Iouri Chepelev, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3407


Genome biology; epigenetics; genetics; autoimmune and inflammatory diseases

MSc: Lomonosov Moscow State University, Moscow, Russia, 1996.

PhD: Stony Brook University, Stony Brook, NY, 2001.

View PubMed Publications

Maunakea AK, Chepelev I, Cui K, Zhao K. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013 Nov;23(11):1256-69.

Chepelev I, Chen X. Alternative splicing switching in stem cell lineages. Front Biol. 2013 Feb 1;8(1):50-59.

Leroy G, Chepelev I, Dimaggio PA, Blanco MA, Zee BM, Zhao K, Garcia BA. Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins. Genome Biol. 2012 Aug 16;13(8):R68.

Chepelev I, Wei G, Wangsa D, Tang Q, Zhao K. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res. 2012 Mar;22(3):490-503.

Chepelev I. Detection of RNA editing events in human cells using high-throughput sequencing. Methods Mol Biol. 2012;815:91-102.

Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G. Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. Nat Struct Mol Biol. 2011 Mar;18(3):372-8.

Maunakea AK, Chepelev I, Zhao K. Epigenome mapping in normal and disease States. Circ Res. 2010 Aug 6;107(3):327-39.

Gan Q, Chepelev I, Wei G, Tarayrah L, Cui K, Zhao K, Chen X. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Cell Res. 2010 Jul;20(7):763-83.

Barski A, Chepelev I, Liko D, Cuddapah S, Fleming AB, Birch J, Cui K, White RJ, Zhao K. Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol. 2010 May;17(5):629-34.

Chepelev I, Wei G, Tang Q, Zhao K. Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq. Nucleic Acids Res. 2009 Sep;37(16):e106.

Psoriatic arthritis causal noncoding genetic variants in IL-23 pathway. Principal Investigator. National Psoriasis Foundation and Arthritis National Research Foundation. Jul 2015-Jun 2017.

Identification of lupus causal variants at 8p23 by mapping 3-dimensional genome. Principal Investigator. Lupus Research Institute. Jan 2015-Dec 2017.

Functional analysis of lupus disease SNPs. Principal Investigator. Cincinnati Children's Hospital Medical Center. Jul 2014-Jun 2016.