A photo of Lin Fei.

Lin Fei, PhD

  • Associate Professor, UC Department of Pediatrics

About

Biography

My research area of interest is biostatistics and involves theoretical aspects of ranking and selection problems. I derived some inequalities that characterize the relationship between sample sizes and the probability of making the correct selection of the best treatment groups. I am also interested in multiple testing problems related to sequential clinical trial designs.

Specifically, my work includes:

  • Statistics
  • Ranking and selection
  • Sequential testing
  • Multiple comparisons
  • Probability modeling
  • Stochastic process inference

I model biological processes such as enzyme reaction rates using exponential approximation, bile duct growth patterns using quantile regression and biochemistry evaluation transition courses.

I have been a researcher for more than 18 years. I began my work at Cincinnati Children’s in 2012. My work has been published in many respected journals, including PLoS ONE, Pediatric Blood and Cancer, Pediatric Critical Care Medicine, Cardiology in the Young, European Journal of Clinical Nutrition, Journal of Pediatric Surgery, Pancreas, Pediatric Obesity and Pediatric Nephrology.

BS: Shanghai Jiaotong University, Shanghai, China, 1982.

MS: The Ohio State University, Columbus, OH, 1984.

PhD: The Ohio State University, Columbus, OH, 1992.

Interests

Statistics; ranking and selection; sequential testing; multiple comparisons; probability modeling; stochastic process inference

Research Areas

Biostatistics and Epidemiology

Publications

Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia. Osborn, J; Mourya, R; Thanekar, U; Su, W; Fei, L; Shivakumar, P; Bezerra, JA. Hepatology Communications. 2021.

Non-Invasive Approaches to Estimate Liver Steatosis and Stiffness in Children with Non-Alcoholic Fatty Liver Disease. Yodoshi, T; Orkin, S; Trout, AT; Arce-Clachar, AC; Bramlage, K; Liu, C; Fei, L; Dillman, JR; Xanthakos, SA; Mouzaki, M. Journal of Pediatric Gastroenterology and Nutrition. 2021.

Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent-perceived general health. Amevor, AA; Yodoshi, T; Trout, AT; Dillman, JR; Singh, R; Jarvis, R; Fei, L; Liu, C; Taylor, A; Miethke, A; et al. Liver International. 2021.

Impedance-based measures of muscle mass can be used to predict severity of hepatic steatosis in pediatric nonalcoholic fatty liver disease. Yodoshi, T; Orkin, S; Romantic, E; Hitchcock, K; Clachar, AC A; Bramlage, K; Sun, Q; Fei, L; Trout, AT; Xanthakos, SA; et al. Nutrition. 2021; 91-92.

Total pancreatectomy with islet autotransplantation reduces resource utilization in pediatric patients. Kassam, AF; Cortez, AR; Johnston, ME; Zang, H; Fei, L; Lin, TK; Abu-El-Haija, M; Nathan, JD. American Journal of Surgery. 2021; 222:786-792.

Effects of Provocative Testing on Phase III Migrating Motor Complex in Children. Damrongmanee, A; El-Chammas, K; Fei, L; Liu, C; Santucci, N; Kaul, A. Journal of Pediatric Gastroenterology and Nutrition. 2021; 73:507-512.

Development and Implementation of Augmented Reality Enhanced High-Fidelity Simulation for Recognition of Patient Decompensation. Zackoff, MW; Cruse, B; Sahay, RD; Fei, L; Saupe, J; Schwartz, J; Klein, M; Geis, GL; Tegtmeyer, K. Simulation in Healthcare. 2021; 16:221-230.

Body composition measured by bioelectrical impedance analysis is a viable alternative to magnetic resonance imaging in children with nonalcoholic fatty liver disease. Orkin, S; Yodoshi, T; Romantic, E; Hitchcock, K; Arce-Clachar, AC; Bramlage, K; Sun, Q; Fei, L; Xanthakos, SA; Trout, AT; et al. Journal of Parenteral and Enteral Nutrition. 2021.

Effect of a Practice-wide Anti-TNF Proactive Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. Lyles, JL; Mulgund, AA; Bauman, LE; Su, W; Fei, L; Chona, DL; Sharma, P; Etter, RK; Hellmann, J; Denson, LA; et al. Inflammatory Bowel Diseases. 2021; 27:482-492.

Establishing Objective Measures of Clinical Competence in Undergraduate Medical Education Through Immersive Virtual Reality. Zackoff, MW; Young, D; Sahay, RD; Fei, L; Real, FJ; Guiot, A; Lehmann, C; Klein, M. Ambulatory Pediatrics. 2021; 21:575-579.