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Andrea M. Gross, MD


  • Director, Neurofibromatosis Program, Division of Oncology
  • Associate Professor, UC Department of Pediatrics

About

Biography

I am an associate professor of pediatrics and the director of the Neurofibromatosis Program within the Division of Oncology. My clinical focus includes neurofibromatosis, plexiform neurofibromas, malignant peripheral nerve sheath tumors and pediatric solid tumors. My research interests center on developmental therapeutics, functional outcome assessments and preventing neurofibromatosis tumor-related morbidity and mortality.

I received my medical degree from the University of Connecticut School of Medicine. I completed my pediatric residency at Cincinnati Children’s, where I also served as chief resident, followed by a fellowship in pediatric hematology/oncology at Children’s National Hospital in Washington, D.C.

BS: University of Connecticut, 2006

MD: University of Connecticut School of Medicine, 2010

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2013

Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2014

Fellowship: Pediatric Hematology / Oncology, Children's National Hospital, 2017

Certifications: General Pediatrics, American Board of Pediatrics, 2013; Pediatric Hematology / Oncology, American Board of Pediatrics, 2019

Interests

Neurofibromatosis; plexiform neurofibromas; malignant peripheral nerve sheath tumors; pediatric solid tumors; clinical research

Services and Specialties

Interests

Developmental therapeutics; functional outcome assessments; prevention of tumor-related morbidity and mortality

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

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Publications

Selected

Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1. Lucas, C-HG; Gross, AM; Romo, CG; Dehner, CA; Lazar, AJ; Miettinen, M; Pekmezci, M; Quezado, M; Rodriguez, FJ; Stemmer-Rachamimov, A; Viskochil, D; Perry, A. Neuro-Oncology. 2025; 27(3):616-624.

Selected

Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial. Gross, AM; O'sullivan Coyne, G; Dombi, E; Tibery, C; Herrick, WG; Martin, S; Angus, SP; Shern, JF; Rhodes, SD; Foster, JC; Srivastava, AK; Doroshow, JH; Chen, AP; Widemann, BC. Nature Medicine. 2025; 31(1):105-115.

Cancer risk in adults with pathogenic germline variants in RAS/MAPK genes using genomic ascertainment. Kim, J; Ney, G; Frone, MN; Haley, JS; Ramos, MLF; Mirshahi, UL; Astiazaran-Symonds, E; Shandrina, M; Urban, G; Rao, HS; Ding, Y; Carey, DJ; Gelb, BD; Stewart, DR. Genetics in Medicine. 2026; 28(6):102561.

Wide Ranging Neurobehavioral Phenotype in Individuals With Costello Syndrome. Curlee, MS; Siegel, A; Little, P; Toledo-Tamula, MA; Martin, S; Gross, AM; Yohe, ME; Aryavand, M; Frone, MN; Ney, GM; Stewart, DR; Wolters, PL. American Journal of Medical Genetics, Part A. 2026; 200(5):1138-1144.

MEK inhibitor-induced dropped head syndrome in pediatrics. Gilene, S; Miller, C; Cronk, JC; Graham, RT; Gross, AM; Hummel, TR; Kotch, C; Mochizuki, AY; Raskin, S; Pillay-Smiley, N; De Blank, P. Neuro-Oncology Pediatrics. 2026; 2(2):wuag024.

Evolution of Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: Opportunities for Prevention and Therapeutic Strategies. Widemann, BC; Gross, AM; Dombi, E; Sankaran, H; Shern, JF. Annual Review of Cancer Biology. 2026; 10(1):223-241.

Abstract 2548: Circulating proteomic signatures for subtyping NF1 associated peripheral nerve sheath tumors. Sachs, CM; Gross, AM; Widemann, BC; Shern, JF; Sundby, RT. Cancer Research. 2026; 86(7_Supplement):2548-2548.

Neurofibromatosis type 1-plexiform neurofibromas: Integrating treatment across pediatric and adult populations. Armstrong, AE; Gross, AM; Klesse, LJ; Rhodes, SD; Ahlawat, S; Staedtke, V; Molina, CA; Hirbe, AC. Neuro-Oncology. 2026; 28(4):847-863.

SARC031: A Phase II Trial of Selumetinib and Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors (MPNST). Kim, A; Ballman, KV; Wolters, PL; Heise, RS; Shern, JF; Sundby, RT; Lindenberg, L; Lee, M-J; Rastogi, S; Sato, N; Gross, AM; Reinke, D; Cichowski, K; Widemann, BC. Clinical Cancer Research. 2026; 32(6):1068-1077.

Rare cancers research: Current state of knowledge and emerging opportunities for prevention and interception. Biswas, K; Ghosh, S; Khincha, PP; Sundby, T; Singh, A; Ault, G; Henderson, M; Gross, AM; Donoghue, M; Savage, SA; Widemann, BC; Shoemaker, RH; Mohammed, A. Journal of the National Cancer Institute. 2026.

Patient Ratings and Comments

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