A photo of Iouri Chepelev.

Iouri Chepelev, PhD

  • Assistant Professor, UC Department of Pediatrics



Although I began my research career in theoretical physics, I soon expanded my focus to include genomics and chromatin (the substance within chromosomes comprised of DNA and proteins). Since joining the Center for Autoimmune Genomics and Etiology at Cincinnati Children’s in 2013, I’ve applied theoretical physics methods to study chromatin biology.

Most disease-susceptibility genetic loci are located in regions of the genome that encode regulatory instructions. These instructions influence where and when gene products are produced in human cells. Because chromatin plays an essential role in regulating gene activity, my lab uses genomic and theoretical methods to better understand chromatin dynamics in regulatory regions of the human genome.

I’ve received several awards throughout my career, including a Scholar Award from the Arthritis National Research Foundation (2015).


Genome-wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis. Her, YR; Wang, L; Chepelev, I; Manterola, M; Berkovits, B; Cui, K; Zhao, K; Wolgemuth, DJ. Molecular Reproduction and Development. 2021; 88:141-157.

Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Li, Y; Liao, Z; Luo, H; Benyoucef, A; Kang, Y; Lai, Q; Dovat, S; Miller, B; Chepelev, I; Li, Y; et al. Nucleic Acids Research. 2020; 48:3119-3133.

Cyclin D1 integrates G9a-mediated histone methylation. Li, Z; Jiao, X; Di Sante, G; Ertel, A; Casimiro, MC; Wang, M; Katiyar, S; Ju, X; Klopfenstein, DV; Tozeren, A; et al. Oncogene. 2019; 38:4232-4249.

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Luo, H; Wang, F; Zha, J; Li, H; Yan, B; Du, Q; Yang, F; Sobh, A; Vulpe, C; Drusbosky, L; et al. Blood. 2018; 132:837-848.