Ajay Dixit, MSc, PhD

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial. Lou, E; Choudhry, MS; Starr, TK; Folsom, TD; Bell, J; Rathmann, B; Defeo, AP; Kim, J; Slipek, N; Jin, Z; Mckenna, DH; Johnson, MJ; Webber, BR; Moriarity, BS. The Lancet Oncology. 2025; 26(5):559-570.

Abstract A033: Blocking TNF-a producing macrophage activates antitumor immunity in pancreatic cancer via IL33. Dixit, A; Provenzano, P; Sarver, A; Zettervall, J; Huang, H; Zheng, K; Brekken, R. Cancer Research. 2024; 84(2_Supplement):a033-a033.

Targeting TNF-α-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling. Dixit, A; Sarver, A; Zettervall, J; Huang, H; Zheng, K; Brekken, RA; Provenzano, PP. JCI Insight. 2022; 7(22).

Immune Cell Metabolism and Function. Dixit, A; Singh, M. In: Immuno-Oncology Crosstalk and Metabolism. Springer Nature; 2022:1-20.

Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Tiwari, A; Tashiro, K; Dixit, A; Soni, A; Vogel, K; Hall, B; Shafqat, I; Slaughter, J; Param, N; Le, A; Deshpande, AJ; Commisso, C; Provenzano, PP; Bagchi, A. Gastroenterology. 2020; 159(5):1882-1897.e5.

Tu1361 Extracellular ATP Promotes Systemic Inflammation During Acute Pancreatitis. Dixit, A; George, J; Cheema, H; Ryu, Y; Dudeja, V; Dawra, R; Saluja, A. Gastroenterology. 2017; 152(5):s896.

Tu1352 Naltrexone as a Disease Modifying Therapy in a Mouse Model of Chronic Pancreatitis. George, J; Modi, S; Dixit, A; Cheema, H; Barlass, U; Dudeja, V; Dawra, R; Roy, S; Saluja, A. Gastroenterology. 2017; 152(5):s893-s894.

Tu1353 Pathogenesis of Chronic Pancreatitis is Independent of Trypsin Activation in L-Arginine Induced Mouse Model of Disease. George, J; Dixit, A; Cheema, H; Giri, B; Dudeja, V; Dawra, R; Saluja, A. Gastroenterology. 2017; 152(5):s894.

Tu1494 Minnelide Reduces Pancreatic Atrophy, Fibrosis and Inflammation in Murine Models of Chronic Pancreatitis. George, J; Modi, S; Giri, B; Dixit, A; Sareen, A; Garg, SK; Yuan, Z; Barlass, U; Dudeja, V; Dawra, R; Saluja, A. Gastroenterology. 2016; 150(4):s916.

Sa1485 Morphine Worsens Pancreatic Injury in Models of Recurrent Acute Pancreatitis. George, J; Modi, S; Barlass, U; Giri, B; Dixit, A; Sareen, A; Yuan, Z; Garg, SK; Roy, S; Dudeja, V; Dawra, R; Saluja, A. Gastroenterology. 2016; 150(4):s328.