Tony J. De Falco, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-3988

Email tony.defalco@cchmc.org

Differentiation of the fetal gonad into a sexually dimorphic and structurally specialized organ; spermatogonial differentiation; roles of myeloid cells in tissue remodeling, organ vascularization and spermatogonial development.

Visit the De Falco Lab.

BA: University of Virginia, Charlottesville, VA.

PhD: Johns Hopkins University, Baltimore, MD.

Postdoc: Duke University Medical Center, Durham, NC.

Postdoc: National Institute of Genetics, Mishima, Japan.

View PubMed Publications

Sun X, Ito J, Potter SJ, Dey SK, DeFalco T. Extra-gonadal oocytes residing in the mouse ovarian hilum contribute to fertility. Biol Reprod. 2017;96(5):1060-1070.

Lin YT, Barske L, DeFalco T, Capel B. Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development. 2017;144(9):1607-1618. (This article was featured in an “In This Issue” preview article in the May 1, 2017 issue of Development.)

Potter SJ, DeFalco T. Role of the testis interstitial compartment in spermatogonial stem cell function. Reproduction. 2017;153(4):R151-R162. 

DeFalco T*, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis**. Cell Rep. 2015;12(7):1107-19. (*corresponding author) (**Featured Article on the cover of the August 18th issue of Cell Reports, and also highlighted as a Preview in Cell Reports and as a featured article in the “World of Reproductive Biology” in Biology of Reproduction)

Potter SJ, DeFalco T. Using ex vivo upright droplet cultures of whole fetal organs to study developmental processes during mouse organogenesis. J Vis Exp. 2015;104:e53262.

DeFalco T*, Bhattacharya I, Williams AV, Sams, DM, Capel, B.* Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-2393. (*co-corresponding authors)

DeFalco T, Saraswathula A, Briot A, Iruela-Arispe ML, Capel B. Testosterone levels influence mouse fetal Leydig cell progenitors through Notch signaling. Biol Reprod. 2013 Apr 11;884:91.

Jameson S, Natarajan A, Cool J, DeFalco T, Maatouk D, Mork L, Munger SC, Capel B. Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. PLoS Genet. 2012;8(3):e1002575.

DeFalco T, Takahashi S, Capel B. Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol. 2011 Apr 1;352(1):14-26.

Cool J, DeFalco TJ, Capel B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):167-172.

Macrophage regulation of the spermatogonial stem cell niche. Principal Investigator. National Institutes of Health Maximizing Investigators’ Research Award (MIRA/R35)/National Institute of General Medical Sciences. Sep 2016 - May 2021.