliopoulos, I; Pluckebaum, S; Alder, MN; Krallman, KA; Sahay, RD; Fei, L; Wong, HR. Pediatric Critical Care Medicine. 2018; 19:705-712.

Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD. Gloude, NJ; Khandelwal, P; Luebbering, N; Lounder, DT; Jodele, S; Alder, MN; Lane, A; Wilkey, A; Lake, KE; Litts, B; et al. Blood. 2017; 130:1259-1266.

Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock. Alder, MN; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Critical Care Medicine. 2017; 45:e426-e432.

A Case of Salicylate Intoxication Complicated by Coagulopathy, Pulmonary Edema, and Pancreatitis. Ayalon, I; Alder, MN; Langner, TR; Hafberg, ET; Miethke, AG; Kaplan, JM. American Journal of Therapeutics. 2016; 23:e1929-e1932.