Elisa Boscolo, PhD

Member, Division of Experimental Hematology & Cancer Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7267

Fax 513-636-3549

Email elisa.boscolo@cchmc.org

Vascular anomalies; endothelial cell biology; mTOR signaling.
Visit the Boscolo Lab.
Elisa Boscolo received her PhD from the University of Padua, Italy. She completed her postdoctoral training and worked as instructor in Joyce Bischoff's laboratory where she investigated the cellular basis and the molecular signaling involved in infantile hemangioma formation. In May 2014, Dr. Boscolo moved to Cincinnati Children’s Hospital Medical Center to study vascular anomalies.

BS: Molecular Biology, University of Padua, Padova, Italy.

PhD: Tissue Engineering, University of Padua, Padova, Italy.

Postdoctoral Fellowship: Vascular Biology, Boston Children’s Hospital, Harvard Medical School, Cambridge, MA.

View PubMed Publications

Li X, Cai Y, Goines J, Pastura P, Brichta L, Lane A, Le Cras TD, Boscolo E*. Ponatinib Combined with Rapamycin Causes Regression of Murine Venous Malformation. Arterioscler Thromb Vasc Biol. 2019 Jan 10:ATVBAHA118312315. *corresponding author

Goines J, Li X, Cai Y, Mobberley-Schuman P, Metcalf M, Fishman SJ, Adams DM, Hammill AM, Boscolo E*. A xenograft model for venous malformation. Angiogenesis. 2018 Nov;21(4):725-735. *corresponding author

Boscolo E*, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Natynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J Clin Invest. 2015;125(9):3491-504. *corresponding author

Boscolo E, Coma S, Luks VL, Greene A, Klagsbrun M, Warman ML, Bischoff J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015;18(2):151-62.

Boscolo E, Mulliken JB, Bischoff J. Pericytes from Infantile Hemangioma Display Pro-angiogenic Properties and Dysregulated Angiopoietin-1. Arterioscler Thromb Vasc Biol. 2013;33(3):501-9.

Boscolo E, Mulliken JB, Bischoff J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol. 2011;179(5):2266-77.

Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J. JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation. Arterioscler Thromb Vasc Biol. 2011;31(10):2181-92.

Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med. 2010;362(11):1005.

Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008;14(11):1236-46.

Khan ZA*, Boscolo E*, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J (* co-first authors). Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 2008;118(7):2592-9.