Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.
Le Cras, TD; Goines, J; Lakes, N; Pastura, P; Hammill, AM; Adams, DM; Boscolo, E.
Angiogenesis.
2020;
23:425-442.
Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment.
Cai, Y; Schrenk, S; Goines, J; Davis, GE; Boscolo, E.
Scientific Reports.
2019;
9.
Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation.
Li, X; Cai, Y; Goines, J; Pastura, P; Brichta, L; Lane, A; Le Cras, TD; Boscolo, E.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2019;
39:496-512.
A xenograft model for venous malformation.
Goines, J; Li, X; Cai, Y; Mobberley-Schuman, P; Metcalf, M; Fishman, SJ; Adams, DM; Hammill, AM; Boscolo, E.
Angiogenesis.
2018;
21:725-735.
Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects.
Boscolo, E; Limaye, N; Huang, L; Kang, K; Soblet, J; Uebelhoer, M; Mendola, A; Natynki, M; Seront, E; Dupont, S; et al.
Journal of Clinical Investigation.
2015;
125:3491-3504.
AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.
Boscolo, E; Coma, S; Luks, VL; Greene, AK; Klagsbrun, M; Warman, ML; Bischoff, J.
Angiogenesis.
2015;
18:151-162.
Pericytes From Infantile Hemangioma Display Proangiogenic Properties and Dysregulated Angiopoietin-1.
Boscolo, E; Mulliken, JB; Bischoff, J.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2013;
33:501-509.
VEGFR-1 Mediates Endothelial Differentiation and Formation of Blood Vessels in a Murine Model of Infantile Hemangioma.
Boscolo, E; Mulliken, JB; Bischoff, J.
The American journal of pathology.
2011;
179:2266-2277.
JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation.
Boscolo, E; Stewart, CL; Greenberger, S; Wu, JK; Durham, JT; Herman, IM; Mulliken, JB; Kitajewski, J; Bischoff, J.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2011;
31:2181-U91.
Corticosteroid Suppression of VEGF-A in Infantile Hemangioma-Derived Stem Cells.
Greenberger, S; Boscolo, E; Adini, I; Mulliken, JB; Bischoff, J.
The New England journal of medicine.
2010;
362:1005-1013.