A photo of Iouri Chepelev.

Assistant Professor, UC Department of Pediatrics

513-636-3407

Biography & Affiliation

Biography

Although I began my research career in theoretical physics, I soon expanded my focus to include genomics and chromatin (the substance within chromosomes comprised of DNA and proteins). Since joining the Center for Autoimmune Genomics and Etiology at Cincinnati Children’s in 2013, I’ve applied theoretical physics methods to study chromatin biology.

Most disease-susceptibility genetic loci are located in regions of the genome that encode regulatory instructions. These instructions influence where and when gene products are produced in human cells. Because chromatin plays an essential role in regulating gene activity, my lab uses genomic and theoretical methods to better understand chromatin dynamics in regulatory regions of the human genome.

I’ve received several awards throughout my career, including a Scholar Award from the Arthritis National Research Foundation (2015).

Research Interests

Genome biology; epigenetics; genetics; autoimmune and inflammatory diseases

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Genomics

Education

MSc: Lomonosov Moscow State University, Moscow, Russia, 1996.

PhD: Stony Brook University, Stony Brook, NY, 2001.

Publications

Genome-wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis. Her, YR; Wang, L; Chepelev, I; Manterola, M; Berkovits, B; Cui, K; Zhao, K; Wolgemuth, DJ. Molecular Reproduction and Development. 2021; 88:141-157.

Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. Li, Y; Liao, Z; Luo, H; Benyoucef, A; Kang, Y; Lai, Q; Dovat, S; Miller, B; Chepelev, I; Li, Y; et al. Nucleic Acids Research. 2020; 48:3119-3133.

Cyclin D1 integrates G9a-mediated histone methylation. Li, Z; Jiao, X; Di Sante, G; Ertel, A; Casimiro, MC; Wang, M; Katiyar, S; Ju, X; Klopfenstein, DV; Tozeren, A; et al. Oncogene. 2019; 38:4232-4249.

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Luo, H; Wang, F; Zha, J; Li, H; Yan, B; Du, Q; Yang, F; Sobh, A; Vulpe, C; Drusbosky, L; et al. Blood. 2018; 132:837-848.