A photo of Biplab DasGupta.

Member, Division of Oncology

Professor, UC Department of Pediatrics

513-803-1370

Biography & Affiliation

Biography

My research areas are cancer metabolism and brain tumors. Our work seeks to identify new metabolic targets that could lead to novel and innovative treatments for cancer. We are also examining the molecular links between cancer and diabetes.

I became interested in cancer research during my graduate research courses in biology. In one of my lab’s groundbreaking discoveries, we identified the energy sensor adenosine monophosphate-activated protein (AMP) kinase as an essential gene for glioblastoma pathology. This work was published in Nature Cell Biology. We also performed the first gene-metabolite interactome of diffuse intrinsic pontine glioma (DIPG).

I am honored to have received the Larry E. Kun Achievement in Excellence award, the TeamConnor Childhood Cancer Foundation award (2019) and the Outstanding Achievement Award from Cincinnati Children’s for Brain Tumor Research (2016). I have been a principal investigator for more than 11 years and began working at Cincinnati Children’s in 2009. Work in my laboratory has been continuously supported by grants from the National Institutes of Health and various private foundation grants.

We have published in many well-respected journals, including Nature Cell Biology, PNAS, Nature Communications, Cancer Cell, Cell Reports, Science Advances, Cell Stem Cell, Developmental Cell, Cancer Research, Clinical Cancer Research, Journal of Neuroscience, Neuro-Oncology, and Trends in Pharmacological Sciences, among others.

Research Interests

Metabolism; cancer development

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Oncology, Cancer and Blood Diseases



Education

PhD: Indian Institute of Chemical Biology, Calcutta, 2003.

Postdoctoral Fellowship: Washington University School of Medicine, St. Louis.

Publications

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Blood. 2020; 136:2607-2619.

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; et al. Cell Reports. 2020; 32:108092-108092.

Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes. Sukumaran, A; Choi, K; Dasgupta, B. Frontiers in Cell and Developmental Biology. 2020; 8.

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. Arora, P; Adams, CH; Gudelsky, G; DasGupta, B; Desai, PB. Cancer Chemotherapy and Pharmacology. 2019; 83:81-89.

AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa, RR; Fan, Q; Anderson, J; Muraleedharan, R; Huang, Y; Ciraolo, G; Chen, X; Waclaw, R; Chow, LM; Khuchua, Z; et al. Nature Cell Biology. 2018; 20:823-835.

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma. Sadahiro, H; Kang, K; Gibson, JT; Minata, M; Yu, H; Shi, J; Chhipa, R; Chen, Z; Lu, S; Simoni, Y; et al. Cancer Research. 2018; 78:3002-3013.

Compound C/Dorsomorphin: Its Use and Misuse as an AMPK Inhibitor. Dasgupta, B; Seibel, W. Methods in Molecular Biology. : Springer New York; Springer New York; 2018.

Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. DiStasio, A; Driver, A; Sund, K; Donlin, M; Muraleedharan, RM; Pooya, S; Kline-Fath, B; Kaufman, KM; Prows, CA; Schorry, E; et al. Human Molecular Genetics. 2017; 26:4836-4848.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.