James P. Bridges, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-0337

Fax 513-636-7868

Email james.bridges@cchmc.org

Research efforts in the Bridges lab are centered on understanding the molecular regulation of alveolar epithelial cell maturation and function in lung development and disease.

Visit the Bridges Lab.

James Bridges, PhD, currently investigates: 1) the role of G protein-coupled receptors in alveolar homeostasis; 2) the role of glucocorticoids in late stage lung development; 3) RNA therapeutics in the treatment of ABCA3-related pediatric lung disease. We utilize gain and loss-of-function mouse models, in concert with in vitro models and bioinformatics, for all three projects to determine the mechanistic basis of alveolar epithelial cell maturation and function in health and disease.
BS: Biochemistry, University of Colorado at Boulder, CO, 1995.

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 2005.

Post-doctoral training: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.

View PubMed Publications

Bridges JP, Schehr A, Wang Y, Huo L, Ikegami M, Whitsett JA, Xu Y. Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes During Perinatal Lung Maturation. PLOS ONE. 2014 May 7;9(5):e91376.

Bittencourt F, We SE, Bridges JP, Miller WE. The M33 GPCR encoded by MCMV is dispensible for hematogenous dissemination but is required for growth within the salivary gland. J Virol. 2014 Oct;88(20):11811-24.

Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae, B, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall R, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk K, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot S, Song S, Talbot WS, Tall GG, White JP, Wolfrum U, Lei Xu L, Piao X. New functions and signaling mechanisms for the family of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333:43-64.

Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M. Orphan G-Protein Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57.  

Bridges JP, Lin S, Ikegami M, Shannon JM. Conditional hypoxia inducible factor 1a induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 1;362(1):24-41.

Starnes S, Pathrose P, Wang J, Succop P, Morris JC, Bridges JP, Kupert E, Anderson M. Clinical and Molecular Predictors of Recurrence in Stage I Non-Small Cell Lung Cancer. Ann Thorac Surg. 2012 May;93(5):1606-12.

Young LR, Gulleman PM, Bridges JP, Weaver TE, Deutsch GH, Blackwell TS, McCormack FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med. 2012 Nov 15;186(10):1014-24.

Bridges JP, Ikegami M, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. Journal of Clinical Investigation. 2010; 120(5):1736.

Ahmad A, Ahmad S, Glover L, Miller S, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2α in pulmonary endothelial cells. Proc Natl Acad Sci. 2009; 106(26):10684-9.

Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. The Meckel-Gruber Syndrome Protein MKS3 is Required for ER-Associated Degradation of Surfactant Protein C. Journal of Biological Chemistry. 2009;  284:33377-83.