Ajay Dixit, MSc, PhD

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial. Lou, E; Choudhry, MS; Starr, TK; Folsom, TD; Bell, J; Rathmann, B; DeFeo, AP; Kim, J; Slipek, N; Jin, Z; McKenna, DH; Johnson, MJ; Webber, BR; Moriarity, BS. The Lancet Oncology. 2025; 26:559-570.

Abstract A033: Blocking TNF-a producing macrophage activates antitumor immunity in pancreatic cancer via IL33. Dixit, A; Provenzano, P; Sarver, A; Zettervall, J; Huang, H; Zheng, K; Brekken, R. Cancer Research. 2024; 84:a033.

Targeting TNF-α-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling. Dixit, A; Sarver, A; Zettervall, J; Huang, H; Zheng, K; Brekken, RA; Provenzano, PP. JCI insight. 2022; 7:e153242.

Immune Cell Metabolism and Function. Dixit, A; Singh, M. Immuno-Oncology Crosstalk and Metabolism. : Springer Nature; Springer Nature; 2022.

Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Tiwari, A; Tashiro, K; Dixit, A; Soni, A; Vogel, K; Hall, B; Shafqat, I; Slaughter, J; Param, N; Le, A; Deshpande, AJ; Commisso, C; Provenzano, PP; Bagchi, A. Gastroenterology. 2020; 159:1882-1897.e5.