A photo of Biplab DasGupta.

Member, Division of Oncology

Associate Professor, UC Department of Pediatrics

513-803-1370

Biography & Affiliation

Biography

Biplab Dasgupta, PhD, did doctoral research in molecular biology and immunology at Indian Institute of Chemical Biology, Calcutta, and postdoctoral research at Washington University School of Medicine, St. Louis. Dr. Dasgupta joined Cincinnati Children's in 2009 as a tenure track assistant professor of pediatrics within the University of Cincinnati College of Medicine. He rose through the ranks and is now a tenured associate professor of pediatrics. Broadly, he is interested in understanding the mechanisms of cancer development and progression. Using various state-of-the-art techniques and brain tumor as a model, his lab examines cancer stem cell metabolism, bioenergetics, signal transduction and the potential link between and cell-intrinsic and cell-extrinsic factors that influence cancer incidence and penetrance.

Research Interests

Metabolism; cancer development

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Experimental Hematology and Cancer Biology, Oncology, Cancer and Blood Diseases

Science Blog

Education

PhD: Indian Institute of Chemical Biology, Calcutta, 2003.

Postdoctoral Fellowship: Washington University School of Medicine, St. Louis.

Publications

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. Arora, P; Adams, CH; Gudelsky, G; DasGupta, B; Desai, PB. Cancer Chemotherapy and Pharmacology. 2019; 83:81-89.

AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa, RR; Fan, Q; Anderson, J; Muraleedharan, R; Huang, Y; Ciraolo, G; Chen, X; Waclaw, R; Chow, LM; Khuchua, Z; et al. Nature Cell Biology. 2018; 20:823-835.

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma. Sadahiro, H; Kang, K; Gibson, JT; Minata, M; Yu, H; Shi, J; Chhipa, R; Chen, Z; Lu, S; Simoni, Y; et al. Cancer Research. 2018; 78:3002-3013.

Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. DiStasio, A; Driver, A; Sund, K; Donlin, M; Muraleedharan, RM; Pooya, S; Kline-Fath, B; Kaufman, KM; Prows, CA; Schorry, E; et al. Human Molecular Genetics. 2017; 26:4836-4848.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.

FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cheng, P; Wang, J; Waghmare, I; Sartini, S; Coviello, V; Zhang, Z; Kim, S; Mohyeldin, A; Pavlyukov, MS; Minata, M; et al. Cancer Research. 2016; 76:7219-7230.

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Dasgupta, B; Chhipa, RR. Trends in Pharmacological Sciences. 2016; 37:192-206.

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-kappa B-dependent Manner. Kim, S; Ezhilarasan, R; Phillips, E; Gallego-Perez, D; Sparks, A; Taylor, D; Ladner, K; Furuta, T; Sabit, H; Chhipa, R; et al. Cancer Cell. 2016; 29:201-213.

Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Patel, AV; Johansson, G; Colbert, MC; Dasgupta, B; Ratner, N. Neuro-Oncology. 2015; 17:1599-1608.