Fred D. Finkelman, MD

Biography & Affiliation Education Publications

Adjunct Professor, UC Department of Internal Medicine; UC Department of Pediatrics

finkelfd@ucmail.uc.edu

Biography & Affiliation

Biography

Dr. Finkelman's group’s contributions to immunology and medicine have focused on the use of mouse models of normal and abnormal immune function. They have included the initial demonstrations that: 1) IL-4 is required for induction of IgE responses in vivo, IFN-γ promotes the induction of IgG2a responses in vivo, and IL-12 suppresses IgE responses in vivo; 2) IL-4, IL-13, IL-4Rα, and Stat6 are required for host protection against intestinal worms, and protect predominantly through effects on intestinal epithelial cells, including induction of RELMβ; 3) inflammatory stimuli are required to induce dendritic cells to present antigen in a stimulatory, rather than a tolerogenic fashion; 4) complement and macrophages are required for development of murine transfusion-related acute lung injury; 5) rapid desensitization with anti-FcεRIα monoclonal antibody is a safe and effective way to rapidly suppress IgE-mediated disorders; and 6) immunoglobulin isotypes that are relatively ineffective in the induction of antibody effector mechanisms protect against inflammatory disease.

In addition, his group has developed three important in vivo techniques: 1) the use of anti-IgD antibodies to stimulate polyclonal B cell and T cell activation and antibody secretion; 2) the use of cytokine/anti-cytokine monoclonal antibody complexes to induce long-lasting increases in cytokine effects; and 3) the in vivo cytokine capture assay for measurement of in vivo cytokine secretion.

Clinical Interests

Internal medicine; rheumatology

Research Interests

Cytokine and antibody roles in disease and host protection.

Academic Affiliation

Adjunct Professor, UC Department of Internal Medicine; UC Department of Pediatrics

Department

Immunobiology

Education

BA: Queens College, Queens, NY, 1967.

MD: Yale University School of Medicine, New Haven, CN, 1971.

Residency: Internal Medicine, Yale-New Haven Hospital, New Haven, CN.

Fellowship: Laboratory of Immunology, NIAID, NIH, Bethesda, MD.

Fellowship: Rheumatology, University of Texas-Southwestern Medical School, Dallas, TX.

Certification: Internal Medicine, 1976; Rheumatology, 1980.

Publications

Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Köhl J, Ehlers M, Stringer K, Shanmukappa SK, Witte D, Hossain MM, Khodoun M, Herr AB, Finkelman FD. IgG1 protects against renal disease in a mouse model of cryoglobulinemia. Nature. 2014.

Khodoun M, Kucuk ZY, Strait RT, Krishnamurthy D, Janek K, Lewkowich IP, Morris SE, Finkelman FD. Rapid polyclonal desensitization with antibodies to IgE and FcεRIα. J Allergy Clin. Immunol. 2013 133(6):1555-64.

Strait RT, Hicks W, Barasa N, Mahler A, Khodoun M, Köhl J, Stringer K, Witte D, Van Rooijen N, Susskind BM, Finkelman FD. MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion related acute lung injury in mice. J Exp Med. 2011 208(12):2525-44.

Herbert, DR, Yang J-Q, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF Jr, Rothenberg ME, Finkelman FD. Intestinal epithelial cell secretion of RELMβ protects against gastrointestinal worm infection. J Exp Med. 2009 206(13):2947-57.

Strait RT, Morris SC, Finkelman FD. IgG blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcγRIIb crosslinking. J Clin Invest. 2006 116(3):833-41.

Morris SC, Madden KB, Adamovicz JJ, Gause WC, Hubbard BR, Gately MK, Finkelman FD. Effects of Interleukin-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol. 1994 152(3):1047-56.

Urban JF Jr, Katona IM, Paul WE, Finkelman FD. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci. USA. 1991 88(13):5513-7.

Finkelman FD, Lees A, Birnbaum R, Gause WC, Morris SC. Dendritic cells can present antigen in vivo in a tolerogenic or an immunogenic fashion. J Immunol. 1996 157(4):1406-14.

Urban JF Jr, Noben-Trauth N, Donaldson DD, Madden KB, Morris SC, Collins M, Finkelman FD. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity. 1998 8(2):255-64.

Finkelman FD, Katona IM, Mosmann TR, Coffman RL. Interferon-γ regulates the isotypes of immunoglobulin secreted during in vivo humoral immune responses.J Immunol. 1988 140(4):1022-7.