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Brenna C. Carey, MS, PhD


  • Member, Translational Pulmonary Center
  • Member, Division of Pulmonary Biology
  • Assistant Professor, UC Department of Pediatrics

About

MS: Pharmaceutical Sciences with Specialization in Drug Development, University of Cincinnati, College of Pharmacy, Cincinnati, OH, 2010.

Post-doctoral Research Fellow: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008.

PhD: Molecular and Developmental Biology, University of Cincinnati, College of Medicine, Cincinnati, OH, 2003.

BS: Biology, John Carroll University, University Heights, OH, 1998.

Interests

Regulations, management, and coordination of clinical research trials in rare lung diseases, specifically pulmonary alveolar proteinosis (PAP); pathogenesis of PAP; developing and validating clinical research tests to diagnose PAP; evaluating several therapeutic options for individuals with PAP; translational pulmonary science; rare lung disease clinical research diagnostic testing; diagnosis of individuals with hereditary or autoimmune PAP clinical trials; National PAP Registry; inhaled GM-CSF treatment for individuals with autoimmune PAP and hereditary PAP; safety and efficacy of Pioglitazone for autoimmune PAP patients

Research Areas

Pulmonary Biology

Publications

Pulmonary hypertension during high-dose GM-CSF therapy of autoimmune pulmonary alveolar proteinosis. Ataya, A; Mitchel, S; Carey, B; Sippel, J; McCarthy, C; Trapnell, BC. Pulmonary Circulation. 2024; 14:e70020.

A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice. Arumugam, P; Carey, BC; Wikenheiser-Brokamp, KA; Krischer, J; Wessendarp, M; Shima, K; Chalk, C; Stock, J; Ma, Y; Black, D; Lowe-Daniels, D; Reeves, L; Kaiser, A; Trapnell, BC. Molecular Therapy-Methods & Clinical Development. 2024; 32:101213.

Disseminated nocardiosis and anti-GM-CSF antibodies. Brugnoli, B; Salvati, L; Di Lauria, N; Botta, A; Tozzetti, C; Biscarini, A; Capone, M; Ferrentino, F; Naldi, C; Ascione, G; Bartoloni, A; Annunziato, F; Parronchi, P; Palterer, B. European Journal of Clinical Microbiology and Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases. 2024; 43:1003-1007.

Human inherited CCR2 deficiency underlies progressive polycystic lung disease. Neehus, AL; Carey, B; Landekic, M; Panikulam, P; Deutsch, G; Ogishi, M; Arango-Franco, CA; Philippot, Q; Modaresi, M; Mohammadzadeh, I; Aladjidi, N; Trapnell, BC; Casanova, JL; Bustamante, J. Cell. 2024; 187:390-408.e23.

Inhaled recombinant GM-CSF reduces the need for whole lung lavage and improves gas exchange in autoimmune pulmonary alveolar proteinosis patients. Campo, I; Carey, BC; Paracchini, E; Kadija, Z; De Silvestri, A; Rodi, G; De Amici, M; Torre, C; Zorzetto, M; Griese, M; Meloni, F; Corsico, AG; Trapnell, BC; Mariani, F. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2024; 63:2301233.

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Frontiers in Immunology. 2023; 13:1023553.

A dried blood spot test for diagnosis of autoimmune pulmonary alveolar proteinosis. Carey, B; Chalk, C; Stock, J; Toth, A; Klingler, M; Greenberg, H; Uchida, K; Arumugam, P; Trapnell, BC. Journal of Immunological Methods. 2022; 511:113366.

Two-year follow-up of exposure, engineering controls, respiratory protection and respiratory health among workers at an indium-tin oxide (ITO) production and reclamation facility. Harvey, RR; Virji, MA; Blackley, BH; Stanton, ML; Trapnell, BC; Carey, B; Healey, T; Cummings, KJ. Occupational and Environmental Medicine. 2022; 79:550-556.

Signal Transducer and Activator of Transcription 5B Deficiency-associated Lung Disease. Krone, KA; Foley, CL; Fishman, MP; Vargas, SO; Forbes, LR; Vece, TJ; Al-Herz, W; Carey, B; Pai, SY; Hwa, V; Trapnell, BC. American Journal of Respiratory and Critical Care Medicine. 2022; 205:1245-1250.

Autoimmune Pulmonary Alveolar Proteinosis. McCarthy, C; Carey, BC; Trapnell, BC. American Journal of Respiratory and Critical Care Medicine. 2022; 205:1016-1035.